6YDR
| |
6Y9N
| Crystal structure of Whirlin PDZ3_C-ter in complex with Myosin 15a C-terminal PDZ binding motif peptide | 分子名称: | Unconventional myosin-XV, Whirlin | 著者 | Zhu, Y, Delhommel, F, Haouz, A, Caillet-Saguy, C, Vaney, M, Mechaly, A.E, Wolff, N. | 登録日 | 2020-03-10 | 公開日 | 2020-10-07 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners. J.Mol.Biol., 432, 2020
|
|
6Y9O
| Crystal structure of Whirlin PDZ3_C-ter in complex with CASK internal PDZ binding motif peptide | 分子名称: | Peripheral plasma membrane protein CASK, Whirlin | 著者 | Zhu, Y, Delhommel, F, Haouz, A, Caillet-Saguy, C, Vaney, M, Mechaly, A.E, Wolff, N. | 登録日 | 2020-03-10 | 公開日 | 2020-10-07 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.632 Å) | 主引用文献 | Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners. J.Mol.Biol., 432, 2020
|
|
6FZL
| |
8T83
| |
6YAC
| Plant PSI-ferredoxin supercomplex | 分子名称: | (1~{S})-3,5,5-trimethyl-4-[(1~{E},3~{E},5~{E},7~{E},9~{E},11~{E},13~{E},15~{E},17~{E})-3,7,12,16-tetramethyl-18-[(4~{S})-2,6,6-trimethyl-4-oxidanyl-cyclohexen-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohex-3-en-1-ol, (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, ... | 著者 | Caspy, I, Nelson, N, Shkolnisky, Y, Klaiman, D, Sheinker, A. | 登録日 | 2020-03-12 | 公開日 | 2020-09-30 | 最終更新日 | 2020-10-21 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | The structure of a triple complex of plant photosystem I with ferredoxin and plastocyanin. Nat.Plants, 6, 2020
|
|
6G13
| C-terminal domain of MERS-CoV nucleocapsid | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Nucleoprotein, ... | 著者 | Nguyen, T.H.V, Ferron, F.P, Lichiere, J, Canard, B, Papageorgiou, N, Coutard, B. | 登録日 | 2018-03-20 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein. Acta Crystallogr D Struct Biol, 75, 2019
|
|
6FUI
| Complement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol | 分子名称: | (1~{R},2~{S})-2-[[4-[[3-(aminomethyl)phenyl]amino]quinazolin-2-yl]amino]cyclohexane-1-carboxylic acid, Complement factor D | 著者 | Mac Sweeney, A, Ostermann, N, Vulpetti, A, Maibaum, J, Erbel, P, Lorthiois, E, Yoon, T, Randl, S, Ruedisser, S. | 登録日 | 2018-02-27 | 公開日 | 2018-06-06 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D. ACS Med Chem Lett, 9, 2018
|
|
6YAT
| Crystal structure of STK4 (MST1) in complex with compound 6 | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 4-[5-(3-chlorophenyl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine, GLYCEROL, ... | 著者 | Chaikuad, A, Bata, N, Limpert, A.S, Lambert, L.J, Bakas, N.A, Cosford, N.D.P, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-03-13 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia. J.Med.Chem., 65, 2022
|
|
6YE2
| |
6G4G
| Full length ectodomain of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) including the SMB domains but with a partially disordered active site structure | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Dohler, C, Zebisch, M, Strater, N. | 登録日 | 2018-03-27 | 公開日 | 2018-11-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystallization of ectonucleotide phosphodiesterase/pyrophosphatase-3 and orientation of the SMB domains in the full-length ectodomain. Acta Crystallogr F Struct Biol Commun, 74, 2018
|
|
6G1J
| Phosphotriesterase PTE_C23M_1 | 分子名称: | 1-ethyl-1-methyl-cyclohexane, FORMIC ACID, GLYCEROL, ... | 著者 | Dym, O, Aggarwal, N, Albeck, S, Unger, T, Hamer Rogotner, S, Silman, I, Leader, H, Ashani, Y, Goldsmith, M, Greisen, P, Tawfik, D, Sussman, L.J. | 登録日 | 2018-03-21 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Phosphotriesterase
PTE_C23M_1 To Be Published
|
|
6G1T
| TraN, a repressor of an Enterococcus conjugative type IV secretion system | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AM32, DNA (34-MER) | 著者 | Goessweiner-Mohr, N, Kohler, V, Keller, W. | 登録日 | 2018-03-22 | 公開日 | 2018-07-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | TraN: A novel repressor of an Enterococcus conjugative type IV secretion system. Nucleic Acids Res., 46, 2018
|
|
6YSB
| Crystal structure of Malus domestica Double Bond Reductase (MdDBR) apo form | 分子名称: | 2-alkenal reductase (NADP(+)-dependent)-like, SULFATE ION | 著者 | Caliandro, R, Polsinelli, I, Demitri, N, Benini, S. | 登録日 | 2020-04-21 | 公開日 | 2021-02-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | The structural and functional characterization of Malus domestica double bond reductase MdDBR provides insights towards the identification of its substrates. Int.J.Biol.Macromol., 171, 2021
|
|
6GDI
| Structure of P-glycoprotein(ABCB1) in the post-hydrolytic state | 分子名称: | Multidrug resistance protein 1A | 著者 | Ford, R.C, Thonghin, N, Collins, R.F, Barbieri, A, Shafi, T, Siebert, A. | 登録日 | 2018-04-23 | 公開日 | 2018-05-23 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (7.9 Å) | 主引用文献 | Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9 angstrom resolution. Bmc Struct.Biol., 18, 2018
|
|
8TFT
| Fab of O13-1 human IgG1 antibody bound to IgV domain of human TIM-3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, O-13-1 IgG1 Fab heavy chain, O-13-1 IgG1 Fab light chain, ... | 著者 | Oganesyan, V.Y, van Dyk, N, Mazor, Y, Yang, C. | 登録日 | 2023-07-11 | 公開日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3 To be published
|
|
8TCI
| Crystal structure of DNMT3C-DNMT3L in complex with CGG DNA | 分子名称: | (5'-D(P*CP*AP*TP*G)-R(P*(PYO))-D(P*GP*GP*TP*CP*TP*AP*AP*TP*TP*AP*GP*AP*CP*CP*GP*CP*AP*TP*G)-3'), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3C, ... | 著者 | Khudaverdyan, N, Song, J. | 登録日 | 2023-07-01 | 公開日 | 2024-08-14 | 最終更新日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | The structure of DNA methyltransferase DNMT3C reveals an activity-tuning mechanism for DNA methylation. J.Biol.Chem., 300, 2024
|
|
6FO8
| Vitamin D nuclear receptor complex 4 | 分子名称: | (1~{R},3~{S},5~{Z})-4-methylidene-5-[(~{E})-3-[3-(6-methyl-6-oxidanyl-heptyl)phenyl]non-2-enylidene]cyclohexane-1,3-diol, Nuclear receptor coactivator 1, Vitamin D3 receptor A | 著者 | Rochel, N. | 登録日 | 2018-02-06 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists. J. Med. Chem., 61, 2018
|
|
8T3X
| TNA polymerase, closed ternary | 分子名称: | 10-92, TNA polymerase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Maola, V, Chaput, J, Chim, N. | 登録日 | 2023-06-07 | 公開日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Directed Evolution of a Highly Efficient TNA Polymerase Achieved by Homologous Recombination To Be Published
|
|
8TBB
| F9S, novel TIM-3 targeting antibody, bound to IgV domain of TIM-3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, F9S Fab heavy chain, F9S Fab light chain, ... | 著者 | Oganesyan, V, van Dyk, N, Mazor, Y, Yang, C. | 登録日 | 2023-06-28 | 公開日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3 To be published
|
|
5VKG
| Solution-state NMR structural ensemble of human Tsg101 UEV in complex with tenatoprazole | 分子名称: | 4-methoxy-1-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)-3,5-dimethyl-2-(sulfanylmethyl)pyridin-1-ium, Tumor susceptibility gene 101 protein | 著者 | Strickland, M, Ehrlich, L.S, Watanabe, S, Khan, M, Strub, M.-P, Luan, C.H, Powell, M.D, Leis, J, Tjandra, N, Carter, C. | 登録日 | 2017-04-21 | 公開日 | 2017-11-15 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Tsg101 chaperone function revealed by HIV-1 assembly inhibitors. Nat Commun, 8, 2017
|
|
6FRZ
| Phosphotriesterase PTE_A53_7 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-methylcyclohexane-1,1,3,3-tetrol, DI(HYDROXYETHYL)ETHER, ... | 著者 | Dym, O, Aggarwal, N, Albeck, S, Unger, T, Hamer Rogotner, S, Silman, I, Leader, H, Ashani, Y, Goldsmith, M, Greisen, P, Tawfik, D, Sussman, L.J. | 登録日 | 2018-02-18 | 公開日 | 2019-03-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Phosphotriesterase
PTE_A53_7 To Be Published
|
|
6FSD
| Mus musculus acetylcholinesterase in complex with 2-(4-Biphenylyloxy)-N-[3-(1-piperidinyl)propyl]-acetamide hydrochloride (10) | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 2-(4-phenylphenoxy)-~{N}-(3-piperidin-1-ylpropyl)ethanamide, ... | 著者 | Knutsson, S, Engdahl, C, Kumari, R, Kindahl, T, Forsgren, N, Lindgren, C, Kitur, S, Kamau, L, Ekstrom, F, Linusson, A. | 登録日 | 2018-02-19 | 公開日 | 2018-10-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Noncovalent Inhibitors of Mosquito Acetylcholinesterase 1 with Resistance-Breaking Potency. J.Med.Chem., 61, 2018
|
|
5WEJ
| 1.95 A resolution structure of Norovirus 3CL protease in complex with a dipeptidyl oxazolidinone-based inhibitor | 分子名称: | (2S)-2-{(5S)-5-[(3-chlorophenyl)methyl]-2-oxo-1,3-oxazolidin-3-yl}-4-methyl-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}pentanamide, Genome polyprotein | 著者 | Lovell, S, Battaile, K.P, Mehzabeen, N, Damalanka, V.C, Kim, Y, Kankanamalage, A.C.G, Rathnayake, A.D, Nguyen, H.N, Chang, K.O, Groutas, W.C. | 登録日 | 2017-07-10 | 公開日 | 2017-12-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease. Eur J Med Chem, 143, 2017
|
|
5WCW
| Phosphotriesterase variant S3 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase, ... | 著者 | Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N. | 登録日 | 2017-07-02 | 公開日 | 2019-01-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.457 Å) | 主引用文献 | Phosphotriesterase variant S4 To Be Published
|
|