7MRU
 
 | | Crystal structure of S62A MIF2 mutant | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, D-dopachrome decarboxylase | | 著者 | Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E. | | 登録日 | 2021-05-09 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | | 主引用文献 | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
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7MSE
 | | High-resolution crystal structure of hMIF2 with tartrate at the active site | | 分子名称: | D-dopachrome decarboxylase, L(+)-TARTARIC ACID | | 著者 | Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E. | | 登録日 | 2021-05-11 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | | 主引用文献 | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
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7MRV
 | | F100A mutant structure of MIF2 (D-DT) | | 分子名称: | D-dopachrome decarboxylase, SULFATE ION | | 著者 | Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E. | | 登録日 | 2021-05-09 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
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4A71
 | | cytochrome c peroxidase in complex with phenol | | 分子名称: | CYTOCHROME C PEROXIDASE, MITOCHONDRIAL, PHENOL, ... | | 著者 | Murphy, E.J, Metcalfe, C.L, Raven, E.L, Moody, P.C.E. | | 登録日 | 2011-11-10 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Crystal Structure of Guaiacol and Phenol Bound to a Heme Peroxidase.
FEBS J., 279, 2012
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4A6Z
 | | Cytochrome c peroxidase with bound guaiacol | | 分子名称: | CYTOCHROME C PEROXIDASE, MITOCHONDRIAL, Guaiacol, ... | | 著者 | Murphy, E.J, Metcalfe, C.L, Nnamchi, C, Raven, E.L, Moody, P.C.E. | | 登録日 | 2011-11-10 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Crystal Structure of Guaiacol and Phenol Bound to a Heme Peroxidase.
FEBS J., 279, 2012
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4A78
 | | cytochrome c peroxidase M119W in complex with guiacol | | 分子名称: | CYTOCHROME C PEROXIDASE, MITOCHONDRIAL, Guaiacol, ... | | 著者 | Murphy, E.J, Metcalfe, C.L, Raven, E.L, Moody, P.C.E. | | 登録日 | 2011-11-11 | | 公開日 | 2012-11-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Crystal Structure of Guaiacol and Phenol Bound to a Heme Peroxidase.
FEBS J., 279, 2012
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4A7M
 | | cytochrome c peroxidase S81W mutant | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, CYTOCHROME C PEROXIDASE, MITOCHONDRIAL, ... | | 著者 | Murphy, E.J, Metcalfe, C.L, Raven, E.L, Moody, P.C.E. | | 登録日 | 2011-11-14 | | 公開日 | 2012-11-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Crystal Structure of Guaiacol and Phenol Bound to a Heme Peroxidase.
FEBS J., 279, 2012
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2X08
 | | cytochrome c peroxidase: ascorbate bound to the engineered ascorbate binding site | | 分子名称: | ASCORBIC ACID, CYTOCHROME C PEROXIDASE, MITOCHONDRIAL, ... | | 著者 | Murphy, E.J, Metcalfe, C.L, Gumiero, A, Raven, E.L, Moody, P.C.E. | | 登録日 | 2009-12-07 | | 公開日 | 2010-11-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Engineering the substrate specificity and reactivity of a heme protein: creation of an ascorbate binding site in cytochrome c peroxidase.
Biochemistry, 47, 2008
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2X07
 | | cytochrome c peroxidase: engineered ascorbate binding site | | 分子名称: | Cytochrome c peroxidase, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Murphy, E.J, Metcalfe, C.L, Gumiero, A, Raven, E.L, Moody, P.C.E. | | 登録日 | 2009-12-07 | | 公開日 | 2010-11-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Engineering the substrate specificity and reactivity of a heme protein: creation of an ascorbate binding site in cytochrome c peroxidase.
Biochemistry, 47, 2008
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4KVB
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4FQT
 | | Structure of AgamOBP1 Bound to 6-methyl-5-hepten-2-one | | 分子名称: | 6-methylhept-5-en-2-one, Anopheles Gambiae Odorant Binding protein 1, TETRAETHYLENE GLYCOL | | 著者 | Murphy, E.J, Booth, J.C. | | 登録日 | 2012-06-25 | | 公開日 | 2013-01-02 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Interactions of Anopheles gambiae Odorant-binding Proteins with a Human-derived Repellent: IMPLICATIONS FOR THE MODE OF ACTION OF N,N-DIETHYL-3-METHYLBENZAMIDE (DEET).
J.Biol.Chem., 288, 2013
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8UDU
 | | The X-RAY co-crystal structure of human FGFR3 and Compound 17 | | 分子名称: | 3-[(6-chloro-1-cyclopropyl-1H-benzimidazol-5-yl)ethynyl]-1-[(3S,5S)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)-1H-pyrazole-4-carboxamide, CHLORIDE ION, Fibroblast growth factor receptor 3 | | 著者 | Tyhonas, J.S, Arnold, L.D, Cox, J, Franovic, A, Gardiner, E, Grandinetti, K, Kania, R, Kanouni, T, Lardy, M, Li, C, Martin, E.S, Miller, N, Mohan, A, Murphy, E.A, Perez, M, Soroceanu, L, Timple, N, Uryu, S, Womble, S, Kaldor, S.W. | | 登録日 | 2023-09-29 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.737 Å) | | 主引用文献 | Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
J.Med.Chem., 67, 2024
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8UDT
 | | The X-RAY co-crystal structure of human FGFR3 and KIN-3248 | | 分子名称: | 3-[(1-cyclopropyl-4,6-difluoro-1H-benzimidazol-5-yl)ethynyl]-1-[(3R,5R)-5-(methoxymethyl)-1-propanoylpyrrolidin-3-yl]-5-(methylamino)-1H-pyrazole-4-carboxamide, D-MALATE, Fibroblast growth factor receptor 3 | | 著者 | Tyhonas, J.S, Arnold, L.D, Cox, J, Franovic, A, Gardiner, E, Grandinetti, K, Kania, R, Kanouni, T, Lardy, M, Li, C, Martin, E.S, Miller, N, Mohan, A, Murphy, E.A, Perez, M, Soroceanu, L, Timple, N, Uryu, S, Womble, S, Kaldor, S.W. | | 登録日 | 2023-09-29 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.829 Å) | | 主引用文献 | Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
J.Med.Chem., 67, 2024
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7MW7
 | | Crystal structure of P1G mutant of D-dopachrome tautomerase | | 分子名称: | D-dopachrome decarboxylase, SODIUM ION, SULFATE ION | | 著者 | Manjula, R, Murphy, E.L, Murphy, J.W, Lolis, E. | | 登録日 | 2021-05-15 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
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4DR6
 | | Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, near-cognate transfer RNA anticodon stem-loop mismatched at the first codon position and streptomycin bound | | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. | | 登録日 | 2012-02-16 | | 公開日 | 2012-11-14 | | 最終更新日 | 2013-01-30 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | A structural basis for streptomycin-induced misreading of the genetic code.
Nat Commun, 4, 2013
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4DR2
 | | Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with multiple copies of paromomycin molecules bound | | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. | | 登録日 | 2012-02-16 | | 公開日 | 2012-11-14 | | 最終更新日 | 2013-01-30 | | 実験手法 | X-RAY DIFFRACTION (3.249 Å) | | 主引用文献 | A structural basis for streptomycin-induced misreading of the genetic code.
Nat Commun, 4, 2013
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4DR3
 | | Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with streptomycin bound | | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. | | 登録日 | 2012-02-16 | | 公開日 | 2012-11-14 | | 最終更新日 | 2013-01-30 | | 実験手法 | X-RAY DIFFRACTION (3.348 Å) | | 主引用文献 | A structural basis for streptomycin-induced misreading of the genetic code.
Nat Commun, 4, 2013
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4DR5
 | | Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, crystallographically disordered cognate transfer RNA anticodon stem-loop and streptomycin bound | | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. | | 登録日 | 2012-02-16 | | 公開日 | 2012-11-14 | | 最終更新日 | 2013-01-30 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | A structural basis for streptomycin-induced misreading of the genetic code.
Nat Commun, 4, 2013
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4DR4
 | | Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, cognate transfer RNA anticodon stem-loop and multiple copies of paromomycin molecules bound | | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. | | 登録日 | 2012-02-16 | | 公開日 | 2012-11-14 | | 最終更新日 | 2013-01-30 | | 実験手法 | X-RAY DIFFRACTION (3.969 Å) | | 主引用文献 | A structural basis for streptomycin-induced misreading of the genetic code.
Nat Commun, 4, 2013
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4DR7
 | | Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, crystallographically disordered near-cognate transfer RNA anticodon stem-loop mismatched at the second codon position, and streptomycin bound | | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. | | 登録日 | 2012-02-16 | | 公開日 | 2012-11-14 | | 最終更新日 | 2013-01-30 | | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | | 主引用文献 | A structural basis for streptomycin-induced misreading of the genetic code.
Nat Commun, 4, 2013
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4DR1
 | | Crystal structure of the apo 30S ribosomal subunit from Thermus thermophilus (HB8) | | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. | | 登録日 | 2012-02-16 | | 公開日 | 2012-11-14 | | 最終更新日 | 2013-01-30 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | A structural basis for streptomycin-induced misreading of the genetic code.
Nat Commun, 4, 2013
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4DV6
 | | Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, A915G | | 分子名称: | 16S rRNA, MAGNESIUM ION, ZINC ION, ... | | 著者 | Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. | | 登録日 | 2012-02-22 | | 公開日 | 2013-02-27 | | 実験手法 | X-RAY DIFFRACTION (3.297 Å) | | 主引用文献 | A structural basis for streptomycin resistance
To be Published
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4DV0
 | | Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, U20G | | 分子名称: | 16S rRNA, MAGNESIUM ION, ZINC ION, ... | | 著者 | Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. | | 登録日 | 2012-02-22 | | 公開日 | 2013-02-27 | | 実験手法 | X-RAY DIFFRACTION (3.853 Å) | | 主引用文献 | A structural basis for streptomycin resistance
To be Published
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4DV1
 | | Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, U20G, bound with streptomycin | | 分子名称: | 16S rRNA, MAGNESIUM ION, STREPTOMYCIN, ... | | 著者 | Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. | | 登録日 | 2012-02-22 | | 公開日 | 2013-02-27 | | 実験手法 | X-RAY DIFFRACTION (3.849 Å) | | 主引用文献 | A structural basis for streptomycin resistance
To be Published
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4DV7
 | | Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, A915G, bound with streptomycin | | 分子名称: | 16S rRNA, MAGNESIUM ION, STREPTOMYCIN, ... | | 著者 | Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. | | 登録日 | 2012-02-22 | | 公開日 | 2013-02-27 | | 実験手法 | X-RAY DIFFRACTION (3.294 Å) | | 主引用文献 | A structural basis for streptomycin resistance
To be Published
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