1XX1
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![BU of 1xx1 by Molmil](/molmil-images/mine/1xx1) | Structural basis for ion-coordination and the catalytic mechanism of sphingomyelinases D | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MAGNESIUM ION, SULFATE ION, ... | Authors: | Murakami, M.T, Tambourgi, D.V, Arni, R.K. | Deposit date: | 2004-11-03 | Release date: | 2005-01-18 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases d J.Biol.Chem., 280, 2005
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1ZLB
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![BU of 1zlb by Molmil](/molmil-images/mine/1zlb) | Crystal structure of catalytically-active phospholipase A2 in the absence of calcium | Descriptor: | hypotensive phospholipase A2 | Authors: | Murakami, M.T, Cintra, A.C, Gabdoulkhakov, A, Genov, N, Betzel, C, Arni, R.K. | Deposit date: | 2005-05-05 | Release date: | 2006-04-25 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (0.97 Å) | Cite: | Insights into metal ion binding in phospholipases A(2): ultra high-resolution crystal structures of an acidic phospholipase A(2) in the Ca(2+) free and bound states. Biochimie, 88, 2006
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1ZL7
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![BU of 1zl7 by Molmil](/molmil-images/mine/1zl7) | Crystal structure of catalytically-active phospholipase A2 with bound calcium | Descriptor: | CALCIUM ION, GLYCEROL, hypotensive phospholipase A2 | Authors: | Murakami, M.T, Cintra, A.C, Gabdoulkhakov, A, Genov, N, Betzel, C, Arni, R.K. | Deposit date: | 2005-05-05 | Release date: | 2006-04-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Insights into metal ion binding in phospholipases A(2): ultra high-resolution crystal structures of an acidic phospholipase A(2) in the Ca(2+) free and bound states. Biochimie, 88, 2006
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1XXN
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![BU of 1xxn by Molmil](/molmil-images/mine/1xxn) | Crystal structure of a mesophilic xylanase A from Bacillus subtilis 1A1 | Descriptor: | Endo-1,4-beta-xylanase A, S,R MESO-TARTARIC ACID | Authors: | Murakami, M.T, Ruller, R, Ward, R.J, Arni, R.K. | Deposit date: | 2004-11-07 | Release date: | 2005-10-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Correlation of temperature induced conformation change with optimum catalytic activity in the recombinant G/11 xylanase A from Bacillus subtilis strain 168 (1A1). Febs Lett., 579, 2005
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1Y4L
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![BU of 1y4l by Molmil](/molmil-images/mine/1y4l) | Crystal structure of Bothrops asper myotoxin II complexed with the anti-trypanosomal drug suramin | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID, ISOPROPYL ALCOHOL, ... | Authors: | Murakami, M.T, Arruda, E.Z, Melo, P.A, Martinez, A.B, Calil-Elias, S, Tomaz, M.A, Lomonte, B, Gutierrez, J.M, Arni, R.K. | Deposit date: | 2004-12-01 | Release date: | 2005-06-28 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Inhibition of Myotoxic Activity of Bothrops asper Myotoxin II by the Anti-trypanosomal Drug Suramin. J.Mol.Biol., 350, 2005
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2AIP
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![BU of 2aip by Molmil](/molmil-images/mine/2aip) | |
2AIQ
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![BU of 2aiq by Molmil](/molmil-images/mine/2aiq) | |
2PH4
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![BU of 2ph4 by Molmil](/molmil-images/mine/2ph4) | Crystal structure of a novel Arg49 phospholipase A2 homologue from Zhaoermia mangshanensis venom | Descriptor: | DI(HYDROXYETHYL)ETHER, SULFATE ION, Zhaoermiatoxin | Authors: | Murakami, M.T, Kuch, U, Mebs, D, Arni, R.K. | Deposit date: | 2007-04-10 | Release date: | 2008-03-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of a novel myotoxic Arg49 phospholipase A(2) homolog (zhaoermiatoxin) from Zhaoermia mangshanensis snake venom: Insights into Arg49 coordination and the role of Lys122 in the polarization of the C-terminus. Toxicon, 51, 2008
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2F9R
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![BU of 2f9r by Molmil](/molmil-images/mine/2f9r) | Crystal structure of the inactive state of the Smase I, a sphingomyelinase D from Loxosceles laeta venom | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MAGNESIUM ION, Sphingomyelinase D 1 | Authors: | Murakami, M.T, Gabdoulkhakov, A, Fernandes-Pedrosa, M.F, Betzel, C, Tambourgi, D.V, Arni, R.K. | Deposit date: | 2005-12-06 | Release date: | 2006-06-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases D. J.Biol.Chem., 280, 2005
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2H9E
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![BU of 2h9e by Molmil](/molmil-images/mine/2h9e) | Crystal Structure of FXa/selectide/NAPC2 ternary complex | Descriptor: | ACETATE ION, Anti-coagulant protein C2, Coagulation factor X heavy chain, ... | Authors: | Murakami, M.T, Geiger, G, Tulinsky, A, Arni, R.K. | Deposit date: | 2006-06-09 | Release date: | 2007-02-13 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Intermolecular Interactions and Characterization of the Novel Factor Xa Exosite Involved in Macromolecular Recognition and Inhibition: Crystal Structure of Human Gla-domainless Factor Xa Complexed with the Anticoagulant Protein NAPc2 from the Hematophagous Nematode Ancylostoma caninum. J.Mol.Biol., 366, 2007
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2H8U
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2H8I
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1UMR
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![BU of 1umr by Molmil](/molmil-images/mine/1umr) | Crystal structure of the platelet activator convulxin, a disulfide linked a4b4 cyclic tetramer from the venom of Crotalus durissus terrificus | Descriptor: | CONVULXIN ALPHA, CONVULXIN BETA | Authors: | Murakami, M.T, Zela, S.P, Gava, L.M, Michelan-Duarte, S, Cintra, A.C.O, Arni, R.K. | Deposit date: | 2003-08-28 | Release date: | 2003-11-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of the Platelet Activator Convulxin, a Disulfide Linked A4B4 Cyclic Tetramer from the Venom of Crotalus Durissus Terrificus Biochem.Biophys.Res.Commun., 310, 2003
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1UMV
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![BU of 1umv by Molmil](/molmil-images/mine/1umv) | Crystal structure of an acidic, non-myotoxic phospholipase A2 from the venom of Bothrops jararacussu | Descriptor: | CALCIUM ION, HYPOTENSIVE PHOSPHOLIPASE A2 | Authors: | Murakami, M.T, Watanabe, L, Cintra, A.C.O, Arni, R.K. | Deposit date: | 2003-08-28 | Release date: | 2003-09-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Crystal Structure of an Acidic Platelet Aggregation Inhibitor and Hypotensive Phospholipase A(2) in the Monomeric and Dimeric States: Insights Into its Oligomeric State Biochem.Biophys.Res.Commun., 323, 2004
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4E2B
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![BU of 4e2b by Molmil](/molmil-images/mine/4e2b) | High resolution crystal structure of the old yellow enzyme from Trypanosoma cruzi | Descriptor: | DI(HYDROXYETHYL)ETHER, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Murakami, M.T, Rodrigues, N.C, Gava, L.M, Canduri, F, Oliva, G, Barbosa, L.R.S, Borgers, J.C. | Deposit date: | 2012-03-08 | Release date: | 2013-03-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.269 Å) | Cite: | High resolution crystal structure and in solution studies of the old yellow enzyme from Trypanosoma cruzi: Insights into oligomerization, enzyme dynamics and specificity To be Published
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4E2D
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![BU of 4e2d by Molmil](/molmil-images/mine/4e2d) | Structure of the old yellow enzyme from Trypanosoma cruzi | Descriptor: | DIMETHYL SULFOXIDE, FLAVIN MONONUCLEOTIDE, Old Yellow Protein | Authors: | Murakami, M.T, Rodrigues, N.C, Gava, L.M, Canduri, F, Oliva, G, Barbosa, L.R.S, Borgers, J.C. | Deposit date: | 2012-03-08 | Release date: | 2013-03-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.997 Å) | Cite: | High resolution crystal structure and in solution studies of the Old Yellow Enzyme from Trypanosoma cruzi: Insights into oligomerization, enzyme dynamics and specificity To be Published
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4GSO
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![BU of 4gso by Molmil](/molmil-images/mine/4gso) | structure of Jararacussin-I | Descriptor: | Thrombin-like enzyme BjussuSP-1 | Authors: | Ullah, A, Souza, T.C.A.B, Zanphorlin, L.M, Mariutti, R, Sanata, S.V, Murakami, M.T, Arni, R.K. | Deposit date: | 2012-08-28 | Release date: | 2012-12-12 | Last modified: | 2013-01-02 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of Jararacussin-I: The highly negatively charged catalytic interface contributes to macromolecular selectivity in snake venom thrombin-like enzymes. Protein Sci., 22, 2013
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4W7V
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4W85
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![BU of 4w85 by Molmil](/molmil-images/mine/4w85) | Crystal structure of XEG5A, a GH5 xyloglucan-specific endo-beta-1,4-glucanase from ruminal metagenomic library, in complex with glucose | Descriptor: | MAGNESIUM ION, Xyloglucan-specific endo-beta-1,4-glucanase, beta-D-glucopyranose | Authors: | Santos, C.R, Cordeiro, R.L, Wong, D.W.S, Murakami, M.T. | Deposit date: | 2014-08-22 | Release date: | 2015-03-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural Basis for Xyloglucan Specificity and alpha-d-Xylp(1 6)-d-Glcp Recognition at the -1 Subsite within the GH5 Family. Biochemistry, 54, 2015
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4W8A
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![BU of 4w8a by Molmil](/molmil-images/mine/4w8a) | Crystal structure of XEG5B, a GH5 xyloglucan-specific beta-1,4-glucanase from ruminal metagenomic library, in the native form | Descriptor: | Exo-xyloglucanase, GLYCEROL, SULFATE ION | Authors: | Santos, C.R, Cordeiro, R.L, Wong, D.W.S, Murakami, M.T. | Deposit date: | 2014-08-22 | Release date: | 2015-03-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Structural Basis for Xyloglucan Specificity and alpha-d-Xylp(1 6)-d-Glcp Recognition at the -1 Subsite within the GH5 Family. Biochemistry, 54, 2015
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4W84
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![BU of 4w84 by Molmil](/molmil-images/mine/4w84) | Crystal structure of XEG5A, a GH5 xyloglucan-specific endo-beta-1,4-glucanase from ruminal metagenomic library, in the native form | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, Xyloglucan-specific endo-beta-1,4-glucanase | Authors: | Santos, C.R, Cordeiro, R.L, Wong, D.W.S, Murakami, M.T. | Deposit date: | 2014-08-22 | Release date: | 2015-03-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structural Basis for Xyloglucan Specificity and alpha-d-Xylp(1 6)-d-Glcp Recognition at the -1 Subsite within the GH5 Family. Biochemistry, 54, 2015
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8D89
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![BU of 8d89 by Molmil](/molmil-images/mine/8d89) | Crystal structure of a novel GH5 enzyme retrieved from capybara gut metagenome | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Martins, M.P, Morais, M.A.B, Murakami, M.T. | Deposit date: | 2022-06-08 | Release date: | 2022-11-02 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Glycoside hydrolase subfamily GH5_57 features a highly redesigned catalytic interface to process complex hetero-beta-mannans. Acta Crystallogr D Struct Biol, 78, 2022
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7OVA
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![BU of 7ova by Molmil](/molmil-images/mine/7ova) | Crystal structure of an AA9 LPMO | Descriptor: | (2S)-2-hydroxybutanedioic acid, COPPER (II) ION, Endoglucanase, ... | Authors: | Males, A, Correa, T.L.R, Murakami, M.T, Walton, P.H, Davies, G.J. | Deposit date: | 2021-06-14 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structure of an AA9 LPMO To Be Published
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3KVE
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![BU of 3kve by Molmil](/molmil-images/mine/3kve) | Structure of native L-amino acid oxidase from Vipera ammodytes ammodytes: stabilization of the quaternary structure by divalent ions and structural changes in the dynamic active site | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, L-amino acid oxidase, ... | Authors: | Gergiova, D, Murakami, M.T, Perbandt, M, Arni, R.K, Betzel, C. | Deposit date: | 2009-11-30 | Release date: | 2010-10-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Structure of native L-amino acid oxidase from Vipera ammodytes ammodytes: stabilization of the quaternary structure by divalent ions and structural changes in the dynamic active site To be Published
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6UB3
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![BU of 6ub3 by Molmil](/molmil-images/mine/6ub3) | Crystal structure of a GH128 (subgroup IV) endo-beta-1,3-glucanase from Lentinula edodes (LeGH128_IV) with laminaribiose at the surface-binding site | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, SULFATE ION, ... | Authors: | Santos, C.R, Lima, E.A, Mandelli, F, Murakami, M.T. | Deposit date: | 2019-09-11 | Release date: | 2020-05-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural insights into beta-1,3-glucan cleavage by a glycoside hydrolase family. Nat.Chem.Biol., 16, 2020
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