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PDB: 19 件
4J03
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Crystal structure of human soluble epoxide hydrolase complexed with fulvestrant
分子名称: (7beta,9beta,13alpha,17beta)-7-{9-[(R)-(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17-diol, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ...
著者Morisseau, C, Pakhomova, S, Hwang, S.H, Newcomer, M.E, Hammock, B.D.
登録日2013-01-30
公開日2013-06-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides.
Bioorg.Med.Chem.Lett., 23, 2013
1VJ5
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Human soluble Epoxide Hydrolase- N-cyclohexyl-N'-(4-iodophenyl)urea complex
分子名称: HEXAETHYLENE GLYCOL, MAGNESIUM ION, N-CYCLOHEXYL-N'-(4-IODOPHENYL)UREA, ...
著者Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
登録日2004-02-03
公開日2004-04-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
Biochemistry, 43, 2004
1S8O
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Human soluble Epoxide Hydrolase
分子名称: HEXAETHYLENE GLYCOL, epoxide hydrolase 2, cytoplasmic
著者Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
登録日2004-02-03
公開日2004-04-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
Biochemistry, 43, 2004
6N3K
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Crystal structure of an epoxide hydrolase from Trichoderma reesei in complex with inhibitor 1
分子名称: Epoxide hydrolase, N-{cis-4-[(2,6-difluorophenyl)methoxy]cyclohexyl}-N'-(3-phenylpropyl)urea
著者de Oliveira, G.S, Adriani, P.P, Ribeiro, J.A, Morisseau, C, Hammock, B.D, Dias, M.V, Chambergo, F.S.
登録日2018-11-15
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.
Int. J. Biol. Macromol., 129, 2019
6AUM
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Crystal structure of human soluble epoxide hydrolase complexed with trans-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]-benzoic acid.
分子名称: 4-{[trans-4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)cyclohexyl]oxy}benzoic acid, Bifunctional epoxide hydrolase 2, CHLORIDE ION, ...
著者Kodani, S.D, Bahkta, S, Hwang, S.H, Pakhomova, S, Newcomer, M.E, Morisseau, C, Hammock, B.
登録日2017-09-01
公開日2018-02-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.
Bioorg. Med. Chem. Lett., 28, 2018
4OD0
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Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
分子名称: 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ...
著者Lee, K.S.S, Liu, J, Wagner, K.M, Pakhomova, S, Dong, H, Morisseau, C, Fu, S.H, Yang, J, Wang, P, Ulu, A, Mate, C, Nguyen, L, Wullf, H, Eldin, M.L, Mara, A.A, Newcomer, M.E, Zeldin, D.C, Hammock, B.D.
登録日2014-01-09
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
J.Med.Chem., 57, 2014
1CR6
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CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CPU INHIBITOR
分子名称: EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-(PROPYL)PHENYL UREA
著者Argiriadi, M.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
登録日1999-08-13
公開日1999-11-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase.
Proc.Natl.Acad.Sci.USA, 96, 1999
1EK1
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CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CIU INHIBITOR
分子名称: EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-(4-IODOPHENYL)UREA
著者Argiriadi, M.A, Morisseau, C, Goodrow, M.H, Dowdy, D.L, Hammock, B.D, Christianson, D.W.
登録日2000-03-06
公開日2000-05-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation.
J.Biol.Chem., 275, 2000
1EK2
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CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CDU INHIBITOR
分子名称: EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-DECYLUREA
著者Argiriadi, M.A, Morisseau, C, Goodrow, M.H, Dowdy, D.L, Hammock, B.D, Christianson, D.W.
登録日2000-03-06
公開日2000-05-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation.
J.Biol.Chem., 275, 2000
1ZD2
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Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-ethanoic acid complex
分子名称: MAGNESIUM ION, N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE, PHOSPHATE ION, ...
著者Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
登録日2005-04-14
公開日2006-03-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
1ZD5
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Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-heptanoic acid complex
分子名称: 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
著者Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
登録日2005-04-14
公開日2006-03-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
1ZD4
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Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-hexanoic acid complex
分子名称: 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
著者Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
登録日2005-04-14
公開日2006-03-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
1ZD3
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Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-butyric acid complex
分子名称: 4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
著者Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
登録日2005-04-14
公開日2006-03-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
6N3Z
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Crystal structure of an epoxide hydrolase from Trichoderma reesei in complex with inhibitor 4
分子名称: Epoxide hydrolase TrEH, N-methyl-4-{[trans-4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)cyclohexyl]oxy}benzamide
著者de Oliveira, G.S, Adriani, P.P, Ribeiro, J.A, Morisseau, C, Hammock, B.D, Dias, M.V, Chambergo, F.S.
登録日2018-11-16
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.238 Å)
主引用文献The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.
Int. J. Biol. Macromol., 129, 2019
6N5H
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Crystal structure of an epoxide hydrolase from Trichoderma reesei in complex with inhibitor 5
分子名称: 4-[(trans-4-{[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylcarbamoyl]amino}cyclohexyl)oxy]benzoic acid, Epoxide hydrolase TrEH
著者Oliveira, G.S, Adriano, P.P, Ribeiro, J.A, Morisseau, C, Hammock, B.D, Dias, M.V, Chambergo, F.S.
登録日2018-11-21
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.717 Å)
主引用文献The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors
Int. J. Biol. Macromol., 129, 2019
6N5F
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Crystal structure of an epoxide hydrolase from Trichoderma reesei in complex with inhibitor 3
分子名称: Epoxide hydrolase TrEH, N-(8-amino-8-oxooctyl)nonanamide
著者Oliveira, G.S, Adriani, P.P, Ribeiro, J.A, Morisseau, C, Hammock, B.D, Dias, M.V, Chambergo, F.S.
登録日2018-11-21
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.
Int. J. Biol. Macromol., 129, 2019
6N5G
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Crystal structure of an epoxide hydrolase from Trichoderma reesei in complex with inhibitor 2
分子名称: 4-[(quinolin-3-yl)methyl]-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide, Epoxide hydrolase TrEH
著者Oliveira, G.S, Adriani, P.P, Ribeiro, J.A, Morisseau, C, Hammock, B.D, Dias, M.V, Chambergo, F.S.
登録日2018-11-21
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.
Int. J. Biol. Macromol., 129, 2019
1CQZ
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CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE.
分子名称: EPOXIDE HYDROLASE
著者Argiriadi, M.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
登録日1999-08-12
公開日1999-11-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase.
Proc.Natl.Acad.Sci.USA, 96, 1999
4HAI
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Crystal structure of human soluble epoxide hydrolase complexed with N-cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide.
分子名称: Bifunctional epoxide hydrolase 2, MAGNESIUM ION, N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide, ...
著者Pecic, S, Pakhomova, S, Newcomer, M.E, Morisseau, C, Hammock, B.D, Zhu, Z, Deng, S.
登録日2012-09-26
公開日2012-12-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013

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