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PDB: 21 件
1CFJ
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BU of 1cfj by Molmil
METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ISOPROPYLMETHYLPHOSPHONOFLUORIDATE (GB, SARIN)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, METHYLPHOSPHONIC ACID ESTER GROUP, PROTEIN (ACETYLCHOLINESTERASE)
著者Millard, C.B, Silman, I, Sussman, J.L.
登録日1999-03-19
公開日1999-06-25
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry, 38, 1999
1VXO
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METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, METHYLPHOSPHONIC ACID ESTER GROUP, PROTEIN (ACETYLCHOLINESTERASE)
著者Millard, C.B, Silman, I, Sussman, J.L.
登録日1999-04-21
公開日1999-11-15
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Reaction Products of Acetylcholinesterase and VX Reveal a Mobile Histidine in the Catalytic Triad
J.Am.Chem.Soc., 121, 1999
1VXR
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O-ETHYLMETHYLPHOSPHONYLATED ACETYLCHOLINESTERASE OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Millard, C.B, Koellner, G, Silman, I, Sussman, J.L.
登録日1999-04-21
公開日1999-11-15
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Reaction Products of Acetylcholinesterase and VX Reveal a Mobile Histidine in the Catalytic Triad
J.Am.Chem.Soc., 121, 1999
2PJO
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BU of 2pjo by Molmil
Ricin a-chain (recombinant) complex with n-methylurea
分子名称: N-METHYLUREA, Ricin (EC 3.2.2.22), SULFATE ION
著者Carra, J.H, Mchugh, C.A, Mulligan, S, Machiesky, L.M, Millard, C.B.
登録日2007-04-16
公開日2007-11-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site.
Bmc Struct.Biol., 7, 2007
1SOM
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BU of 1som by Molmil
TORPEDO CALIFORNICA ACETYLCHOLINESTERASE INHIBITED BY NERVE AGENT GD (SOMAN).
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, METHYLPHOSPHONIC ACID ESTER GROUP, PROTEIN (ACETYLCHOLINESTERASE), ...
著者Greenblatt, H.M, Millard, C.B, Sussman, J.L, Silman, I.
登録日1999-03-17
公開日1999-06-25
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry, 38, 1999
3GEL
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BU of 3gel by Molmil
O-Methylphosphorylated Torpedo Acetylcholinesterase Obtained by Reaction with Methyl Paraoxon (AGED)
分子名称: Acetylcholinesterase
著者Legler, P.M, Millard, C.B.
登録日2009-02-25
公開日2010-09-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献O-Methylphosphorylated Torpedo Acetylcholinesterase Obtained by Reaction with Methyl Paraoxon (AGED)
To be Published
5BWB
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BU of 5bwb by Molmil
ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA IN COMPLEX WITH THE BIS-IMIDAZOLIUM OXIME 2BIM-7
分子名称: (Z,Z)-[heptane-1,7-diylbis(1H-imidazol-1-yl-2-ylidene)]bis(N-hydroxymethanamine), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Legler, P.M, Millard, C.B.
登録日2015-06-07
公開日2015-09-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献A conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oxime.
Acta Crystallogr.,Sect.D, 71, 2015
5BWC
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ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA IN COMPLEX WITH THE BIS-PYRIDINIUM OXIME ORTHO-7
分子名称: 1,7-HEPTYLENE-BIS-N,N'-SYN-2-PYRIDINIUMALDOXIME, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase
著者Legler, P.M, Millard, C.B.
登録日2015-06-07
公開日2015-09-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献A conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oxime.
Acta Crystallogr.,Sect.D, 71, 2015
2DFP
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BU of 2dfp by Molmil
X-RAY STRUCTURE OF AGED DI-ISOPROPYL-PHOSPHORO-FLUORIDATE (DFP) BOUND TO ACETYLCHOLINESTERASE
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Kryger, G, Millard, C.B, Silman, I, Sussman, J.L.
登録日1998-12-07
公開日1999-06-28
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry, 38, 1999
3C6B
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BU of 3c6b by Molmil
Reaction product of paraoxon and S-formylglutathione hydrolase W197I mutant
分子名称: S-formylglutathione hydrolase
著者Legler, P.M, Millard, C.B.
登録日2008-02-04
公開日2008-08-12
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Structural characterization and reversal of the natural organophosphate resistance of a D-type esterase, Saccharomyces cerevisiae S-formylglutathione hydrolase.
Biochemistry, 47, 2008
2R3D
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BU of 2r3d by Molmil
Ricin A-chain (recombinant) complex with Acetamide
分子名称: ACETAMIDE, Ricin A chain (EC 3.2.2.22), SULFATE ION
著者Carra, J.H, McHugh, C.A, Mulligan, S, Machiesky, L.M, Soares, A.S, Millard, C.B.
登録日2007-08-29
公開日2007-11-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site
BMC Struct.Biol., 7, 2007
2R2X
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BU of 2r2x by Molmil
Ricin A-chain (recombinant) complex with Urea
分子名称: Ricin A chain, SULFATE ION, UREA
著者Carra, J.H, McHugh, C.A, Mulligan, S, Machiesky, L.M, Soares, A.S, Millard, C.B.
登録日2007-08-28
公開日2007-11-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site.
Bmc Struct.Biol., 7, 2007
3SRP
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BU of 3srp by Molmil
Structure of Rivax: A Human Ricin Vaccine
分子名称: Ricin A chain, SULFATE ION
著者Legler, P.M, Millard, C.B.
登録日2011-07-07
公開日2011-08-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Structure of RiVax: a recombinant ricin vaccine.
Acta Crystallogr.,Sect.D, 67, 2011
3LC9
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BU of 3lc9 by Molmil
Ricin A-chain variant 1-33/44-198 with engineered disulfide bond
分子名称: Ricin A chain, SULFATE ION
著者Compton, J.R, Legler, P.M, Millard, C.B.
登録日2010-01-10
公開日2010-11-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen.
Proteins, 79, 2011
3MK9
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Stabilized Ricin Immunogen 1-33/44-198
分子名称: Ricin, SULFATE ION
著者Legler, P.M, Compton, J.R, Millard, C.B.
登録日2010-04-14
公開日2010-11-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen.
Proteins, 79, 2011
1GQS
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BU of 1gqs by Molmil
ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH NAP
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(1S)-1-(DIMETHYLAMINO)ETHYL]PHENOL, ACETYLCHOLINESTERASE
著者Bar-on, P, Millard, C.B, Harel, M, Dvir, H, Enz, A, Sussman, J.L, Silman, I.
登録日2001-12-04
公開日2002-03-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine
Biochemistry, 41, 2002
1JJB
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A neutral molecule in cation-binding site: Specific binding of PEG-SH to Acetylcholinesterase from Torpedo californica
分子名称: 1-DEOXY-1-THIO-HEPTAETHYLENE GLYCOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE
著者Koellner, G, Steiner, T, Millard, C.B, Silman, I, Sussman, J.L.
登録日2001-07-04
公開日2002-07-17
最終更新日2021-06-02
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica.
J.Mol.Biol., 320, 2002
4FLM
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BU of 4flm by Molmil
S-formylglutathione Hydrolase W197I Variant containing Copper
分子名称: COPPER (II) ION, S-formylglutathione hydrolase
著者Legler, P.M, Millard, C.B.
登録日2012-06-14
公開日2012-09-05
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献A role for His-160 in peroxide inhibition of S. cerevisiae S-formylglutathione hydrolase: Evidence for an oxidation sensitive motif.
Arch.Biochem.Biophys., 528, 2012
4FOL
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BU of 4fol by Molmil
S-formylglutathione hydrolase Variant H160I
分子名称: S-formylglutathione hydrolase
著者Legler, P.M, Millard, C.B.
登録日2012-06-20
公開日2012-09-05
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献A role for His-160 in peroxide inhibition of S. cerevisiae S-formylglutathione hydrolase: Evidence for an oxidation sensitive motif.
Arch.Biochem.Biophys., 528, 2012
4IMV
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BU of 4imv by Molmil
Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N
分子名称: Ricin, SULFATE ION
著者Legler, P.M, Compton, J.R, Millard, C.B.
登録日2013-01-03
公開日2013-02-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Disruption of the Putative Vascular Leak Peptide Sequence in the Stabilized Ricin Vaccine Candidate RTA1-33/44-198.
Toxins (Basel), 5, 2013
2P8N
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BU of 2p8n by Molmil
Ricin a-chain (recombinant) complex with adenine
分子名称: ADENINE, Ricin A chain, SULFATE ION
著者Carra, J.H, Mchugh, C.A, Mulligan, S, Machiesky, L.M, Millard, C.B.
登録日2007-03-22
公開日2007-11-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site
BMC Struct.Biol., 7, 2007

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