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PDB: 140 件
3LZE
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BU of 3lze by Molmil
Plasmodium vivax 6-pyruvoyltetrahydropterin synthase (PTPS), E37C catalytic residue mutant
分子名称: PTERINE, Putative 6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION
著者Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日2010-03-01
公開日2010-04-07
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites.
to be published
3M4Q
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BU of 3m4q by Molmil
Entamoeba histolytica asparaginyl-tRNA synthetase (AsnRS)
分子名称: Asparaginyl-tRNA synthetase, putative
著者Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日2010-03-11
公開日2010-03-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-ray crystal structure of asparaginyl-tRNA synthetase from the eukaryotic human pathogen Entamoeba histolytica.
to be published
3M0N
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BU of 3m0n by Molmil
Plasmodium vivax 6-pyruvoyltetrahydropterin synthase (PTPS), E37A catalytic residue mutant
分子名称: PTERINE, Putative 6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION
著者Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日2010-03-03
公開日2010-04-07
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites.
to be published
3P0H
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BU of 3p0h by Molmil
Leishmania major Tyrosyl-tRNA synthetase in complex with fisetin, cubic crystal form
分子名称: 3,7,3',4'-TETRAHYDROXYFLAVONE, Tyrosyl-tRNA synthetase
著者Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日2010-09-28
公開日2011-03-23
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer.
J.Mol.Biol., 409, 2011
2F8M
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BU of 2f8m by Molmil
Ribose 5-phosphate isomerase from Plasmodium falciparum
分子名称: PHOSPHATE ION, ribose 5-phosphate isomerase
著者Holmes, M.A, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2005-12-02
公開日2005-12-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.087 Å)
主引用文献Structure of ribose 5-phosphate isomerase from Plasmodium falciparum.
Acta Crystallogr.,Sect.F, 62, 2006
2F84
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BU of 2f84 by Molmil
Crystal Structure of an orotidine-5'-monophosphate decarboxylase homolog from P.falciparum
分子名称: PHOSPHATE ION, orotidine monophosphate decarboxylase
著者Caruthers, J.M, Robein, M, Merritt, E.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2005-12-01
公開日2005-12-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of an orotidine-5'-monophosphate decarboxylase homolog from Plasmodium falciparum
To be Published
3LJN
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BU of 3ljn by Molmil
Ankyrin repeat protein from Leishmania major
分子名称: hypothetical protein
著者Holmes, M.A, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2010-01-26
公開日2010-02-09
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Ankyrin repeat protein from Leishmania major
To be Published
3E3P
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BU of 3e3p by Molmil
Glycogen synthase kinase from Leishmania major
分子名称: Protein kinase, putative Glycogen synthase kinase
著者Arakaki, T.L, Merritt, E.A.
登録日2008-08-07
公開日2008-08-19
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Glycogen synthase kinase from Leishmania major
To be Published
2AMH
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BU of 2amh by Molmil
Crystal Structure of Maf-like Protein Tbru21784AAA from T.brucei
分子名称: MANGANESE (II) ION, SULFATE ION, septum formation protein MAF homologue, ...
著者Caruthers, J, Merritt, E, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2005-08-09
公開日2005-08-16
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of Maf-like Protein Tbru21784AAA from T.brucei
To be Published
3CSS
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BU of 3css by Molmil
Crystal structure of 6-phosphogluconolactonase from Leishmania guyanensis
分子名称: 6-phosphogluconolactonase, PHOSPHATE ION
著者Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2008-04-10
公開日2008-04-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Optimal description of a protein structure in terms of multiple groups undergoing TLS motion.
Acta Crystallogr.,Sect.D, 62, 2006
2B4G
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BU of 2b4g by Molmil
dihydroorotate dehydrogenase
分子名称: BROMIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2005-09-23
公開日2005-10-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
Mol.Microbiol., 68, 2008
2B4W
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BU of 2b4w by Molmil
Hypothetical protein from leishmania major
分子名称: hypothetical protein, conserved
著者Holmes, M.A, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2005-09-26
公開日2005-10-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Hypothetical protein from leishmania major
TO BE PUBLISHED
5TEH
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BU of 5teh by Molmil
c-Src V281C kinase domain in complex with Rao-IV-156
分子名称: (2S)-3-[4-amino-7-(2-methoxyethyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)propanamide, Proto-oncogene tyrosine-protein kinase Src
著者Dieter, E.M, Merritt, E.A, Maly, D.J.
登録日2016-09-21
公開日2017-09-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献A combined approach reveals a regulatory mechanism coupling Src's kinase activity, localization, and phosphotransferase-independent functions
Mol.Cell, 2019
5T0P
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BU of 5t0p by Molmil
c-Src kinase domain in complex with Rao-IV-151
分子名称: (2E)-3-[4-amino-5-(4-chlorophenyl)-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)prop-2-enamide, Proto-oncogene tyrosine-protein kinase Src
著者Dieter, E.M, Merritt, E.A, Maly, D.J.
登録日2016-08-16
公開日2017-08-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A chemical genetic method for conformation-selective kinase inhibition
To Be Published
5SYS
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BU of 5sys by Molmil
c-Src V281C bound to N-[3-({6-[(1E)-2-cyano-3-(methylamino)-3-oxoprop-1-en-1-yl]-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)-4-methylphenyl]-3-(trifluoromethyl)benzamide inhibitor
分子名称: N-[3-({6-[(2S)-2-cyano-3-(methylamino)-3-oxopropyl]-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)-4-methylphenyl]-3-(trifluoromethyl)benzamide, Proto-oncogene tyrosine-protein kinase Src
著者Dieter, E.M, Merritt, E.A, Maly, D.J.
登録日2016-08-11
公開日2017-08-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献A combined approach reveals a regulatory mechanism coupling Src's kinase activity, localization, and phosphotransferase-independent functions
Mol.Cell, 2019

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件を2024-06-12に公開中

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