6SCF
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![BU of 6scf by Molmil](/molmil-images/mine/6scf) | A viral anti-CRISPR subverts type III CRISPR immunity by rapid degradation of cyclic oligoadenylate | Descriptor: | Uncharacterized protein, cyclic oligoadenylate | Authors: | McMahon, S.A, Athukoralage, J.S, Graham, S, White, M.F, Gloster, T.M. | Deposit date: | 2019-07-24 | Release date: | 2019-10-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity. Nature, 577, 2020
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6SCE
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![BU of 6sce by Molmil](/molmil-images/mine/6sce) | Structure of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate | Descriptor: | Uncharacterized protein, cyclic oligoadenylate | Authors: | McMahon, S.A, Zhu, W, Graham, S, White, M.F, Gloster, T.M. | Deposit date: | 2019-07-24 | Release date: | 2020-02-19 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate. Nat Commun, 11, 2020
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3FFE
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![BU of 3ffe by Molmil](/molmil-images/mine/3ffe) | Structure of Achromobactin Synthetase Protein D, (AcsD) | Descriptor: | AcsD | Authors: | McMahon, S.A, Liu, H, Carter, L, Oke, M, Johnson, K.A, Schmelz, S, Challis, G.L, White, M.F, Naismith, J.H, Scottish Structural Proteomics Facility (SSPF) | Deposit date: | 2008-12-03 | Release date: | 2009-02-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis Nat.Chem.Biol., 5, 2009
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1YU4
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![BU of 1yu4 by Molmil](/molmil-images/mine/1yu4) | Major Tropism Determinant U1 Variant | Descriptor: | MAGNESIUM ION, Major Tropism Determinant (Mtd-U1) | Authors: | McMahon, S.A, Miller, J.L, Lawton, J.A, Ghosh, P. | Deposit date: | 2005-02-11 | Release date: | 2005-09-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | The C-type lectin fold as an evolutionary solution for massive sequence variation Nat.Struct.Mol.Biol., 12, 2005
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1YU1
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![BU of 1yu1 by Molmil](/molmil-images/mine/1yu1) | Major Tropism Determinant P3c Variant | Descriptor: | MAGNESIUM ION, METHYL MERCURY ION, Major Tropism Determinant (Mtd-P3c) | Authors: | McMahon, S.A, Miller, J.L, Lawton, J.A, Ghosh, P. | Deposit date: | 2005-02-11 | Release date: | 2005-09-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | The C-type lectin fold as an evolutionary solution for massive sequence variation Nat.Struct.Mol.Biol., 12, 2005
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1YU2
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![BU of 1yu2 by Molmil](/molmil-images/mine/1yu2) | Major Tropism Determinant M1 Variant | Descriptor: | MAGNESIUM ION, Major Tropism Determinant (Mtd-M1) | Authors: | McMahon, S.A, Miller, J.L, Lawton, J.A, Ghosh, P. | Deposit date: | 2005-02-11 | Release date: | 2005-09-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | The C-type lectin fold as an evolutionary solution for massive sequence variation Nat.Struct.Mol.Biol., 12, 2005
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1YU0
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![BU of 1yu0 by Molmil](/molmil-images/mine/1yu0) | Major Tropism Determinant P1 Variant | Descriptor: | CALCIUM ION, Major Tropism Determinant (Mtd-P1) | Authors: | McMahon, S.A, Miller, J.L, Lawton, J.A, Ghosh, P. | Deposit date: | 2005-02-11 | Release date: | 2005-09-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | The C-type lectin fold as an evolutionary solution for massive sequence variation Nat.Struct.Mol.Biol., 12, 2005
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1YU3
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![BU of 1yu3 by Molmil](/molmil-images/mine/1yu3) | Major Tropism Determinant I1 Variant | Descriptor: | MAGNESIUM ION, Major Tropism Determinant (Mtd-I1) | Authors: | McMahon, S.A, Miller, J.L, Lawton, J.A, Ghosh, P. | Deposit date: | 2005-02-11 | Release date: | 2005-09-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | The C-type lectin fold as an evolutionary solution for massive sequence variation Nat.Struct.Mol.Biol., 12, 2005
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4CQJ
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4AVF
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![BU of 4avf by Molmil](/molmil-images/mine/4avf) | Crystal structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase | Descriptor: | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE | Authors: | McMahon, S.A, Moynie, L, Liu, H, Duthie, F, Naismith, J.H. | Deposit date: | 2012-05-25 | Release date: | 2013-01-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery Acta Crystallogr.,Sect.F, 69, 2013
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4AVR
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![BU of 4avr by Molmil](/molmil-images/mine/4avr) | Crystal structure of the hypothetical protein Pa4485 from Pseudomonas aeruginosa | Descriptor: | PA4485 | Authors: | McMahon, S.A, Moynie, L, Liu, H, Duthie, F, Alphey, M.S, Naismith, J.H. | Deposit date: | 2012-05-29 | Release date: | 2013-01-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery. Acta Crystallogr.,Sect.F, 69, 2013
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4CCV
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![BU of 4ccv by Molmil](/molmil-images/mine/4ccv) | Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: Implications for the regulation of angiogenesis | Descriptor: | GLUTATHIONE, GLYCEROL, HISTIDINE-RICH GLYCOPROTEIN, ... | Authors: | McMahon, S.A, Kassaar, O, Stewart, A.J, Naismith, J.H. | Deposit date: | 2013-10-29 | Release date: | 2014-02-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal Structure of Histidine-Rich Glycoprotein N2 Domain Reveals Redox Activity at an Interdomain Disulfide Bridge: Implications for Angiogenic Regulation. Blood, 123, 2014
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4BQQ
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2WR8
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![BU of 2wr8 by Molmil](/molmil-images/mine/2wr8) | Structure of Pyrococcus horikoshii SAM hydroxide adenosyltransferase in complex with SAH | Descriptor: | PUTATIVE UNCHARACTERIZED PROTEIN PH0463, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | McMahon, S.A, Deng, H, O'Hagan, D, Johnson, K.A, Naismith, J.H. | Deposit date: | 2009-08-31 | Release date: | 2009-09-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Mechanistic Insights Into Water Activation in Sam Hydroxide Adenosyltransferase (Duf-62). Chembiochem, 10, 2009
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2W82
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![BU of 2w82 by Molmil](/molmil-images/mine/2w82) | The structure of ArdA | Descriptor: | ORF18 | Authors: | McMahon, S.A, Roberts, G.A, Carter, L.G, Cooper, L.P, Liu, H, White, J.H, Johnson, K.A, Sanghvi, B, Oke, M, Walkinshaw, M.D, Blakely, G, Naismith, J.H, Dryden, D.T.F. | Deposit date: | 2009-01-08 | Release date: | 2009-01-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Extensive DNA Mimicry by the Arda Anti-Restriction Protein and its Role in the Spread of Antibiotic Resistance. Nucleic Acids Res., 37, 2009
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2W03
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![BU of 2w03 by Molmil](/molmil-images/mine/2w03) | Co-complex Structure of Achromobactin Synthetase Protein D (AcsD) with adenosine, sulfate and citrate from Pectobacterium Chrysanthemi | Descriptor: | ACSD, ADENOSINE, CITRIC ACID, ... | Authors: | Schmelz, S, McMahon, S.A, Kadi, N, Song, L, Oves-Costales, D, Oke, M, Liu, H, Johnson, K.A, Carter, L, White, M.F, Challis, G.L, Naismith, J.H. | Deposit date: | 2008-08-08 | Release date: | 2009-01-13 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Acsd Catalyzes Enantioselective Citrate Desymmetrization in Siderophore Biosynthesis Nat.Chem.Biol., 5, 2009
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2W04
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![BU of 2w04 by Molmil](/molmil-images/mine/2w04) | Co-complex Structure of Achromobactin Synthetase Protein D (AcsD) with citrate in ATP binding site from Pectobacterium Chrysanthemi | Descriptor: | ACSD, CITRATE ANION | Authors: | Schmelz, S, McMahon, S.A, Kadi, N, Song, L, Oves-Costales, D, Oke, M, Liu, H, Johnson, K.A, Carter, L, White, M.F, Challis, G.L, Naismith, J.H. | Deposit date: | 2008-08-08 | Release date: | 2009-01-13 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Acsd Catalyzes Enantioselective Citrate Desymmetrization in Siderophore Biosynthesis Nat.Chem.Biol., 5, 2009
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7BDV
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![BU of 7bdv by Molmil](/molmil-images/mine/7bdv) | Structure of Can2 from Sulfobacillus thermosulfidooxidans in complex with cyclic tetra-adenylate (cA4) | Descriptor: | Can2, Cyclic tetraadenosine monophosphate (cA4) | Authors: | McQuarrie, S, McMahon, S.A, Gloster, T.M, White, M.F, Graham, S, Zhu, W, Gruschow, S. | Deposit date: | 2020-12-22 | Release date: | 2021-03-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence. Nucleic Acids Res., 49, 2021
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2VXZ
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![BU of 2vxz by Molmil](/molmil-images/mine/2vxz) | Crystal Structure of hypothetical protein PyrSV_gp04 from Pyrobaculum spherical virus | Descriptor: | CHLORIDE ION, GLYCEROL, PYRSV_GP04 | Authors: | Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, Oke, M, Naismith, J.H, White, M.F. | Deposit date: | 2008-07-15 | Release date: | 2009-11-17 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Scottish Structural Proteomics Facility: Targets, Methods and Outputs. J.Struct.Funct.Genomics, 11, 2010
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2VHS
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![BU of 2vhs by Molmil](/molmil-images/mine/2vhs) | Cathsilicatein, a chimera | Descriptor: | CATHSILICATEIN, SULFATE ION | Authors: | Fairhead, M, Kowatz, T, McMahon, S.A, Carter, L.G, Oke, M, Johnson, K.A, Liu, H, Naismith, J.H, Wal, C.F.V.D. | Deposit date: | 2007-11-24 | Release date: | 2008-03-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal Structure and Silica Condensing Activities of Silicatein Alpha-Cathepsin L Chimeras. Chem. Commun., 2008
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8PCW
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![BU of 8pcw by Molmil](/molmil-images/mine/8pcw) | Structure of Csm6' from Streptococcus thermophilus | Descriptor: | CRISPR system endoribonuclease Csm6' | Authors: | McQuarrie, S.J, Athukoralage, J.S, McMahon, S.A, Graham, S, Ackerman, K, Bode, B.E, White, M.F, Gloster, T.M. | Deposit date: | 2023-06-11 | Release date: | 2023-10-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.54 Å) | Cite: | Activation of Csm6 ribonuclease by cyclic nucleotide binding: in an emergency, twist to open. Nucleic Acids Res., 51, 2023
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8PE3
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![BU of 8pe3 by Molmil](/molmil-images/mine/8pe3) | Structure of Csm6' from Streptococcus thermophilus in complex with cyclic hexa-adenylate (cA6) | Descriptor: | CRISPR system endoribonuclease Csm6', Cyclic hexaadenosine monophosphate (cA6), RNA | Authors: | McQuarrie, S.J, Athukoralage, J.S, McMahon, S.A, Graham, S, Ackerman, K, Bode, B.E, White, M.F, Gloster, T.M. | Deposit date: | 2023-06-13 | Release date: | 2023-10-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Activation of Csm6 ribonuclease by cyclic nucleotide binding: in an emergency, twist to open. Nucleic Acids Res., 51, 2023
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5N4B
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![BU of 5n4b by Molmil](/molmil-images/mine/5n4b) | Prolyl oligopeptidase B from Galerina marginata bound to 25mer macrocyclization substrate - S577A mutant | Descriptor: | Alpha-amanitin proprotein, Prolyl oligopeptidase | Authors: | Czekster, C.M, McMahon, S.A, Ludewig, H, Naismith, J.H. | Deposit date: | 2017-02-10 | Release date: | 2017-11-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates. Nat Commun, 8, 2017
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5FIU
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![BU of 5fiu by Molmil](/molmil-images/mine/5fiu) | Binding and structural studies of a 5,5-difluoromethyl adenosine nucleoside with the fluorinase enzyme | Descriptor: | 5'-FLUORO-5'-DEOXY-ADENOSINE SYNTHASE, 5,5-DIFLUOROMETHYL ADENOSINE, L(+)-TARTARIC ACID | Authors: | Thompson, S, McMahon, S.A, Naismith, J.H, O'Hagan, D. | Deposit date: | 2015-10-02 | Release date: | 2015-12-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Exploration of a Potential Difluoromethyl-Nucleoside Substrate with the Fluorinase Enzyme. Bioorg.Chem., 64, 2015
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6I6X
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![BU of 6i6x by Molmil](/molmil-images/mine/6i6x) | New Irreversible a-l-Iduronidase Inhibitors and Activity-Based Probes | Descriptor: | (1~{R},2~{R},3~{R},4~{S},5~{S},6~{R})-7-methyl-3,4,5-tris(oxidanyl)-7-azabicyclo[4.1.0]heptane-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gloster, T.M, McMahon, S.A, Oehler, V. | Deposit date: | 2018-11-15 | Release date: | 2018-12-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | New Irreversible alpha-l-Iduronidase Inhibitors and Activity-Based Probes. Chemistry, 24, 2018
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