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PDB: 51 件

4MZX
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Crystal Structure of Benzoylformate Decarboxylase Mutant T377L/A460Y
分子名称: 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Benzoylformate decarboxlyase, CALCIUM ION, ...
著者Andrews, F.H, McLeish, M.J.
登録日2013-09-30
公開日2015-04-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.558 Å)
主引用文献Mechanistic and structural insight to an evolved benzoylformate decarboxylase with enhanced activity towards pyruvate
To be Published
4Q9D
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X-ray structure of a putative thiamin diphosphate-dependent enzyme isolated from Mycobacterium smegmatis
分子名称: Benzoylformate decarboxylase, FORMIC ACID, MAGNESIUM ION
著者Andrews, F.H, Horton, J.D, Yoon, H.J, Malik, A.M.K, Logsdon, M.G, Shin, D.H, Kneen, M.M, Suh, S.W, McLeish, M.J.
登録日2014-04-30
公開日2015-04-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The kinetic characterization and X-ray structure of a putative benzoylformate decarboxylase from M. smegmatis highlights the difficulties in the functional annotation of ThDP-dependent enzymes.
Biochim.Biophys.Acta, 1854, 2015
4QEL
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BU of 4qel by Molmil
Crystal Structure of Benzoylformate Decarboxylase Mutant H70A
分子名称: 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Benzoylformate decarboxylase, CALCIUM ION, ...
著者Andrews, F.H, Rogers, M.P, Brodkin, H.R, McLeish, M.J.
登録日2014-05-16
公開日2015-05-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.432 Å)
主引用文献Structural investigation of benzoylformate decarboxylase active site variants
To be Published
4MQ5
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Crystal Structure of Benzoylformate Decarboxylase Mutant A306F
分子名称: Benzoylformate decarboxylase, CALCIUM ION, SODIUM ION, ...
著者Andrews, F.H, McLeish, M.J.
登録日2013-09-15
公開日2014-08-27
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.502 Å)
主引用文献Perturbation of the monomer-monomer interfaces of the benzoylformate decarboxylase tetramer.
Biochemistry, 53, 2014
1YZ3
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BU of 1yz3 by Molmil
Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139
分子名称: 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Wu, Q, Gee, C.L, Lin, F, Martin, J.L, Grunewald, G.L, McLeish, M.J.
登録日2005-02-27
公開日2006-02-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase
J.Med.Chem., 48, 2005
2AN5
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Structure of human PNMT complexed with S-adenosyl-homocysteine and an inhibitor, trans-(1S,2S)-2-amino-1-tetralol
分子名称: PHOSPHATE ION, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Gee, C.L, Tyndall, J.D.A, Grunewald, G.L, Wu, Q, McLeish, M.J, Martin, J.L.
登録日2005-08-11
公開日2006-03-14
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis
Biochemistry, 44, 2005
2AN3
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Structure of PNMT with S-adenosyl-L-homocysteine and the semi-rigid analogue acceptor substrate cis-(1R,2S)-2-amino-1-tetralol.
分子名称: CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Gee, C.L, Tyndall, J.D.A, Grunewald, G.L, Wu, Q, McLeish, M.J, Martin, J.L.
登録日2005-08-11
公開日2006-03-14
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis
Biochemistry, 44, 2005
2AN4
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Structure of PNMT complexed with S-adenosyl-L-homocysteine and the acceptor substrate octopamine
分子名称: 4-(2R-AMINO-1-HYDROXYETHYL)PHENOL, PHOSPHATE ION, Phenylethanolamine N-methyltransferase, ...
著者Gee, C.L, Tyndall, J.D.A, Grunewald, G.L, Wu, Q, McLeish, M.J, Martin, J.L.
登録日2005-08-11
公開日2006-03-14
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis
Biochemistry, 44, 2005
3FSJ
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BU of 3fsj by Molmil
Crystal structure of benzoylformate decarboxylase in complex with the inhibitor MBP
分子名称: 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(S)-hydroxy[(R)-hydroxy(methoxy)phosphoryl]phenylmethyl}-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, Benzoylformate decarboxylase, CALCIUM ION
著者Brandt, G.S, Kenyon, G.L, McLeish, M.J, Jordan, F, Petsko, G.A, Ringe, D.
登録日2009-01-09
公開日2009-01-27
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor.
Biochemistry, 48, 2009
3F6B
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Crystal structure of benzoylformate decarboxylase in complex with the pyridyl inhibitor PAA
分子名称: 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-2-[(1S,2E)-1-hydroxy-3-pyridin-3-ylprop-2-en-1-yl]-4-methyl-1,3-thiazol-3-ium, Benzoylformate decarboxylase, MAGNESIUM ION
著者Brandt, G.S, McLeish, M.J, Kenyon, G.L, Petsko, G.A, Ringe, D, Jordan, F.
登録日2008-11-05
公開日2008-12-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase.
Biochemistry, 48, 2009
3IAE
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BU of 3iae by Molmil
Structure of benzaldehyde lyase A28S mutant with benzoylphosphonate
分子名称: 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(S)-hydroxy[(R)-hydroxy(methoxy)phosphoryl]phenylmethyl}-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, Benzaldehyde lyase, CALCIUM ION
著者Brandt, G.S, Petsko, G.A, Ringe, D, McLeish, M.J.
登録日2009-07-13
公開日2010-03-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition.
J.Am.Chem.Soc., 132, 2010
3IAF
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BU of 3iaf by Molmil
Structure of benzaldehyde lyase A28S mutant with monomethyl benzoylphosphonate
分子名称: Benzaldehyde lyase, MAGNESIUM ION, THIAMINE DIPHOSPHATE
著者Brandt, G.S, Petsko, G.A, Ringe, D, McLeish, M.J.
登録日2009-07-13
公開日2010-03-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition.
J.Am.Chem.Soc., 132, 2010
4GM1
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BU of 4gm1 by Molmil
Crystal Structure of Benzoylformate Decarboxylase Mutant L403S
分子名称: 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Benzoylformate decarboxylase, CALCIUM ION, ...
著者Novak, W.R.P, Andrews, F.H, Tom, A.R, Gunderman, P.R, McLeish, M.J.
登録日2012-08-15
公開日2013-05-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
4GM4
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Crystal Structure of Benzoylformate Decarboxylase Mutant L403I
分子名称: 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Benzoylformate decarboxylase, CALCIUM ION, ...
著者Novak, W.R.P, Andrews, F.H, Tom, A.R, Gunderman, P.R, McLeish, M.J.
登録日2012-08-15
公開日2013-05-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
4GPE
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Crystal Structure of Benzoylformate Decarboxylase Mutant L403M
分子名称: 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Benzoylformate decarboxylase, CALCIUM ION, ...
著者Novak, W.R.P, Andrews, F.H, Tom, A.R, Gunderman, P.R, McLeish, M.J.
登録日2012-08-20
公開日2013-05-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
4GP9
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Crystal Structure of Benzoylformate Decarboxylase Mutant L403F
分子名称: 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Benzoylformate decarboxylase, CALCIUM ION, ...
著者Novak, W.R.P, Andrews, F.H, Tom, A.R, Gunderman, P.R, McLeish, M.J.
登録日2012-08-20
公開日2013-05-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.07 Å)
主引用文献A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
4GM0
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Crystal Structure of Benzoylformate Decarboxylase Mutant L403N
分子名称: 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Benzoylformate decarboxylase, CALCIUM ION, ...
著者Novak, W.R.P, Andrews, F.H, Tom, A.R, Gunderman, P.R, McLeish, M.J.
登録日2012-08-15
公開日2013-05-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.07 Å)
主引用文献A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
4GG1
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Crystal Structure of Benzoylformate Decarboxylase Mutant L403T
分子名称: 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Benzoylformate decarboxylase, CALCIUM ION, ...
著者Novak, W.R.P, Andrews, F.H, Tom, A.R, Gunderman, P.R, McLeish, M.J.
登録日2012-08-04
公開日2013-05-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.069 Å)
主引用文献A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
4K9M
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BU of 4k9m by Molmil
Crystal Structure of the His281Asn mutant of Benzoylformate Decarboxylase from Pseudomonas putida
分子名称: Benzoylformate decarboxylase, CALCIUM ION, MAGNESIUM ION, ...
著者Brodkin, H.R, McLeish, M.J.
登録日2013-04-20
公開日2013-05-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Crystal Structure of the His281Asn mutant of Benzoylformate Decarboxylase from Pseudomonas putida
To be Published
4K9O
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BU of 4k9o by Molmil
Crystal Structure of the Phe397Ala mutant of Benzoylformate Decarboxylase from Pseudomonas putida
分子名称: Benzoylformate decarboxylase, CALCIUM ION, GLYCEROL, ...
著者Brodkin, H.R, McLeish, M.J.
登録日2013-04-20
公開日2013-05-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.888 Å)
主引用文献Crystal Structure of the Phe397Ala mutant of Benzoylformate Decarboxylase from Pseudomonas putida
To be Published
4K9P
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Crystal Structure of the His281Tyr/Ala460Ile Double Mutant of Benzoylformate Decarboxylase from Pseudomonas putida
分子名称: Benzoylformate decarboxylase, CALCIUM ION, GLYCEROL, ...
著者Brodkin, H.R, McLeish, M.J.
登録日2013-04-20
公開日2013-05-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.244 Å)
主引用文献Crystal Structure of the His281Tyr/Ala460Ile Double Mutant of Benzoylformate Decarboxylase from Pseudomonas putida
To be Published
4K9L
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Crystal Structure of the His281Thr mutant of Benzoylformate Decarboxylase from Pseudomonas putida
分子名称: 1,2-ETHANEDIOL, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Benzoylformate decarboxylase, ...
著者Brodkin, H.R, McLeish, M.J.
登録日2013-04-20
公開日2013-05-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.649 Å)
主引用文献Crystal Structure of the His281Thr mutant of Benzoylformate Decarboxylase from Pseudomonas putida
To be Published
4K9K
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BU of 4k9k by Molmil
Crystal Structure of the His281Tyr mutant of Benzoylformate Decarboxylase from Pseudomonas putida
分子名称: Benzoylformate decarboxylase, CALCIUM ION, MAGNESIUM ION, ...
著者Brodkin, H.R, McLeish, M.J.
登録日2013-04-20
公開日2013-05-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.301 Å)
主引用文献Crystal Structure of the His281Tyr mutant of Benzoylformate Decarboxylase from Pseudomonas putida
To be Published
4JD5
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Crystal Structure of Benzoylformate Decarboxylase Mutant L403E
分子名称: 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Benzoylformate decarboxylase, CALCIUM ION, ...
著者Novak, W.R.P, Andrews, F.H, Tom, A.R, Gunderman, P.R, McLeish, M.J.
登録日2013-02-23
公開日2013-05-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
4K9Q
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The Crystal Structure of Benzoylformate Decarboxylase from Polynucleobacter necessarius
分子名称: Benzoylformate Decarboxylase, MAGNESIUM ION, THIAMINE DIPHOSPHATE
著者Brodkin, H.R, Novak, W.R.P, McLeish, M.J.
登録日2013-04-20
公開日2014-04-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.598 Å)
主引用文献The Crystal Structure of Benzoylformate Decarboxylase from Polynucleobacter necessarius
To be Published

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