3FL5
| Protein kinase CK2 in complex with the inhibitor Quinalizarin | 分子名称: | 1,2,5,8-tetrahydroxyanthracene-9,10-dione, Casein kinase II subunit alpha, DI(HYDROXYETHYL)ETHER | 著者 | Mazzorana, M, Franchin, C, Battistutta, R. | 登録日 | 2008-12-18 | 公開日 | 2009-08-18 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2 Biochem.J., 421, 2009
|
|
6FSW
| Structure of Archaeoglobus fulgidus SBDS protein at 1.9 Angstrom | 分子名称: | DI(HYDROXYETHYL)ETHER, Ribosome maturation protein SDO1-like protein | 著者 | Mazzorana, M, Foadi, J, Siliqi, D, Sanchez-Puig, N. | 登録日 | 2018-02-20 | 公開日 | 2018-03-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Conformational flexibility of proteins involved in ribosome biogenesis: investigations via Small Angle X-ray Scattering (SAXS) Crystals, 8, 2018
|
|
4A7C
| Crystal structure of PIM1 kinase with ETP46546 | 分子名称: | ACETATE ION, IMIDAZOLE, N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethyloxy)phenyl]-[1,2,3]triazolo[4,5-b]pyridin-5-amine, ... | 著者 | Mazzorana, M, Montoya, G. | 登録日 | 2011-11-12 | 公開日 | 2012-02-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Hit to Lead Evaluation of 1,2,3-Triazolo[4,5-B]Pyridines as Pim Kinase Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
|
|
6QS5
| |
8R5J
| Crystal structure of MERS-CoV main protease | 分子名称: | Non-structural protein 11 | 著者 | Balcomb, B.H, Fairhead, M, Koekemoer, L, Lithgo, R.M, Aschenbrenner, J.C, Chandran, A.V, Godoy, A.S, Lukacik, P, Marples, P.G, Mazzorana, M, Ni, X, Strain-Damerell, C, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Fearon, D, Walsh, M.A, von Delft, F. | 登録日 | 2023-11-16 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | 主引用文献 | Crystal structure of MERS-CoV main protease To Be Published
|
|
4DGN
| Crystal Structure of maize CK2 in complex with the inhibitor luteolin | 分子名称: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, Casein kinase II subunit alpha | 著者 | Lolli, G, Mazzorana, M, Battistutta, R. | 登録日 | 2012-01-26 | 公開日 | 2012-08-01 | 最終更新日 | 2013-01-02 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. Biochemistry, 51, 2012
|
|
4DGM
| Crystal Structure of maize CK2 in complex with the inhibitor apigenin | 分子名称: | 1,2-ETHANEDIOL, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Casein kinase II subunit alpha, ... | 著者 | Lolli, G, Mazzorana, M, Battistutta, R. | 登録日 | 2012-01-26 | 公開日 | 2012-08-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. Biochemistry, 51, 2012
|
|
3PWD
| Crystal structure of maize CK2 in complex with NBC (Z1) | 分子名称: | 8-hydroxy-4-methyl-9-nitro-2H-benzo[g]chromen-2-one, Casein kinase II subunit alpha | 著者 | Battistutta, R, Mazzorana, M. | 登録日 | 2010-12-08 | 公開日 | 2011-11-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A Cell.Mol.Life Sci., 69, 2012
|
|
8AGI
| Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in complex with JMC31 | 分子名称: | 1-[2,4-bis(oxidanyl)-5-propan-2-yl-phenyl]-5-[4-[(cyclohexylmethylamino)methyl]phenyl]-~{N}-ethyl-1,2,3-triazole-4-carboxamide, Heat shock protein HSP 90-alpha | 著者 | Tassone, G, Pozzi, C, Mazzorana, M, Mangani, S, Maramai, S. | 登録日 | 2022-07-20 | 公開日 | 2022-09-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor. Int J Mol Sci, 23, 2022
|
|
8AGL
| Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R in complex with JMC31 | 分子名称: | 1-[2,4-bis(oxidanyl)-5-propan-2-yl-phenyl]-5-[4-[(cyclohexylmethylamino)methyl]phenyl]-~{N}-ethyl-1,2,3-triazole-4-carboxamide, Heat shock protein HSP 90-alpha | 著者 | Tassone, G, Pozzi, C, Mazzorana, M, Mangani, S, Maramai, S. | 登録日 | 2022-07-20 | 公開日 | 2022-09-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor. Int J Mol Sci, 23, 2022
|
|
8AGJ
| Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with JMC31 | 分子名称: | 1-[2,4-bis(oxidanyl)-5-propan-2-yl-phenyl]-5-[4-[(cyclohexylmethylamino)methyl]phenyl]-~{N}-ethyl-1,2,3-triazole-4-carboxamide, Heat shock protein HSP 90-alpha | 著者 | Tassone, G, Pozzi, C, Mazzorana, M, Mangani, S, Maramai, S. | 登録日 | 2022-07-20 | 公開日 | 2022-09-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor. Int J Mol Sci, 23, 2022
|
|
1ZOG
| Crystal structure of protein kinase CK2 in complex with TBB-derivatives | 分子名称: | 4,5,6,7-TETRABROMO-2-(METHYLSULFANYL)-1H-BENZIMIDAZOLE, PROTEIN KINASE CK2, alpha SUBUNIT | 著者 | Battistutta, R, Mazzorana, M, Sarno, S, Kazimierczuk, Z, Zanotti, G, Pinna, L.A. | 登録日 | 2005-05-13 | 公開日 | 2005-11-29 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole. Chem.Biol., 12, 2005
|
|
1ZOH
| Crystal structure of protein kinase CK2 in complex with TBB-derivatives inhibitors | 分子名称: | 1,2-ETHANEDIOL, 5,6,7,8-TETRABROMO-1-METHYL-2,3-DIHYDRO-1H-IMIDAZO[1,2-A]BENZIMIDAZOLE, CHLORIDE ION, ... | 著者 | Battistutta, R, Mazzorana, M, Sarno, S, Kazimierczuk, Z, Zanotti, G, Pinna, L.A. | 登録日 | 2005-05-13 | 公開日 | 2005-11-29 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole. Chem.Biol., 12, 2005
|
|
1ZOE
| Crystal structure of protein kinase CK2 in complex with TBB-derivatives inhibitors | 分子名称: | 4,5,6,7-TETRABROMO-N,N-DIMETHYL-1H-BENZIMIDAZOL-2-AMINE, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Battistutta, R, Mazzorana, M, Sarno, S, Kazimierczuk, Z, Zanotti, G, Pinna, L.A. | 登録日 | 2005-05-13 | 公開日 | 2005-11-29 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole. Chem.Biol., 12, 2005
|
|
6YB7
| SARS-CoV-2 main protease with unliganded active site (2019-nCoV, coronavirus disease 2019, COVID-19). | 分子名称: | 3C-like proteinase, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE | 著者 | Owen, C.D, Lukacik, P, Strain-Damerell, C.M, Douangamath, A, Powell, A.J, Fearon, D, Brandao-Neto, J, Crawshaw, A.D, Aragao, D, Williams, M, Flaig, R, Hall, D.R, McAuley, K.E, Mazzorana, M, Stuart, D.I, von Delft, F, Walsh, M.A. | 登録日 | 2020-03-16 | 公開日 | 2020-03-25 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | COVID-19 main protease with unliganded active site To Be Published
|
|
6Y84
| SARS-CoV-2 main protease with unliganded active site (2019-nCoV, coronavirus disease 2019, COVID-19) | 分子名称: | 3C-like proteinase nsp5, DIMETHYL SULFOXIDE | 著者 | Owen, C.D, Lukacik, P, Strain-Damerell, C.M, Douangamath, A, Powell, A.J, Fearon, D, Brandao-Neto, J, Crawshaw, A.D, Aragao, D, Williams, M, Flaig, R, Hall, D.R, McAuley, K.E, Mazzorana, M, Stuart, D.I, von Delft, F, Walsh, M.A. | 登録日 | 2020-03-03 | 公開日 | 2020-03-11 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | COVID-19 main protease with unliganded active site To Be Published
|
|
3PZH
| |