8AGI
Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in complex with JMC31
Summary for 8AGI
Entry DOI | 10.2210/pdb8agi/pdb |
Descriptor | Heat shock protein HSP 90-alpha, 1-[2,4-bis(oxidanyl)-5-propan-2-yl-phenyl]-5-[4-[(cyclohexylmethylamino)methyl]phenyl]-~{N}-ethyl-1,2,3-triazole-4-carboxamide (3 entities in total) |
Functional Keywords | hsp90, ntd, 1, 2, 3-triazole-based compound, complex, chaperone |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 58529.54 |
Authors | Tassone, G.,Pozzi, C.,Mazzorana, M.,Mangani, S.,Maramai, S. (deposition date: 2022-07-20, release date: 2022-09-07, Last modification date: 2024-01-31) |
Primary citation | Tassone, G.,Mazzorana, M.,Mangani, S.,Petricci, E.,Cini, E.,Giannini, G.,Pozzi, C.,Maramai, S. Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor. Int J Mol Sci, 23:-, 2022 Cited by PubMed: 36012721DOI: 10.3390/ijms23169458 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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