8AGJ

Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with JMC31

Summary for 8AGJ

• Entry DOI: 10.2210/pdb8agj/pdb
• Related: 8AGI
• Descriptor: Heat shock protein HSP 90-alpha, 1-[2,4-bis(oxidanyl)-5-propan-2-yl-phenyl]-5-[4-[(cyclohexylmethylamino)methyl]phenyl]-~{N}-ethyl-1,2,3-triazole-4-carboxamide (3 entities in total)
• Functional Keywords: hsp90, ntd, k112a, 1, 2, 3-triazole-based compound, complex, chaperone
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 58413.34

Authors

Tassone, G.,Pozzi, C.,Mazzorana, M.,Mangani, S.,Maramai, S. (deposition date: 2022-07-20, release date: 2022-09-07, Last modification date: 2024-01-31)

• Primary citation: Tassone, G.,Mazzorana, M.,Mangani, S.,Petricci, E.,Cini, E.,Giannini, G.,Pozzi, C.,Maramai, S.; Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor.; Int J Mol Sci, 23:-, 2022; PubMed: 36012721; DOI: 10.3390/ijms23169458

Experimental method

X-RAY DIFFRACTION (2.32 Å)