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PDB: 37 件
4O66
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Crystal Structure of SMARCAL1 HARP substrate recognition domain
分子名称: SODIUM ION, SULFATE ION, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
著者Mason, A.C, Eichman, B.F.
登録日2013-12-20
公開日2014-05-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A structure-specific nucleic acid-binding domain conserved among DNA repair proteins.
Proc.Natl.Acad.Sci.USA, 111, 2014
6RZC
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Winter flounder 4 in SDS micelles
分子名称: Pleurocidin-like peptide WF4
著者Mason, A.J, Clarke, M.
登録日2019-06-13
公開日2020-07-15
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Winter flounder 4 in SDS micelles
To Be Published
6RYQ
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Winter flounder 1a in SDS micelles
分子名称: Pleurocidin-like prepropolypeptide
著者Mason, A.J, Clarke, M.
登録日2019-06-11
公開日2020-07-15
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Winter flounder 1a in SDS micelles
To Be Published
6RZ1
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Winter flounder 3 in SDS micelles
分子名称: Pleurocidin-like peptide WF3
著者Mason, A.J, Clarke, M.
登録日2019-06-12
公開日2020-07-15
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Structure of winter flounder AMP 3
To Be Published
1DTG
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HUMAN TRANSFERRIN N-LOBE MUTANT H249E
分子名称: CARBONATE ION, FE (III) ION, TRANSFERRIN
著者MacGillivray, R.T, Bewley, M.C, Smith, C.A, He, Q.Y, Mason, A.B.
登録日2000-01-12
公開日2000-01-21
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Mutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine "trigger" but does not significantly affect iron release.
Biochemistry, 39, 2000
2VH6
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Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs
分子名称: 2-(5-chlorothiophen-2-yl)-N-{(3S)-1-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-2-oxopyrrolidin-3-yl}ethanesulfonamide, ACTIVATED FACTOR XA HEAVY CHAIN, ACTIVATED FACTOR XA LIGHT CHAIN
著者Young, R.J, Borthwick, A.D, Brown, D, Burns-Kurtis, C.L, Campbell, M, Chan, C, Charbaut, M, Chung, C.W, Convery, M.A, Kelly, H.A, King, N.P, Kleanthous, S, Mason, A.M, Pateman, A.J, Patikis, A.N, Pinto, I.L, Pollard, D.R, Senger, S, Shah, G.P, Toomey, J.R, Watson, N.S, Weston, H.E.
登録日2007-11-19
公開日2008-12-16
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure and Property Based Design of Factor Xa Inhibitors: Pyrrolidin-2-Ones with Biaryl P4 Motifs.
Bioorg.Med.Chem.Lett., 18, 2008
2VH0
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Structure and property based design of factor Xa inhibitors:biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs
分子名称: 2-(5-chlorothiophen-2-yl)-N-[(3S)-1-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-2-oxopyrrolidin-3-yl]ethanesulfonamide, ACTIVATED FACTOR XA HEAVY CHAIN, ACTIVATED FACTOR XA LIGHT CHAIN, ...
著者Young, R.J, Borthwick, A.D, Brown, D, Burns-Kurtis, C.L, Campbell, M, Chan, C, Charbaut, M, Convery, M.A, Diallo, H, Hortense, E, Irving, W.R, Kelly, H.A, King, N.P, Kleanthous, S, Mason, A.M, Pateman, A.J, Patikis, A, Pinto, I.L, Pollard, D.R, Senger, S, Shah, G.P, Toomey, J.R, Watson, N.S, Weston, H.E, Zhou, P.
登録日2007-11-16
公開日2008-11-25
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs.
Bioorg. Med. Chem. Lett., 18, 2008
3FGS
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Crystal structure of G65R/K206E double mutant of the N-lobe human transferrin
分子名称: CARBONATE ION, FE (III) ION, Serotransferrin
著者Halbrooks, P.J, Mason, A.B, Everse, S.J.
登録日2008-12-08
公開日2009-05-19
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and Functional Consequences of the Substitution of Glycine 65 with Arginine in the N-Lobe of Human Transferrin.
Biochemistry, 48, 2009
1OQH
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Crystal Structure of the R124A mutant of the N-lobe human transferrin
分子名称: CARBONATE ION, FE (III) ION, POTASSIUM ION, ...
著者Baker, H.M, He, Q.-Y, Brigg, S.K, Mason, A.B, N Baker, E.
登録日2003-03-10
公開日2003-03-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural and functional consequences of binding site mutations in transferrin: crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin
Biochemistry, 42, 2003
1D3K
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HUMAN SERUM TRANSFERRIN
分子名称: CARBONATE ION, FE (III) ION, SERUM TRANSFERRIN
著者Yang, H.-W, MacGillivray, R.T.A, Chen, J, Luo, Y, Wang, Y, Brayer, G.D, Mason, A, Woodworth, R.C, Murphy, M.E.P.
登録日1999-09-29
公開日2000-03-01
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for iron.
Protein Sci., 9, 2000
1D4N
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HUMAN SERUM TRANSFERRIN
分子名称: CARBONATE ION, FE (III) ION, TRANSFERRIN
著者Yang, H.-W, MacGillivray, R.T.A, Chen, J, Luo, Y, Wang, Y, Brayer, G.D, Mason, A, Woodworth, R.C, Murphy, M.E.P.
登録日1999-10-04
公開日2000-03-01
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for iron.
Protein Sci., 9, 2000
1RYO
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Human serum transferrin, N-lobe bound with oxalate
分子名称: FE (III) ION, OXALATE ION, Serotransferrin
著者Halbrooks, P.J, Mason, A.B, Adams, T.E, Briggs, S.K, Everse, S.J.
登録日2003-12-22
公開日2004-05-11
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献The oxalate effect on release of iron from human serum transferrin explained.
J.Mol.Biol., 339, 2004
1N7X
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HUMAN SERUM TRANSFERRIN, N-LOBE Y45E MUTANT
分子名称: CARBONATE ION, FE (III) ION, Serotransferrin
著者Adams, T.E, Mason, A.B, He, Q.Y, Halbrooks, P.J, Briggs, S.K, Smith, V.C, Macgillivray, R.T, Everse, S.J.
登録日2002-11-18
公開日2003-03-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献THE POSITION OF ARGININE 124 CONTROLS THE RATE OF IRON RELEASE FROM THE N-LOBE OF HUMAN SERUM TRANSFERRIN. A STRUCTURAL STUDY
J.Biol.Chem., 278, 2003
1N7W
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Crystal Structure of Human Serum Transferrin, N-Lobe L66W mutant
分子名称: CARBONATE ION, FE (III) ION, Serotransferrin
著者Adams, T.E, Mason, A.B, He, Q.Y, Halbrooks, P.J, Briggs, S.K, Smith, V.C, MacGillivray, R.T, Everse, S.J.
登録日2002-11-18
公開日2003-03-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Position of Arginine 124 Controls the Rate of Iron Release from the N-lobe of Human Serum Transferrin. A Structural Study
J.Biol.Chem., 278, 2003
1N84
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HUMAN SERUM TRANSFERRIN, N-LOBE
分子名称: CARBONATE ION, FE (III) ION, Serotransferrin
著者Adams, T.E, Mason, A.B, He, Q.Y, Halbrooks, P.J, Briggs, S.K, Smith, V.C, Macgillivray, R.T, Everse, S.J.
登録日2002-11-19
公開日2003-03-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献THE POSITION OF ARGININE 124 CONTROLS THE RATE OF IRON RELEASE FROM THE N-LOBE OF HUMAN SERUM TRANSFERRIN. A STRUCTURAL STUDY
J.Biol.Chem., 278, 2003
1A8F
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HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE
分子名称: CARBONATE ION, FE (III) ION, SERUM TRANSFERRIN
著者Macgillivray, R.T.A, Moore, S.A, Chen, J, Anderson, B.F, Baker, H, Luo, Y, Bewley, M, Smith, C.A, Murphy, M.E.P, Wang, Y, Mason, A.B, Woodworth, R.C, Brayer, G.D, Baker, E.N.
登録日1998-03-25
公開日1998-06-17
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release.
Biochemistry, 37, 1998
1A8E
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HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE
分子名称: CARBONATE ION, FE (III) ION, SERUM TRANSFERRIN
著者Macgillivray, R.T.A, Moore, S.A, Chen, J, Anderson, B.F, Baker, H, Luo, Y, Bewley, M, Smith, C.A, Murphy, M.E.P, Wang, Y, Mason, A.B, Woodworth, R.C, Brayer, G.D, Baker, E.N.
登録日1998-03-24
公開日1998-06-17
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release.
Biochemistry, 37, 1998
1BTJ
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HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE, APO FORM, CRYSTAL FORM 2
分子名称: PROTEIN (SERUM TRANSFERRIN)
著者Jeffrey, P.D, Bewley, M.C, Macgillivray, R.T.A, Mason, A.B, Woodworth, R.C, Baker, E.N.
登録日1998-09-01
公開日1999-01-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Ligand-induced conformational change in transferrins: crystal structure of the open form of the N-terminal half-molecule of human transferrin.
Biochemistry, 37, 1998
1BP5
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HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE, APO FORM
分子名称: PROTEIN (SERUM TRANSFERRIN)
著者Jeffrey, P.D, Bewley, M.C, Macgillivray, R.T.A, Mason, A.B, Woodworth, R.C, Baker, E.N.
登録日1998-08-12
公開日1999-01-13
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Ligand-induced conformational change in transferrins: crystal structure of the open form of the N-terminal half-molecule of human transferrin.
Biochemistry, 37, 1998
1B3E
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HUMAN SERUM TRANSFERRIN, N-TERMINAL LOBE, EXPRESSED IN PICHIA PASTORIS
分子名称: CARBONATE ION, FE (III) ION, PROTEIN (SERUM TRANSFERRIN)
著者Bewley, M.C, Tam, B.M, Grewal, J, He, S, Shewry, S, Murphy, M.E.P, Mason, A.B, Woodworth, R.C, Baker, E.N, Macgillivray, R.T.A.
登録日1998-12-09
公開日1999-03-26
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献X-ray crystallography and mass spectroscopy reveal that the N-lobe of human transferrin expressed in Pichia pastoris is folded correctly but is glycosylated on serine-32.
Biochemistry, 38, 1999
1JQF
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Human Transferrin N-Lobe Mutant H249Q
分子名称: CARBONATE ION, FE (III) ION, POTASSIUM ION, ...
著者Baker, H.M, Mason, A.B, He, Q.-Y, MacGillivray, R.T.A, Baker, E.N.
登録日2001-08-06
公開日2001-10-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Ligand variation in the transferrin family: the crystal structure of the H249Q mutant of the human transferrin N-lobe as a model for iron binding in insect transferrins.
Biochemistry, 40, 2001
6S2D
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Winter flounder 1 in SDS micelles
分子名称: Pleurocidin-like prepropolypeptide
著者Clarke, M, Mason, A.J.
登録日2019-06-20
公開日2020-07-15
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Winter flounder 1 in SDS micelles
To Be Published
1OQG
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Crystal structure of the D63E mutant of the N-lobe human transferrin
分子名称: CARBONATE ION, FE (III) ION, Serotransferrin
著者Baker, H.M, He, Q.-Y, Brigg, S.K, Mason, A.B, Baker, E.N.
登録日2003-03-09
公開日2003-03-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional consequences of binding site mutations in transferrin: crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin
Biochemistry, 42, 2003
2CJI
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Crystal structure of a Human Factor Xa inhibitor complex
分子名称: 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ...
著者Watson, N.S, Campbell, M, Chan, C, Convery, M.A, Hamblin, J.N, Kelly, H.A, King, N.P, Mason, A.M, Mitchell, C, Patel, V.K, Senger, S, Shah, G.P, Weston, H.E, Whitworth, C, Young, R.J.
登録日2006-04-03
公開日2006-05-17
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Design and Synthesis of Orally Active Pyrrolidin-2-One-Based Factor Xa Inhibitors
Bioorg.Med.Chem.Lett., 16, 2006
6RSG
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NMR structure of pleurocidin VA in SDS micelles
分子名称: Pleurocidin
著者Manzo, G, Mason, A.J.
登録日2019-05-21
公開日2020-12-09
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy.
Commun Biol, 3, 2020

 

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