Crystal structure of G65R/K206E double mutant of the N-lobe human transferrin

Summary for 3FGS

Related2O84 1a8e
DescriptorSerotransferrin, CARBONATE ION, FE (III) ION, ... (4 entities in total)
Functional Keywordshuman transferrin, iron binding protein, dilysine pair, disease mutation, glycoprotein, ion transport, iron, iron transport, metal-binding, methylation, phosphoprotein, polymorphism, secreted, transport, metal transport
Biological sourceHomo sapiens (human)
Cellular locationSecreted P02787
Total number of polymer chains1
Total molecular weight37431.2
Halbrooks, P.J.,Mason, A.B.,Everse, S.J. (deposition date: 2008-12-08, release date: 2009-05-19, Last modification date: 2017-11-01)
Primary citation
Mason, A.B.,Halbrooks, P.J.,James, N.G.,Byrne, S.L.,Grady, J.K.,Chasteen, N.D.,Bobst, C.E.,Kaltashov, I.A.,Smith, V.C.,Macgillivray, R.T.,Everse, S.J.
Structural and Functional Consequences of the Substitution of Glycine 65 with Arginine in the N-Lobe of Human Transferrin.
Biochemistry, 48:1945-1953, 2009
PubMed: 19219998 (PDB entries with the same primary citation)
DOI: 10.1021/bi802254x
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24610 0.3% 2.9% 4.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21