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PDB: 401 件
1X7S
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The X-ray crystallographic structure of the amyloidogenic variant TTR Tyr78Phe
分子名称: Transthyretin
著者Neto-Silva, R.M, Macedo-Ribeiro, S, Pereira, P.J.B, Saraiva, M.J, Damas, A.M.
登録日2004-08-16
公開日2005-03-22
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献X-ray crystallographic studies of two transthyretin variants: further insights into amyloidogenesis.
Acta Crystallogr.,Sect.D, 61, 2005
2HM1
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Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)
分子名称: Beta-secretase 1, N-{(1S)-2-({(1S,2R)-1-(3,5-DIFLUOROBENZYL)-3-[(3-ETHYLBENZYL)AMINO]-2-HYDROXYPROPYL}AMINO)-2-OXO-1-[(PENTYLSULFONYL)METHYL]ETHYL}NICOTINAMIDE
著者Benson, T.E, Prince, D.B, Tomasselli, A.G, Emmons, T.L, Paddock, D.J.
登録日2006-07-10
公開日2007-01-23
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Design of potent inhibitors of human beta-secretase. Part 2.
Bioorg.Med.Chem.Lett., 17, 2007
2HIZ
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Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor
分子名称: BENZYL [(1S)-2-({(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}AMINO)-2-OXO-1-{[(1-PROPYLBUTYL)SULFONYL]METHYL}ETHYL]CARBAMATE, Beta-secretase 1, PHOSPHATE ION
著者Benson, T.E, Prince, D.B, Tomasselli, A.G, Emmons, T.L, Paddock, D.J.
登録日2006-06-29
公開日2007-01-23
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Design of potent inhibitors of human beta-secretase. Part 1.
Bioorg.Med.Chem.Lett., 17, 2007
1UUY
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Structure of a molybdopterin-bound cnx1g domain links molybdenum and copper metabolism
分子名称: ADENOSINE MONOPHOSPHATE, COPPER (I) ION, FORMIC ACID, ...
著者Kuper, J, Llamas, A, Hecht, H.J, Mendel, R.R, Schwarz, G.
登録日2004-01-12
公開日2004-08-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structure of a Molybdopterin-Bound Cnx1G Domain Links Molybdenum and Copper Metabolism
Nature, 430, 2004
1X7T
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Structure of TTR R104H: a non-amyloidogenic variant with protective clinical effects
分子名称: Transthyretin
著者Neto-Silva, R.M, Macedo-Ribeiro, S, Pereira, P.J.B, Coll, M, Saraiva, M.J, Damas, A.M.
登録日2004-08-16
公開日2005-03-22
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献X-ray crystallographic studies of two transthyretin variants: further insights into amyloidogenesis.
Acta Crystallogr.,Sect.D, 61, 2005
2IQG
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Crystal Structure of Hydroxyethyl Secondary Amine-based Peptidomimetic Inhibitor of Human Beta-Secretase (BACE)
分子名称: Beta-secretase 1, N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-IODOBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE
著者Benson, T.E, Woods, D.D, Prince, D.B, Tomasselli, A.G, Emmons, T.L.
登録日2006-10-13
公開日2007-02-27
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human beta-Secretase.
J.Med.Chem., 50, 2007
1KU9
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X-ray Structure of a Methanococcus jannaschii DNA-Binding Protein: Implications for Antibiotic Resistance in Staphylococcus aureus
分子名称: hypothetical protein MJ223
著者Ray, S.S, Bonanno, J.B, Chen, H, de Lencastre, H, Wu, S, Tomasz, A, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2002-01-21
公開日2002-12-25
最終更新日2021-02-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献X-ray structure of an M. jannaschii DNA-binding protein: implications for antibiotic resistance in S. aureus
Proteins, 50, 2002
1BP5
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HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE, APO FORM
分子名称: PROTEIN (SERUM TRANSFERRIN)
著者Jeffrey, P.D, Bewley, M.C, Macgillivray, R.T.A, Mason, A.B, Woodworth, R.C, Baker, E.N.
登録日1998-08-12
公開日1999-01-13
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Ligand-induced conformational change in transferrins: crystal structure of the open form of the N-terminal half-molecule of human transferrin.
Biochemistry, 37, 1998
1B3E
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HUMAN SERUM TRANSFERRIN, N-TERMINAL LOBE, EXPRESSED IN PICHIA PASTORIS
分子名称: CARBONATE ION, FE (III) ION, PROTEIN (SERUM TRANSFERRIN)
著者Bewley, M.C, Tam, B.M, Grewal, J, He, S, Shewry, S, Murphy, M.E.P, Mason, A.B, Woodworth, R.C, Baker, E.N, Macgillivray, R.T.A.
登録日1998-12-09
公開日1999-03-26
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献X-ray crystallography and mass spectroscopy reveal that the N-lobe of human transferrin expressed in Pichia pastoris is folded correctly but is glycosylated on serine-32.
Biochemistry, 38, 1999
1BTJ
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HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE, APO FORM, CRYSTAL FORM 2
分子名称: PROTEIN (SERUM TRANSFERRIN)
著者Jeffrey, P.D, Bewley, M.C, Macgillivray, R.T.A, Mason, A.B, Woodworth, R.C, Baker, E.N.
登録日1998-09-01
公開日1999-01-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Ligand-induced conformational change in transferrins: crystal structure of the open form of the N-terminal half-molecule of human transferrin.
Biochemistry, 37, 1998
1D4N
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HUMAN SERUM TRANSFERRIN
分子名称: CARBONATE ION, FE (III) ION, TRANSFERRIN
著者Yang, H.-W, MacGillivray, R.T.A, Chen, J, Luo, Y, Wang, Y, Brayer, G.D, Mason, A, Woodworth, R.C, Murphy, M.E.P.
登録日1999-10-04
公開日2000-03-01
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for iron.
Protein Sci., 9, 2000
1D3K
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HUMAN SERUM TRANSFERRIN
分子名称: CARBONATE ION, FE (III) ION, SERUM TRANSFERRIN
著者Yang, H.-W, MacGillivray, R.T.A, Chen, J, Luo, Y, Wang, Y, Brayer, G.D, Mason, A, Woodworth, R.C, Murphy, M.E.P.
登録日1999-09-29
公開日2000-03-01
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for iron.
Protein Sci., 9, 2000
3B56
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Crystal structure of transthyretin in complex with 3,5-diiodosalicylic acid
分子名称: 2-HYDROXY-3,5-DIIODO-BENZOIC ACID, Transthyretin
著者Gales, L, Damas, A.M.
登録日2007-10-25
公開日2008-01-15
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Iodination of salicylic acid improves its binding to transthyretin
Biochim.Biophys.Acta, 1784, 2008
1M5V
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Transition State Stabilization by a Catalytic RNA
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, RNA HAIRPIN RIBOZYME, ...
著者Rupert, P.B, Massey, A.P, Sigurdsson, S.T, Ferre-D'Amare, A.R.
登録日2002-07-09
公開日2002-10-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Transition state stabilization by a catalytic RNA
Science, 298, 2002
1OIR
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Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation
分子名称: 1-(DIMETHYLAMINO)-3-(4-{{4-(2-METHYLIMIDAZO[1,2-A]PYRIDIN-3-YL)PYRIMIDIN-2-YL]AMINO}PHENOXY)PROPAN-2-OL, CELL DIVISION PROTEIN KINASE 2
著者Beattie, J.F, Breault, G.A, Byth, K.F, Culshaw, J.D, Ellston, R.P.A, Green, S, Minshull, C.A, Norman, R.A, Pauptit, R.A, Thomas, A.P, Jewsbury, P.J.
登録日2003-06-24
公開日2003-09-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Imidazo[1,2-A]Pyridines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors Identified Through Structure-Based Hybridisation
Bioorg.Med.Chem.Lett., 13, 2003
1N2W
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Solution Structure of 8OG:G mismatch containing duplex
分子名称: 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(8OG)P*GP*CP*G)-3'
著者Thiviyanathan, V, Somasunderam, A.D, Hazra, T.K, Mitra, S, Gorenstein, D.G.
登録日2002-10-24
公開日2002-11-13
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution Structure of a DNA Duplex Containing 8-Hydroxy-2'-Deoxyguanosine Opposite Deoxyguanosine
J.Mol.Biol., 325, 2003
1M5O
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Transition State Stabilization by a Catalytic RNA
分子名称: CALCIUM ION, RNA SUBSTRATE, RNA HAIRPIN RIBOZYME, ...
著者Rupert, P.B, Massey, A.P, Sigurdsson, S.T, Ferre-D'Amare, A.R.
登録日2002-07-09
公開日2002-10-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Transition state stabilization by a catalytic RNA
Science, 298, 2002
1M5P
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Transition State Stabilization by a Catalytic RNA
分子名称: CALCIUM ION, RNA HAIRPIN RIBOZYME, RNA INHIBITOR SUBSTRATE, ...
著者Rupert, P.B, Massey, A, Sigurdsson, S.T, Ferre-D'Amare, A.R.
登録日2002-07-09
公開日2002-10-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Transition state stabilization by a catalytic RNA
Science, 298, 2002
1OS0
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Thermolysin with an alpha-amino phosphinic inhibitor
分子名称: CALCIUM ION, DIMETHYL SULFOXIDE, N-{(2R)-3-[(S)-[(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}-L-phenylalanine, ...
著者Selkti, M, Tomas, A, Prange, T.
登録日2003-03-18
公開日2003-03-25
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Interactions of a new alpha-aminophosphinic derivative inside the active site of TLN (thermolysin): a model for zinc-metalloendopeptidase inhibition.
Acta Crystallogr.,Sect.D, 59, 2003
1OIQ
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Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation
分子名称: CELL DIVISION PROTEIN KINASE 2, N-[4-(2-METHYLIMIDAZO[1,2-A]PYRIDIN-3-YL)-2-PYRIMIDINYL]ACETAMIDE
著者Beattie, J.F, Breault, G.A, Byth, K.F, Culshaw, J.D, Ellston, R.P.A, Green, S, Minshull, C.A, Norman, R.A, Pauptit, R.A, Thomas, A.P, Jewsbury, P.J.
登録日2003-06-24
公開日2003-09-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Imidazo[1,2-A]Pyridines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors Identified Through Structure-Based Hybridisation
Bioorg.Med.Chem.Lett., 13, 2003
1OIT
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Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation
分子名称: 4-[(4-IMIDAZO[1,2-A]PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2
著者Beattie, J.F, Breault, G.A, Byth, K.F, Culshaw, J.D, Ellston, R.P.A, Green, S, Minshull, C.A, Norman, R.A, Pauptit, R.A, Thomas, A.P, Jewsbury, P.J.
登録日2003-06-24
公開日2003-09-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Imidazo[1,2-A]Pyridines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors Identified Through Structure-Based Hybridisation
Bioorg.Med.Chem.Lett., 13, 2003
1N7W
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Crystal Structure of Human Serum Transferrin, N-Lobe L66W mutant
分子名称: CARBONATE ION, FE (III) ION, Serotransferrin
著者Adams, T.E, Mason, A.B, He, Q.Y, Halbrooks, P.J, Briggs, S.K, Smith, V.C, MacGillivray, R.T, Everse, S.J.
登録日2002-11-18
公開日2003-03-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Position of Arginine 124 Controls the Rate of Iron Release from the N-lobe of Human Serum Transferrin. A Structural Study
J.Biol.Chem., 278, 2003
1N84
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HUMAN SERUM TRANSFERRIN, N-LOBE
分子名称: CARBONATE ION, FE (III) ION, Serotransferrin
著者Adams, T.E, Mason, A.B, He, Q.Y, Halbrooks, P.J, Briggs, S.K, Smith, V.C, Macgillivray, R.T, Everse, S.J.
登録日2002-11-19
公開日2003-03-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献THE POSITION OF ARGININE 124 CONTROLS THE RATE OF IRON RELEASE FROM THE N-LOBE OF HUMAN SERUM TRANSFERRIN. A STRUCTURAL STUDY
J.Biol.Chem., 278, 2003
1N7X
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HUMAN SERUM TRANSFERRIN, N-LOBE Y45E MUTANT
分子名称: CARBONATE ION, FE (III) ION, Serotransferrin
著者Adams, T.E, Mason, A.B, He, Q.Y, Halbrooks, P.J, Briggs, S.K, Smith, V.C, Macgillivray, R.T, Everse, S.J.
登録日2002-11-18
公開日2003-03-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献THE POSITION OF ARGININE 124 CONTROLS THE RATE OF IRON RELEASE FROM THE N-LOBE OF HUMAN SERUM TRANSFERRIN. A STRUCTURAL STUDY
J.Biol.Chem., 278, 2003
1OQG
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Crystal structure of the D63E mutant of the N-lobe human transferrin
分子名称: CARBONATE ION, FE (III) ION, Serotransferrin
著者Baker, H.M, He, Q.-Y, Brigg, S.K, Mason, A.B, Baker, E.N.
登録日2003-03-09
公開日2003-03-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional consequences of binding site mutations in transferrin: crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin
Biochemistry, 42, 2003

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