7OI9
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![BU of 7oi9 by Molmil](/molmil-images/mine/7oi9) | Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 3B | 分子名称: | 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... | 著者 | Cheng, J, Berninghausen, O, Beckmann, R. | 登録日 | 2021-05-11 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A distinct assembly pathway of the human 39S late pre-mitoribosome. Nat Commun, 12, 2021
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7OI7
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![BU of 7oi7 by Molmil](/molmil-images/mine/7oi7) | Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 2 | 分子名称: | 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... | 著者 | Cheng, J, Berninghausen, O, Beckmann, R. | 登録日 | 2021-05-11 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | A distinct assembly pathway of the human 39S late pre-mitoribosome. Nat Commun, 12, 2021
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7OIA
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![BU of 7oia by Molmil](/molmil-images/mine/7oia) | Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 3C | 分子名称: | 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... | 著者 | Cheng, J, Berninghausen, O, Beckmann, R. | 登録日 | 2021-05-11 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | A distinct assembly pathway of the human 39S late pre-mitoribosome. Nat Commun, 12, 2021
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7OIC
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![BU of 7oic by Molmil](/molmil-images/mine/7oic) | Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 4 | 分子名称: | 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... | 著者 | Cheng, J, Berninghausen, O, Beckmann, R. | 登録日 | 2021-05-11 | 公開日 | 2021-09-15 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A distinct assembly pathway of the human 39S late pre-mitoribosome. Nat Commun, 12, 2021
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7OIE
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![BU of 7oie by Molmil](/molmil-images/mine/7oie) | Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 5B | 分子名称: | 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... | 著者 | Cheng, J, Berninghausen, O, Beckmann, R. | 登録日 | 2021-05-11 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | A distinct assembly pathway of the human 39S late pre-mitoribosome. Nat Commun, 12, 2021
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7OIB
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![BU of 7oib by Molmil](/molmil-images/mine/7oib) | Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 3D | 分子名称: | 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... | 著者 | Cheng, J, Berninghausen, O, Beckmann, R. | 登録日 | 2021-05-11 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A distinct assembly pathway of the human 39S late pre-mitoribosome. Nat Commun, 12, 2021
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7QVP
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![BU of 7qvp by Molmil](/molmil-images/mine/7qvp) | Human collided disome (di-ribosome) stalled on XBP1 mRNA | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | 著者 | Denk, T.G, Tesina, P, Beckmann, R. | 登録日 | 2022-01-22 | 公開日 | 2022-10-12 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation. Nat Commun, 13, 2022
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5NWY
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![BU of 5nwy by Molmil](/molmil-images/mine/5nwy) | 2.9 A cryo-EM structure of VemP-stalled ribosome-nascent chain complex | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Su, T, Cheng, J, Sohmen, D, Hedman, R, Berninghausen, O, von Heijne, G, Wilson, D.N, Beckmann, R. | 登録日 | 2017-05-08 | 公開日 | 2017-07-19 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling. Elife, 6, 2017
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6FTJ
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![BU of 6ftj by Molmil](/molmil-images/mine/6ftj) | Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Non-programmed 80S Ribosome | 分子名称: | 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | 著者 | Braunger, K, Becker, T, Beckmann, R. | 登録日 | 2018-02-22 | 公開日 | 2018-03-21 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum. Science, 360, 2018
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5NVA
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![BU of 5nva by Molmil](/molmil-images/mine/5nva) | Substrate-bound outward-open state of a Na+-coupled sialic acid symporter reveals a novel Na+-site | 分子名称: | N-acetyl-beta-neuraminic acid, Putative sodium:solute symporter, SODIUM ION | 著者 | Wahlgren, W.Y, North, R.A, Dunevall, E, Goyal, P, Grabe, M, Dobson, R, Abramson, J, Ramaswamy, S, Friemann, R. | 登録日 | 2017-05-03 | 公開日 | 2018-04-04 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+site. Nat Commun, 9, 2018
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4BK4
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![BU of 4bk4 by Molmil](/molmil-images/mine/4bk4) | crystal structure of the human EphA4 ectodomain | 分子名称: | EPHRIN TYPE-A RECEPTOR 4 | 著者 | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | 登録日 | 2013-04-22 | 公開日 | 2013-07-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
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4BKA
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![BU of 4bka by Molmil](/molmil-images/mine/4bka) | crystal structure of the human EphA4 ectodomain in complex with human ephrin A5 | 分子名称: | EPHRIN TYPE-A RECEPTOR 4, EPHRIN-A5 | 著者 | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | 登録日 | 2013-04-23 | 公開日 | 2013-07-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (5.3 Å) | 主引用文献 | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
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3J2I
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![BU of 3j2i by Molmil](/molmil-images/mine/3j2i) | Structure of late pre-60S ribosomal subunits with nuclear export factor Arx1 bound at the peptide exit tunnel | 分子名称: | Eukaryotic translation initiation factor 6, Proliferation-associated protein 2G4 | 著者 | Bradatsch, B, Leidig, C, Granneman, S, Gnaedig, M, Tollervey, D, Boettcher, B, Beckmann, R, Hurt, E. | 登録日 | 2012-10-04 | 公開日 | 2012-11-07 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (11.9 Å) | 主引用文献 | Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel. Nat.Struct.Mol.Biol., 19, 2012
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5LW7
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![BU of 5lw7 by Molmil](/molmil-images/mine/5lw7) | S. solfataricus ABCE1 post-splitting state | 分子名称: | ABC transporter ATP-binding protein, IRON/SULFUR CLUSTER | 著者 | Heuer, A, Gerovac, M, Beckmann, R, Tampe, R. | 登録日 | 2016-09-15 | 公開日 | 2016-11-16 | 最終更新日 | 2019-02-20 | 実験手法 | ELECTRON MICROSCOPY (17 Å) | 主引用文献 | Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry. Nat Commun, 7, 2016
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5LQW
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![BU of 5lqw by Molmil](/molmil-images/mine/5lqw) | yeast activated spliceosome | 分子名称: | Pre-mRNA leakage protein 1, Pre-mRNA-processing protein 45, Pre-mRNA-splicing factor 8, ... | 著者 | Rauhut, R, Luehrmann, R. | 登録日 | 2016-08-17 | 公開日 | 2016-10-05 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | 主引用文献 | Molecular architecture of the Saccharomyces cerevisiae activated spliceosome Science, 6306, 2016
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6G5I
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![BU of 6g5i by Molmil](/molmil-images/mine/6g5i) | Cryo-EM structure of a late human pre-40S ribosomal subunit - State R | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. | 登録日 | 2018-03-29 | 公開日 | 2018-06-06 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018
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3J25
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![BU of 3j25 by Molmil](/molmil-images/mine/3j25) | Structural basis for TetM-mediated tetracycline resistance | 分子名称: | PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Tetracycline resistance protein tetM | 著者 | Doenhoefer, A, Franckenberg, S, Wickles, S, Berninghausen, O, Beckmann, R, Wilson, D.N. | 登録日 | 2012-08-22 | 公開日 | 2012-10-17 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | 主引用文献 | Structural basis for TetM-mediated tetracycline resistance. Proc.Natl.Acad.Sci.USA, 109, 2012
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4BK5
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![BU of 4bk5 by Molmil](/molmil-images/mine/4bk5) | crystal structure of the human EphA4 ectodomain in complex with human ephrin A5 (amine-methylated sample) | 分子名称: | EPHRIN TYPE-A RECEPTOR 4, EPHRIN-A5 | 著者 | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | 登録日 | 2013-04-22 | 公開日 | 2013-07-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
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4BKF
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![BU of 4bkf by Molmil](/molmil-images/mine/4bkf) | crystal structure of the human EphA4 ectodomain in complex with human ephrinB3 | 分子名称: | EPHRIN TYPE-A RECEPTOR 4, EPHRIN-B3 | 著者 | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | 登録日 | 2013-04-24 | 公開日 | 2013-07-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (4.65 Å) | 主引用文献 | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
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5MVC
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![BU of 5mvc by Molmil](/molmil-images/mine/5mvc) | Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds | 分子名称: | 4-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]-1,2,5-thiadiazole-3-carboxamide, ACETATE ION, CHLORIDE ION, ... | 著者 | Goyal, P, Andersson, M, Moritzer, A.C, Sainas, S, Pippione, A.C, Boschi, D, Al-Kadaraghi, S, Lolli, M, Friemann, R. | 登録日 | 2017-01-16 | 公開日 | 2017-03-08 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur J Med Chem, 129, 2017
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5M5H
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![BU of 5m5h by Molmil](/molmil-images/mine/5m5h) | RIBOSOME-BOUND YIDC INSERTASE | 分子名称: | Membrane protein insertase YidC | 著者 | Kedrov, A, Wickles, S, Crevenna, A.H, van der Sluis, E, Buschauer, R, Berninghausen, O, Lamb, D.C, Beckmann, R. | 登録日 | 2016-10-21 | 公開日 | 2016-12-14 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis. Cell Rep, 17, 2016
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6F78
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![BU of 6f78 by Molmil](/molmil-images/mine/6f78) | Potent and selective Aldo-Keto Reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: Application of a Bioisosteric Scaffold Hopping Approach to Flufenamic acid | 分子名称: | 4-[[3,5-bis(trifluoromethyl)phenyl]amino]-1,2-benzoxazol-3-one, Aldo-keto reductase family 1 member C3, CHLORIDE ION, ... | 著者 | Goyal, P, Wahlgren, W.Y, Friemann, R. | 登録日 | 2017-12-07 | 公開日 | 2018-04-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid. Eur J Med Chem, 150, 2018
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5NCK
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![BU of 5nck by Molmil](/molmil-images/mine/5nck) | |
6F2U
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![BU of 6f2u by Molmil](/molmil-images/mine/6f2u) | Potent and selective Aldo-Keto Reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a Bioisosteric Scaffold Hopping Approach to Flufenamic acid | 分子名称: | 3-[(4-methoxyphenyl)methyl]-5-oxidanyl-~{N}-[3-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxamide, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Goyal, P, Wahlgren, W.Y, Friemann, R. | 登録日 | 2017-11-27 | 公開日 | 2018-04-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid. Eur J Med Chem, 150, 2018
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5MUT
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![BU of 5mut by Molmil](/molmil-images/mine/5mut) | Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds | 分子名称: | 2-methyl-5-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]-1,2,3-triazole-4-carboxamide, ACETATE ION, CHLORIDE ION, ... | 著者 | Goyal, P, Andersson, M, Moritzer, A.C, Sainas, S, Pippione, A.C, Boschi, D, Al-Kadaraghi, S, Lolli, M, Friemann, R. | 登録日 | 2017-01-14 | 公開日 | 2017-03-08 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur J Med Chem, 129, 2017
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