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PDB: 1322 件
1M4J
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BU of 1m4j by Molmil
CRYSTAL STRUCTURE OF THE N-TERMINAL ADF-H DOMAIN OF MOUSE TWINFILIN ISOFORM-1
分子名称: A6 gene product
著者Paavilainen, V.O, Merckel, M.C, Falck, S, Ojala, P.J, Pohl, E, Wilmanns, M, Lappalainen, P.
登録日2002-07-03
公開日2002-11-13
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Conservation Between the Actin Monomer-binding Sites of Twinfilin and Actin-depolymerizing Factor (ADF)/Cofilin
J.Biol.Chem., 277, 2002
3J8D
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BU of 3j8d by Molmil
Cryoelectron microscopy of dengue-Fab E104 complex at pH 5.5
分子名称: Envelope protein E, antibody E111 Fab fragment, glycoprotein DIII
著者Zhang, X.Z, Sheng, J, Austin, S.K, Hoornweg, T, Smit, J.M, Kuhn, R.J, Diamond, M.S, Rossmann, M.G.
登録日2014-10-13
公開日2014-11-12
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (26 Å)
主引用文献Structure of Acidic pH Dengue Virus Showing the Fusogenic Glycoprotein Trimers.
J.Virol., 89, 2015
1O9Z
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BU of 1o9z by Molmil
F17-aG lectin domain from Escherichia coli (ligand free)
分子名称: F17-AG LECTIN DOMAIN
著者Buts, L, De Genst, E, Loris, R, Oscarson, S, Lahmann, M, Messens, J, Brosens, E, Wyns, L, Bouckaert, J, De Greve, H.
登録日2002-12-23
公開日2003-05-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The Fimbrial Adhesin F17-G of Enterotoxigenic Escherichia Coli Has an Immunoglobulin-Like Lectin Domain that Binds N-Acetylglucosamine
Mol.Microbiol., 49, 2003
1TUD
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BU of 1tud by Molmil
ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48
分子名称: ALPHA-SPECTRIN
著者Viguera, A.R, Serrano, L, Wilmanns, M.
登録日1996-02-29
公開日1996-08-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献The order of secondary structure elements does not determine the structure of a protein but does affect its folding kinetics.
J.Mol.Biol., 247, 1995
1YRP
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BU of 1yrp by Molmil
Catalytic domain of human ZIP kinase phosphorylated at Thr265
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Death-associated protein kinase 3
著者Kursula, P, Vahokoski, J, Wilmanns, M.
登録日2005-02-04
公開日2006-06-20
最終更新日2016-05-18
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites
Structure, 2016
6MZI
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BU of 6mzi by Molmil
CryoEM structure of human enterovirus D68 expanded 1 particle (pH 6.5, 4 degrees Celsius, 3 min)
分子名称: viral protein 1, viral protein 2, viral protein 3, ...
著者Liu, Y, Rossmann, M.G.
登録日2018-11-05
公開日2018-12-19
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Molecular basis for the acid-initiated uncoating of human enterovirus D68.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8BDO
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BU of 8bdo by Molmil
VCB in complex with compound 21
分子名称: (2~{S},4~{R})-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-~{N}-[4-(4-methyl-1,3-thiazol-5-yl)phenoxy]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
著者Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.
登録日2022-10-19
公開日2023-02-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023
8BDS
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BU of 8bds by Molmil
Ternary complex between VCB, BRD4-BD1 and PROTAC 48
分子名称: (2S,4R)-N-[(1S)-1-(4-chlorophenyl)-3-[2-[2-[2-[2-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8$l^{5},11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethylamino]-3-oxidanylidene-propyl]-1-[(2R)-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ...
著者Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.
登録日2022-10-20
公開日2023-02-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023
8BDT
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Ternary complex between VCB, BRD4-BD2 and PROTAC 51
分子名称: (2~{S},4~{R})-~{N}-[(1~{S})-3-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethylamino]-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-3-oxidanylidene-propyl]-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 4, Elongin-B, ...
著者Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.A.
登録日2022-10-20
公開日2023-02-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023
8BDM
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BU of 8bdm by Molmil
VCB in complex with compound 26
分子名称: (2~{S},4~{R})-~{N}-[[2-(2-methoxyethoxy)-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
著者Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.
登録日2022-10-19
公開日2023-02-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.021 Å)
主引用文献Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023
8BDL
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BU of 8bdl by Molmil
VCB in complex with compound 27
分子名称: (2~{S},4~{R})-~{N}-[(1~{S})-1-[2-(2-methoxyethoxy)-4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
著者Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.
登録日2022-10-19
公開日2023-02-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.295 Å)
主引用文献Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023
8BDJ
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BU of 8bdj by Molmil
VCB in complex with compound 30
分子名称: (2~{S},4~{R})-~{N}-[(1~{S})-1-[4-chloranyl-2-(2-methoxyethoxy)phenyl]ethyl]-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
著者Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.
登録日2022-10-19
公開日2023-02-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023
8BDI
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BU of 8bdi by Molmil
VCB in complex with compound 32
分子名称: (2~{S},4~{R})-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[(1~{S})-3-(methylamino)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-3-oxidanylidene-propyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
著者Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.
登録日2022-10-19
公開日2023-02-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.108 Å)
主引用文献Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Chemmedchem, 18, 2023
8OU3
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Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 8d
分子名称: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-fluoranyl-benzamide, Cereblon isoform 4, PHOSPHATE ION, ...
著者Heim, C, Bischof, L, Maiwald, S, Hartmann, M.D.
登録日2023-04-21
公開日2023-11-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU4
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Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11a
分子名称: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-chloranyl-benzamide, Cereblon isoform 4, ZINC ION
著者Heim, C, Bischof, L, Hartmann, M.D.
登録日2023-04-21
公開日2023-11-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU5
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BU of 8ou5 by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11b
分子名称: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-(trifluoromethyl)benzamide, Cereblon isoform 4, ZINC ION
著者Heim, C, Bischof, L, Hartmann, M.D.
登録日2023-04-21
公開日2023-11-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU6
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Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11c
分子名称: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-methyl-benzamide, Cereblon isoform 4, PHOSPHATE ION, ...
著者Heim, C, Bischof, L, Hartmann, M.D.
登録日2023-04-21
公開日2023-11-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU7
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Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11d
分子名称: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-methoxy-benzamide, Cereblon isoform 4, ZINC ION
著者Heim, C, Bischof, L, Hartmann, M.D.
登録日2023-04-22
公開日2023-11-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU9
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BU of 8ou9 by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11e
分子名称: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-oxidanyl-benzamide, Cereblon isoform 4, ZINC ION
著者Heim, C, Bischof, L, Hartmann, M.D.
登録日2023-04-22
公開日2023-11-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OUA
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BU of 8oua by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11f
分子名称: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(fluoranyl)-3-methoxy-benzamide, Cereblon isoform 4, PHOSPHATE ION, ...
著者Heim, C, Bischof, L, Hartmann, M.D.
登録日2023-04-22
公開日2023-11-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
2L41
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Nab3 RRM - UCUU complex
分子名称: RNA (5'-R(P*UP*CP*UP*U)-3'), RRM domain from Nuclear polyadenylated RNA-binding protein 3
著者Stefl, R, Pergoli, R, Hobor, F, Kubicek, K, Zimmermann, M, Pasulka, J, Hofr, C.
登録日2010-09-28
公開日2010-11-17
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Recognition of transcription termination signal by the nuclear polyadenylated RNA-binding (NAB) 3 protein
J.Biol.Chem., 286, 2011
1HZ3
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BU of 1hz3 by Molmil
ALZHEIMER'S DISEASE AMYLOID-BETA PEPTIDE (RESIDUES 10-35)
分子名称: A-BETA AMYLOID
著者Zhang, S, Iwata, K, Lachenmann, M.J, Peng, J.W, Li, S, Stimson, E.R, Lu, Y, Felix, A.M, Maggio, J.E, Lee, J.P.
登録日2001-01-23
公開日2001-01-31
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The Alzheimer's peptide a beta adopts a collapsed coil structure in water.
J.Struct.Biol., 130, 2000
3OY7
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BU of 3oy7 by Molmil
Crystal structure of a virus encoded glycosyltransferase in complex with GDP-mannose
分子名称: GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, Glycosyltransferase B736L
著者Xiang, Y, Rossmann, M.G.
登録日2010-09-23
公開日2010-11-17
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Crystal structure of a virus-encoded putative glycosyltransferase.
J.Virol., 84, 2010
8B9S
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BU of 8b9s by Molmil
NATIVE FORM, THERMOSTABLE LIPASE FROM THERMOANAEROBACTER THERMOHYDROSULFURICUS
分子名称: DECANE, GLYCEROL, PHOSPHATE ION, ...
著者Pinotsis, N, Wilmanns, M.
登録日2022-10-06
公開日2023-10-18
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex.
Nat Commun, 14, 2023
3H6P
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Crystal structure of Rv3019c-Rv3020c from Mycobacterium tuberculosis
分子名称: ESAT-6 LIKE PROTEIN ESXS, ESAT-6-like protein esxR, GLYCEROL
著者Chan, S, Arbing, M, Phan, T, Kaufmann, M, Cascio, D, Eisenberg, D, TB Structural Genomics Consortium (TBSGC), Integrated Center for Structure and Function Innovation (ISFI)
登録日2009-04-23
公開日2009-06-30
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Crystal structure of Rv3019c-Rv3020c from Mycobacterium tuberculosis
To be Published

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