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PDB: 93 件
7F98
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Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95
分子名称: Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, CHLORIDE ION, ...
著者Malhotra, N, Manickam, Y, Sharma, A.
登録日2021-07-04
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7F9C
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BU of 7f9c by Molmil
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96
分子名称: 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ...
著者Malhotra, N, Manickam, Y, Sharma, A.
登録日2021-07-04
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.196 Å)
主引用文献Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7WAL
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BU of 7wal by Molmil
Glutamyl-tRNA synthetase from Plasmodium falciparum (PfERS) in complex with Co
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, COBALT (II) ION, ...
著者Sharma, V, Manickam, Y, Babbar, P, Sharma, A.
登録日2021-12-14
公開日2022-12-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum.
Mol.Biochem.Parasitol., 253, 2022
7WAK
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BU of 7wak by Molmil
Glutamyl-tRNA synthetase from Plasmodium falciparum (PfERS) in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Glutamyl-tRNA synthetase, ...
著者Sharma, V, Manickam, Y, Babbar, P, Sharma, A.
登録日2021-12-14
公開日2022-12-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.782 Å)
主引用文献Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum.
Mol.Biochem.Parasitol., 253, 2022
7WAJ
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BU of 7waj by Molmil
Glutamyl-tRNA synthetase from Plasmodium falciparum (PfERS) complexed with ATP and Co
分子名称: ADENOSINE-5'-TRIPHOSPHATE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
著者Sharma, V, Manickam, Y, Babbar, P, Sharma, A.
登録日2021-12-14
公開日2022-12-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.254 Å)
主引用文献Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum.
Mol.Biochem.Parasitol., 253, 2022
7WAI
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BU of 7wai by Molmil
Glutamyl-tRNA synthetase from Plasmodium falciparum (PfERS)
分子名称: CHLORIDE ION, Glutamyl-tRNA synthetase
著者Sharma, V, Manickam, Y, Harlos, K, Sharma, A.
登録日2021-12-14
公開日2022-12-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.105 Å)
主引用文献Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum.
Mol.Biochem.Parasitol., 253, 2022
7WAO
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BU of 7wao by Molmil
Glutamyl-tRNA synthetase from Plasmodium falciparum (PfERS) in complex with Mn
分子名称: CHLORIDE ION, Glutamyl-tRNA synthetase, MANGANESE (II) ION
著者Sharma, V, Manickam, Y, Babbar, P, Sharma, A.
登録日2021-12-14
公開日2022-12-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.582 Å)
主引用文献Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum.
Mol.Biochem.Parasitol., 253, 2022
5ZKG
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BU of 5zkg by Molmil
Crystal Structure of C-terminal Domain of Plasmodium vivax p43
分子名称: Aminoacyl-tRna synthetase-interacting multifunctional protein P43
著者Gupta, S, Sharma, M, Manickam, Y, Sharma, A.
登録日2018-03-23
公開日2019-04-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein.
Acta Crystallogr D Struct Biol, 76, 2020
5ZH4
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CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-7
分子名称: (3R)-6,8-dihydroxy-3-{[(2S,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, CHLORIDE ION, LYSINE, ...
著者Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A.
登録日2018-03-11
公開日2018-06-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
5ZDK
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Crystal Structure Analysis of TtQRS in complex with ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CESIUM ION, CHLORIDE ION, ...
著者Mutharasappan, N, Jain, V, Sharma, A, Manickam, Y, Jeyaraman, J.
登録日2018-02-23
公開日2018-12-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes
Int. J. Biol. Macromol., 120, 2018
5ZH3
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BU of 5zh3 by Molmil
CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-6
分子名称: (3S)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, LYSINE, Lysine-tRNA ligase
著者Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A.
登録日2018-03-11
公開日2018-06-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
5ZH2
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BU of 5zh2 by Molmil
CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-5
分子名称: (3R)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ...
著者Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A.
登録日2018-03-11
公開日2018-06-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
5ZDL
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BU of 5zdl by Molmil
Crystal Structure Analysis of TtQRS in co-crystallised with ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Glutamine--tRNA ligase
著者Mutharasappan, N, Jain, V, Sharma, A, Manickam, Y, Jeyaraman, J.
登録日2018-02-23
公開日2018-12-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes
Int. J. Biol. Macromol., 120, 2018
5ZKE
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BU of 5zke by Molmil
Crystal Structure of N-terminal Domain of Plasmodium vivax p43 in space group P212121
分子名称: Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein p43
著者Gupta, S, Sharma, M, Harlos, K, Manickam, Y, Sharma, A.
登録日2018-03-23
公開日2019-04-24
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.492 Å)
主引用文献Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein.
Acta Crystallogr D Struct Biol, 76, 2020
5ZKF
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BU of 5zkf by Molmil
Crystal Structure of N-terminal Domain of Plasmodium vivax p43 in space group P21
分子名称: Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein p43
著者Gupta, S, Sharma, M, Harlos, K, Manickam, Y, Sharma, A.
登録日2018-03-23
公開日2019-04-24
最終更新日2020-03-11
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein.
Acta Crystallogr D Struct Biol, 76, 2020
5ZDO
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BU of 5zdo by Molmil
Crystal Structure Analysis of TtQRS in co-crystallised with ATP
分子名称: CHLORIDE ION, Glutamine-tRNA ligase
著者Mutharasappan, N, Jain, V, Sharma, A, Manickam, Y, Jeyaraman, J.
登録日2018-02-23
公開日2018-12-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes
Int. J. Biol. Macromol., 120, 2018
5ZH5
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BU of 5zh5 by Molmil
CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-2
分子名称: (3S)-6,8-dihydroxy-3-{[(2R,6S)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, CHLORIDE ION, LYSINE, ...
著者Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A.
登録日2018-03-11
公開日2018-06-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
7BY6
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BU of 7by6 by Molmil
Plasmodium vivax cytoplasmic Phenylalanyl-tRNA synthetase in complex with BRD1389
分子名称: (3S,4R,8R,9R,10S)-N-(4-cyclopropyloxyphenyl)-10-(methoxymethyl)-3,4-bis(oxidanyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide, MAGNESIUM ION, Phenylalanyl-tRNA synthetase beta chain, ...
著者Malhotra, N, Manmohan, S, Harlos, K, Melillo, B, Schreiber, S.L, Manickam, Y, Sharma, S.
登録日2020-04-21
公開日2020-11-04
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.997 Å)
主引用文献Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.
Nat Commun, 12, 2021
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件を2024-08-07に公開中

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