6MEP
 
 | | Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC3437 | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Tyrosine-protein kinase Mer, ... | | 著者 | Da, C, Zhang, D, Stashko, M.A, Cheng, A, Hunter, D, Norris-Drouin, J, Graves, L, Machius, M, Miley, M.J, DeRyckere, D, Earp, H.S, Graham, D.K, Frye, S.V, Wang, X, Kireev, D. | | 登録日 | 2018-09-06 | | 公開日 | 2019-09-11 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.893 Å) | | 主引用文献 | Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology.
J.Am.Chem.Soc., 141, 2019
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3EXF
 | | Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex | | 分子名称: | MAGNESIUM ION, POTASSIUM ION, Pyruvate dehydrogenase E1 component subunit alpha, ... | | 著者 | Kato, M, Wynn, R.M, Chuang, J.L, Tso, S.-C, Machius, M, Li, J, Chuang, D.T. | | 登録日 | 2008-10-16 | | 公開日 | 2008-11-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.998 Å) | | 主引用文献 | Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.
Structure, 16, 2008
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3EXG
 | | Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex | | 分子名称: | POTASSIUM ION, Pyruvate dehydrogenase E1 component subunit alpha, somatic form, ... | | 著者 | Kato, M, Wynn, R.M, Chuang, J.L, Tso, S.-C, Machius, M, Li, J, Chuang, D.T. | | 登録日 | 2008-10-16 | | 公開日 | 2008-11-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.011 Å) | | 主引用文献 | Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.
Structure, 16, 2008
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3EXE
 | | Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex | | 分子名称: | GLYCEROL, MANGANESE (II) ION, POTASSIUM ION, ... | | 著者 | Kato, M, Wynn, R.M, Chuang, J.L, Tso, S.-C, Machius, M, Li, J, Chuang, D.T. | | 登録日 | 2008-10-16 | | 公開日 | 2008-11-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.979 Å) | | 主引用文献 | Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.
Structure, 16, 2008
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3EXI
 | | Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex with the subunit-binding domain (SBD) of E2p, but SBD cannot be modeled into the electron density | | 分子名称: | CHLORIDE ION, POTASSIUM ION, Pyruvate dehydrogenase E1 component subunit alpha, ... | | 著者 | Kato, M, Wynn, R.M, Chuang, J.L, Tso, S.-C, Machius, M, Li, J, Chuang, D.T. | | 登録日 | 2008-10-16 | | 公開日 | 2008-11-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.
Structure, 16, 2008
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3EXH
 | | Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex | | 分子名称: | GLYCEROL, MANGANESE (II) ION, POTASSIUM ION, ... | | 著者 | Kato, M, Wynn, R.M, Chuang, J.L, Tso, S.-C, Machius, M, Li, J, Chuang, D.T. | | 登録日 | 2008-10-16 | | 公開日 | 2008-11-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.444 Å) | | 主引用文献 | Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.
Structure, 16, 2008
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5VPA
 | | Transcription factor FosB/JunD bZIP domain | | 分子名称: | CHLORIDE ION, Protein fosB, SODIUM ION, ... | | 著者 | Yin, Z, Machius, M, Rudenko, G. | | 登録日 | 2017-05-04 | | 公開日 | 2017-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic Acids Res., 45, 2017
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5VPF
 | | Transcription factor FosB/JunD bZIP domain in complex with cognate DNA, type-II crystal | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*GP*TP*CP*GP*GP*TP*GP*AP*CP*TP*CP*AP*CP*CP*GP*AP*CP*G)-3'), ... | | 著者 | Yin, Z, Rudenko, G, Machius, M. | | 登録日 | 2017-05-04 | | 公開日 | 2017-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.694 Å) | | 主引用文献 | Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic Acids Res., 45, 2017
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5V5V
 | | Complex of NLGN2 with MDGA1 Ig1-Ig2 | | 分子名称: | MAM domain-containing glycosylphosphatidylinositol anchor protein 1, Neuroligin-2 | | 著者 | Gangwar, S.P, Machius, M, Rudenko, G. | | 登録日 | 2017-03-15 | | 公開日 | 2017-07-05 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (4.11 Å) | | 主引用文献 | Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges.
Neuron, 94, 2017
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5VPE
 | | Transcription factor FosB/JunD bZIP domain in complex with cognate DNA, type-I crystal | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*GP*TP*CP*GP*GP*TP*GP*AP*CP*TP*CP*AP*CP*CP*GP*AP*CP*G)-3'), ... | | 著者 | Yin, Z, Machius, M, Rudenko, G. | | 登録日 | 2017-05-04 | | 公開日 | 2017-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | | 主引用文献 | Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic Acids Res., 45, 2017
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5VPB
 | | Transcription factor FosB/JunD bZIP domain in its oxidized form, type-I crystal | | 分子名称: | CHLORIDE ION, Protein fosB, Transcription factor jun-D | | 著者 | Yin, Z, Machius, M, Rudenko, G. | | 登録日 | 2017-05-04 | | 公開日 | 2017-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.691 Å) | | 主引用文献 | Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic Acids Res., 45, 2017
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5VPD
 | | Transcription factor FosB/JunD bZIP domain in its oxidized form, type-III crystal | | 分子名称: | CHLORIDE ION, Protein fosB, SODIUM ION, ... | | 著者 | Yin, Z, Machius, M, Rudenko, G. | | 登録日 | 2017-05-04 | | 公開日 | 2017-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic Acids Res., 45, 2017
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1N11
 | | D34 REGION OF HUMAN ANKYRIN-R AND LINKER | | 分子名称: | Ankyrin, BROMIDE ION, CHLORIDE ION | | 著者 | Michaely, P, Tomchick, D.R, Machius, M, Anderson, R.G.W. | | 登録日 | 2002-10-16 | | 公開日 | 2002-12-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of a 12 ANK repeat stack from human ankyrinR
Embo J., 21, 2002
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2FQW
 | | PnrA from Treponema pallidum as purified from E. coli (bound to inosine) | | 分子名称: | INOSINE, Membrane lipoprotein tmpC | | 著者 | Brautigam, C.A, Deka, R.K, Tomchick, D.R, Machius, M, Norgard, M.V. | | 登録日 | 2006-01-18 | | 公開日 | 2006-02-14 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum
J.Biol.Chem., 281, 2006
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2FQY
 | | PnrA from Treponema pallidum complexed with adenosine. | | 分子名称: | ADENOSINE, Membrane lipoprotein tmpC | | 著者 | Brautigam, C.A, Deka, R.K, Tomchick, D.R, Machius, M, Norgard, M.V. | | 登録日 | 2006-01-18 | | 公開日 | 2006-02-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum
J.Biol.Chem., 281, 2006
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1NHH
 | | Crystal structure of N-terminal 40KD MutL protein (LN40) complex with ADPnP and one Rubidium | | 分子名称: | 1,2-ETHANEDIOL, DNA mismatch repair protein mutL, MAGNESIUM ION, ... | | 著者 | Hu, X, Machius, M, Yang, W. | | 登録日 | 2002-12-19 | | 公開日 | 2003-06-10 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Monovalent cation dependence and preference of GHKL ATPases and kinases
FEBS Lett., 544, 2003
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1NHJ
 | | Crystal structure of N-terminal 40KD MutL/A100P mutant protein complex with ADPnP and one sodium | | 分子名称: | DNA mismatch repair protein mutL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Hu, X, Machius, M, Yang, W. | | 登録日 | 2002-12-19 | | 公開日 | 2003-06-10 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Monovalent cation dependence and preference of GHKL ATPases and kinases
FEBS Lett., 544, 2003
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1NHI
 | | Crystal structure of N-terminal 40KD MutL (LN40) complex with ADPnP and one potassium | | 分子名称: | 1,2-ETHANEDIOL, DNA mismatch repair protein mutL, MAGNESIUM ION, ... | | 著者 | Hu, X, Machius, M, Yang, W. | | 登録日 | 2002-12-19 | | 公開日 | 2003-06-10 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Monovalent cation dependence and preference of GHKL ATPases and kinases
FEBS Lett., 544, 2003
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1O75
 | | Tp47, the 47-Kilodalton Lipoprotein of Treponema pallidum | | 分子名称: | 2,3-di-O-sulfo-alpha-D-glucopyranose-(1-6)-2,3-di-O-sulfo-alpha-D-glucopyranose, 47 KDA MEMBRANE ANTIGEN, XENON | | 著者 | Deka, R.K, Machius, M, Norgard, M.V, Tomchick, D.R. | | 登録日 | 2002-10-23 | | 公開日 | 2002-11-01 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal structure of the 47-kDa lipoprotein of Treponema pallidum reveals a novel penicillin-binding protein.
J. Biol. Chem., 277, 2002
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2FQX
 | | PnrA from Treponema pallidum complexed with guanosine | | 分子名称: | GUANOSINE, Membrane lipoprotein tmpC | | 著者 | Brautigam, C.A, Deka, R.K, Tomchick, D.R, Machius, M, Norgard, M.V. | | 登録日 | 2006-01-18 | | 公開日 | 2006-02-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum
J.Biol.Chem., 281, 2006
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1OLS
 | | Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase | | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, GLYCEROL, ... | | 著者 | Wynn, R.M, Machius, M, Chuang, J.L, Li, J, Tomchick, D.R, Chuang, D.T. | | 登録日 | 2003-08-12 | | 公開日 | 2003-08-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Roles of His291-Alpha and His146-Beta' in the Reductive Acylation Reaction Catalyzed by Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site.
J.Biol.Chem., 278, 2003
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1OLU
 | | Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase | | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, GLYCEROL, ... | | 著者 | Wynn, R.M, Machius, M, Chuang, J.L, Li, J, Tomchick, D.R, Chuang, D.T. | | 登録日 | 2003-08-15 | | 公開日 | 2003-08-28 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Roles of His291-Alpha and His146-Beta' in the Reductive Acylation Reaction Catalyzed by Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site.
J.Biol.Chem., 278, 2003
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1OLX
 | | Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase | | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, GLYCEROL, ... | | 著者 | Wynn, R.M, Machius, M, Chuang, J.L, Li, J, Tomchick, D.R, Chuang, D.T. | | 登録日 | 2003-08-18 | | 公開日 | 2003-08-28 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Roles of His291-Alpha and His146-Beta' in the Reductive Acylation Reaction Catalyzed by Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site.
J.Biol.Chem., 278, 2003
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2VLG
 | | KinA PAS-A domain, homodimer | | 分子名称: | ACETATE ION, CHLORIDE ION, SPORULATION KINASE A | | 著者 | Lee, J, Tomchick, D.R, Brautigam, C.A, Machius, M, Kort, R, Hellingwerf, K.J, Gardner, K.H. | | 登録日 | 2008-01-14 | | 公開日 | 2008-03-18 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Changes at the Kina Pas-A Dimerization Interface Influence Histidine Kinase Function.
Biochemistry, 47, 2008
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2F5Z
 | | Crystal Structure of Human Dihydrolipoamide Dehydrogenase (E3) Complexed to the E3-Binding Domain of Human E3-Binding Protein | | 分子名称: | Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, Pyruvate dehydrogenase protein X component, ... | | 著者 | Brautigam, C.A, Chuang, J.L, Wynn, R.M, Tomchick, D.R, Machius, M, Chuang, D.T. | | 登録日 | 2005-11-28 | | 公開日 | 2006-01-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structural Insight into Interactions between Dihydrolipoamide Dehydrogenase (E3) and E3 Binding Protein of Human Pyruvate Dehydrogenase Complex.
Structure, 14, 2006
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