7UET
 
 | | PANK3 complex structure with compound PZ-4140 | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, N-(4-{2-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-oxoethyl}phenyl)methanesulfonamide, ... | | Authors: | White, S.W, Yun, M, Lee, R.E. | | Deposit date: | 2022-03-22 | | Release date: | 2023-03-29 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Discovery of hPANK Activators with Improved Pharmacological Properties
To Be Published
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8WIE
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7UEV
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7UEY
 | | PANK3 complex structure with compound PZ-4128 | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, N-(4-{2-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-oxoethyl}phenyl)-2-hydroxyacetamide, ... | | Authors: | White, S.W, Yun, M, Lee, R.E. | | Deposit date: | 2022-03-22 | | Release date: | 2023-03-29 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Discovery of hPANK Activators with Improved Pharmacological Properties
To Be Published
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1EGC
 | | STRUCTURE OF T255E, E376G MUTANT OF HUMAN MEDIUM CHAIN ACYL-COA DEHYDROGENASE COMPLEXED WITH OCTANOYL-COA | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, MEDIUM CHAIN ACYL-COA DEHYDROGENASE, OCTANOYL-COENZYME A | | Authors: | Lee, H.J, Wang, M, Paschke, R, Nandy, A, Ghisla, S, Kim, J.P. | | Deposit date: | 1996-04-11 | | Release date: | 1997-11-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity.
Biochemistry, 35, 1996
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8WFH
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7UI2
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1ERD
 | | THE NMR SOLUTION STRUCTURE OF THE PHEROMONE ER-2 FROM THE CILIATED PROTOZOAN EUPLOTES RAIKOVI | | Descriptor: | PHEROMONE ER-2 | | Authors: | Ottiger, M, Szyperski, T, Luginbuhl, P, Ortenzi, C, Luporini, P, Bradshaw, R.A, Wuthrich, K. | | Deposit date: | 1994-02-14 | | Release date: | 1994-10-15 | | Last modified: | 2024-10-09 | | Method: | SOLUTION NMR | | Cite: | The NMR solution structure of the pheromone Er-2 from the ciliated protozoan Euplotes raikovi.
Protein Sci., 3, 1994
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1EH2
 | | STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15, NMR, 20 STRUCTURES | | Descriptor: | CALCIUM ION, EPS15 | | Authors: | De Beer, T, Carter, R.E, Lobel-Rice, K.E, Sorkin, A, Overduin, M. | | Deposit date: | 1998-07-10 | | Release date: | 1999-07-22 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain.
Science, 281, 1998
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8VCA
 | | Crystal Structure of plant Carboxylesterase 15 | | Descriptor: | Carboxylesterase 15, GLYCEROL | | Authors: | Palayam, M, Shabek, N. | | Deposit date: | 2023-12-13 | | Release date: | 2024-08-07 | | Last modified: | 2024-08-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural insights into strigolactone catabolism by carboxylesterases reveal a conserved conformational regulation.
Nat Commun, 15, 2024
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1EXH
 | | SOLUTION STRUCTURE OF A CELLULOSE BINDING DOMAIN FROM CELLULOMONAS FIMI BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY | | Descriptor: | EXO-1,4-BETA-D-GLYCANASE | | Authors: | Xu, G.-Y, Ong, E, Gilkes, N.R, Kilburn, D.G, Muhandiram, D.R, Harris-Brandts, M, Carver, J.P, Kay, L.E, Harvey, T.S. | | Deposit date: | 1995-03-14 | | Release date: | 1995-06-03 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Solution structure of a cellulose-binding domain from Cellulomonas fimi by nuclear magnetic resonance spectroscopy.
Biochemistry, 34, 1995
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7UEU
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7UEX
 | | PANK3 complex structure with compound PZ-4127 | | Descriptor: | 1,2-ETHANEDIOL, 2-(4-{2-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-oxoethyl}anilino)-2-oxoethyl acetate, ACETATE ION, ... | | Authors: | White, S.W, Yun, M, Lee, R.E. | | Deposit date: | 2022-03-22 | | Release date: | 2023-03-29 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Discovery of hPANK Activators with Improved Pharmacological Properties
To Be Published
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8W7A
 | | Cryo-EM structure of ClassIII Lanthipeptide modification enzyme PneKC in the presence of GTP. | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Protein kinase domain-containing protein | | Authors: | Li, Y, Luo, M, Shao, K, Li, J. | | Deposit date: | 2023-08-30 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.77 Å) | | Cite: | Mechanistic insights into lanthipeptide modification by a distinct subclass of LanKC enzyme that forms dimers.
Nat Commun, 15, 2024
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8W7J
 | | Cryo-EM structure of ClassIII Lanthipeptide modification enzyme PneKC with chain A bounded to substrate PneA and GTP. | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, PneA LP, ... | | Authors: | Li, Y, Luo, M, Shao, K, Li, J, Li, Z. | | Deposit date: | 2023-08-30 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.98 Å) | | Cite: | Mechanistic insights into lanthipeptide modification by a distinct subclass of LanKC enzyme that forms dimers.
Nat Commun, 15, 2024
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8VMG
 | | Crystal structure of GSK-3 26-383 bound to Axin 383-435 | | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Enos, M.D, Gavagan, M, Jameson, N, Zalatan, J.G, Weis, W.I. | | Deposit date: | 2024-01-13 | | Release date: | 2024-08-28 | | Last modified: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3 beta.
Sci.Signal., 17, 2024
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8VMF
 | | Crystal structure of a transition-state mimic of the GSK-3/Axin complex bound to a beta-catenin S45D peptide | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Axin-1, ... | | Authors: | Enos, M.D, Gavagan, M, Jameson, N, Zalatan, J.G, Weis, W.I. | | Deposit date: | 2024-01-13 | | Release date: | 2024-08-28 | | Last modified: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3 beta.
Sci.Signal., 17, 2024
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8VME
 | | Crystal structure of the GSK-3/Axin complex bound to a phosphorylated beta-catenin T41A peptide | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Axin-1, Catenin beta-1, ... | | Authors: | Enos, M.D, Gavagan, M, Jameson, N, Zalatan, J.G, Weis, W.I. | | Deposit date: | 2024-01-13 | | Release date: | 2024-08-28 | | Last modified: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3 beta.
Sci.Signal., 17, 2024
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1E5M
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8W7Y
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1E5P
 | | Crystal structure of aphrodisin, a sex pheromone from female hamster | | Descriptor: | APHRODISIN | | Authors: | Vincent, F, Brown, K, Spinelli, S, Cambillau, C, Tegoni, M. | | Deposit date: | 2000-07-28 | | Release date: | 2001-07-26 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Crystal structure of aphrodisin, a sex pheromone from female hamster.
J.Mol.Biol., 305, 2001
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6JID
 | | Human MTHFD2 in complex with Compound 1 | | Descriptor: | 5-(4-oxo-2-phenyl-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carbonyl)-1,3-dihydro-2H-2lambda~6~,1-benzothiazole-2,2-dione, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ... | | Authors: | Suzuki, M, Matsui, Y, Matsuhashi, N, Kawai, J. | | Deposit date: | 2019-02-20 | | Release date: | 2019-06-05 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.
Acs Med.Chem.Lett., 10, 2019
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6JIL
 | | Crystal structure of D-cycloserine synthetase DcsG | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cycloserine biosynthesis protein DcsG, L(+)-TARTARIC ACID, ... | | Authors: | Matoba, Y, Sugiyama, M. | | Deposit date: | 2019-02-22 | | Release date: | 2019-12-18 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | Cyclization mechanism catalyzed by an ATP-grasp enzyme essential for d-cycloserine biosynthesis.
Febs J., 287, 2020
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8VQC
 | | Structure of the voltage-gated sodium channel NavPas from American Cockroach Periplaneta Americana in complex with scorpion alpha-toxin LqhaIT | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-insect toxin LqhaIT, ... | | Authors: | Phulera, S, Khoshouei, M, Whicher, J, Weihofen, W.A. | | Deposit date: | 2024-01-18 | | Release date: | 2024-09-04 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Scorpion alpha-toxin Lqh alpha IT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels.
Structure, 32, 2024
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8W7L
 | | Cryo-EM structure of ClassIII Lanthipeptide modification enzyme PneKC mutant H522A. | | Descriptor: | PHOSPHATE ION, PneA, Protein kinase domain-containing protein | | Authors: | Li, Y, Luo, M, Shao, K, Li, J, Li, Z. | | Deposit date: | 2023-08-30 | | Release date: | 2024-09-04 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.75 Å) | | Cite: | Structure of PneA bound PneKC at 3.75 Angstroms resolution.
To Be Published
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