4RFP
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4R7Q
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![BU of 4r7q by Molmil](/molmil-images/mine/4r7q) | The structure of a sensor domain of a histidine kinase from Vibrio cholerae O1 biovar eltor str. N16961 | Descriptor: | ACETATE ION, GLYCEROL, SULFATE ION, ... | Authors: | Tan, K, Zhou, M, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2014-08-28 | Release date: | 2014-09-10 | Last modified: | 2022-11-16 | Method: | X-RAY DIFFRACTION (1.981 Å) | Cite: | Sensor Domain of Histidine Kinase VxrA of Vibrio cholerae - A Hairpin-swapped Dimer and its Conformational Change. J.Bacteriol., 203, 2021
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4QVN
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![BU of 4qvn by Molmil](/molmil-images/mine/4qvn) | yCP beta5-M45V mutant in complex with bortezomib | Descriptor: | CHLORIDE ION, MAGNESIUM ION, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, ... | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | Deposit date: | 2014-07-15 | Release date: | 2015-02-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4R8G
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![BU of 4r8g by Molmil](/molmil-images/mine/4r8g) | Crystal Structure of Myosin-1c tail in complex with Calmodulin | Descriptor: | Calmodulin, SULFATE ION, Unconventional myosin-Ic | Authors: | Lu, Q, Li, J, Ye, F, Zhang, M. | Deposit date: | 2014-09-02 | Release date: | 2014-12-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.503 Å) | Cite: | Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational coupling. Nat.Struct.Mol.Biol., 22, 2015
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4R98
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![BU of 4r98 by Molmil](/molmil-images/mine/4r98) | Chimera of the N-terminal domain of E. coli FeoB | Descriptor: | AMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ferrous iron transport protein B | Authors: | Maher, M.J, Jormakka, M. | Deposit date: | 2014-09-03 | Release date: | 2015-02-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | A GTPase Chimera Illustrates an Uncoupled Nucleotide Affinity and Release Rate, Providing Insight into the Activation Mechanism. Biophys.J., 107, 2014
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4QWF
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![BU of 4qwf by Molmil](/molmil-images/mine/4qwf) | yCP beta5-M45I mutant in complex with carfilzomib | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | Deposit date: | 2014-07-16 | Release date: | 2015-02-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4RA8
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![BU of 4ra8 by Molmil](/molmil-images/mine/4ra8) | Structure analysis of the Mip1a P8A mutant | Descriptor: | C-C motif chemokine 3 | Authors: | Liang, W.G, Ren, M, Guo, Q, Tang, W.J. | Deposit date: | 2014-09-09 | Release date: | 2014-09-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme. J.Mol.Biol., 427, 2015
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4RAL
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![BU of 4ral by Molmil](/molmil-images/mine/4ral) | Crystal structure of insulin degrading enzyme in complex with macrophage inflammatory protein 1 beta | Descriptor: | C-C motif chemokine 4, Insulin-degrading enzyme, ZINC ION | Authors: | Liang, W.G, Ren, M, Guo, Q, Tang, W.J. | Deposit date: | 2014-09-10 | Release date: | 2015-05-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.148 Å) | Cite: | Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme. J.Mol.Biol., 427, 2015
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6PDH
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![BU of 6pdh by Molmil](/molmil-images/mine/6pdh) | Crystal Structure of EcDsbA in a complex with purified pyrazole 9 | Descriptor: | 2-[4-(4-cyano-3-methylphenoxy)phenyl]-N-ethyl-N-[2-(1H-pyrazol-1-yl)ethyl]acetamide, TRIETHYLENE GLYCOL, Thiol:disulfide interchange protein DsbA | Authors: | Ilyichova, O.V, Bentley, M, Doak, B, Scanlon, M.J. | Deposit date: | 2019-06-19 | Release date: | 2020-05-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiL X ). J.Med.Chem., 63, 2020
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7KFR
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4QY4
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![BU of 4qy4 by Molmil](/molmil-images/mine/4qy4) | Crystal structure of the bromodomain of human SMARCA2 | Descriptor: | SMARCA2 protein, ZINC ION | Authors: | Tallant, C, Savitsky, P, Nunez-Alonso, G, Fonseca, M, Krojer, T, Filippakopoulos, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2014-07-23 | Release date: | 2014-08-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Crystal structure of the bromodomain of human SMARCA2 To be Published
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4QYN
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![BU of 4qyn by Molmil](/molmil-images/mine/4qyn) | The Crystal Structures of holo-wt human Cellular Retinol Binding protein II (hCRBPII) bound to Retinol | Descriptor: | ACETATE ION, RETINOL, Retinol-binding protein 2 | Authors: | Nossoni, Z, Assar, Z, Yapici, I, Nosrati, M, Wang, W, Berbasova, T, Vasileiou, C, Borhan, B, Geiger, H. | Deposit date: | 2014-07-24 | Release date: | 2014-12-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal. Acta Crystallogr.,Sect.D, 70, 2014
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4OMW
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![BU of 4omw by Molmil](/molmil-images/mine/4omw) | Crystal structure of goat beta-lactoglobulin (orthorhombic form) | Descriptor: | Beta-lactoglobulin, GLYCEROL, SULFATE ION, ... | Authors: | Loch, J.I, Swiatek, S, Czub, M, Ludwikowska, M, Lewinski, K. | Deposit date: | 2014-01-27 | Release date: | 2014-11-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Conformational variability of goat beta-lactoglobulin: Crystallographic and thermodynamic studies. Int.J.Biol.Macromol., 72C, 2014
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6PG1
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![BU of 6pg1 by Molmil](/molmil-images/mine/6pg1) | Crystal Structure of EcDsbA in a complex with unpurified reaction product F1 (methylpiperazinone 6) | Descriptor: | 1,2-ETHANEDIOL, 2-methyl-4-{4-[2-(4-methyl-3-oxopiperazin-1-yl)-2-oxoethyl]phenoxy}benzonitrile, COPPER (II) ION, ... | Authors: | Ilyichova, O.V, Bentley, M, Doak, B, Scanlon, M.J. | Deposit date: | 2019-06-23 | Release date: | 2020-07-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiL X ). J.Med.Chem., 63, 2020
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4RAN
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![BU of 4ran by Molmil](/molmil-images/mine/4ran) | Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents | Descriptor: | (2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](3-aminopropyl)amino}ethyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION | Authors: | Keough, D.T, Hockova, D, Janeba, Z, Wang, T.-H, Naesens, L, Edstein, M.D, Chavchich, M, Guddat, L.W. | Deposit date: | 2014-09-10 | Release date: | 2015-01-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.549 Å) | Cite: | Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents. J.Med.Chem., 58, 2015
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4OQ2
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![BU of 4oq2 by Molmil](/molmil-images/mine/4oq2) | 5hmC specific restriction endonuclease PvuRTs1I | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Restriction endonuclease PvuRts1 I | Authors: | Kazrani, A.A, Kowalska, M, Czapinska, H, Bochtler, M. | Deposit date: | 2014-02-07 | Release date: | 2014-03-12 | Last modified: | 2018-03-07 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure of the 5hmC specific endonuclease PvuRts1I. Nucleic Acids Res., 42, 2014
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4RC5
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4RDM
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![BU of 4rdm by Molmil](/molmil-images/mine/4rdm) | Crystal structure of R.NgoAVII restriction endonuclease B3 domain with cognate DNA | Descriptor: | DNA (5'-D(*CP*CP*TP*AP*AP*GP*CP*GP*GP*CP*AP*AP*TP*CP*C)-3)', DNA (5'-D(*GP*GP*GP*AP*TP*TP*GP*CP*CP*GP*CP*TP*TP*AP*G)-3)', Restriction endonuclease R.NgoVII, ... | Authors: | Tamulaitiene, G, Silanskas, A, Grazulis, S, Zaremba, M, Siksnys, V. | Deposit date: | 2014-09-19 | Release date: | 2014-12-24 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII. Nucleic Acids Res., 42, 2014
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4R2M
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4RG8
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![BU of 4rg8 by Molmil](/molmil-images/mine/4rg8) | Structural and biochemical studies of a moderately thermophilic Exonuclease I from Methylocaldum szegediense | Descriptor: | Exonuclease I, MAGNESIUM ION | Authors: | Fei, L, Tian, S, Moysey, R, Misca, M, Barker, J.J, Smith, M.A, McEwan, P.A, Pilka, E.S, Crawley, L, Evans, T, Sun, D. | Deposit date: | 2014-09-29 | Release date: | 2015-02-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Structural and Biochemical Studies of a Moderately Thermophilic Exonuclease I from Methylocaldum szegediense. Plos One, 10, 2015
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4R3P
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![BU of 4r3p by Molmil](/molmil-images/mine/4r3p) | Crystal structures of EGFR in complex with Mig6 | Descriptor: | Epidermal growth factor receptor, peptide from ERBB receptor feedback inhibitor 1 | Authors: | Park, E, Kim, N, Yi, Z, Cho, A, Kim, K, Ficarro, S.B, Park, A, Park, W.Y, Murray, B, Meyerson, M, Beroukim, R, Marto, J.A, Cho, J, Eck, M.J. | Deposit date: | 2014-08-17 | Release date: | 2015-08-12 | Last modified: | 2015-09-16 | Method: | X-RAY DIFFRACTION (2.905 Å) | Cite: | Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Nat.Struct.Mol.Biol., 22, 2015
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4RGI
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![BU of 4rgi by Molmil](/molmil-images/mine/4rgi) | Crystal Structure of KTSC Domain Protein YPO2434 from Yersinia pestis | Descriptor: | GLYCEROL, SULFATE ION, Uncharacterized protein | Authors: | Kim, Y, Chhor, G, Endres, M, Babnigg, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-09-30 | Release date: | 2014-12-31 | Method: | X-RAY DIFFRACTION (1.732 Å) | Cite: | Crystal Structure of KTSC Domain Protein YPO2434 from Yersinia pestis To be Published
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4RFN
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![BU of 4rfn by Molmil](/molmil-images/mine/4rfn) | Crystal structure of ADCC-potent Rhesus macaque ANTIBODY JR4 in complex with HIV-1 CLADE A/E GP120 and M48 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB HEAVY CHAIN OF ADCC ANTI-HIV-1 ANTIBODY JR4, FAB LIGHT CHAIN OF ADCC ANTI-HIV-1 ANTIBODY JR4, ... | Authors: | Gohain, N, Tolbert, W.D, Pazgier, M. | Deposit date: | 2014-09-26 | Release date: | 2015-07-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. J.Virol., 89, 2015
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4R7D
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![BU of 4r7d by Molmil](/molmil-images/mine/4r7d) | Fab Hu 15C1 | Descriptor: | Fab Hu 15C1 Heavy chain, Fab Hu 15C1 Light chain | Authors: | Loyau, J, Didelot, G, Malinge, P, Ravn, U, Magistrelli, G, Depoisier, J.F, Kosco-Vilbois, M, Fischer, N, Thore, S, Rousseau, F. | Deposit date: | 2014-08-27 | Release date: | 2015-07-29 | Last modified: | 2015-08-26 | Method: | X-RAY DIFFRACTION (2.753 Å) | Cite: | Robust Antibody-Antigen Complexes Prediction Generated by Combining Sequence Analyses, Mutagenesis, In Vitro Evolution, X-ray Crystallography and In Silico Docking. J.Mol.Biol., 427, 2015
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6LJH
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![BU of 6ljh by Molmil](/molmil-images/mine/6ljh) | Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua in complex with NAD+ | Descriptor: | Alcohol dehydrogenase 1, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Feng, X, Fan, S, Li, M, Zou, S, Lv, G, Wu, G, Jin, Y, Yang, Z. | Deposit date: | 2019-12-16 | Release date: | 2020-12-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua in complex with NAD+ To Be Published
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