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PDB: 52230 results

6MHW
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BU of 6mhw by Molmil
Structure of human TRPV3 in the presence of 2-APB in C2 symmetry (1)
Descriptor: Transient receptor potential cation channel subfamily V member 3
Authors:Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y.
Deposit date:2018-09-18
Release date:2018-10-03
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Conformational ensemble of the human TRPV3 ion channel.
Nat Commun, 9, 2018
6GDQ
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BU of 6gdq by Molmil
Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2
Descriptor: 4-[5-chloranyl-2-(propan-2-ylamino)pyridin-4-yl]-~{N}-[(1~{S})-1-(3-chlorophenyl)-2-oxidanyl-ethyl]-1~{H}-pyrrole-2-carboxamide, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ...
Authors:O'Reilly, M.
Deposit date:2018-04-24
Release date:2018-05-30
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
8OFK
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BU of 8ofk by Molmil
Crystal structure of the cysteine-rich Gallus gallus urate oxidase in complex with the 8-azaxanthine inhibitor under reducing conditions (space group C 2 2 21)
Descriptor: 1,2-ETHANEDIOL, 8-AZAXANTHINE, CHLORIDE ION, ...
Authors:Di Palma, M, Chegkazi, M, Bui, S, Mori, G, Percudani, R, Steiner, R.A.
Deposit date:2023-03-15
Release date:2024-01-17
Method:X-RAY DIFFRACTION (1.713 Å)
Cite:Cysteine Enrichment Mediates Co-Option of Uricase in Reptilian Skin and Transition to Uricotelism.
Mol.Biol.Evol., 40, 2023
1KS6
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BU of 1ks6 by Molmil
Transforming Growth Factor Beta type II receptor ligand binding domain
Descriptor: TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR
Authors:Marlow, M.S, Brown, C.B, Barnett, J.V, Krezel, A.M.
Deposit date:2002-01-10
Release date:2003-02-25
Last modified:2024-10-16
Method:SOLUTION NMR
Cite:Solution structure of the chick TGFb type II receptor ligand binding domain
J.Mol.Biol., 326, 2003
6G9D
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BU of 6g9d by Molmil
Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2
Descriptor: Mitogen-activated protein kinase 1, SULFATE ION, ~{N}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]ethanamide
Authors:O'Reilly, M.
Deposit date:2018-04-10
Release date:2018-05-30
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
6G9M
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BU of 6g9m by Molmil
Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2
Descriptor: 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-(2-phenylpropan-2-yl)ethanamide, Mitogen-activated protein kinase 1, SULFATE ION
Authors:O'Reilly, M.
Deposit date:2018-04-11
Release date:2018-05-30
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
8OIH
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BU of 8oih by Molmil
Crystal structure of the cysteine-rich Gallus gallus urate oxidase in complex with the 8-azaxanthine inhibitor under oxidising conditions (space group C 2 2 21)
Descriptor: 1,2-ETHANEDIOL, 8-AZAXANTHINE, BROMIDE ION, ...
Authors:Di Palma, M, Chegkazi, M, Bui, S, Mori, G, Percudani, R, Steiner, R.A.
Deposit date:2023-03-22
Release date:2024-01-17
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Cysteine Enrichment Mediates Co-Option of Uricase in Reptilian Skin and Transition to Uricotelism.
Mol.Biol.Evol., 40, 2023
6GDM
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BU of 6gdm by Molmil
Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2
Descriptor: (3~{R})-1-[2-oxidanylidene-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-~{N}-(3-pyridin-4-yl-1~{H}-indazol-5-yl)pyrrolidine-3-carboxamide, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ...
Authors:O'Reilly, M.
Deposit date:2018-04-24
Release date:2018-05-30
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
8DEC
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BU of 8dec by Molmil
Cryo-EM Structure of Western Equine Encephalitis Virus
Descriptor: Capsid protein, Spike glycoprotein E1, Spike glycoprotein E2
Authors:Pletnev, S, Verardi, R, Roedeger, M, Kwong, P.
Deposit date:2022-06-20
Release date:2023-07-05
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Vaccine elicitation and structural basis for antibody protection against alphaviruses.
Cell, 186, 2023
7AEN
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BU of 7aen by Molmil
Galectin-8 N-terminal carbohydrate recognition domain in complex with methyl 3-O-((7-carboxy)quinolin-2-yl)-methoxy)-beta-D-galactopyranoside
Descriptor: CHLORIDE ION, GLYCEROL, Isoform 2 of Galectin-8, ...
Authors:Hassan, M, Klavern, V.S, Hakansson, M, Anderluh, M, Tomasic, T, Jakopin, Z, Nilsson, J.U, Kovacic, R, Walse, B, Diehl, C.
Deposit date:2020-09-17
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain
Acs Med.Chem.Lett., 12, 2021
6N9R
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BU of 6n9r by Molmil
Structure of the Quorum Quenching lactonase from Parageobacillus caldoxylosilyticus bound to substrate 3-oxo-C12-AHL
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, COBALT (II) ION, ...
Authors:Bergonzi, C, Schwab, M, Elias, M.
Deposit date:2018-12-03
Release date:2019-04-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The Structural Determinants Accounting for the Broad Substrate Specificity of the Quorum Quenching Lactonase GcL.
Chembiochem, 20, 2019
8OQ5
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BU of 8oq5 by Molmil
AApoAII amyloid fibril Morphology I (ex vivo)
Descriptor: Apolipoprotein A-II
Authors:Andreotti, G, Schmidt, M, Faendrich, M.
Deposit date:2023-04-11
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Insights into the Structural Basis of Amyloid Resistance Provided by Cryo-EM Structures of AApoAII Amyloid Fibrils.
J.Mol.Biol., 436, 2024
8OQ4
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BU of 8oq4 by Molmil
AApoAII amyloid fibril Morphology II (ex vivo)
Descriptor: Apolipoprotein A-II
Authors:Andreotti, G, Schmidt, M, Faendrich, M.
Deposit date:2023-04-11
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Insights into the Structural Basis of Amyloid Resistance Provided by Cryo-EM Structures of AApoAII Amyloid Fibrils.
J.Mol.Biol., 436, 2024
8DED
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BU of 8ded by Molmil
Cryo-EM Structure of Western Equine Encephalitis Virus VLP in complex with SKW19 fab
Descriptor: SKW19 Fab heavy chain, SKW19 Fab light chain, Spike glycoprotein E1, ...
Authors:Pletnev, S, Tsybovsky, Y, Verardi, R, Roedeger, M, Kwong, P.
Deposit date:2022-06-20
Release date:2023-07-05
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Vaccine elicitation and structural basis for antibody protection against alphaviruses.
Cell, 186, 2023
7NEN
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BU of 7nen by Molmil
Crystal structure of outer surface protein C (OspC) from Borrelia garinii
Descriptor: Outer surface protein C
Authors:Sliwiak, J, Bierwagen, P, Ruszkowski, M, Jaskolski, M, Urbanowicz, A.
Deposit date:2021-02-04
Release date:2021-04-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural studies of outer surface proteins (OspC) from different Borrelia strains
To Be Published
6XKP
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BU of 6xkp by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CV07-270
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CV07-270 Heavy Chain, CV07-270 Light Chain, ...
Authors:Liu, H, Yuan, M, Zhu, X, Wu, N.C, Wilson, I.A.
Deposit date:2020-06-26
Release date:2020-10-14
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model.
Cell, 183, 2020
8DEE
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BU of 8dee by Molmil
Asymmetric Unit of Western Equine Encephalitis Virus
Descriptor: Capsid protein, Spike glycoprotein E1, Spike glycoprotein E2
Authors:Pletnev, S, Verardi, R, Roedeger, M, Kwong, P.
Deposit date:2022-06-20
Release date:2023-07-05
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Vaccine elicitation and structural basis for antibody protection against alphaviruses.
Cell, 186, 2023
8DEF
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BU of 8def by Molmil
Cryo-EM Structure of Western Equine Encephalitis Virus VLP in complex with SKW24 fab
Descriptor: SKW24 Fab heavy chain, SKW24 Fab light chain, Spike glycoprotein E1, ...
Authors:Pletnev, S, Tsybovsky, Y, Verardi, R, Roedeger, M, Kwong, P.D.
Deposit date:2022-06-20
Release date:2023-07-05
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Vaccine elicitation and structural basis for antibody protection against alphaviruses.
Cell, 186, 2023
8OT9
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BU of 8ot9 by Molmil
CTE typeIII tau filament from Guam ALS/PDC
Descriptor: Microtubule-associated protein tau
Authors:Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:2023-04-20
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Proc.Natl.Acad.Sci.USA, 120, 2023
8OTD
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BU of 8otd by Molmil
TMEM106B Fold1-s filament from Guam ALS/PDC
Descriptor: Transmembrane protein 106B
Authors:Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:2023-04-20
Release date:2024-03-27
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Proc.Natl.Acad.Sci.USA, 120, 2023
8OTG
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BU of 8otg by Molmil
CTE typeI tau filament from Kii ALS/PDC
Descriptor: Microtubule-associated protein tau
Authors:Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:2023-04-20
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Proc.Natl.Acad.Sci.USA, 120, 2023
8OTH
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BU of 8oth by Molmil
TypeII tau filament from Kii ALS/PDC
Descriptor: Microtubule-associated protein tau
Authors:Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:2023-04-20
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Proc.Natl.Acad.Sci.USA, 120, 2023
6PW7
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BU of 6pw7 by Molmil
X-ray crystal structure of C. elegans STIM EF-SAM domain
Descriptor: CALCIUM ION, Stromal interaction molecule 1
Authors:Enomoto, M, Nishikawa, T, Back, S.I, Ishiyama, N, Zheng, L, Stathopulos, P.B, Ikura, M.
Deposit date:2019-07-22
Release date:2019-11-13
Last modified:2020-02-12
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Coordination of a Single Calcium Ion in the EF-hand Maintains the Off State of the Stromal Interaction Molecule Luminal Domain.
J.Mol.Biol., 432, 2020
8OTF
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BU of 8otf by Molmil
Ab typeII filament from Guam ALS/PDC
Descriptor: Amyloid-beta precursor protein
Authors:Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:2023-04-20
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Proc.Natl.Acad.Sci.USA, 120, 2023
8OTC
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BU of 8otc by Molmil
CTE typeII tau filament from Guam ALS/PDC
Descriptor: Microtubule-associated protein tau
Authors:Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:2023-04-20
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Proc.Natl.Acad.Sci.USA, 120, 2023

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