6XKP

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CV07-270

Summary for 6XKP

Related6XKQ
DescriptorSpike protein S1, CV07-270 Heavy Chain, CV07-270 Light Chain, ... (5 entities in total)
Functional Keywordssars-cov-2, antibody, spike, coronavirus, covid-19, immune system, viral protein-immune system complex, viral protein/immune system
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
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Total number of polymer chains6
Total molecular weight148461.15
Authors
Liu, H.,Yuan, M.,Zhu, X.,Wu, N.C.,Wilson, I.A. (deposition date: 2020-06-26, release date: 2020-10-14)
Primary citation
Kreye, J.,Reincke, S.M.,Kornau, H.,Sanchez-Sendin, E.,Corman, V.M.,Liu, H.,Yuan, M.,Wu, N.C.,Zhu, X.,Lee, C.D.,Trimpert, J.,Holtje, M.,Dietert, K.,Stoffler, L.,von Wardenburg, N.,van Hoof, S.,Homeyer, M.A.,Hoffmann, J.,Abdelgawad, A.,Gruber, A.D.,Bertzbach, L.D.,Vladimirova, D.,Li, L.Y.,Barthel, P.C.,Schmitz, D.,Jeworowski, L.M.,Richter, A.,Schmidt, M.L.,Schwarz, T.,Muller, M.A.,Drosten, C.,Wendisch, D.,Sander, L.E.,Osterrieder, N.,Wilson, I.A.,Pruss, H.
A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model
Cell(Cambridge,Mass.), 2020
DOI: 10.1016/j.cell.2020.09.049
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.72 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26780 2.5% 4.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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169963
PDB entries from 2020-10-14