1LM8
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![BU of 1lm8 by Molmil](/molmil-images/mine/1lm8) | Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex | Descriptor: | ELONGIN B, ELONGIN C, Hypoxia-inducible factor 1 alpha, ... | Authors: | Min, J.-H, Yang, H, Ivan, M, Gertler, F, Kaelin JR, W.G, Pavletich, N.P. | Deposit date: | 2002-04-30 | Release date: | 2002-06-12 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science, 296, 2002
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6GPT
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![BU of 6gpt by Molmil](/molmil-images/mine/6gpt) | Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in complex with AMPCP | Descriptor: | Heat shock protein HSP 90-alpha, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | Authors: | Tassone, G, Pozzi, C, Mangani, S, Botta, M. | Deposit date: | 2018-06-07 | Release date: | 2018-10-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart. Biochim Biophys Acta Proteins Proteom, 1866, 2018
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4KZL
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![BU of 4kzl by Molmil](/molmil-images/mine/4kzl) | Crystal structure of human tankyrase 2 in complex with 4'-fluoro flavone | Descriptor: | 2-(4-fluorophenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ... | Authors: | Narwal, M, Haikarainen, T, Lehtio, L. | Deposit date: | 2013-05-30 | Release date: | 2013-10-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56, 2013
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6JYA
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![BU of 6jya by Molmil](/molmil-images/mine/6jya) | Structure of dark-state marine bacterial chloride importer, NM-R3, with CW laser (ND-10%) at 95K. | Descriptor: | CHLORIDE ION, Chloride pumping rhodopsin, OLEIC ACID, ... | Authors: | Yun, J.H, Ohki, M, Park, S.Y, Lee, W. | Deposit date: | 2019-04-26 | Release date: | 2020-03-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.803 Å) | Cite: | Pumping mechanism of NM-R3, a light-driven bacterial chloride importer in the rhodopsin family. Sci Adv, 6, 2020
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3NGH
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![BU of 3ngh by Molmil](/molmil-images/mine/3ngh) | Molecular Analysis of the Interaction of the HDL Receptor SR-BI with the Adaptor Protein PDZK1 | Descriptor: | PDZ domain-containing protein 1 | Authors: | Kocher, O, Birrane, G, Krieger, M, Ladias, J.A. | Deposit date: | 2010-06-11 | Release date: | 2010-08-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | In vitro and in vivo analysis of the binding of the C terminus of the HDL receptor scavenger receptor class B, type I (SR-BI), to the PDZ1 domain of its adaptor protein PDZK1. J.Biol.Chem., 285, 2010
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6JYV
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![BU of 6jyv by Molmil](/molmil-images/mine/6jyv) | Structure of an isopenicillin N synthase from Pseudomonas aeruginosa PAO1 | Descriptor: | Probable iron/ascorbate oxidoreductase, SODIUM ION | Authors: | Hao, Z, Che, S, Wang, R, Liu, R, Zhang, Q, Bartlam, M. | Deposit date: | 2019-04-28 | Release date: | 2019-05-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.651 Å) | Cite: | Structural characterization of an isopenicillin N synthase family oxygenase from Pseudomonas aeruginosa PAO1. Biochem.Biophys.Res.Commun., 514, 2019
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4L7B
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![BU of 4l7b by Molmil](/molmil-images/mine/4l7b) | Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid | Descriptor: | (1S,2R)-2-{[(1S)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid, ACETATE ION, Kelch-like ECH-associated protein 1, ... | Authors: | Jnoff, E, Brookfield, F, Albrecht, C, Barker, J.J, Barker, O, Beaumont, E, Bromidge, S, Brooks, M, Ceska, T, Courade, J.P, Crabbe, T, Duclos, S, Fryatt, T, Jigorel, E, Kwong, J, Sands, Z, Smith, M.A. | Deposit date: | 2013-06-13 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex. Chemmedchem, 9, 2014
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6K0M
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![BU of 6k0m by Molmil](/molmil-images/mine/6k0m) | Catalytic domain of GH87 alpha-1,3-glucanase from Paenibacillus glycanilyticus FH11 | Descriptor: | Alpha-1,3-glucanase, CALCIUM ION, GLYCEROL, ... | Authors: | Itoh, T, Intuy, R, Suyotha, W, Hayashi, J, Yano, S, Makabe, K, Wakayama, M, Hibi, T. | Deposit date: | 2019-05-07 | Release date: | 2019-12-25 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural insights into substrate recognition and catalysis by glycoside hydrolase family 87 alpha-1,3-glucanase from Paenibacillus glycanilyticus FH11. Febs J., 287, 2020
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4L0S
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![BU of 4l0s by Molmil](/molmil-images/mine/4l0s) | Tankyrase 2 in complex with 4'-cyano flavone | Descriptor: | 4-(4-oxo-4H-chromen-2-yl)benzonitrile, GLYCEROL, SULFATE ION, ... | Authors: | Narwal, M, Haikarainen, T, Lehtio, L. | Deposit date: | 2013-06-01 | Release date: | 2013-10-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56, 2013
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8AQL
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![BU of 8aql by Molmil](/molmil-images/mine/8aql) | High-resolution crystal structure of human SHMT2 | Descriptor: | 1,2-ETHANEDIOL, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], Serine hydroxymethyltransferase, ... | Authors: | Tran, L.H, Ruszkowski, M. | Deposit date: | 2022-08-12 | Release date: | 2022-10-05 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | High-resolution crystal structure of human SHMT2 To Be Published
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5A1Y
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![BU of 5a1y by Molmil](/molmil-images/mine/5a1y) | The structure of the COPI coat linkage IV | Descriptor: | ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT ALPHA, COATOMER SUBUNIT BETA, ... | Authors: | Dodonova, S.O, Diestelkoetter-Bachert, P, von Appen, A, Hagen, W.J.H, Beck, R, Beck, M, Wieland, F, Briggs, J.A.G. | Deposit date: | 2015-05-06 | Release date: | 2015-07-08 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (21 Å) | Cite: | Vesicular Transport. A Structure of the Copi Coat and the Role of Coat Proteins in Membrane Vesicle Assembly. Science, 349, 2015
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4YSS
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![BU of 4yss by Molmil](/molmil-images/mine/4yss) | Structure of copper nitrite reductase from Geobacillus thermodenitrificans - 16.7 MGy | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, COPPER (II) ION, Nitrite reductase, ... | Authors: | Fukuda, Y, Tse, K.M, Suzuki, M, Diedrichs, K, Hirata, K, Nakane, T, Sugahara, M, Nango, E, Tono, K, Joti, Y, Kameshima, T, Song, C, Hatsui, T, Yabashi, M, Nureki, O, Matsumura, H, Inoue, T, Iwata, S, Mizohata, E. | Deposit date: | 2015-03-17 | Release date: | 2016-02-24 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography J.Biochem., 159, 2016
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4L10
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![BU of 4l10 by Molmil](/molmil-images/mine/4l10) | Tankyrase 2 in complex with 4'-methoxy flavone | Descriptor: | 2-(4-methoxyphenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ... | Authors: | Narwal, M, Haikarainen, T, Lehtio, L. | Deposit date: | 2013-06-01 | Release date: | 2013-10-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56, 2013
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6K0U
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![BU of 6k0u by Molmil](/molmil-images/mine/6k0u) | Catalytic domain of GH87 alpha-1,3-glucanase D1068A in complex with tetrasaccharides | Descriptor: | Alpha-1,3-glucanase, CALCIUM ION, SULFATE ION, ... | Authors: | Itoh, T, Intuy, R, Suyotha, W, Hayashi, J, Yano, S, Makabe, K, Wakayama, M, Hibi, T. | Deposit date: | 2019-05-07 | Release date: | 2019-12-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural insights into substrate recognition and catalysis by glycoside hydrolase family 87 alpha-1,3-glucanase from Paenibacillus glycanilyticus FH11. Febs J., 287, 2020
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3NIR
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![BU of 3nir by Molmil](/molmil-images/mine/3nir) | Crystal structure of small protein crambin at 0.48 A resolution | Descriptor: | Crambin, ETHANOL | Authors: | Schmidt, A, Teeter, M, Weckert, E, Lamzin, V.S. | Deposit date: | 2010-06-16 | Release date: | 2011-05-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (0.48 Å) | Cite: | Crystal structure of small protein crambin at 0.48 A resolution Acta Crystallogr.,Sect.F, 67, 2011
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5O5O
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![BU of 5o5o by Molmil](/molmil-images/mine/5o5o) | X-ray crystal structure of RapZ from Escherichia coli (P32 space group) | Descriptor: | RNase adapter protein RapZ, SULFATE ION | Authors: | Gonzalez, G.M, Durica-Mitic, S, Hardwick, S.W, Moncrieffe, M, Resch, M, Neumann, P, Ficner, R, Gorke, B, Luisi, B.F. | Deposit date: | 2017-06-02 | Release date: | 2017-08-30 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (3.404 Å) | Cite: | Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism. Nucleic Acids Res., 45, 2017
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5A8O
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![BU of 5a8o by Molmil](/molmil-images/mine/5a8o) | Crystal structure of beta-glucanase SdGluc5_26A from Saccharophagus degradans in complex with cellotetraose | Descriptor: | CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... | Authors: | Sulzenbacher, G, Lafond, M, Freyd, T, Henrissat, B, Coutinho, R.M, Berrin, J.G, Garron, M.L. | Deposit date: | 2015-07-16 | Release date: | 2016-01-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Quaternary Structure of a Glycoside Hydrolase Dictates Specificity Towards Beta-Glucans J.Biol.Chem., 291, 2016
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6GIH
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![BU of 6gih by Molmil](/molmil-images/mine/6gih) | Crystal Structure of CK2alpha with CAM187 bound | Descriptor: | ACETATE ION, Casein kinase II subunit alpha, [3-chloranyl-5-(1~{H}-indol-4-yl)phenyl]methanamine | Authors: | Brear, P, Iegre, J, North, A, De Fusco, C, Georgiou, K, Lubin, A, Carro, L, Sore, H, Hyvonen, M, Spring, D. | Deposit date: | 2018-05-11 | Release date: | 2018-05-23 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Novel non-ATP competitive small molecules targeting the CK2 alpha / beta interface. Bioorg. Med. Chem., 26, 2018
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6GIR
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![BU of 6gir by Molmil](/molmil-images/mine/6gir) | Arabidopsis thaliana cytosolic seryl-tRNA synthetase | Descriptor: | Serine--tRNA ligase, cytoplasmic | Authors: | Kekez, I, Kekez, M, Rokov-Plavec, J, Matkovic-Calogovic, D. | Deposit date: | 2018-05-15 | Release date: | 2019-01-02 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.343 Å) | Cite: | Arabidopsis seryl-tRNA synthetase: the first crystal structure and novel protein interactor of plant aminoacyl-tRNA synthetase. FEBS J., 286, 2019
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3NJM
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![BU of 3njm by Molmil](/molmil-images/mine/3njm) | P117A mutant of SO1698 protein, an aspartic peptidase from Shewanella oneidensis. | Descriptor: | Peptidase | Authors: | Osipiuk, J, Mulligan, R, Bargassa, M, Collart, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2010-06-17 | Release date: | 2010-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Characterization of member of DUF1888 protein family, self-cleaving and self-assembling endopeptidase. J.Biol.Chem., 287, 2012
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3NJU
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![BU of 3nju by Molmil](/molmil-images/mine/3nju) | Crystal structure of the complex of group I phospholipase A2 with 4-Methoxy-benzoicacid at 1.4A resolution | Descriptor: | 4-METHOXYBENZOIC ACID, CALCIUM ION, Phospholipase A2 isoform 3 | Authors: | Kaushik, S, Prem Kumar, R, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2010-06-18 | Release date: | 2010-07-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structure of the complex of group I phospholipase A2 with 4-Methoxy-benzoicacid at 1.4A resolution To be Published
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5AAC
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![BU of 5aac by Molmil](/molmil-images/mine/5aac) | Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib | Descriptor: | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, ALK TYROSINE KINASE RECEPTOR | Authors: | McTigue, M, Deng, Y, Liu, W, Brooun, A, Stewart, A. | Deposit date: | 2015-07-23 | Release date: | 2016-06-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Resensitization to Crizotinib by the Lorlatinib Alk Resistance Mutation L1198F. N.Engl.J.Med., 374, 2016
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4LLA
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![BU of 4lla by Molmil](/molmil-images/mine/4lla) | Crystal structure of D3D4 domain of the LILRB2 molecule | Descriptor: | Leukocyte immunoglobulin-like receptor subfamily B member 2 | Authors: | Nam, G, Shi, Y, Ryu, M, Wang, Q, Song, H, Liu, J, Yan, J, Qi, J, Gao, G.F. | Deposit date: | 2013-07-09 | Release date: | 2013-09-11 | Last modified: | 2013-11-06 | Method: | X-RAY DIFFRACTION (2.502 Å) | Cite: | Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding Protein Cell, 4, 2013
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3JWP
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![BU of 3jwp by Molmil](/molmil-images/mine/3jwp) | Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, TRIETHYLENE GLYCOL, Transcriptional regulatory protein sir2 homologue, ... | Authors: | Wernimont, A.K, Hutchinson, A, Lin, Y.H, MacKenzie, F, Senisterra, G, Allali-Hassanali, A, Vedadi, M, Ravichandran, M, Cossar, D, Kozieradzki, I, Zhao, Y, Schapira, M, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Qiu, W, Brand, V, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-18 | Release date: | 2009-10-20 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP TO BE PUBLISHED
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5A67
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![BU of 5a67 by Molmil](/molmil-images/mine/5a67) | |