6GIH
Crystal Structure of CK2alpha with CAM187 bound
Summary for 6GIH
Entry DOI | 10.2210/pdb6gih/pdb |
Descriptor | Casein kinase II subunit alpha, ACETATE ION, [3-chloranyl-5-(1~{H}-indol-4-yl)phenyl]methanamine, ... (4 entities in total) |
Functional Keywords | ck2alpha, ck2a, fragment based drug discovery, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 39406.21 |
Authors | Brear, P.,Iegre, J.,North, A.,De Fusco, C.,Georgiou, K.,Lubin, A.,Carro, L.,Sore, H.,Hyvonen, M.,Spring, D. (deposition date: 2018-05-11, release date: 2018-05-23, Last modification date: 2024-01-17) |
Primary citation | Brear, P.,North, A.,Iegre, J.,Hadje Georgiou, K.,Lubin, A.,Carro, L.,Green, W.,Sore, H.F.,Hyvonen, M.,Spring, D.R. Novel non-ATP competitive small molecules targeting the CK2 alpha / beta interface. Bioorg. Med. Chem., 26:3016-3020, 2018 Cited by PubMed: 29759799DOI: 10.1016/j.bmc.2018.05.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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