3NHL
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6NW1
| Crystal Structure Desulfovibrio desulfuricans Nickel-Substituted Rubredoxin V37N | Descriptor: | NICKEL (II) ION, Rubredoxin | Authors: | Slater, J.W, Marguet, S.C, Gray, M.E, Sotomayor, M, Shafaat, H.S. | Deposit date: | 2019-02-05 | Release date: | 2019-08-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | The Power of the Secondary Sphere: Modulating Hydrogenase Activity in Nickel-Substituted Rubredoxin Acs Catalysis, 2019
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1BJM
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6WIF
| Class C beta-lactamase from Acinetobacter baumannii in complex with 4-(Ethyl(methyl)carbamoyl)phenyl boronic acid | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase, ... | Authors: | Chang, C, Maltseva, N, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-04-09 | Release date: | 2020-04-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | class C beta-lactamase from Acinetobacter baumannii in complex with 4-(Ethyl(methyl)carbamoyl)phenyl boronic acid To Be Published
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6GIB
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7OCV
| Human TNKS1 in complex with 3-[4-(1-Hydroxy-1-methyl-ethyl)-phenyl]-6-methyl-2H-pyrrolo[1,2-a]pyrazin-1-one | Descriptor: | 6-methyl-3-[4-(2-oxidanylpropan-2-yl)phenyl]-4~{H}-pyrrolo[1,2-a]pyrazin-1-one, ACETATE ION, Poly [ADP-ribose] polymerase, ... | Authors: | Musil, D, Lehmann, M, Buchstaller, H.-P. | Deposit date: | 2021-04-28 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.432 Å) | Cite: | Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. J.Med.Chem., 64, 2021
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3NHY
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1BSW
| ACUTOLYSIN A FROM SNAKE VENOM OF AGKISTRODON ACUTUS AT PH 7.5 | Descriptor: | CALCIUM ION, PROTEIN (ACUTOLYSIN A), ZINC ION | Authors: | Gong, W, Zhu, X, Liu, S, Teng, M, Niu, L. | Deposit date: | 1998-08-31 | Release date: | 1999-08-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structures of acutolysin A, a three-disulfide hemorrhagic zinc metalloproteinase from the snake venom of Agkistrodon acutus. J.Mol.Biol., 283, 1998
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6WHF
| class C beta-lactamase from Escherichia coli in complex with cephalothin | Descriptor: | (2R)-5-[(acetyloxy)methyl]-2-{(1R)-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase | Authors: | Chang, C, Maltseva, N, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-04-08 | Release date: | 2020-04-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | class C beta-lactamase from Escherichia coli in complex with Cephalothin To Be Published
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8OO6
| Pol I bound to extended and displaced DNA section - closed conformation | Descriptor: | DNA polymerase I, Displaced primer, Extending Primer, ... | Authors: | Botto, M, Borsellini, A, Lamers, M.H. | Deposit date: | 2023-04-04 | Release date: | 2023-08-09 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | A four-point molecular handover during Okazaki maturation. Nat.Struct.Mol.Biol., 30, 2023
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2P22
| Structure of the Yeast ESCRT-I Heterotetramer Core | Descriptor: | Hypothetical 12.0 kDa protein in ADE3-SER2 intergenic region, Protein SRN2, SULFATE ION, ... | Authors: | Kostelansky, M.S, Hurley, J.H. | Deposit date: | 2007-03-06 | Release date: | 2007-06-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell(Cambridge,Mass.), 129, 2007
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6WF2
| Crystal structure of mouse SCD1 with a diiron center | Descriptor: | Acyl-CoA desaturase 1, FE (III) ION, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) | Authors: | Shen, J, Zhou, M. | Deposit date: | 2020-04-03 | Release date: | 2020-06-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.51 Å) | Cite: | Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase. J.Mol.Biol., 432, 2020
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3NK3
| Crystal structure of full-length sperm receptor ZP3 at 2.6 A resolution | Descriptor: | CITRATE ANION, Zona pellucida 3, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-galactopyranose | Authors: | Monne, M, Jovine, L. | Deposit date: | 2010-06-18 | Release date: | 2010-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Insights into Egg Coat Assembly and Egg-Sperm Interaction from the X-Ray Structure of Full-Length ZP3. Cell(Cambridge,Mass.), 143, 2010
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7TH5
| Thermus thermophilus methylenetetrahydrofolate reductase | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Methylenetetrahydrofolate reductase, SODIUM ION | Authors: | Yamada, K, Koutmos, M. | Deposit date: | 2022-01-10 | Release date: | 2023-01-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | 5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity. J.Biol.Chem., 299, 2022
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6WIP
| Class A beta-lactamase from Micromonospora aurantiaca ATCC 27029 | Descriptor: | ACETATE ION, Beta-lactamase, SULFATE ION | Authors: | Chang, C, Tesar, C, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-04-10 | Release date: | 2020-04-22 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | class A beta-lactamase from
Micromonospora aurantiaca ATCC 27029 To Be Published
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6NHS
| Crystal Structure of the Beta Lactamase Class D YbXI from Nostoc | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... | Authors: | Kim, Y, Tesar, C, Endres, M, Babnigg, G, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-12-23 | Release date: | 2019-01-16 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of the Beta Lactamase Class D YbXI from Nostoc To Be Published
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7TH4
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8OX7
| Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited "closed" conformation | Descriptor: | (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, ... | Authors: | Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P. | Deposit date: | 2023-05-01 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.56 Å) | Cite: | Activation and substrate specificity of the human P4-ATPase ATP8B1. Nat Commun, 14, 2023
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6Q94
| Crystal structure of human GDP-D-mannose 4,6-dehydratase (S156D) in complex with GDP-Man | Descriptor: | 1,2-ETHANEDIOL, GDP-mannose 4,6 dehydratase, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, ... | Authors: | Pfeiffer, M, Krojer, T, Johansson, C, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Nidetzky, B, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2018-12-17 | Release date: | 2019-04-24 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase. Acs Catalysis, 9, 2019
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6NI6
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6Q2Q
| Crystal structure of mouse viperin bound to uridine triphosphate and S-adenosylhomocysteine | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, IRON/SULFUR CLUSTER, ... | Authors: | Fenwick, M.K, Dong, M, Lin, H, Ealick, S.E. | Deposit date: | 2019-08-08 | Release date: | 2020-01-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.892 Å) | Cite: | Structural Basis of the Substrate Selectivity of Viperin. Biochemistry, 59, 2020
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4L29
| Structure of wtMHC class I with NY-ESO1 double mutant | Descriptor: | Beta-2-microglobulin, CHLORIDE ION, GLYCEROL, ... | Authors: | Halabelian, L, Giorgetti, S, Bellotti, V, Bolognesi, M, Ricagno, S. | Deposit date: | 2013-06-04 | Release date: | 2013-12-25 | Last modified: | 2014-02-26 | Method: | X-RAY DIFFRACTION (3.09 Å) | Cite: | Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin. J.Biol.Chem., 289, 2014
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7U9I
| Co-crystal structure of human CARM1 in complex with MT556 inhibitor | Descriptor: | 7-[5-S-(4-{[(4-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Histone-arginine methyltransferase CARM1, UNKNOWN ATOM OR ION | Authors: | Zeng, H, Perveen, S, Dong, A, Hutchinson, A, Seitova, A, Gibson, E, Hajian, T, Li, Y, Gao, Y.D, Schneider, S, Siliphaivanh, P, Sloman, D, Nicholson, B, Fischer, C, Hicks, J, Vedadi, M, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | Deposit date: | 2022-03-10 | Release date: | 2023-01-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Co-crystal structure of human CARM1 in complex with MT556 inhibitor To Be Published
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6Q35
| Crystal structure of GES-5 beta-lactamase in complex with boronic inhibitor cpd 3 | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase, DIMETHYL SULFOXIDE, ... | Authors: | Maso, L, Quotadamo, A, Bellio, P, Montanari, M, Venturelli, A, Celenza, G, Costi, M.P, Tondi, D, Cendron, L. | Deposit date: | 2018-12-03 | Release date: | 2019-04-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | X-ray Crystallography Deciphers the Activity of Broad-Spectrum Boronic Acid beta-Lactamase Inhibitors. Acs Med.Chem.Lett., 10, 2019
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6VVX
| Mycobacterium tuberculosis WT RNAP transcription initiation intermediate structure with Sorangicin | Descriptor: | DNA (63-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Lilic, M, Boyaci, H, Chen, J, Campbell, E.A, Darst, S.A. | Deposit date: | 2020-02-18 | Release date: | 2020-10-21 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
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