7MZW
 
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6QAQ
 | | ERK2 mini-fragment binding | | 分子名称: | Mitogen-activated protein kinase 1, SULFATE ION, thiophen-3-ylmethylazanium | | 著者 | O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. | | 登録日 | 2018-12-19 | | 公開日 | 2019-03-27 | | 最終更新日 | 2019-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design.
Drug Discov Today, 24, 2019
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7MXY
 | | Cryo-EM structure of PfFNT-inhibitor complex | | 分子名称: | (Z)-4,4,5,5,5-pentakis(fluoranyl)-1-(4-methoxy-2-oxidanyl-phenyl)-3-oxidanyl-pent-2-en-1-one, Formate-nitrite transporter | | 著者 | Yu, E.W, Su, C, Lyu, M. | | 登録日 | 2021-05-19 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.18 Å) | | 主引用文献 | Structural basis of transport and inhibition of the Plasmodium falciparum transporter PfFNT
EMBO Rep, 22, 2021
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3T60
 | | 5'-Diphenyl Nucleoside Inhibitors of Plasmodium falciparum dUTPase | | 分子名称: | 2',5'-dideoxy-5'-(tritylamino)uridine, Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, ... | | 著者 | Hampton, S.E, Baragana, B, Schipani, A, Bosch-Navarrete, C, Musso-Buendia, A, Recio, E, Kaiser, M, Whittingham, J.L, Roberts, S.M, Shevtsov, M, Brannigan, J.A, Kahnberg, P, Brun, R, Wilson, K.S, Gonzalez-Pacanowska, D, Johansson, N.G, Gilbert, I.H. | | 登録日 | 2011-07-28 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.396 Å) | | 主引用文献 | Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
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6QBD
 | | Crystal structure of NLPPya P41A, D44N, N48E mutant | | 分子名称: | 25 kDa protein elicitor, MAGNESIUM ION | | 著者 | Lenarcic, T, Podobnik, M, Anderluh, G. | | 登録日 | 2018-12-21 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Molecular basis for functional diversity among microbial Nep1-like proteins.
Plos Pathog., 15, 2019
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1ROW
 | | Structure of SSP-19, an MSP-domain protein like family member in Caenorhabditis elegans | | 分子名称: | MSP-domain protein like family member | | 著者 | Schormann, N, Symersky, J, Carson, M, Luo, M, Lin, G, Li, S, Qiu, S, Arabashi, A, Bunzel, B, Luo, D, Nagy, L, Gray, R, Luan, C.-H, Zhang, J, Lu, S, DeLucas, L, Southeast Collaboratory for Structural Genomics (SECSG) | | 登録日 | 2003-12-02 | | 公開日 | 2003-12-23 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of sperm-specific protein SSP-19 from Caenorhabditis elegans.
Acta Crystallogr.,Sect.D, 60, 2004
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6QBV
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6BHB
 | | Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 2-aminopyrimidin-5-ol | | 分子名称: | 2-aminopyrimidin-5-ol, DIMETHYL SULFOXIDE, Purine nucleoside phosphorylase | | 著者 | Faheem, M, Neto, J.B, Collins, P, Pearce, N.M, Valadares, N.F, Bird, L, Pereira, H.M, Delft, F.V, Barbosa, J.A.R.G. | | 登録日 | 2017-10-30 | | 公開日 | 2018-11-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 2-aminopyrimidin-5-ol
To Be Published
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5V2U
 | | Ethylene forming enzyme apo form | | 分子名称: | 2-oxoglutarate-dependent ethylene/succinate-forming enzyme | | 著者 | Fellner, M, Martinez, S, Hu, J, Hausinger, R.P. | | 登録日 | 2017-03-06 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.058 Å) | | 主引用文献 | Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme: Substrate Binding Creates a Twist.
J. Am. Chem. Soc., 139, 2017
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7NK0
 | | Structure of the BIR1 domain of cIAP2 | | 分子名称: | Baculoviral IAP repeat-containing protein 3, ZINC ION | | 著者 | Cossu, F, Milani, M, Mastrangelo, E, Mirdita, D. | | 登録日 | 2021-02-17 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-kappa B pathway.
Comput Struct Biotechnol J, 19, 2021
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5V32
 | | Ethylene forming enzyme in complex with manganese and malic acid | | 分子名称: | 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, D-MALATE, MANGANESE (II) ION | | 著者 | Fellner, M, Martinez, S, Hu, J, Hausinger, R.P. | | 登録日 | 2017-03-06 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.486 Å) | | 主引用文献 | Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme: Substrate Binding Creates a Twist.
J. Am. Chem. Soc., 139, 2017
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7NGE
 | | Crystal structure of L-Trp/Indoleamine 2,3-dioxygenagse 1 (hIDO1) complex with the JK-loop refined in the closed conformation | | 分子名称: | CHLORIDE ION, GLYCEROL, Indoleamine 2,3-dioxygenase 1, ... | | 著者 | Mirgaux, M, Wouters, J. | | 登録日 | 2021-02-09 | | 公開日 | 2021-12-29 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Temporary Intermediates of L-Trp Along the Reaction Pathway of Human Indoleamine 2,3-Dioxygenase 1 and Identification of an Exo Site.
Int J Tryptophan Res, 14, 2021
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6QHN
 | | Metagenome-derived salicylaldehyde dehydrogenase from alpine soil in complex with protocatechuic acid | | 分子名称: | 3,4-DIHYDROXYBENZOIC ACID, GLYCEROL, SALICYLALDEHYDE DEHYDROGENASE | | 著者 | Hakansson, M, Svensson, L.A, Shamsudeen, D.U, Allen, C.C.R. | | 登録日 | 2019-01-17 | | 公開日 | 2020-02-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Expression, purification and crystallization of a novel metagenome-derived salicylaldehyde dehydrogenase from Alpine soil.
Acta Crystallogr.,Sect.F, 78, 2022
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6BGJ
 | | Cryo-EM structure of the TMEM16A calcium-activated chloride channel in LMNG | | 分子名称: | Anoctamin-1, CALCIUM ION | | 著者 | Dang, S, Feng, S, Tien, J, Peters, C.J, Bulkley, D, Lolicato, M, Zhao, J, Zuberbuhler, K, Ye, W, Qi, L, Chen, T, Craik, C.S, Jan, Y.N, Minor Jr, D.L, Cheng, Y, Jan, L.Y. | | 登録日 | 2017-10-28 | | 公開日 | 2017-12-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
Nature, 552, 2017
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6BKB
 | | Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab AR3A heavy chain, ... | | 著者 | Tzarum, N, Wilson, I.A, Law, M. | | 登録日 | 2017-11-08 | | 公開日 | 2018-12-26 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.799 Å) | | 主引用文献 | Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies.
Sci Adv, 5, 2019
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6QHE
 | | Alcohol Dehydrogenase from Arthrobacter sp. TS-15 in complex with NAD+ | | 分子名称: | Alcohol Dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION | | 著者 | Lockie, C, Beloti, L, Shanati, T, Ansorge-Schumacher, M, Grogan, G. | | 登録日 | 2019-01-16 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Two Enantiocomplementary Ephedrine Dehydrogenases from Arthrobacter sp. TS-15 with Broad Substrate Specificity
Acs Catalysis, 9, 2019
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5V2P
 | | CaV beta2a subunit: CaV1.2 AID-CAP complex | | 分子名称: | 1,3-bis(bromomethyl)benzene, NICKEL (II) ION, PENTAETHYLENE GLYCOL, ... | | 著者 | Findeisen, F, Campiglio, M, Jo, H, Rumpf, C.H, Pope, L, Flucher, B, Degrado, W.F, Minor, D.L. | | 登録日 | 2017-03-06 | | 公開日 | 2017-07-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Stapled Voltage-Gated Calcium Channel (CaV) alpha-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.
ACS Chem Neurosci, 8, 2017
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5V34
 | | Ethylene forming enzyme in complex with manganese, malic acid and L-arginine | | 分子名称: | 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, ARGININE, D-MALATE, ... | | 著者 | Fellner, M, Martinez, S, Hu, J, Hausinger, R.P. | | 登録日 | 2017-03-06 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme: Substrate Binding Creates a Twist.
J. Am. Chem. Soc., 139, 2017
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5V5W
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1JIT
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5CRJ
 | | Crystal Structure of the MTERF1 F322A substitution bound to the termination sequence. | | 分子名称: | DNA (5'-D(*AP*TP*TP*AP*CP*CP*GP*GP*GP*CP*TP*CP*TP*GP*CP*CP*AP*TP*CP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*CP*CP*CP*GP*GP*TP*AP*AP*T)-3'), Transcription termination factor 1, ... | | 著者 | Byrnes, J, Hauser, K, Norona, L, Mejia, E, Simmerling, C, Garcia-Diaz, M. | | 登録日 | 2015-07-23 | | 公開日 | 2015-11-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Base Flipping by MTERF1 Can Accommodate Multiple Conformations and Occurs in a Stepwise Fashion.
J.Mol.Biol., 428, 2016
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6C83
 | | Structure of Aurora A (122-403) bound to inhibitory Monobody Mb2 and AMPPCP | | 分子名称: | Aurora kinase A, Mb2 Monobody, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | | 著者 | Hoemberger, M, Kutter, S, Zorba, A, Nguyen, V, Shohei, A, Shohei, K, Kern, D. | | 登録日 | 2018-01-24 | | 公開日 | 2019-02-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Allosteric modulation of a human protein kinase with monobodies.
Proc.Natl.Acad.Sci.USA, 116, 2019
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2MTX
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6BZV
 | | Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody 19B3 | | 分子名称: | 19B3 GL Heavy Chain, 19B3 GL Light Chain, E2 AS412 peptide | | 著者 | Tzarum, N, Aleman, F, Wilson, I.A, Law, M. | | 登録日 | 2017-12-26 | | 公開日 | 2018-06-20 | | 最終更新日 | 2022-02-02 | | 実験手法 | X-RAY DIFFRACTION (2.654 Å) | | 主引用文献 | Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5V5V
 | | Complex of NLGN2 with MDGA1 Ig1-Ig2 | | 分子名称: | MAM domain-containing glycosylphosphatidylinositol anchor protein 1, Neuroligin-2 | | 著者 | Gangwar, S.P, Machius, M, Rudenko, G. | | 登録日 | 2017-03-15 | | 公開日 | 2017-07-05 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (4.11 Å) | | 主引用文献 | Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges.
Neuron, 94, 2017
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