5D9B
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![BU of 5d9b by Molmil](/molmil-images/mine/5d9b) | Luciferin-regenerating enzyme solved by SIRAS using XFEL (refined against native data) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Luciferin regenerating enzyme, MAGNESIUM ION | 著者 | Yamashita, K, Pan, D, Okuda, T, Murai, T, Kodan, A, Yamaguchi, T, Gomi, K, Kajiyama, N, Kato, H, Ago, H, Yamamoto, M, Nakatsu, T. | 登録日 | 2015-08-18 | 公開日 | 2015-09-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | An isomorphous replacement method for efficient de novo phasing for serial femtosecond crystallography. Sci Rep, 5, 2015
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8AQ2
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![BU of 8aq2 by Molmil](/molmil-images/mine/8aq2) | In meso structure of the membrane integral lipoprotein N-acyltransferase Lnt from P. aeruginosa covalently linked with TITC | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Apolipoprotein N-acyltransferase, CITRATE ANION, ... | 著者 | Huang, C.-Y, Weichert, D, Boland, C, Smithers, L, Olieric, V, Wang, M, Caffrey, M. | 登録日 | 2022-08-11 | 公開日 | 2023-07-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N -acyltransferase. Sci Adv, 9, 2023
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6CP3
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![BU of 6cp3 by Molmil](/molmil-images/mine/6cp3) | Monomer yeast ATP synthase (F1Fo) reconstituted in nanodisc with inhibitor of oligomycin bound. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase protein 8, ... | 著者 | Srivastava, A.P, Luo, M, Symersky, J, Liao, M.F, Mueller, D.M. | 登録日 | 2018-03-13 | 公開日 | 2018-04-11 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane. Science, 360, 2018
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5K44
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![BU of 5k44 by Molmil](/molmil-images/mine/5k44) | Structure of Mycobacterium thermoresistibile trehalose-6-phosphate synthase in a complex with Trehalose-6-phosphate. | 分子名称: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 6-O-phosphono-alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose, ... | 著者 | Mendes, V, Verma, N, Blaszczyk, M, Blundell, T.L. | 登録日 | 2016-05-20 | 公開日 | 2017-06-21 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.925 Å) | 主引用文献 | Mycobacterial OtsA Structures Unveil Substrate Preference Mechanism and Allosteric Regulation by 2-Oxoglutarate and 2-Phosphoglycerate. Mbio, 10, 2019
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1ZYI
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![BU of 1zyi by Molmil](/molmil-images/mine/1zyi) | Solution structure of ICLN, a multifunctional protein involved in regulatory mechanisms as different as cell volume regulation and rna splicing | 分子名称: | Methylosome subunit pICln | 著者 | Fuerst, J, Schedlbauer, A, Gandini, R, Garavaglia, M.L, Siano, S, Gschwentner, M, Sarg, B, Kontaxis, G, Konrat, R, Paulmichl, M. | 登録日 | 2005-06-10 | 公開日 | 2005-06-28 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4 J.Biol.Chem., 280, 2005
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207L
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![BU of 207l by Molmil](/molmil-images/mine/207l) | MUTANT HUMAN LYSOZYME C77A | 分子名称: | LYSOZYME, N-ACETYL-L-CYSTEINE | 著者 | Matsushima, M, Song, H. | 登録日 | 1996-03-26 | 公開日 | 1996-10-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A role of PDI in the reductive cleavage of mixed disulfides. J.Biochem.(Tokyo), 120, 1996
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5HNG
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![BU of 5hng by Molmil](/molmil-images/mine/5hng) | DISCOVERY OF NOVEL 7-AZAINDOLES AS PDK1 INHIBITORS | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, 6-methoxy-2-(1H-pyrazol-5-yl)-1H-benzimidazole, SULFATE ION | 著者 | Wucherer-Plietker, M, Esdar, C, Knoechel, T, Hillertz, P, Heinrich, T, Buchstaller, H.P, Greiner, H, Dorsch, D, Calderini, M, Bruge, D, Mueller, T.J.J, Graedler, U. | 登録日 | 2016-01-18 | 公開日 | 2016-06-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Discovery of novel 7-azaindoles as PDK1 inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
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8B0O
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![BU of 8b0o by Molmil](/molmil-images/mine/8b0o) | Cryo-EM structure apolipoprotein N-acyltransferase Lnt from E.coli in complex with FP3 | 分子名称: | Apolipoprotein N-acyltransferase, [(2~{R})-3-[(2~{R})-3-[[(2~{R})-1-[[(2~{R})-1-[[(2~{R})-6-[(2-aminophenyl)carbonylamino]-1-azanyl-1-oxidanylidene-hexan-2-yl]amino]-3-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-3-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-2-(hexadecanoylamino)-3-oxidanylidene-propyl]sulfanyl-2-hexadecanoyloxy-propyl] hexadecanoate | 著者 | Degtjarik, O, Smithers, L, Boland, C, Caffrey, M, Shalev Benami, M. | 登録日 | 2022-09-07 | 公開日 | 2023-07-12 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N -acyltransferase. Sci Adv, 9, 2023
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8B0L
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![BU of 8b0l by Molmil](/molmil-images/mine/8b0l) | Cryo-EM structure of apolipoprotein N-acyltransferase Lnt from E. coli in complex with PE | 分子名称: | Apolipoprotein N-acyltransferase, PHOSPHATIDYLETHANOLAMINE | 著者 | Degtjarik, O, Smithers, L, Boland, C, Caffrey, M, Shalev Benami, M. | 登録日 | 2022-09-07 | 公開日 | 2023-07-12 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N -acyltransferase. Sci Adv, 9, 2023
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8B0M
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![BU of 8b0m by Molmil](/molmil-images/mine/8b0m) | Cryo-EM structure of apolipoprotein N-acyltransferase Lnt from E. coli in complex with PE (C387S mutant) | 分子名称: | Apolipoprotein N-acyltransferase, PHOSPHATIDYLETHANOLAMINE | 著者 | Degtjarik, O, Smithers, L, Boland, C, Caffrey, M, Shalev Benami, M. | 登録日 | 2022-09-07 | 公開日 | 2023-07-12 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N -acyltransferase. Sci Adv, 9, 2023
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8AQ3
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![BU of 8aq3 by Molmil](/molmil-images/mine/8aq3) | In surfo structure of the membrane integral lipoprotein N-acyltransferase Lnt from E. coli in complex with PE | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Huang, C.-Y, Weichert, D, Boland, C, Smithers, L, Olieric, V, Wang, M, Caffrey, M. | 登録日 | 2022-08-11 | 公開日 | 2023-07-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.395 Å) | 主引用文献 | Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N -acyltransferase. Sci Adv, 9, 2023
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8AQ4
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![BU of 8aq4 by Molmil](/molmil-images/mine/8aq4) | In surfo structure of the membrane integral lipoprotein N-acyltransferase Lnt from E. coli in complex with TITC and lyso-PE | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Huang, C.-Y, Weichert, D, Boland, C, Smithers, L, Olieric, V, Wang, M, Caffrey, M. | 登録日 | 2022-08-11 | 公開日 | 2023-07-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N -acyltransferase. Sci Adv, 9, 2023
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8B0N
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![BU of 8b0n by Molmil](/molmil-images/mine/8b0n) | Cryo-EM structure of apolipoprotein N-acyltransferase Lnt from E. coli in complex with Lyso-PE | 分子名称: | Apolipoprotein N-acyltransferase, [(2~{S})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-oxidanyl-propan-2-yl] (~{Z})-octadec-9-enoate | 著者 | Degtjarik, O, Smithers, L, Boland, C, Caffrey, M, Shalev Benami, M. | 登録日 | 2022-09-07 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (2.67 Å) | 主引用文献 | Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N -acyltransferase. Sci Adv, 9, 2023
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8B0P
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![BU of 8b0p by Molmil](/molmil-images/mine/8b0p) | Cryo-EM structure of apolipoprotein N-acyltransferase Lnt from E. coli in complex with Pam3 | 分子名称: | Apolipoprotein N-acyltransferase, Pam3-SKKKK, [(2~{S})-3-[(2~{S})-3-azanyl-2-(hexadecanoylamino)-3-oxidanylidene-propyl]sulfanyl-2-hexadecanoyloxy-propyl] hexadecanoate | 著者 | Degtjarik, O, Smithers, L, Boland, C, Caffrey, M, Shalev Benami, M. | 登録日 | 2022-09-07 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N -acyltransferase. Sci Adv, 9, 2023
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5K41
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![BU of 5k41 by Molmil](/molmil-images/mine/5k41) | Structure of Mycobacterium thermoresistibile trehalose-6-phosphate synthase in a complex with ADP-glucose. | 分子名称: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE-GLUCOSE, ... | 著者 | Mendes, V, Verma, N, Blaszczyk, M, Blundell, T.L. | 登録日 | 2016-05-20 | 公開日 | 2017-06-21 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.971 Å) | 主引用文献 | Mycobacterial OtsA Structures Unveil Substrate Preference Mechanism and Allosteric Regulation by 2-Oxoglutarate and 2-Phosphoglycerate. Mbio, 10, 2019
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5K6L
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![BU of 5k6l by Molmil](/molmil-images/mine/5k6l) | |
8AX8
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![BU of 8ax8 by Molmil](/molmil-images/mine/8ax8) | |
5K6M
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![BU of 5k6m by Molmil](/molmil-images/mine/5k6m) | |
5CSB
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![BU of 5csb by Molmil](/molmil-images/mine/5csb) | The crystal structure of beta2-microglobulin D76N mutant at room temperature | 分子名称: | Beta-2-microglobulin | 著者 | de Rosa, M, Mota, C.S, de Sanctis, D, Bolognesi, M, Ricagno, S. | 登録日 | 2015-07-23 | 公開日 | 2016-08-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.719 Å) | 主引用文献 | Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity. Nat Commun, 9, 2018
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5V7W
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![BU of 5v7w by Molmil](/molmil-images/mine/5v7w) | Crystal structure of human PARP14 bound to 2-{[(1-methylpiperidin-4-yl)methyl]amino}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one inhibitor | 分子名称: | 2-{[(1-methylpiperidin-4-yl)methyl]amino}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one, Poly [ADP-ribose] polymerase 14 | 著者 | saikatendu, k.s, Hirozane, M. | 登録日 | 2017-03-20 | 公開日 | 2017-05-10 | 最終更新日 | 2018-11-14 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation. Biochem. Biophys. Res. Commun., 486, 2017
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6CY0
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![BU of 6cy0 by Molmil](/molmil-images/mine/6cy0) | RNA octamer containing 2'-F, 4'-Cbeta-OMe U. | 分子名称: | RNA (5'-R(*(CBV)P*GP*AP*AP*(UFB)P*UP*CP*G)-3') | 著者 | Harp, J.M, Egli, M. | 登録日 | 2018-04-04 | 公開日 | 2018-08-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.398 Å) | 主引用文献 | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity. Nucleic Acids Res., 46, 2018
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1ZT3
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![BU of 1zt3 by Molmil](/molmil-images/mine/1zt3) | C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid | 分子名称: | 1,4-DIETHYLENE DIOXIDE, Insulin-like growth factor binding protein 1 | 著者 | Sala, A, Capaldi, S, Campagnoli, M, Faggion, B, Labo, S, Perduca, M, Romano, A, Carrizo, M.E, Valli, M, Visai, L, Minchiotti, L, Galliano, M, Monaco, H.L. | 登録日 | 2005-05-26 | 公開日 | 2005-06-28 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure and Properties of the C-terminal Domain of Insulin-like Growth Factor-binding Protein-1 Isolated from Human Amniotic Fluid J.Biol.Chem., 280, 2005
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5HGQ
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![BU of 5hgq by Molmil](/molmil-images/mine/5hgq) | Loa loa Lysyl-tRNA synthetase in complex with Cladosporin. | 分子名称: | GLYCEROL, LYSINE, Lysine--tRNA ligase, ... | 著者 | Sharma, A, Sharma, M, Yogavel, M, Sharma, A. | 登録日 | 2016-01-08 | 公開日 | 2016-10-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.283 Å) | 主引用文献 | Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis PLoS Negl Trop Dis, 10, 2016
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1LHJ
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![BU of 1lhj by Molmil](/molmil-images/mine/1lhj) | ROLE OF PROLINE RESIDUES IN HUMAN LYSOZYME STABILITY: A SCANNING CALORIMETRIC STUDY COMBINED WITH X-RAY STRUCTURE ANALYSIS OF PROLINE MUTANTS | 分子名称: | HUMAN LYSOZYME | 著者 | Inaka, K, Matsushima, M, Herning, T, Kuroki, R, Yutani, K, Kikuchi, M. | 登録日 | 1992-03-27 | 公開日 | 1994-01-31 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Role of proline residues in human lysozyme stability: a scanning calorimetric study combined with X-ray structure analysis of proline mutants. Biochemistry, 31, 1992
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6WXC
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![BU of 6wxc by Molmil](/molmil-images/mine/6wxc) | Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with potential repurposing drug Tipiracil | 分子名称: | 1,2-ETHANEDIOL, 5-CHLORO-6-(1-(2-IMINOPYRROLIDINYL) METHYL) URACIL, FORMIC ACID, ... | 著者 | Kim, Y, Maltseva, N, Jedrzejczak, R, Welk, L, Endres, M, Chang, C, Michalska, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-05-10 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Commun Biol, 4, 2021
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