6OYR
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![BU of 6oyr by Molmil](/molmil-images/mine/6oyr) | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-002 | 分子名称: | (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl {(2S,3R)-1-(3-fluorophenyl)-3-hydroxy-4-[(2-methylpropyl)({2-[(propan-2-yl)amino]-1,3-benzoxazol-6-yl}sulfonyl)amino]butan-2-yl}carbamate, Protease | 著者 | Bulut, H, Hattori, S.I, Aoki-Ogata, H, Hayashi, H, Aoki, M, Ghosh, A.K, Mitsuya, H. | 登録日 | 2019-05-15 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity. Sci Rep, 10, 2020
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6OZ3
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6AJ6
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![BU of 6aj6 by Molmil](/molmil-images/mine/6aj6) | Crystal structure of Trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADP+ | 分子名称: | Isocitrate dehydrogenase [NADP], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Wang, X, Inaoka, D.K, Shiba, T, Balogun, E.O, Ziebart, N, Allman, S, Watanabe, Y, Nozaki, T, Boshart, M, Bringaud, F, Harada, S, Kita, K. | 登録日 | 2018-08-27 | 公開日 | 2019-08-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Biochemical characterization of a novel Trypanosoma brucei glycosomal isocitrate dehydrogenase with dual coenzyme specificity (NADP+/NAD+) To Be Published
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6A8K
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6OZV
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![BU of 6ozv by Molmil](/molmil-images/mine/6ozv) | The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module in complex with AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, GLYCEROL, SULFATE ION, ... | 著者 | Tan, K, Zhou, M, Jedrzejczak, R, Babnigg, G, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2019-05-16 | 公開日 | 2019-05-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Structures of teixobactin-producing nonribosomal peptide synthetase condensation and adenylation domains. Curr Res Struct Biol, 2, 2020
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6P3O
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![BU of 6p3o by Molmil](/molmil-images/mine/6p3o) | Tetrahydroprotoberberine N-methyltransferase in complex with (S)-cis-N-methylstylopine and S-adenosylhomocysteine | 分子名称: | (5S,12bS)-5-methyl-6,7,12b,13-tetrahydro-2H,4H,10H-[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquinolino[3,2-a]isoquinolin-5-ium, S-ADENOSYL-L-HOMOCYSTEINE, Tetrahydroprotoberberine N-methyltransferase | 著者 | Lang, D.E, Morris, J.S, Rowley, M, Torres, M.A, Maksimovich, V.A, Facchini, P.J, Ng, K.K.S. | 登録日 | 2019-05-24 | 公開日 | 2019-08-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-function studies of tetrahydroprotoberberineN-methyltransferase reveal the molecular basis of stereoselective substrate recognition. J.Biol.Chem., 294, 2019
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8PE2
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![BU of 8pe2 by Molmil](/molmil-images/mine/8pe2) | Crystal structure of Gel4 in complex with Nanobody 3 | 分子名称: | 1,3-beta-glucanosyltransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody 3, ... | 著者 | Macias-Leon, J, Redrado-Hernandez, S, Castro-Lopez, J, Sanz, A.B, Arias, M, Farkas, V, Vincke, C, Muyldermans, S, Pardo, J, Arroyo, J, Galvez, E, Hurtado-Guerrero, R. | 登録日 | 2023-06-13 | 公開日 | 2024-06-19 | 最終更新日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Broad Protection against Invasive Fungal Disease from a Nanobody Targeting the Active Site of Fungal beta-1,3-Glucanosyltransferases. Angew.Chem.Int.Ed.Engl., 63, 2024
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8PI8
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![BU of 8pi8 by Molmil](/molmil-images/mine/8pi8) | DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA | 分子名称: | Chains: E, Chains: F, GLYCEROL, ... | 著者 | Kind, L, Myllykoski, M, Raasakka, A, Kursula, P. | 登録日 | 2023-06-21 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes. JCI Insight, 9, 2024
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6AAN
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![BU of 6aan by Molmil](/molmil-images/mine/6aan) | Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with mEtZLys | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | 著者 | Yanagisawa, T, Kuratani, M, Yokoyama, S. | 登録日 | 2018-07-18 | 公開日 | 2019-04-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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8PE1
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![BU of 8pe1 by Molmil](/molmil-images/mine/8pe1) | Crystal structure of Gel4 in complex with Nanobody 4 | 分子名称: | 1,3-beta-glucanosyltransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody 4, ... | 著者 | Macias-Leon, J, Redrado-Hernandez, S, Castro-Lopez, J, Sanz, A.B, Arias, M, Farkas, V, Vincke, C, Muyldermans, S, Pardo, J, Arroyo, J, Galvez, E, Hurtado-Guerrero, R. | 登録日 | 2023-06-13 | 公開日 | 2024-06-19 | 最終更新日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Broad Protection against Invasive Fungal Disease from a Nanobody Targeting the Active Site of Fungal beta-1,3-Glucanosyltransferases. Angew.Chem.Int.Ed.Engl., 63, 2024
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8PI9
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![BU of 8pi9 by Molmil](/molmil-images/mine/8pi9) | DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -181G>A) | 分子名称: | Chains: E, Chains: F, Hepatocyte nuclear factor 1-alpha | 著者 | Kind, L, Myllykoski, M, Raasakka, A, Kursula, P. | 登録日 | 2023-06-21 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes. JCI Insight, 9, 2024
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8PUT
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![BU of 8put by Molmil](/molmil-images/mine/8put) | IF5A in complex with Deoxyhypusine synthase | 分子名称: | DI(HYDROXYETHYL)ETHER, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Probable deoxyhypusine synthase, ... | 著者 | Ennifar, E, D'agostino, M. | 登録日 | 2023-07-17 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of archaeal IF5A-DHS complex reveals insights into the hypusination mechanism. Structure, 32, 2024
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8PI0
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6ACK
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6P59
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![BU of 6p59 by Molmil](/molmil-images/mine/6p59) | Crystal structure of SIVrcm Vif-CBFbeta-ELOB-ELOC complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Core-binding factor subunit beta, Elongin-B, ... | 著者 | Binning, J.M, Chesarino, N.M, Emerman, M, Gross, J.D. | 登録日 | 2019-05-29 | 公開日 | 2019-12-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.942214 Å) | 主引用文献 | Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism. Cell Host Microbe, 26, 2019
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8TNP
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![BU of 8tnp by Molmil](/molmil-images/mine/8tnp) | Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40 | 分子名称: | DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, Protein cereblon, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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8TNQ
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![BU of 8tnq by Molmil](/molmil-images/mine/8tnq) | Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1 | 分子名称: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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5ZZ4
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![BU of 5zz4 by Molmil](/molmil-images/mine/5zz4) | Crystal structure of bruton's tyrosine kinase in complex with inhibitor 2e | 分子名称: | N-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide, Tyrosine-protein kinase BTK | 著者 | Kawahata, W, Asami, T, Irie, T, Kiyoi, T, Taniguchi, H, Asamitsu, Y, Inoue, T, Miyake, T, Sawa, M. | 登録日 | 2018-05-30 | 公開日 | 2018-09-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Design and Synthesis of Novel Amino-triazine Analogues as Selective Bruton's Tyrosine Kinase Inhibitors for Treatment of Rheumatoid Arthritis. J. Med. Chem., 61, 2018
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1AC5
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![BU of 1ac5 by Molmil](/molmil-images/mine/1ac5) | CRYSTAL STRUCTURE OF KEX1(DELTA)P, A PROHORMONE-PROCESSING CARBOXYPEPTIDASE FROM SACCHAROMYCES CEREVISIAE | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, KEX1(DELTA)P | 著者 | Shilton, B.H, Thomas, D.Y, Cygler, M. | 登録日 | 1997-02-13 | 公開日 | 1997-05-15 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of Kex1deltap, a prohormone-processing carboxypeptidase from Saccharomyces cerevisiae. Biochemistry, 36, 1997
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6AC7
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![BU of 6ac7 by Molmil](/molmil-images/mine/6ac7) | Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter | 分子名称: | 5'-D(*TP*GP*GP*GP*GP*TP*CP*CP*GP*AP*GP*GP*CP*GP*GP*GP*GP*CP*TP*TP*GP*GP*G)-3' | 著者 | Sengar, A, Vandana, J.J, Chambers, V.S, Di Antonio, M, Winnerdy, F.R, Balasubramanian, S, Phan, A.T. | 登録日 | 2018-07-25 | 公開日 | 2019-02-27 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter. Nucleic Acids Res., 47, 2019
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6P1J
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![BU of 6p1j by Molmil](/molmil-images/mine/6p1j) | The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module | 分子名称: | ACETATE ION, CHLORIDE ION, CITRATE ANION, ... | 著者 | Tan, K, Zhou, M, Jedrzejczak, R, Babnigg, G, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2019-05-20 | 公開日 | 2019-05-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structures of teixobactin-producing nonribosomal peptide synthetase condensation and adenylation domains. Curr Res Struct Biol, 2, 2020
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1AKR
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![BU of 1akr by Molmil](/molmil-images/mine/1akr) | G61A OXIDIZED FLAVODOXIN MUTANT | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVODOXIN | 著者 | Mccarthy, A, Walsh, M, Higgins, T. | 登録日 | 1997-05-27 | 公開日 | 1998-05-27 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Modulation of the redox potentials of FMN in Desulfovibrio vulgaris flavodoxin: thermodynamic properties and crystal structures of glycine-61 mutants. Biochemistry, 37, 1998
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5ZRZ
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![BU of 5zrz by Molmil](/molmil-images/mine/5zrz) | Crystal Structure of EphA5/SAMD5 Complex | 分子名称: | Ephrin type-A receptor 5, Sterile alpha motif domain-containing protein 5 | 著者 | Wang, Y, Shang, Y, Li, J, Chen, W, Li, G, Wan, J, Liu, W, Zhang, M. | 登録日 | 2018-04-25 | 公開日 | 2018-05-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions. Elife, 7, 2018
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1AKW
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![BU of 1akw by Molmil](/molmil-images/mine/1akw) | G61L OXIDIZED FLAVODOXIN MUTANT | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVODOXIN | 著者 | Mccarthy, A, Walsh, M, Higgins, T. | 登録日 | 1997-05-27 | 公開日 | 1998-05-27 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Modulation of the redox potentials of FMN in Desulfovibrio vulgaris flavodoxin: thermodynamic properties and crystal structures of glycine-61 mutants. Biochemistry, 37, 1998
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6P3M
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![BU of 6p3m by Molmil](/molmil-images/mine/6p3m) | Tetrahydroprotoberberine N-methyltransferase in complex with S-adenosylhomocysteine | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, tetrahydroprotoberberine N-methyltransferase | 著者 | Lang, D.E, Morris, J.S, Rowley, M, Torres, M.A, Maksimovich, V.A, Facchini, P.J, Ng, K.K.S. | 登録日 | 2019-05-24 | 公開日 | 2019-08-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-function studies of tetrahydroprotoberberineN-methyltransferase reveal the molecular basis of stereoselective substrate recognition. J.Biol.Chem., 294, 2019
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