6P3O

Tetrahydroprotoberberine N-methyltransferase in complex with (S)-cis-N-methylstylopine and S-adenosylhomocysteine

Summary for 6P3O

Entry DOI	10.2210/pdb6p3o/pdb
Descriptor	Tetrahydroprotoberberine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, (5S,12bS)-5-methyl-6,7,12b,13-tetrahydro-2H,4H,10H-[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquinolino[3,2-a]isoquinolin-5-ium, ... (4 entities in total)
Functional Keywords	methyltransferase, transferase
Biological source	Glaucium flavum
Total number of polymer chains	1
Total formula weight	44524.71
Authors	Lang, D.E.,Morris, J.S.,Rowley, M.,Torres, M.A.,Maksimovich, V.A.,Facchini, P.J.,Ng, K.K.S. (deposition date: 2019-05-24, release date: 2019-08-14, Last modification date: 2023-10-11)
Primary citation	Lang, D.E.,Morris, J.S.,Rowley, M.,Torres, M.A.,Maksimovich, V.A.,Facchini, P.J.,Ng, K.K.S. Structure-function studies of tetrahydroprotoberberineN-methyltransferase reveal the molecular basis of stereoselective substrate recognition. J.Biol.Chem., 294:14482-14498, 2019 Cited by PubMed: 31395658 DOI: 10.1074/jbc.RA119.009214 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation