5T4J
| PLP and GABA Trigger GabR-Mediated Transcription Regulation in Bacillus subsidies via External Aldimine Formation | 分子名称: | GAMMA-AMINO-BUTANOIC ACID, HTH-type transcriptional regulatory protein GabR, PYRIDOXAL-5'-PHOSPHATE | 著者 | Wu, R, Sanishvili, R, Belitsky, B.R, Juncosa, J.I, Le, H.V, Lehrer, H.J.S, Farley, M, Silverman, R.B, Petsko, G.A, Ringe, D, Liu, D. | 登録日 | 2016-08-29 | 公開日 | 2017-03-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.231 Å) | 主引用文献 | PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5CRK
| Crystal Structure of the MTERF1 F243A substitution bound to the termination sequence. | 分子名称: | DNA (5'-D(*AP*TP*TP*AP*CP*CP*GP*GP*GP*CP*TP*CP*TP*GP*CP*CP*AP*TP*CP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*CP*CP*CP*GP*GP*TP*AP*AP*T)-3'), Transcription termination factor 1, ... | 著者 | Byrnes, J, Hauser, K, Norona, L, Mejia, E, Simmerling, C, Garcia-Diaz, M. | 登録日 | 2015-07-23 | 公開日 | 2015-11-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Base Flipping by MTERF1 Can Accommodate Multiple Conformations and Occurs in a Stepwise Fashion. J.Mol.Biol., 428, 2016
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5T4N
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8DQW
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5FKZ
| Structure of E.coli Constitutive lysine decarboxylase | 分子名称: | LYSINE DECARBOXYLASE, CONSTITUTIVE | 著者 | Kandiah, E, Carriel, D, Perard, J, Malet, H, Bacia, M, Liu, K, Chan, S.W.S, Houry, W.A, Ollagnier de Choudens, S, Elsen, S, Gutsche, I. | 登録日 | 2015-10-20 | 公開日 | 2016-09-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | 主引用文献 | Structural Insights Into the Escherichia Coli Lysine Decarboxylases and Molecular Determinants of Interaction with the Aaa+ ATPase Rava. Sci.Rep., 6, 2016
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8DVP
| Glycosylase MutY variant N146S in complex with DNA containing d(8-oxo-G) paired with substrate purine | 分子名称: | ACETATE ION, Adenine DNA glycosylase, CALCIUM ION, ... | 著者 | Demir, M, Russelburg, L.P, Horvath, M.P, David, S.S. | 登録日 | 2022-07-29 | 公開日 | 2022-11-30 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism. Nucleic Acids Res., 51, 2023
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8DW0
| Glycosylase MutY variant N146S in complex with DNA containing d(8-oxo-G) paired with an enzyme-generated abasic site (AP) product and crystallized with sodium acetate | 分子名称: | 1,2-ETHANEDIOL, Adenine DNA glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), ... | 著者 | Demir, M, Russelburg, L.P, Horvath, M.P, David, S.S. | 登録日 | 2022-07-30 | 公開日 | 2022-11-30 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism. Nucleic Acids Res., 51, 2023
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8GDA
| Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein | 分子名称: | (2S,5R)-5-[(1E,3S)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Shenming, H, Mengyao, X, Lei, L, Jiangqian, M, Sheng, C, Jinpeng, S. | 登録日 | 2023-03-03 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
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7RSL
| Seipin forms a flexible cage at lipid droplet formation sites | 分子名称: | Seipin | 著者 | Arlt, H, Sui, X, Folger, B, Adams, C, Chen, X, Remme, R, Hamprecht, F.A, DiMaio, F, Liao, M, Goodman, J.M, Farese Jr, R.V, Walther, T.C. | 登録日 | 2021-08-11 | 公開日 | 2022-02-09 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Seipin forms a flexible cage at lipid droplet formation sites. Nat.Struct.Mol.Biol., 29, 2022
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5SVL
| Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, closed (desensitized) state | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | 登録日 | 2016-08-06 | 公開日 | 2016-10-05 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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5SVS
| Anomalous Mn2+ signal reveals a divalent cation-binding site in the head domain of the ATP-gated human P2X3 ion channel | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... | 著者 | Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. | 登録日 | 2016-08-07 | 公開日 | 2016-09-28 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (4.025 Å) | 主引用文献 | X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
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8GDB
| Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein | 分子名称: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Shenming, H, Mengyao, X, Lei, L, Jianqiang, M, Jinpeng, S. | 登録日 | 2023-03-03 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
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5SW2
| Thaumatin Structure at pH 6.0, orthorhombic type1 | 分子名称: | GLYCEROL, Thaumatin I | 著者 | Masuda, T, Sano, A, Murata, K, Okubo, K, Suzuki, M, Mikami, B. | 登録日 | 2016-08-08 | 公開日 | 2017-08-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Thaumatin Structure at pH 6.0, orthorhombic type1 To Be Published
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7YFI
| Structure of the Rat tri-heteromeric GluN1-GluN2A-GluN2C NMDA receptor in complex with glycine and glutamate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | 著者 | Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S. | 登録日 | 2022-07-08 | 公開日 | 2023-03-29 | 最終更新日 | 2023-07-26 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
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5SWB
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8DW7
| DNA glycosylase MutY variant N146S in complex with DNA containing the transition state analog 1N paired with d(8-oxo-G) | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Adenine DNA glycosylase, ... | 著者 | Demir, M, Russelburg, L.P, Horvath, M.P, David, S.S. | 登録日 | 2022-07-31 | 公開日 | 2022-11-30 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism. Nucleic Acids Res., 51, 2023
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5FIA
| Structure of the effector protein LpiR1 (Lpg0634) from Legionella pneumophila | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, LpiR1 | 著者 | Beyrakhova, K, van Straaten, K, Cygler, M. | 登録日 | 2015-12-22 | 公開日 | 2016-01-27 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural and Functional Investigations of the Effector Protein LpiR1 from Legionella pneumophila. J.Biol.Chem., 291, 2016
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1KCZ
| Crystal Structure of beta-methylaspartase from Clostridium tetanomorphum. Mg-complex. | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, beta-methylaspartase | 著者 | Asuncion, M, Blankenfeldt, W, Barlow, J.N, Gani, D, Naismith, J.H. | 登録日 | 2001-11-12 | 公開日 | 2001-12-19 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The structure of 3-methylaspartase from Clostridium tetanomorphum functions via the common enolase chemical step. J.Biol.Chem., 277, 2002
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5T2G
| mPI3Kd IN COMPLEX WITH 7i | 分子名称: | 4-[3-azanyl-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]pyrazole-1-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 著者 | Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L. | 登録日 | 2016-08-23 | 公開日 | 2017-04-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
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5GAD
| RNC-SRP-SR complex early state | 分子名称: | 1A9L SS, 23S rRNA, 50S ribosomal protein L10, ... | 著者 | Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. | 登録日 | 2015-11-24 | 公開日 | 2016-01-27 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
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5KGV
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8DVY
| DNA glycosylase MutY variant N146S in complex with DNA containing d(8-oxo-G) paired with an enzyme-generated abasic site product (AP) and crystalized with calcium acetate | 分子名称: | ACETATE ION, Adenine DNA glycosylase, CALCIUM ION, ... | 著者 | Demir, M, Russelburg, L.P, Horvath, M.P, David, S.S. | 登録日 | 2022-07-30 | 公開日 | 2022-11-30 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism. Nucleic Acids Res., 51, 2023
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5K47
| CryoEM structure of the human Polycystin-2/PKD2 TRP channel | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2 | 著者 | Pike, A.C.W, Grieben, M, Shintre, C.A, Tessitore, A, Shrestha, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2016-05-20 | 公開日 | 2016-08-24 | 最終更新日 | 2020-10-21 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2). Nat. Struct. Mol. Biol., 24, 2017
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3MAV
| Crystal structure of Plasmodium vivax putative farnesyl pyrophosphate synthase (Pv092040) | 分子名称: | Farnesyl pyrophosphate synthase, SULFATE ION | 著者 | Dong, A, Dunford, J, Lew, J, Wernimont, A.K, Ren, H, Zhao, Y, Koeieradzki, I, Opperman, U, Sundstrom, M, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC) | 登録日 | 2010-03-24 | 公開日 | 2010-04-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites. J.Biol.Chem., 286, 2011
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5D3J
| First bromodomain of BRD4 bound to inhibitor XD33 | 分子名称: | 4-acetyl-N-[3-(diethylsulfamoyl)phenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 | 著者 | Wohlwend, D, Huegle, M. | 登録日 | 2015-08-06 | 公開日 | 2016-01-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016
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