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PDB: 264 results

1S9Z
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BU of 1s9z by Molmil
SYNTHETIC 17 AMINO ACID LONG PEPTIDE THAT FORMS A NATIVE-LIKE COILED-COIL AT AMBIENT TEMPERATURE AND AGGREGATES INTO AMYLOID-LIKE FIBRILS AT HIGHER TEMPERATURES.
Descriptor: SODIUM ION, SYNTHETIC COILED-COIL PEPTIDE, ZINC ION
Authors:Kammerer, R.A, Kostrewa, D, Zurdo, J, Detken, A, Garcia-Echeverria, C, Green, J.D, Muller, S.A, Meier, B.H, Winkler, F.K, Dobson, C.M, Steinmetz, M.O.
Deposit date:2004-02-06
Release date:2004-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Exploring amyloid formation by a de novo design
Proc.Natl.Acad.Sci.USA, 101, 2004
6FTR
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BU of 6ftr by Molmil
Serial Femtosecond Crystallography at Megahertz pulse rates
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ...
Authors:Wiedorn, M.O, Oberthuer, D, Barty, A, Chapman, H.N.
Deposit date:2018-02-23
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.76000106 Å)
Cite:Megahertz serial crystallography.
Nat Commun, 9, 2018
6GJ4
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BU of 6gj4 by Molmil
Tubulin-6j complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-(quinolin-5-yl)naphtho[2,3-b]pyrrolo[1,2-d][1,4]oxazepin-4-yl acetate, CALCIUM ION, ...
Authors:Brindisi, M, Ulivieri, C, Alfano, G, Gemma, S, Balaguer, F.d.A, Khan, T, Grillo, A, Chemi, G, Menchon, G, Prota, A.E, Olieric, N, Agell, D.L, Barasoain, I, Diaz, J.F, Nebbioso, A, Conte, M.R, Lopresti, L, Magnano, S, Amet, R, Kinsella, P, Zisterer, D.M, Ibrahim, O, O'Sullivan, J, Morbidelli, L, Spaccapelo, R, Baldari, C, Butini, S, Novellino, E, Campiani, G, Altucci, L, Steinmetz, M.O, Brogi, S.
Deposit date:2018-05-16
Release date:2018-12-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.
Eur J Med Chem, 162, 2018
8A9Z
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BU of 8a9z by Molmil
Tubulin-[1,2]oxazoloisoindole-2e complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7-[(3,5-dimethoxyphenyl)methyl]pyrrolo[3,4-g][1,2]benzoxazole, CALCIUM ION, ...
Authors:Prota, A.E, Abel, A.-C, Steinmetz, M.O, Barraja, P, Montalbano, A, Spano, V.
Deposit date:2022-06-29
Release date:2022-11-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.294 Å)
Cite:Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas.
Eur.J.Med.Chem., 243, 2022
8A0L
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BU of 8a0l by Molmil
Tubulin-CW1-complex
Descriptor: (3~{S},4~{R},8~{S},10~{S},12~{S},14~{S})-14-[(~{Z},4~{R})-4-(hydroxymethyl)hex-2-en-2-yl]-4,12-dimethoxy-9,9-dimethyl-3,8,10-tris(oxidanyl)-1-oxacyclotetradecan-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Prota, A.E, Diaz, J.F, Steinmetz, M.O, Oliva, M.A.
Deposit date:2022-05-28
Release date:2022-12-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9981 Å)
Cite:Chemical modulation of microtubule structure through the laulimalide/peloruside site.
Structure, 31, 2023
8BDG
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BU of 8bdg by Molmil
Tubulin-taxane-2b complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Prota, A.E, Lucena-Agell, D, Ma, Y, Estevez-Gallego, J, Li, S, Bargsten, K, Altmann, K.H, Gaillard, N, Kamimura, S, Muehlethaler, T, Gago, F, Oliva, M.A, Steinmetz, M.O, Fang, W.S, Diaz, J.F.
Deposit date:2022-10-19
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural insight into the stabilization of microtubules by taxanes.
Elife, 12, 2023
8BDF
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BU of 8bdf by Molmil
Tubulin-taxane-2a complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Prota, A.E, Lucena-Agell, D, Ma, Y, Estevez-Gallego, J, Li, S, Bargsten, K, Altmann, K.H, Gaillard, N, Kamimura, S, Muehlethaler, T, Gago, F, Oliva, M.A, Steinmetz, M.O, Fang, W.S, Diaz, J.F.
Deposit date:2022-10-19
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural insight into the stabilization of microtubules by taxanes.
Elife, 12, 2023
8BDE
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BU of 8bde by Molmil
Tubulin-baccatin III complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Prota, A.E, Lucena-Agell, D, Ma, Y, Estevez-Gallego, J, Li, S, Bargsten, K, Altmann, K.H, Gaillard, N, Kamimura, S, Muehlethaler, T, Gago, F, Oliva, M.A, Steinmetz, M.O, Fang, W.S, Diaz, J.F.
Deposit date:2022-10-19
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.902 Å)
Cite:Structural insight into the stabilization of microtubules by taxanes.
Elife, 12, 2023
8A9T
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BU of 8a9t by Molmil
Tubulin-[1,2]oxazoloisoindole-1 complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Prota, A.E, Abel, A.-C, Steinmetz, M.O, Barraja, P, Montalbano, A, Spano, V.
Deposit date:2022-06-29
Release date:2022-11-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas.
Eur.J.Med.Chem., 243, 2022
6Z3C
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BU of 6z3c by Molmil
High resolution structure of RgNanOx
Descriptor: CITRATE ANION, Gfo/Idh/MocA family oxidoreductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Naismith, J.H, Lee, M.O.
Deposit date:2020-05-19
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria.
J.Biol.Chem., 295, 2020
6ZFW
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BU of 6zfw by Molmil
X-ray structure of the soluble N-terminal domain of T. cruzi PEX-14
Descriptor: ACETATE ION, BETA-MERCAPTOETHANOL, GLYCEROL, ...
Authors:Softley, C.A, Ostertag, M.O, Sattler, M, Popowicz, G.P.
Deposit date:2020-06-18
Release date:2020-12-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Deep learning model predicts water interaction sites on the surface of proteins using limited-resolution data.
Chem.Commun.(Camb.), 56, 2020
3P90
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BU of 3p90 by Molmil
Crystal Structure Analysis of H207F Mutant of Human CLIC1
Descriptor: Chloride intracellular channel protein 1
Authors:Cross, M.O, Fanucchi, S, Achilonu, I.A, Fernandes, M.A, Dirr, H.W.
Deposit date:2010-10-15
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1.
Biochemistry, 51, 2012
5M8G
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BU of 5m8g by Molmil
Tubulin-MTD265 complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-(2-morpholin-4-yl-6-pyrrolidin-1-yl-pyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine, CALCIUM ION, ...
Authors:Bohnacker, T, Prota, A.E, Steinmetz, M.O, Wymann, M.P.
Deposit date:2016-10-28
Release date:2017-02-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.147 Å)
Cite:Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017
5MF4
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BU of 5mf4 by Molmil
Tubulin-Dictyostatin complex
Descriptor: (3~{Z},5~{E},7~{R},8~{S},10~{S},11~{Z},13~{S},14~{R},15~{S},17~{S},20~{R},21~{S},22~{S})-22-[(2~{S},3~{Z})-hexa-3,5-dien-2-yl]-7,13,15,17,21-pentamethyl-8,10,14,20-tetrakis(oxidanyl)-1-oxacyclodocosa-3,5,11-trien-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Trigili, C, Barasoain, I, Sanchez-Murcia, P.A, Bargsten, K, Redondo-Horcajo, M, Nogales, A, Gardner, N.M, Meyer, A, Naylor, G.J, Gomez-Rubio, E, Gago, F, Steinmetz, M.O, Paterson, I, Prota, A.E, Diaz, J.F.
Deposit date:2016-11-17
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.
ACS Omega, 1, 2016
5NBT
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BU of 5nbt by Molmil
Apo structure of p60N/p80C katanin
Descriptor: Katanin p60 ATPase-containing subunit A1, Katanin p80 WD40 repeat-containing subunit B1
Authors:Jiang, K, Rezabkova, L, Hua, S, Liu, Q, Capitani, G, Altelaar, A.F.M, Heck, A.J.R, Kammerer, R.A, Steinmetz, M.O, Akhmanova, A.
Deposit date:2017-03-02
Release date:2017-04-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.
Nat. Cell Biol., 19, 2017
5NR4
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BU of 5nr4 by Molmil
Crystal structure of Clasp2 TOG1 domain
Descriptor: CLIP-associating protein 2
Authors:Sharma, A, Olieric, N, Weinert, T, Olieric, V, Steinmetz, M.O.
Deposit date:2017-04-21
Release date:2018-05-30
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.198 Å)
Cite:CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain.
Dev. Cell, 46, 2018
5NG4
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BU of 5ng4 by Molmil
Human CEP135 parallel dimeric coiled coil 82-144
Descriptor: Centrosomal protein of 135 kDa
Authors:Kraatz, S.H.W, Bianchi, S, Steinmetz, M.O.
Deposit date:2017-03-16
Release date:2018-05-02
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Combinatorial use of disulfide bridges and native sulfur-SAD phasing for rapid structure determination of coiled-coils.
Biosci. Rep., 38, 2018
5NFD
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BU of 5nfd by Molmil
Antiparallel monomeric coiled coil of Kif21A
Descriptor: Kinesin-like protein KIF21A
Authors:Kraatz, S.H.W, Bianchi, S, Steinmetz, M.O.
Deposit date:2017-03-13
Release date:2018-05-02
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Combinatorial use of disulfide bridges and native sulfur-SAD phasing for rapid structure determination of coiled-coils.
Biosci. Rep., 38, 2018
5NJH
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BU of 5njh by Molmil
Triazolopyrimidines stabilize microtubules by binding to the vinca inhibitor site of tubulin
Descriptor: 5-chloranyl-7-[(1~{R},5~{S})-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl]-6-[2,4,6-tris(fluoranyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidine, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Sharma, A, Calvo, G.S, Prota, A.E, Diaz, J.F, Steinmetz, M.O.
Deposit date:2017-03-28
Release date:2017-06-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.394 Å)
Cite:Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin.
Cell Chem Biol, 24, 2017
5NM5
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BU of 5nm5 by Molmil
Tubulin Darpin room-temperature structure in complex with Colchicine determined by serial millisecond crystallography
Descriptor: Designed Ankyrin Repeat Protein (DARPIN) D1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Weinert, T, Olieric, N, James, D, Gashi, D, Nogly, P, Jaeger, K, Steinmetz, M.O, Standfuss, J.
Deposit date:2017-04-05
Release date:2017-09-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.
Nat Commun, 8, 2017
5LXT
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BU of 5lxt by Molmil
Tubulin-Discodermolide complex
Descriptor: (+)-Discodermolide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Prota, A.E, Steinmetz, M.O.
Deposit date:2016-09-22
Release date:2017-03-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis of Microtubule Stabilization by Discodermolide.
Chembiochem, 18, 2017
5LYJ
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BU of 5lyj by Molmil
Tubulin-Combretastatin A4 complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Combretastatin A4, ...
Authors:Gaspari, R, Prota, A.E, Cavalli, A, Steinmetz, M.O.
Deposit date:2016-09-28
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.397 Å)
Cite:Structural basis of cis- and trans-combretastatin binding to tubulin
Chem, 2017
5O7A
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BU of 5o7a by Molmil
Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin
Descriptor: (2~{R})-2-(3-ethynylquinolin-6-yl)oxy-2-methoxy-~{N}-[(1~{E})-1-methoxyimino-2-methyl-propan-2-yl]ethanamide, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Sharma, A, Olieric, N, Steinmetz, M.O.
Deposit date:2017-06-08
Release date:2017-07-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin.
Int J Mol Sci, 18, 2017
5NQT
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BU of 5nqt by Molmil
Tubulin Darpin room-temperature structure determined by serial millisecond crystallography
Descriptor: DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) D1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Weinert, T, Olieric, N, James, D, Gashi, D, Nogly, P, Jaeger, K, Steinmetz, M.O, Standfuss, J.
Deposit date:2017-04-21
Release date:2017-09-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.
Nat Commun, 8, 2017
5M54
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BU of 5m54 by Molmil
Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins
Descriptor: Calmodulin-regulated spectrin-associated protein 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Akhmanova, A, Moores, C.A, Baldus, M, Steinmetz, M.O, Topf, M, Roberts, A.J, Grant, B.J, Scarabelli, G, Joseph, A.-J, van Hooff, J.J.E, Houben, K, Hua, S, Luo, Y, Stangier, M.M, Jiang, K, Atherton, J.
Deposit date:2016-10-20
Release date:2017-10-04
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (8 Å)
Cite:A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.
Nat. Struct. Mol. Biol., 24, 2017

221051

数据于2024-06-12公开中

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