3HCU
 
 | | Crystal structure of TRAF6 in complex with Ubc13 in the C2 space group | | Descriptor: | TNF receptor-associated factor 6, Ubiquitin-conjugating enzyme E2 N, ZINC ION | | Authors: | Yin, Q, Lin, S.-C, Lamothe, B, Lu, M, Lo, Y.-C, Hura, G, Zheng, L, Rich, R.L, Campos, A.D, Myszka, D.G, Lenardo, M.J, Darnay, B.G, Wu, H. | | Deposit date: | 2009-05-06 | | Release date: | 2009-05-26 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | E2 interaction and dimerization in the crystal structure of TRAF6.
Nat.Struct.Mol.Biol., 16, 2009
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1JCC
 | | Crystal Structure of a Novel Alanine-Zipper Trimer at 1.7 A Resolution, V13A,L16A,V20A,L23A,V27A,M30A,V34A mutations | | Descriptor: | MAJOR OUTER MEMBRANE LIPOPROTEIN, ZINC ION | | Authors: | Liu, J, Dai, J, Lu, M. | | Deposit date: | 2001-06-08 | | Release date: | 2003-06-17 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Zinc-Mediated Helix Capping in A Triple-Helical Protein
Biochemistry, 42, 2003
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1JPX
 | | Mutation that destabilize the gp41 core: determinants for stabilizing the SIV/CPmac envelope glycoprotein complex. Wild type. | | Descriptor: | gp41 envelope protein | | Authors: | Liu, J, Wang, S, LaBranche, C.C, Hoxie, J.A, Lu, M. | | Deposit date: | 2001-08-03 | | Release date: | 2002-04-24 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Mutations that destabilize the gp41 core are determinants for stabilizing the simian immunodeficiency virus-CPmac envelope glycoprotein complex.
J.Biol.Chem., 277, 2002
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8W7E
 | | Design, synthesis and biological evaluations of novel small molecular hyper-activators of human caseinolytic peptidase P (hClpP) | | Descriptor: | 3-[(3-chlorophenyl)methyl]-6-[(4-chlorophenyl)methyl]-2,4-dihydro-1H-pyrido[2,3-c][2,7]naphthyridin-5-one, ATP-dependent Clp protease proteolytic subunit, mitochondrial | | Authors: | Jiang, J.-X, Ding, H, Chen, M.-R, Lu, M.-L, Sun, H.-Y, Xiao, Y.-B. | | Deposit date: | 2023-08-30 | | Release date: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Design, synthesis and biological evaluations of novel small molecular hyper-activators of human caseinolytic peptidase P (hClpP)
To Be Published
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8W7C
 | | Activation of mitochondrial Caseinolytic Protease P (ClpP) induces selective cancer cell lethality | | Descriptor: | 11-[(3-chlorophenyl)methyl]-7-[[4-(trifluoromethyl)phenyl]methyl]-2,5,7,11-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),3,5-trien-8-one, ATP-dependent Clp protease proteolytic subunit, mitochondrial | | Authors: | Jiang, J.-X, Ding, H, Lu, M.-L, Chen, M.-R, Sun, H.-Y, Xiao, Y.-B. | | Deposit date: | 2023-08-30 | | Release date: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Activation of mitochondrial Caseinolytic Protease P (ClpP) induces selective cancer cell lethality
To Be Published
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1JCD
 | | Crystal Structure of a Novel Alanine-Zipper Trimer at 1.3 A Resolution, I6A,L9A,V13A,L16A,V20A,L23A,V27A,M30A,V34A,L48A,M51A mutations | | Descriptor: | MAJOR OUTER MEMBRANE LIPOPROTEIN | | Authors: | Liu, J, Lu, M. | | Deposit date: | 2001-06-08 | | Release date: | 2003-06-17 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | An Alanine-Zipper Structure
Determined by Long Range
Intermolecular Interactions
J.Biol.Chem., 277, 2002
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7DHY
 | | Arsenic-bound p53 DNA-binding domain mutant G245S | | Descriptor: | ARSENIC, Cellular tumor antigen p53, GLYCEROL, ... | | Authors: | Chen, S, Lu, M. | | Deposit date: | 2020-11-18 | | Release date: | 2021-03-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
Cancer Cell, 39, 2021
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3N27
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1KFN
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3HCT
 | | Crystal structure of TRAF6 in complex with Ubc13 in the P1 space group | | Descriptor: | TNF receptor-associated factor 6, Ubiquitin-conjugating enzyme E2 N, ZINC ION | | Authors: | Yin, Q, Lin, S.-C, Lamothe, B, Lu, M, Lo, Y.-C, Hura, G, Zheng, L, Rich, R.L, Campos, A.D, Myszka, D.G, Lenardo, M.J, Darnay, B.G, Wu, H. | | Deposit date: | 2009-05-06 | | Release date: | 2009-05-26 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | E2 interaction and dimerization in the crystal structure of TRAF6.
Nat.Struct.Mol.Biol., 16, 2009
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3UIA
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8WUZ
 | | Development of 2-imino-2,3,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-4(1H)-one derivatives as human caseinolytic peptidase P (hClpP) activators | | Descriptor: | 5-[(3-fluorophenyl)methyl]-9-[[4-(trifluoromethyl)phenyl]methyl]-1,5,9,11-tetrazatricyclo[8.4.0.0^{2,7}]tetradeca-2(7),10-dien-8-one, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ... | | Authors: | Jiang, J.-X, Ding, H, Chen, M.-R, Lu, M.-L, Sun, H.-Y, Xiao, Y.-B. | | Deposit date: | 2023-10-22 | | Release date: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Development of 2-imino-2,3,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-4(1H)-one derivatives as human caseinolytic peptidase P (hClpP) activators
To Be Published
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1JQ0
 | | Mutation that destabilize the gp41 core: determinants for stabilizing the SIV/CPmac envelope glycoprotein complex. Mutant structure. | | Descriptor: | gp41 envelope protein | | Authors: | Liu, J, Wang, S, LaBranche, C.C, Hoxie, J.A, Lu, M. | | Deposit date: | 2001-08-03 | | Release date: | 2002-04-24 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Mutations that destabilize the gp41 core are determinants for stabilizing the simian immunodeficiency virus-CPmac envelope glycoprotein complex.
J.Biol.Chem., 277, 2002
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1KFM
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1ZV8
 | | A structure-based mechanism of SARS virus membrane fusion | | Descriptor: | ACETATE ION, CACODYLATE ION, E2 glycoprotein, ... | | Authors: | Deng, Y, Liu, J, Zheng, Q, Yong, W, Dai, J, Lu, M. | | Deposit date: | 2005-06-01 | | Release date: | 2006-05-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Structures and Polymorphic Interactions of Two Heptad-Repeat Regions of the SARS Virus S2 Protein.
Structure, 14, 2006
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3U91
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2GUV
 | | Conformational Transition between Four- and Five-stranded Phenylalanine Zippers Determined by a Local Packing Interaction | | Descriptor: | Major outer membrane lipoprotein | | Authors: | Liu, J, Zheng, Q, Deng, Y, Kallenbach, N.R, Lu, M. | | Deposit date: | 2006-05-01 | | Release date: | 2006-07-25 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Conformational Transition between Four and Five-stranded Phenylalanine Zippers Determined by a Local Packing Interaction.
J.Mol.Biol., 361, 2006
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2GUS
 | | Conformational Transition between Four- and Five-stranded Phenylalanine Zippers Determined by a Local Packing Interaction | | Descriptor: | Major outer membrane lipoprotein | | Authors: | Liu, J, Zheng, Q, Deng, Y, Kallenbach, N.R, Lu, M. | | Deposit date: | 2006-05-01 | | Release date: | 2006-07-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Conformational Transition between Four and Five-stranded Phenylalanine Zippers Determined by a Local Packing Interaction.
J.Mol.Biol., 361, 2006
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1S1D
 | | Structure and protein design of human apyrase | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CALCIUM ION, ... | | Authors: | Dai, J, Liu, J, Deng, Y, Smith, T.M, Lu, M. | | Deposit date: | 2004-01-06 | | Release date: | 2004-03-16 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure and protein design of a human platelet function inhibitor.
Cell(Cambridge,Mass.), 116, 2004
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7SD4
 | | SARS-CoV-2 Nucleocapsid N-terminal domain (N-NTD) protein | | Descriptor: | Nucleoprotein | | Authors: | Sarkar, S, Runge, B, Russell, R.W, Calero, D, Zeinalilathori, S, Quinn, C.M, Lu, M, Calero, G, Gronenborn, A.M, Polenova, T. | | Deposit date: | 2021-09-29 | | Release date: | 2022-06-08 | | Last modified: | 2024-05-15 | | Method: | SOLID-STATE NMR | | Cite: | Atomic-Resolution Structure of SARS-CoV-2 Nucleocapsid Protein N-Terminal Domain.
J.Am.Chem.Soc., 144, 2022
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8I0A
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1S18
 | | Structure and protein design of human apyrase | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CALCIUM ION, ... | | Authors: | Dai, J, Liu, J, Deng, Y, Smith, T.M, Lu, M. | | Deposit date: | 2004-01-05 | | Release date: | 2004-03-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure and protein design of a human platelet function inhibitor.
Cell(Cambridge,Mass.), 116, 2004
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7DHZ
 | | Arsenic-bound p53 DNA-binding domain mutant R249S | | Descriptor: | ARSENIC, Cellular tumor antigen p53, GLYCEROL, ... | | Authors: | Chen, S, Lu, M. | | Deposit date: | 2020-11-18 | | Release date: | 2021-03-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
Cancer Cell, 39, 2021
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5ZQI
 | | Alginate lyase AlgAT5 from Polysaccharide Lyase family 7 | | Descriptor: | Alginate lyase AlgAT5, SULFATE ION | | Authors: | Su, H, Dong, S, Feng, Y.G, Ji, S.Q, Lu, M, Li, F.L. | | Deposit date: | 2018-04-19 | | Release date: | 2019-04-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Alginate lyase AlgAT5 from Polysaccharide Lyase family 7
To Be Published
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2HY6
 | | A seven-helix coiled coil | | Descriptor: | General control protein GCN4, HEXANE-1,6-DIOL | | Authors: | Liu, J, Zheng, Q, Deng, Y, Cheng, C.S, Kallenbach, N.R, Lu, M. | | Deposit date: | 2006-08-04 | | Release date: | 2006-10-24 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | A seven-helix coiled coil.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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