1JCE
 
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2MF8
 | | HADDOCK model of MyT1 F4F5 - DNA complex | | Descriptor: | DNA (5'-D(*AP*CP*CP*GP*AP*AP*AP*GP*TP*TP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*AP*AP*CP*TP*TP*TP*CP*GP*GP*T)-3'), Myelin transcription factor 1, ... | | Authors: | Gamsjaeger, R, O'Connell, M.R, Cubeddu, L, Shepherd, N.E, Lowry, J.A, Kwan, A.H, Vandevenne, M, Swanton, M.K, Matthews, J.M, Mackay, J.P. | | Deposit date: | 2013-10-08 | | Release date: | 2013-11-06 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers.
J.Biol.Chem., 288, 2013
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1JCG
 | | MREB FROM THERMOTOGA MARITIMA, AMPPNP | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ROD SHAPE-DETERMINING PROTEIN MREB | | Authors: | van den Ent, F, Amos, L.A, Lowe, J. | | Deposit date: | 2001-06-09 | | Release date: | 2001-09-19 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Prokaryotic origin of the actin cytoskeleton.
Nature, 413, 2001
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1JCF
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3EDZ
 | | Crystal structure of catalytic domain of TACE with hydroxamate inhibitor | | Descriptor: | ADAM 17, CITRIC ACID, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... | | Authors: | Mazzola, R.D, Zhu, Z, Sinning, L, McKittrick, B, Lavey, B, Spitler, J, Kozlowski, J, Neng-Yang, S, Zhou, G, Guo, Z, Orth, P, Madison, V, Sun, J, Lundell, D, Niu, X. | | Deposit date: | 2008-09-03 | | Release date: | 2008-09-23 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket.
Bioorg.Med.Chem.Lett., 18, 2008
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2FF1
 | | Crystal structure of Trypanosoma vivax nucleoside hydrolase soaked with ImmucillinH | | Descriptor: | 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, CALCIUM ION, IAG-nucleoside hydrolase | | Authors: | Versees, W, Barlow, J, Steyaert, J. | | Deposit date: | 2005-12-18 | | Release date: | 2006-05-23 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Transition-state Complex of the Purine-specific Nucleoside Hydrolase of T.vivax: Enzyme Conformational Changes and Implications for Catalysis.
J.Mol.Biol., 359, 2006
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2FF2
 | | Crystal structure of Trypanosoma vivax nucleoside hydrolase co-crystallized with ImmucillinH | | Descriptor: | 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, CALCIUM ION, IAG-nucleoside hydrolase, ... | | Authors: | Versees, W, Barlow, J, Steyaert, J. | | Deposit date: | 2005-12-18 | | Release date: | 2006-05-23 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Transition-state Complex of the Purine-specific Nucleoside Hydrolase of T.vivax: Enzyme Conformational Changes and Implications for Catalysis.
J.Mol.Biol., 359, 2006
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2WO9
 | | MMP12 complex with a beta hydroxy carboxylic acid | | Descriptor: | (3S)-5-(4'-ACETYLBIPHENYL-4-YL)-3-HYDROXYPENTANOIC ACID, CALCIUM ION, GLYCEROL, ... | | Authors: | Holmes, I.P, Gaines, S, Watson, S.P, Lorthioir, O, Walker, A, Baddeley, S.J, Herbert, S, Egan, D, Convery, M.A, Singh, O.M.P, Gross, J.W, Strelow, J.M, Smith, R.H, Amour, A.J, Brown, D, Martin, S.L. | | Deposit date: | 2009-07-22 | | Release date: | 2009-09-08 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The Identification of Beta-Hydroxy Carboxylic Acids as Selective Mmp-12 Inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
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2WOA
 | | MMP12 complex with a beta hydroxy carboxylic acid | | Descriptor: | (3S)-5-(9H-FLUOREN-2-YL)-3-HYDROXYPENTANOIC ACID, CALCIUM ION, GLYCEROL, ... | | Authors: | Holmes, I.P, Gaines, S, Watson, S.P, Lorthioir, O, Walker, A, Baddeley, S.J, Herbert, S, Egan, D, Convery, M.A, Singh, O.M.P, Gross, J.W, Strelow, J.M, Smith, R.H, Amour, A.J, Brown, D, Martin, S.L. | | Deposit date: | 2009-07-22 | | Release date: | 2009-09-08 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Identification of Beta-Hydroxy Carboxylic Acids as Selective Mmp-12 Inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
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1HA4
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2WO8
 | | MMP12 complex with a beta hydroxy carboxylic acid | | Descriptor: | (3S)-5-biphenyl-4-yl-3-hydroxypentanoic acid, CALCIUM ION, GLYCEROL, ... | | Authors: | Holmes, I.P, Gaines, S, Watson, S.P, Lorthioir, O, Walker, A, Baddeley, S.J, Herbert, S, Egan, D, Convery, M.A, Singh, O.M.P, Gross, J.W, Strelow, J.M, Smith, R.H, Amour, A.J, Brown, D, Martin, S.L. | | Deposit date: | 2009-07-22 | | Release date: | 2009-09-08 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Identification of Beta-Hydroxy Carboxylic Acids as Selective Mmp-12 Inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
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2JYD
 | | Structure of the fifth zinc finger of Myelin Transcription Factor 1 | | Descriptor: | F5 domain of Myelin transcription factor 1, ZINC ION | | Authors: | Gamsjaeger, R, Swanton, M.K, Kobus, F.J, Lehtomaki, E, Lowry, J.A, Kwan, A.H, Matthews, J.M, Mackay, J.P. | | Deposit date: | 2007-12-12 | | Release date: | 2008-01-15 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1.
J.Biol.Chem., 283, 2008
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2JX1
 | | Structure of the fifth zinc finger of Myelin Transcription Factor 1 in complex with RARE DNA | | Descriptor: | DNA (5'-D(*DAP*DCP*DCP*DGP*DAP*DAP*DAP*DGP*DTP*DTP*DCP*DAP*DC)-3'), DNA (5'-D(*DGP*DTP*DGP*DAP*DAP*DCP*DTP*DTP*DTP*DCP*DGP*DGP*DT)-3'), Myelin transcription factor 1 | | Authors: | Gamsjaeger, R, Swanton, M.K, Kobus, F.J, Lehtomaki, E, Lowry, J.A, Kwan, A.H, Matthews, J.M, Mackay, J.P. | | Deposit date: | 2007-11-01 | | Release date: | 2007-12-11 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structure of the fifth zinc finger of Myelin Transcription Factor 1 in complex with RARE DNA
To be Published
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2L96
 | | Solution structure of LAK160-P7 | | Descriptor: | LAK160-P7 | | Authors: | Vermeer, L.S, Bui, T.T, Lan, Y, Jumagulova, E, Kozlowska, J, McIntyre, C, Drake, A.F, Mason, J.A. | | Deposit date: | 2011-02-01 | | Release date: | 2012-02-01 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | The role of proline induced conformational flexibility in determining the antibacterial potency of linear cationic alpha-helical peptides
To be Published
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2LS9
 | | Pleurocidin-NH2 | | Descriptor: | Pleurocidin | | Authors: | Vermeer, L.S, Kozlowska, J, Mason, J.A. | | Deposit date: | 2012-04-24 | | Release date: | 2013-04-03 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | All Atom Simulations of the Initial Binding of Magainin and Pleurocidin to Membranes Comprising of a Mixture of Anionic and Zwitterionic Lipids
To be Published
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2L99
 | | Solution structure of LAK160-P10 | | Descriptor: | LAK160-P10 | | Authors: | Vermeer, L.S, Bui, T.T, Lan, Y, Jumagulova, E, Kozlowska, J, McIntyre, C, Drake, A.F, Mason, J.A. | | Deposit date: | 2011-02-03 | | Release date: | 2012-02-01 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | The role of proline induced conformational flexibility in determining the antibacterial potency of linear cationic alpha-helical peptides
To be Published
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2L9A
 | | Solution structure of LAK160-P12 | | Descriptor: | LAK160-P12 | | Authors: | Vermeer, L.S, Bui, T.T, Lan, Y, Jumagulova, E, Kozlowska, J, McIntyre, C, Drake, A.F, Mason, J.A. | | Deposit date: | 2011-02-03 | | Release date: | 2012-02-01 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | The role of proline induced conformational flexibility in determining the antibacterial potency of linear cationic alpha-helical peptides
To be Published
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1RAL
 | | THREE-DIMENSIONAL STRUCTURE OF RAT LIVER 3ALPHA-HYDROXYSTEROID(SLASH)DIHYDRODIOL DEHYDROGENASE: A MEMBER OF THE ALDO-KETO REDUCTASE SUPERFAMILY | | Descriptor: | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | | Authors: | Hoog, S.S, Pawlowski, J.E, Alzari, P.M, Penning, T.M, Lewis, M. | | Deposit date: | 1994-02-04 | | Release date: | 1994-04-30 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily.
Proc.Natl.Acad.Sci.USA, 91, 1994
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1NVM
 | | Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-hydroxy-2-oxovalerate aldolase, MANGANESE (II) ION, ... | | Authors: | Manjasetty, A.B, Powlowski, J, Vrielink, A. | | Deposit date: | 2003-02-04 | | Release date: | 2003-06-17 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of a bifunctional aldolase-dehydrogenase: Sequestering a
reactive and volatile intermediate
Proc.Natl.Acad.Sci.USA, 100, 2003
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1KD0
 | | Crystal Structure of beta-methylaspartase from Clostridium tetanomorphum. Apo-structure. | | Descriptor: | 1,2-ETHANEDIOL, beta-methylaspartase | | Authors: | Asuncion, M, Blankenfeldt, W, Barlow, J.N, Gani, D, Naismith, J.H. | | Deposit date: | 2001-11-12 | | Release date: | 2001-12-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The structure of 3-methylaspartase from Clostridium tetanomorphum functions via the common enolase chemical step.
J.Biol.Chem., 277, 2002
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1KCZ
 | | Crystal Structure of beta-methylaspartase from Clostridium tetanomorphum. Mg-complex. | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, beta-methylaspartase | | Authors: | Asuncion, M, Blankenfeldt, W, Barlow, J.N, Gani, D, Naismith, J.H. | | Deposit date: | 2001-11-12 | | Release date: | 2001-12-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The structure of 3-methylaspartase from Clostridium tetanomorphum functions via the common enolase chemical step.
J.Biol.Chem., 277, 2002
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1JSS
 | | Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4). | | Descriptor: | cholesterol-regulated START protein 4 | | Authors: | Romanowski, M.J, Soccio, R.E, Breslow, J.L, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2001-08-17 | | Release date: | 2002-04-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1LEY
 | | STRUCTURE OF A DICATIONIC MONOIMIDAZOLE LEXITROPSIN BOUND TO DNA (ORIENTATION 2) | | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MONOIMIDAZOLE LEXITROPSIN | | Authors: | Goodsell, D.S, Ng, H.L, Kopka, M.L, Lown, J.W, Dickerson, R.E. | | Deposit date: | 1995-10-10 | | Release date: | 1996-04-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structure of a dicationic monoimidazole lexitropsin bound to DNA.
Biochemistry, 34, 1995
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1LEX
 | | STRUCTURE OF A DICATIONIC MONOIMIDAZOLE LEXITROPSIN BOUND TO DNA (ORIENTATION 1) | | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MONOIMIDAZOLE LEXITROPSIN | | Authors: | Goodsell, D.S, Ng, H.L, Kopka, M.L, Lown, J.W, Dickerson, R.E. | | Deposit date: | 1995-10-10 | | Release date: | 1996-04-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structure of a dicationic monoimidazole lexitropsin bound to DNA.
Biochemistry, 34, 1995
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