1JCE
MREB FROM THERMOTOGA MARITIMA
Summary for 1JCE
| Entry DOI | 10.2210/pdb1jce/pdb |
| Related | 1JCF 1JCG |
| Descriptor | ROD SHAPE-DETERMINING PROTEIN MREB (2 entities in total) |
| Functional Keywords | rod-shape determining, mreb, mbl, actin, hsp-70, ftsz, structural protein |
| Biological source | Thermotoga maritima |
| Total number of polymer chains | 1 |
| Total formula weight | 37174.74 |
| Authors | van den Ent, F.,Amos, L.A.,Lowe, J. (deposition date: 2001-06-09, release date: 2001-09-19, Last modification date: 2011-07-13) |
| Primary citation | van den Ent, F.,Amos, L.A.,Lowe, J. Prokaryotic origin of the actin cytoskeleton. Nature, 413:39-44, 2001 Cited by PubMed Abstract: It was thought until recently that bacteria lack the actin or tubulin filament networks that organize eukaryotic cytoplasm. However, we show here that the bacterial MreB protein assembles into filaments with a subunit repeat similar to that of F-actin-the physiological polymer of eukaryotic actin. By elucidating the MreB crystal structure we demonstrate that MreB and actin are very similar in three dimensions. Moreover, the crystals contain protofilaments, allowing visualization of actin-like strands at atomic resolution. The structure of the MreB protofilament is in remarkably good agreement with the model for F-actin, showing that the proteins assemble in identical orientations. The actin-like properties of MreB explain the finding that MreB forms large fibrous spirals under the cell membrane of rod-shaped cells, where they are involved in cell-shape determination. Thus, prokaryotes are now known to possess homologues both of tubulin, namely FtsZ, and of actin. PubMed: 11544518DOI: 10.1038/35092500 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report
