1BY3
 
 | | FHUA FROM E. COLI | | Descriptor: | N-OCTYL-2-HYDROXYETHYL SULFOXIDE, PROTEIN (FERRICHROME-IRON RECEPTOR PRECURSOR (FHUA)) | | Authors: | Locher, K.P, Rees, B, Koebnik, R, Mitschler, A, Moulinier, L, Rosenbusch, J.P, Moras, D. | | Deposit date: | 1998-10-22 | | Release date: | 1999-01-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes.
Cell(Cambridge,Mass.), 95, 1998
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1BY5
 | | FHUA FROM E. COLI, WITH ITS LIGAND FERRICHROME | | Descriptor: | FE (III) ION, FERRIC HYDROXAMATE UPTAKE PROTEIN, FERRICHROME, ... | | Authors: | Locher, K.P, Rees, B, Koebnik, R, Mitschler, A, Moulinier, L, Rosenbusch, J.P, Moras, D. | | Deposit date: | 1998-10-23 | | Release date: | 1999-01-13 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes.
Cell(Cambridge,Mass.), 95, 1998
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1HUX
 | | CRYSTAL STRUCTURE OF THE ACIDAMINOCOCCUS FERMENTANS (R)-2-HYDROXYGLUTARYL-COA DEHYDRATASE COMPONENT A | | Descriptor: | ACTIVATOR OF (R)-2-HYDROXYGLUTARYL-COA DEHYDRATASE, ADENOSINE-5'-DIPHOSPHATE, IRON/SULFUR CLUSTER | | Authors: | Locher, K.P, Hans, M, Yeh, A.P, Schmid, B, Buckel, W, Rees, D.C. | | Deposit date: | 2001-01-04 | | Release date: | 2001-03-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of the Acidaminococcus fermentans 2-hydroxyglutaryl-CoA dehydratase component A.
J.Mol.Biol., 307, 2001
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1L7V
 | | Bacterial ABC Transporter Involved in B12 Uptake | | Descriptor: | CYCLO-TETRAMETAVANADATE, VITAMIN B12 TRANSPORT SYSTEM PERMEASE PROTEIN BTUC, Vitamin B12 transport ATP-binding protein btuD | | Authors: | Locher, K.P, Lee, A.T, Rees, D.C. | | Deposit date: | 2002-03-18 | | Release date: | 2002-05-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism.
Science, 296, 2002
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7RTH
 | | Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab "NabFab" | | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fragment Antigen-Binding Heavy Chain, ... | | Authors: | Filippova, E.V, Mukherjee, S, Bloch, J.S, Locher, K.P, Kossiakoff, A.A. | | Deposit date: | 2021-08-13 | | Release date: | 2021-09-01 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.19 Å) | | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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2HYD
 | | Multidrug ABC transporter SAV1866 | | Descriptor: | ABC transporter homolog, ADENOSINE-5'-DIPHOSPHATE, SODIUM ION | | Authors: | Dawson, R.J.P, Locher, K.P. | | Deposit date: | 2006-08-05 | | Release date: | 2006-09-05 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure of a bacterial multidrug ABC transporter.
Nature, 443, 2006
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5NO0
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1N2Z
 | | 2.0 Angstrom structure of BtuF, the vitamin B12 binding protein of E. coli | | Descriptor: | CADMIUM ION, CHLORIDE ION, CYANOCOBALAMIN, ... | | Authors: | Borths, E.L, Locher, K.P, Lee, A.T, Rees, D.C. | | Deposit date: | 2002-10-24 | | Release date: | 2002-12-18 | | Last modified: | 2021-08-18 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter
Proc.Natl.Acad.Sci.USA, 99, 2002
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4FI3
 | | Structure of vitamin B12 transporter BtuCD-F in a nucleotide-bound state | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Vitamin B12 import ATP-binding protein BtuD, ... | | Authors: | Korkhov, V.M, Mireku, S.A, Locher, K.P. | | Deposit date: | 2012-06-07 | | Release date: | 2012-09-19 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.466 Å) | | Cite: | Structure of AMP-PNP-bound vitamin B12 transporter BtuCD-F.
Nature, 490, 2012
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2QI9
 | | ABC-transporter BtuCD in complex with its periplasmic binding protein BtuF | | Descriptor: | DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, PHOSPHATE ION, ... | | Authors: | Hvorup, R.N, Goetz, B.A, Niederer, M, Hollenstein, K, Perozo, E, Locher, K.P. | | Deposit date: | 2007-07-03 | | Release date: | 2007-08-14 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF.
Science, 317, 2007
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6QEX
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3CFZ
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3CG1
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3RCE
 | | Bacterial oligosaccharyltransferase PglB | | Descriptor: | MAGNESIUM ION, Oligosaccharide transferase to N-glycosylate proteins, Substrate Mimic Peptide | | Authors: | Lizak, C, Gerber, S, Numao, S, Aebi, M, Locher, K.P. | | Deposit date: | 2011-03-31 | | Release date: | 2011-06-15 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | X-ray structure of a bacterial oligosaccharyltransferase.
Nature, 474, 2011
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3NU1
 | | Structure of holo form of a periplasmic heme binding protein | | Descriptor: | Hemin-binding periplasmic protein, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Mattle, D, Goetz, B.A, Woo, J.S, Locher, K.P. | | Deposit date: | 2010-07-06 | | Release date: | 2010-10-13 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Two stacked heme molecules in the binding pocket of the periplasmic heme-binding protein HmuT from Yersinia pestis.
J.Mol.Biol., 404, 2010
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3MD9
 | | Structure of apo form of a periplasmic heme binding protein | | Descriptor: | BROMIDE ION, GLYCEROL, Hemin-binding periplasmic protein hmuT, ... | | Authors: | Mattle, D, Goetz, B.A, Locher, K.P. | | Deposit date: | 2010-03-30 | | Release date: | 2010-09-15 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Two stacked heme molecules in the binding pocket of the periplasmic heme-binding protein HmuT from Yersinia pestis.
J.Mol.Biol., 404, 2010
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4G1U
 | | X-ray structure of the bacterial heme transporter HmuUV from Yersinia pestis | | Descriptor: | Hemin import ATP-binding protein HmuV, Hemin transport system permease protein hmuU, PHOSPHATE ION | | Authors: | Woo, J.-S, Goetz, B.A, Zeltina, A, Locher, K.P. | | Deposit date: | 2012-07-11 | | Release date: | 2012-12-19 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.008 Å) | | Cite: | X-ray structure of the Yersinia pestis heme transporter HmuUV.
Nat.Struct.Mol.Biol., 19, 2012
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4R9U
 | | Structure of vitamin B12 transporter BtuCD in a nucleotide-bound outward facing state | | Descriptor: | LAURYL DIMETHYLAMINE-N-OXIDE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Korkhov, V.M, Mireku, S.A, Veprintsev, D.B, Locher, K.P. | | Deposit date: | 2014-09-08 | | Release date: | 2014-11-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.785 Å) | | Cite: | Structure of AMP-PNP-bound BtuCD and mechanism of ATP-powered vitamin B12 transport by BtuCD-F.
Nat.Struct.Mol.Biol., 21, 2014
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7QBG
 | | TC:CD320 in complex with nanobody TC-Nb4 | | Descriptor: | Anti-TC:CD320 nanobody TC-Nb4, CALCIUM ION, CD320 antigen, ... | | Authors: | Bloch, J.S, Locher, K.P. | | Deposit date: | 2021-11-19 | | Release date: | 2022-03-16 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route.
Faseb J., 36, 2022
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7QBD
 | | TC:CD320 in complex with nanobody TC-Nb26 | | Descriptor: | Antitranscobalamin-nanobody TC-Nb26, CALCIUM ION, CD320 antigen, ... | | Authors: | Bloch, J.S, Locher, K.P. | | Deposit date: | 2021-11-19 | | Release date: | 2022-03-16 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (4.18 Å) | | Cite: | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route.
Faseb J., 36, 2022
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7QBF
 | | TC:CD320 in complex with nanobody TC-Nb34 | | Descriptor: | 1,2-ETHANEDIOL, Anti-transcobalamin-2 nanobody TC-Nb34, CALCIUM ION, ... | | Authors: | Bloch, J.S, Locher, K.P. | | Deposit date: | 2021-11-19 | | Release date: | 2022-03-16 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route.
Faseb J., 36, 2022
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7QBE
 | | TC:CD320 in complex with nanobody TC-Nb11 | | Descriptor: | Anti-transcobalamin-2 nanobody TC-Nb11, CALCIUM ION, CD320 antigen, ... | | Authors: | Bloch, J.S, Locher, K.P. | | Deposit date: | 2021-11-19 | | Release date: | 2022-03-16 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route.
Faseb J., 36, 2022
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3CFX
 | | Crystal structure of M. acetivorans periplasmic binding protein ModA/WtpA with bound tungstate | | Descriptor: | GLYCEROL, MAGNESIUM ION, TUNGSTATE(VI)ION, ... | | Authors: | Comellas-Bigler, M, Hollenstein, K, Locher, K.P. | | Deposit date: | 2008-03-04 | | Release date: | 2009-03-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Distorted octahedral coordination of tungstate in a subfamily of specific binding proteins.
J.Biol.Inorg.Chem., 14, 2009
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3CG3
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7A69
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