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PDB: 312 件

5V02
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A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA
分子名称: 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine, CALCIUM ION, Calmodulin-1, ...
著者Liu, S.
登録日2017-02-28
公開日2018-03-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
Structure, 26, 2018
3BLU
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BU of 3blu by Molmil
crystal structure YopH complexed with inhibitor PVS
分子名称: (ethenylsulfonyl)benzene, Tyrosine-protein phosphatase yopH
著者Liu, S, Zhang, Z.-Y.
登録日2007-12-11
公開日2008-10-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases
J.Am.Chem.Soc., 130, 2008
3BLT
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BU of 3blt by Molmil
Crystal structures of YopH complexed with PVSN and PVS, inhibitors of YopH which co-valent bind to Cys of active site
分子名称: Tyrosine-protein phosphatase yopH, phenyl ethenesulfonate
著者Liu, S, Zhang, Z.-Y.
登録日2007-12-11
公開日2009-02-10
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases.
J.Am.Chem.Soc., 130, 2008
5J95
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BU of 5j95 by Molmil
MAP4K4 in complex with inhibitor
分子名称: 1-{4-[6-amino-5-(4-chlorophenyl)pyridin-3-yl]phenyl}cyclopentane-1-carboxylic acid, Mitogen-activated protein kinase kinase kinase kinase 4
著者Liu, S.
登録日2016-04-08
公開日2017-04-19
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献MAP4K4 in complex with inhibitor
To Be Published
4ZXA
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BU of 4zxa by Molmil
Crystal Structure of hydroquinone 1,2-dioxygenase PnpCD in complex with Cd2+ and 4-hydroxybenzonitrile
分子名称: 4-hydroxybenzonitrile, CADMIUM ION, Hydroquinone dioxygenase large subunit, ...
著者Liu, S, Su, T, Zhang, C, Gu, L.
登録日2015-05-20
公開日2015-09-02
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.488 Å)
主引用文献Crystal Structure of PnpCD, a Two-subunit Hydroquinone 1,2-Dioxygenase, Reveals a Novel Structural Class of Fe2+-dependent Dioxygenases.
J.Biol.Chem., 290, 2015
8CUH
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BU of 8cuh by Molmil
Crystal structure of human TEAD2 complexed with its inhibitor TM2.
分子名称: 4-[3-(2-cyclohexylethoxy)benzoyl]-N-phenylpiperazine-1-carboxamide, Transcriptional enhancer factor TEF-4
著者Liu, S, Luo, X.
登録日2022-05-17
公開日2022-11-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of a new class of reversible TEA-domain transcription factor inhibitors with a novel binding mode.
Elife, 11, 2022
6N7P
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BU of 6n7p by Molmil
S. cerevisiae spliceosomal E complex (UBC4)
分子名称: 56 kDa U1 small nuclear ribonucleoprotein component, Nuclear cap-binding protein complex subunit 1, Nuclear cap-binding protein subunit 2, ...
著者Liu, S, Li, X, Zhou, Z.H, Zhao, R.
登録日2018-11-27
公開日2019-09-18
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献A unified mechanism for intron and exon definition and back-splicing.
Nature, 573, 2019
4ZXD
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BU of 4zxd by Molmil
Crystal Structure of hydroquinone 1,2-dioxygenase PnpCD
分子名称: Hydroquinone dioxygenase large subunit, Hydroquinone dioxygenase small subunit
著者Liu, S, Su, T, Zhang, C, Gu, L.
登録日2015-05-20
公開日2015-09-02
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.052 Å)
主引用文献Crystal Structure of PnpCD, a Two-subunit Hydroquinone 1,2-Dioxygenase, Reveals a Novel Structural Class of Fe2+-dependent Dioxygenases.
J.Biol.Chem., 290, 2015
4ZXC
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Crystal Structure of hydroquinone 1,2-dioxygenase PnpCD in complex with Fe3+
分子名称: FE (III) ION, Hydroquinone dioxygenase large subunit, Hydroquinone dioxygenase small subunit
著者Liu, S, Su, T, Zhang, C, Gu, L.
登録日2015-05-20
公開日2015-09-02
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Crystal Structure of PnpCD, a Two-subunit Hydroquinone 1,2-Dioxygenase, Reveals a Novel Structural Class of Fe2+-dependent Dioxygenases.
J.Biol.Chem., 290, 2015
1S2T
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BU of 1s2t by Molmil
Crystal Structure Of Apo Phosphoenolpyruvate Mutase
分子名称: Phosphoenolpyruvate phosphomutase
著者Liu, S, Lu, Z, Han, Y, Jia, Y, Howard, A, Dunaway-Mariano, D, Herzberg, O.
登録日2004-01-11
公開日2004-05-04
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Conformational Flexibility of PEP Mutase
Biochemistry, 43, 2004
4LTY
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BU of 4lty by Molmil
Crystal Structure of E.coli SbcD at 1.8 A Resolution
分子名称: Exonuclease subunit SbcD, GLYCEROL
著者Liu, S, Tian, L.F, Yan, X.X, Liang, D.C.
登録日2013-07-24
公開日2014-02-26
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for DNA recognition and nuclease processing by the Mre11 homologue SbcD in double-strand breaks repair.
Acta Crystallogr.,Sect.D, 70, 2014
1S2W
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BU of 1s2w by Molmil
Crystal structure of phosphoenolpyruvate mutase in high ionic strength
分子名称: Phosphoenolpyruvate phosphomutase, SULFATE ION
著者Liu, S, Lu, Z, Han, Y, Jia, Y, Howard, A, Dunaway-Mariano, D, Herzberg, O.
登録日2004-01-11
公開日2004-05-04
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Conformational Flexibility of PEP Mutase
Biochemistry, 43, 2004
1S2U
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BU of 1s2u by Molmil
Crystal structure of the D58A phosphoenolpyruvate mutase mutant protein
分子名称: DI(HYDROXYETHYL)ETHER, Phosphoenolpyruvate phosphomutase
著者Liu, S, Lu, Z, Han, Y, Jia, Y, Howard, A, Dunaway-Mariano, D, Herzberg, O.
登録日2004-01-11
公開日2004-05-04
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Conformational Flexibility of PEP Mutase
Biochemistry, 43, 2004
4M0V
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BU of 4m0v by Molmil
Crystal structure of E.coli SbcD with Mn2+
分子名称: Exonuclease subunit SbcD, GLYCEROL, MANGANESE (II) ION
著者Liu, S, Tian, L.F, Yan, X.X, Liang, D.C.
登録日2013-08-02
公開日2014-02-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Structural basis for DNA recognition and nuclease processing by the Mre11 homologue SbcD in double-strand breaks repair.
Acta Crystallogr.,Sect.D, 70, 2014
4LU9
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BU of 4lu9 by Molmil
Crystal structure of E.coli SbcD at 2.5 angstrom resolution
分子名称: Exonuclease subunit SbcD, GLYCEROL
著者Liu, S, Tian, L.F, Yan, X.X, Liang, D.C.
登録日2013-07-25
公開日2014-08-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for DNA recognition and nuclease processing by the Mre11 homologue SbcD in double-strand breaks repair.
Acta Crystallogr.,Sect.D, 70, 2014
6N7R
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BU of 6n7r by Molmil
Saccharomyces cerevisiae spliceosomal E complex (ACT1)
分子名称: 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA, Pre-mRNA-processing factor 39, ...
著者Liu, S, Li, X, Zhou, Z.H, Zhao, R.
登録日2018-11-28
公開日2019-09-18
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献A unified mechanism for intron and exon definition and back-splicing.
Nature, 573, 2019
1S2V
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BU of 1s2v by Molmil
Crystal structure of phosphoenolpyruvate mutase complexed with Mg(II)
分子名称: MAGNESIUM ION, Phosphoenolpyruvate phosphomutase
著者Liu, S, Lu, Z, Han, Y, Jia, Y, Howard, A, Dunaway-Mariano, D, Herzberg, O.
登録日2004-01-11
公開日2004-05-04
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Conformational Flexibility of PEP Mutase
Biochemistry, 43, 2004
4KB8
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BU of 4kb8 by Molmil
CK1d in complex with 1-{4-[3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOL-4-YL]PYRIDIN-2-YL}-N-METHYLMETHANAMINE ligand
分子名称: 1-{4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]pyridin-2-yl}-N-methylmethanamine, Casein kinase I isoform delta, N-benzyl-4-(pyridin-3-yl)pyrimidin-2-amine, ...
著者Liu, S.
登録日2013-04-23
公開日2013-09-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Ligand-protein interactions of selective casein kinase 1 delta inhibitors.
J.Med.Chem., 56, 2013
8EQB
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BU of 8eqb by Molmil
FAM46C/BCCIPalpha/Nanobody complex
分子名称: Isoform 2 of BRCA2 and CDKN1A-interacting protein, Synthetic nanobody 1, Terminal nucleotidyltransferase 5C
著者Liu, S, Chen, H, Yin, Y, Bai, X, Zhang, X.
登録日2022-10-07
公開日2023-03-15
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (6.5 Å)
主引用文献Inhibition of FAM46/TENT5 activity by BCCIP alpha adopting a unique fold.
Sci Adv, 9, 2023
8EXE
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BU of 8exe by Molmil
Crystal structure of human FAM46A-BCCIPa complex at 3.5 angstrom resolution
分子名称: Isoform 2 of BRCA2 and CDKN1A-interacting protein, Terminal nucleotidyltransferase 5A
著者Liu, S, Zhang, X.
登録日2022-10-25
公開日2023-03-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Inhibition of FAM46/TENT5 activity by BCCIP alpha adopting a unique fold.
Sci Adv, 9, 2023
8EXF
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BU of 8exf by Molmil
Crystal structure of human FAM46A-BCCIPa complex at 3.2 angstrom resolution
分子名称: BCCIPa, Terminal nucleotidyltransferase 5A
著者Liu, S, Zhang, X.
登録日2022-10-25
公開日2023-03-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献Inhibition of FAM46/TENT5 activity by BCCIP alpha adopting a unique fold.
Sci Adv, 9, 2023
8FBD
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BU of 8fbd by Molmil
Crystal structure of OrfX1-OrfX3 complex from Clostridium botulinum E1
分子名称: ACETATE ION, Neurotoxin complex component Orf-X1, Neurotoxin complex component Orf-X3
著者Liu, S, Gao, L.
登録日2022-11-29
公開日2022-12-21
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structures of OrfX1, OrfX2 and the OrfX1-OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1.
Febs Lett., 597, 2023
8FBE
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BU of 8fbe by Molmil
Crystal structure of OrfX1 from Clostridium botulinum E1
分子名称: Neurotoxin complex component Orf-X1
著者Liu, S, Gao, L.
登録日2022-11-29
公開日2022-12-21
最終更新日2023-03-08
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Crystal structures of OrfX1, OrfX2 and the OrfX1-OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1.
Febs Lett., 597, 2023
8FJP
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BU of 8fjp by Molmil
Cryo-EM structure of native mosquito salivary gland surface protein 1 (SGS1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, salivary gland surface protein 1
著者Liu, S, Xia, X, Calvo, E, Zhou, Z.H.
登録日2022-12-20
公開日2023-03-01
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Native structure of mosquito salivary protein uncovers domains relevant to pathogen transmission.
Nat Commun, 14, 2023
1XG3
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Crystal structure of the C123S 2-methylisocitrate lyase mutant from Escherichia coli in complex with the reaction product, Mg(II)-pyruvate and succinate
分子名称: MAGNESIUM ION, PYRUVIC ACID, Probable methylisocitrate lyase, ...
著者Liu, S, Lu, Z, Han, Y, Melamud, E, Dunaway-Mariano, D, Herzberg, O.
登録日2004-09-16
公開日2005-03-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structures of 2-Methylisocitrate Lyase in Complex with Product and with Isocitrate Inhibitor Provide Insight into Lyase Substrate Specificity, Catalysis and Evolution
Biochemistry, 44, 2005

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