8VWS
 
 | |
8VWT
 | |
8VWV
 | |
2M7P
 | | RXFP1 utilises hydrophobic moieties on a signalling surface of the LDLa module to mediate receptor activation | | Descriptor: | CALCIUM ION, Low-density lipoprotein receptor, Relaxin receptor 1 | | Authors: | Kong, R.CK, Petrie, E.J, Mohanty, B, Ling, J, Lee, J.C.Y, Gooley, P.R, Bathgate, R.A.D. | | Deposit date: | 2013-04-29 | | Release date: | 2013-08-14 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | The relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation.
J.Biol.Chem., 288, 2013
|
|
4W4T
 | | The crystal structure of the terminal R domain from the myxalamid PKS-NRPS biosynthetic pathway | | Descriptor: | ACETATE ION, MxaA | | Authors: | Tsai, S.C, Keasling, J.D, Luo, R, Barajas, J.F, Phelan, R.M, Schaub, A.J, Kliewer, J. | | Deposit date: | 2014-08-15 | | Release date: | 2015-08-12 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.845 Å) | | Cite: | Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols.
Chem.Biol., 22, 2015
|
|
3ZWU
 | | Pseudomonas fluorescens PhoX in complex with vanadate, a transition state analogue | | Descriptor: | ALKALINE PHOSPHATASE PHOX, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Yong, S.C, Roversi, P, Lillington, J.E.D, Zeldin, O.B, Garman, E.F, Lea, S.M, Berks, B.C. | | Deposit date: | 2011-08-02 | | Release date: | 2012-08-08 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | A Complex Iron-Calcium Cofactor Catalyzing Phosphotransfer Chemistry
Science, 345, 2014
|
|
1QZ6
 | | Structure of rabbit actin in complex with jaspisamide A | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Klenchin, V.A, Allingham, J.S, King, R, Tanaka, J, Marriott, G, Rayment, I. | | Deposit date: | 2003-09-15 | | Release date: | 2003-11-11 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin
Nat.Struct.Biol., 10, 2003
|
|
4MNE
 | | Crystal structure of the BRAF:MEK1 complex | | Descriptor: | 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-{[(2S)-2-hydroxypropyl]oxy}furo[3,2-c]pyridine-2-carboxamide, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... | | Authors: | Sudhamsu, J, Haling, J.R, Morales, T, Brandhuber, B, Hymowitz, S.G. | | Deposit date: | 2013-09-10 | | Release date: | 2014-06-18 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.8483 Å) | | Cite: | Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling.
Cancer Cell, 26, 2014
|
|
4MNF
 | | Crystal structure of BRAF-V600E bound to GDC0879 | | Descriptor: | 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, CHLORIDE ION, Serine/threonine-protein kinase B-raf | | Authors: | Sudhamsu, J, Haling, J.R, Morales, T, Brandhuber, B, Hymowitz, S.G. | | Deposit date: | 2013-09-10 | | Release date: | 2014-06-18 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.802 Å) | | Cite: | Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling.
Cancer Cell, 26, 2014
|
|
3BM9
 | | Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90 | | Descriptor: | 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol, Heat shock protein HSP 90-alpha | | Authors: | Gopalsamy, A, Shi, M, Vogan, E.M, Golas, J, Jacob, J, Johnson, J, Lee, F, Nilakantan, R, Peterson, R, Svenson, K, Tam, M.S, Wen, Y, Chopra, R, Ellingboe, J, Arndt, K, Boschelli, F. | | Deposit date: | 2007-12-12 | | Release date: | 2008-07-08 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
J.Med.Chem., 51, 2008
|
|
3BMY
 | | Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90 | | Descriptor: | 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol, Heat shock protein HSP 90-alpha | | Authors: | Gopalsamy, A, Shi, M, Vogan, E.M, Golas, J, Jacob, J, Johnson, J, Lee, F, Nilakantan, R, Peterson, R, Svenson, K, Tam, M.S, Wen, Y, Chopra, R, Ellingboe, J, Arndt, K, Boschelli, F. | | Deposit date: | 2007-12-13 | | Release date: | 2008-07-08 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
J.Med.Chem., 51, 2008
|
|
5WLZ
 | | Crystal Structure of Amino Acids 1677-1758 of Human Beta Cardiac Myosin Fused to Xrcc4 | | Descriptor: | DNA repair protein XRCC4,Myosin-7 | | Authors: | Andreas, M.P, Ajay, G, Gellings, J, Rayment, I. | | Deposit date: | 2017-07-28 | | Release date: | 2017-08-23 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod.
J. Struct. Biol., 200, 2017
|
|
4LTM
 | | Crystal structures of NADH:FMN oxidoreductase (EMOB) - FMN complex | | Descriptor: | FLAVIN MONONUCLEOTIDE, NADH-dependent FMN reductase, SULFATE ION | | Authors: | Nissen, M.S, Youn, B, Knowles, B.D, Ballinger, J.W, Jun, S, Belchik, S.M, Xun, L, Kang, C. | | Deposit date: | 2013-07-23 | | Release date: | 2013-08-07 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.497 Å) | | Cite: | Crystal structures of NADH:FMN oxidoreductase (EmoB) at different stages of catalysis.
J.Biol.Chem., 283, 2008
|
|
5WLQ
 | | Crystal Structure of Amino Acids 1677-1755 of Human Beta Cardiac Myosin Fused to Gp7 and Eb1 | | Descriptor: | Capsid assembly scaffolding protein,Myosin-7,Microtubule-associated protein RP/EB family member 1, SULFATE ION, trimethylamine oxide | | Authors: | Andreas, M.P, Ajay, G, Gellings, J, Rayment, I. | | Deposit date: | 2017-07-27 | | Release date: | 2017-08-09 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.104 Å) | | Cite: | Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod.
J. Struct. Biol., 200, 2017
|
|
5WME
 | | Crystal Structure of Amino Acids 1729-1786 of Human Beta Cardiac Myosin Fused to Gp7 as Anti-Parallel Four-Helix Bundle | | Descriptor: | Capsid assembly scaffolding protein,Myosin-7 | | Authors: | Andreas, M.P, Ajay, G, Gellings, J, Rayment, I. | | Deposit date: | 2017-07-28 | | Release date: | 2017-08-23 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod.
J. Struct. Biol., 200, 2017
|
|
5WJB
 | | Crystal Structure of Amino Acids 1733-1797 of Human Beta Cardiac Myosin Fused to Gp7 | | Descriptor: | Capsid assembly scaffolding protein,Myosin-7 | | Authors: | Andreas, M.P, Ajay, G, Gellings, J, Rayment, I. | | Deposit date: | 2017-07-21 | | Release date: | 2017-08-09 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.905 Å) | | Cite: | Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod.
J. Struct. Biol., 200, 2017
|
|
6U1V
 | | Crystal structure of acyl-ACP/acyl-CoA dehydrogenase from allylmalonyl-CoA and FK506 biosynthesis, TcsD | | Descriptor: | Acyl-CoA dehydrogenase domain-containing protein, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE | | Authors: | Blake-Hedges, J.M, Pereira, J.H, Barajas, J.F, Adams, P.D, Keasling, J.D. | | Deposit date: | 2019-08-16 | | Release date: | 2019-12-18 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural Mechanism of Regioselectivity in an Unusual Bacterial Acyl-CoA Dehydrogenase.
J.Am.Chem.Soc., 142, 2020
|
|
5WJ7
 | | Crystal Structure of Amino Acids 1733-1797 of Human Beta Cardiac Myosin Fused to Xrcc4 | | Descriptor: | DNA repair protein XRCC4,Myosin-7 | | Authors: | Andreas, M.P, Ajay, G, Gellings, J, Rayment, I. | | Deposit date: | 2017-07-21 | | Release date: | 2017-08-09 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod.
J. Struct. Biol., 200, 2017
|
|
1YBJ
 | | Structural and Dynamics studies of both apo and holo forms of the hemophore HasA | | Descriptor: | Hemophore HasA | | Authors: | Wolff, N, Izadi-Pruneyre, N, Couprie, J, Habeck, M, Linge, J, Rieping, W, Wandersman, C, Nilges, M, Delepierre, M, Lecroisey, A. | | Deposit date: | 2004-12-21 | | Release date: | 2005-12-27 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Comparative analysis of structural and dynamic properties of the loaded and unloaded hemophore HasA: functional implications.
J.Mol.Biol., 376, 2008
|
|
8CVD
 | | Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, succinate, and scopolamine | | Descriptor: | (1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FE (II) ION, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.717 Å) | | Cite: | Structure of the H6H cyclization product complex
To Be Published
|
|
8CVA
 | | Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, succinate, and 6-OH-hyoscyamine | | Descriptor: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FE (II) ION, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.581 Å) | | Cite: | Structure of the H6H hydroxylation product complex
To Be Published
|
|
8CVC
 | | Structure of Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and 6-OH-hyoscyamine | | Descriptor: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FORMIC ACID, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.791 Å) | | Cite: | Structure mimicking the H6H cyclization ferryl complex
To Be Published
|
|
8CV8
 | | Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, 2-oxoglutarate, and hyoscyamine | | Descriptor: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, FE (II) ION, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.532 Å) | | Cite: | Structure of the H6H hydroxylation reactant complex
To Be Published
|
|
8CVB
 | | Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, 2-oxoglutarate, and 6-OH-hyoscyamine | | Descriptor: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.532 Å) | | Cite: | Structure of the H6H cyclization reactant complex
To Be Published
|
|
8CV9
 | | Structure of Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and hyoscyamine | | Descriptor: | 1,2-ETHANEDIOL, FORMIC ACID, Hyoscyamine 6-beta-hydroxylase, ... | | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | | Deposit date: | 2022-05-18 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Structure of the H6H hydroxylation reactant complex
To Be Published
|
|
