7DIJ
 
 | | Falcilysin in complex with MK-4815 | | 分子名称: | 1,2-ETHANEDIOL, 2-(aminomethyl)-3,5-ditert-butyl-phenol, ACETATE ION, ... | | 著者 | Lin, J.Q, El Sahili, A, Lescar, J. | | 登録日 | 2020-11-19 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.
Cell Chem Biol, 31, 2024
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8HO4
 | | Falcilysin in complex with MMV000848 | | 分子名称: | (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol, 1,2-ETHANEDIOL, Falcilysin, ... | | 著者 | Lin, J.Q, Chung, Z, Lescar, J. | | 登録日 | 2022-12-09 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.
Cell Chem Biol, 31, 2024
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8HO5
 | | Falcilysin in complex with MMV665806 | | 分子名称: | (2S)-1-(2,3-dimethyl-1H-indol-1-yl)-3-{[(1S,2S)-2-methylcyclohexyl]amino}propan-2-ol, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Lin, J.Q, Chung, Z, Lescar, J. | | 登録日 | 2022-12-09 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | | 主引用文献 | Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.
Cell Chem Biol, 31, 2024
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6K4F
 | | SiaC of Pseudomonas aeruginosa | | 分子名称: | DUF1987 domain-containing protein | | 著者 | Lin, J.Q, Lescar, J. | | 登録日 | 2019-05-23 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.735 Å) | | 主引用文献 | The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa.
Plos One, 15, 2020
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6K4E
 | | SiaA-PP2C domain of Pseudomonas aeruginosa | | 分子名称: | MAGNESIUM ION, Putative serine phosphatase | | 著者 | Lin, J.Q, Lescar, J. | | 登録日 | 2019-05-23 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.094 Å) | | 主引用文献 | The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa.
Plos One, 15, 2020
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7VPE
 | | Falcilysin in complex with A1 | | 分子名称: | (4S,5S)-1-[[3-[[(4S,5S)-4,5-diphenyl-4,5-dihydroimidazol-1-yl]methyl]phenyl]methyl]-4,5-diphenyl-4,5-dihydroimidazole, ACETATE ION, CHLORIDE ION, ... | | 著者 | Lin, J.Q, El Sahili, A, Lescar, J. | | 登録日 | 2021-10-16 | | 公開日 | 2022-10-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Title is not available yet as we are preparing the manuscript. Will update again once the paper is out.
To Be Published
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7DU3
 | | ThiL in complex with AMP-PNP | | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Lin, J.Q, Lescar, J. | | 登録日 | 2021-01-07 | | 公開日 | 2022-03-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | ThiL in complex with AMP-PNP
To Be Published
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8WYY
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8WYU
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8WYT
 | | Partially closed Falcilysin bound to MK-4815, from MK-4815-treated dataset | | 分子名称: | 2-(aminomethyl)-3,5-ditert-butyl-phenol, Falcilysin, ZINC ION | | 著者 | Lin, J.Q, Yan, X.F, Lescar, J. | | 登録日 | 2023-10-31 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Partially closed Falcilysin bound to MK-4815, from MK-4815-treated dataset
To Be Published
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8WYX
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8WXZ
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8WXW
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8YKU
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7WPH
 | | SARS-CoV2 RBD bound to Fab06 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB06 light chain, Fab06 heavy chain, ... | | 著者 | Lin, J.Q, El Sahili, A, Lescar, J. | | 登録日 | 2022-01-23 | | 公開日 | 2022-03-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
Nat Commun, 13, 2022
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7WPV
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7XXL
 | | RBD in complex with Fab14 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab14 heavy chain, Fab14 light chain, ... | | 著者 | Lin, J.Q, Tan, Y.J.E, Wu, B, Lescar, J. | | 登録日 | 2022-05-30 | | 公開日 | 2022-09-14 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (7.3 Å) | | 主引用文献 | Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
Nat Commun, 13, 2022
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7DIA
 | | Falcilysin in complex with mefloquine | | 分子名称: | (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2S)-piperidin-2-yl]methanol, 1,2-ETHANEDIOL, ACETATE ION, ... | | 著者 | Lin, J.Q, El Sahili, A, Lescar, J. | | 登録日 | 2020-11-18 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.
Cell Chem Biol, 31, 2024
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7DI7
 | | Falcilysin in complex with chloroquine | | 分子名称: | ACETATE ION, Falcilysin, N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE, ... | | 著者 | Lin, J.Q, El Sahili, A, Lescar, J. | | 登録日 | 2020-11-18 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.
Cell Chem Biol, 31, 2024
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5XVU
 | | Crystal structure of the protein kinase CK2 catalytic domain from Plasmodium falciparum bound to ATP | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | | 著者 | El Sahili, A, Lescar, J, Ruiz-Carrillo, D, Lin, J.Q. | | 登録日 | 2017-06-28 | | 公開日 | 2017-07-12 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition.
Sci Rep, 8, 2018
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8W7H
 | | Purine Nucleoside Phosphorylase in complex with MMV000848 | | 分子名称: | (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol, 1,2-ETHANEDIOL, PHOSPHATE ION, ... | | 著者 | Chung, Z, Lin, J.Q, Lescar, J. | | 登録日 | 2023-08-30 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848.
J.Biol.Chem., 300, 2023
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