2NQU
 
 | | MoeA E188Q | | Descriptor: | GLYCEROL, Molybdopterin biosynthesis protein moeA | | Authors: | Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V. | | Deposit date: | 2006-10-31 | | Release date: | 2007-01-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
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2NQQ
 | | MoeA R137Q | | Descriptor: | GLYCEROL, Molybdopterin biosynthesis protein moeA | | Authors: | Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V. | | Deposit date: | 2006-10-31 | | Release date: | 2007-01-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
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3PR5
 | | Dpo4 Y12A mutant incorporating ADP opposite template dT | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*CP*TP*C)-3'), ... | | Authors: | Kirouac, K.N, Ling, H. | | Deposit date: | 2010-11-29 | | Release date: | 2011-02-23 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural mechanism of ribonucleotide discrimination by a Y-family DNA polymerase.
J.Mol.Biol., 407, 2011
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2GH9
 | | Thermus thermophilus maltotriose binding protein bound with maltotriose | | Descriptor: | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, maltose/maltodextrin-binding protein | | Authors: | Cuneo, M.J, Changela, A, Beese, L.S, Hellinga, H.W. | | Deposit date: | 2006-03-27 | | Release date: | 2007-02-06 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural adaptations that modulate monosaccharide, disaccharide, and trisaccharide specificities in periplasmic maltose-binding proteins.
J.Mol.Biol., 389, 2009
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2NQN
 | | MoeA T100W | | Descriptor: | GLYCEROL, Molybdopterin biosynthesis protein moeA | | Authors: | Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V. | | Deposit date: | 2006-10-31 | | Release date: | 2007-01-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
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3Q8P
 | | Human DNA polymerase iota incorporating dCTP opposite 8-oxo-guanine | | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*AP*(8OG)P*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ... | | Authors: | Kirouac, K.N, Ling, H. | | Deposit date: | 2011-01-06 | | Release date: | 2011-02-23 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota.
Proc.Natl.Acad.Sci.USA, 108, 2011
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4ABM
 | | Crystal Structure of CHMP4B hairpin | | Descriptor: | CHARGED MULTIVESICULAR BODY PROTEIN 4B | | Authors: | Martinelli, N, Hartlieb, B, Usami, Y, Sabin, C, Dordor, A, Ribeiro, E.A, Gottlinger, H, Weissenhorn, W. | | Deposit date: | 2011-12-08 | | Release date: | 2012-05-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Cc2D1A is a Regulator of Escrt-III Chmp4B.
J.Mol.Biol., 419, 2012
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3Q8Q
 | | Human DNA polymerase iota incorporating dATP opposite 8-oxo-guanine | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*AP*(8OG)P*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ... | | Authors: | Kirouac, K.N, Ling, H. | | Deposit date: | 2011-01-06 | | Release date: | 2011-02-23 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.031 Å) | | Cite: | Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2NQR
 | | MoeA D142N | | Descriptor: | GLYCEROL, Molybdopterin biosynthesis protein moeA | | Authors: | Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V. | | Deposit date: | 2006-10-31 | | Release date: | 2007-01-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
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2NQV
 | | MoeA D228A | | Descriptor: | GLYCEROL, Molybdopterin biosynthesis protein moeA | | Authors: | Nciolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V. | | Deposit date: | 2006-10-31 | | Release date: | 2007-01-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.82 Å) | | Cite: | Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
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3R3M
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4D82
 | | Metallosphera sedula Vps4 crystal structure | | Descriptor: | AAA ATPase, central domain protein, ADENOSINE-5'-DIPHOSPHATE | | Authors: | Caillat, C, Macheboeuf, P, Wu, Y, McCarthy, A.A, Boeri-Erba, E, Effantin, G, Gottlinger, H.G, Weissenhorn, W, Renesto, P. | | Deposit date: | 2014-12-02 | | Release date: | 2015-11-25 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Asymmetric Ring Structure of Vps4 Required for Escrt-III Disassembly.
Nat.Commun., 6, 2015
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2GHB
 | | Thermotoga maritima maltotriose binding protein, ligand free form | | Descriptor: | maltose ABC transporter, periplasmic maltose-binding protein | | Authors: | Cuneo, M.J, Changela, A, Hocker, B, Beese, L.S, Hellinga, H.W. | | Deposit date: | 2006-03-27 | | Release date: | 2007-02-06 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | T. maritima maltotriose binding protein open form
To be Published
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2G9F
 | | Crystal structure of intein-tagged mouse PNGase C-terminal domain | | Descriptor: | CHLORIDE ION, GLYCEROL, peptide N-glycanase | | Authors: | Zhou, X, Zhao, G, Wang, L, Li, G, Lennarz, W.J, Schindelin, H. | | Deposit date: | 2006-03-06 | | Release date: | 2006-10-24 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2GHA
 | | Thermotoga maritima maltotriose binding protein bound with maltotriose | | Descriptor: | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, maltose ABC transporter, periplasmic maltose-binding protein | | Authors: | Cuneo, M.J, Changela, A, Hocker, B, Beese, L.S, Hellinga, H.W. | | Deposit date: | 2006-03-27 | | Release date: | 2007-02-06 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | T. maritima maltotriose binding protein
To be Published
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3Q8R
 | | Human DNA polymerase iota incorporating dGTP opposite 8-oxo-guanine | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*AP*(8OG)P*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ... | | Authors: | Kirouac, K.N, Ling, H. | | Deposit date: | 2011-01-06 | | Release date: | 2011-02-23 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3QE9
 | | Crystal structure of human exonuclease 1 Exo1 (D173A) in complex with DNA (complex I) | | Descriptor: | CALCIUM ION, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ... | | Authors: | Orans, J, McSweeney, E.A, Iyer, R.R, Hast, M.A, Hellinga, H.W, Modrich, P, Beese, L.S. | | Deposit date: | 2011-01-20 | | Release date: | 2011-04-20 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
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3QEB
 | | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA and Mn2+ (complex III) | | Descriptor: | DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), Exonuclease 1, ... | | Authors: | Orans, J, McSweeney, E.A, Iyer, R.R, Hast, M.A, Hellinga, H.W, Modrich, P, Beese, L.S. | | Deposit date: | 2011-01-20 | | Release date: | 2011-04-20 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
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2GX6
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3QQ8
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2HPJ
 | | Crystal structure of the PUB domain of mouse PNGase | | Descriptor: | GLYCEROL, PNGase | | Authors: | Zhao, G, Zhou, X, Wang, L, Li, G, Lennarz, W, Schindelin, H. | | Deposit date: | 2006-07-17 | | Release date: | 2007-05-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2HPG
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5T28
 | | mPI3Kd IN COMPLEX WITH 5k | | Descriptor: | 3-(benzotriazol-1-yl)-5-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | | Authors: | Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L. | | Deposit date: | 2016-08-23 | | Release date: | 2017-04-12 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
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5T2L
 | | mPI3Kd IN COMPLEX WITH 7l | | Descriptor: | 1-[3-azanyl-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]pyrazole-3-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | | Authors: | Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L. | | Deposit date: | 2016-08-23 | | Release date: | 2017-04-19 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
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2HPH
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