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PDB: 19 件
1AP4
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REGULATORY DOMAIN OF HUMAN CARDIAC TROPONIN C IN THE CALCIUM-SATURATED STATE, NMR, 40 STRUCTURES
分子名称: CALCIUM ION, CARDIAC N-TROPONIN C
著者Li, M.X, Spyracopoulos, L, Sia, S.K, Gagne, S.M, Chandra, M, Solaro, R.J, Sykes, B.D.
登録日1997-07-24
公開日1998-07-15
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Calcium-induced structural transition in the regulatory domain of human cardiac troponin C.
Biochemistry, 36, 1997
1MXL
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STRUCTURE OF CARDIAC TROPONIN C-TROPONIN I COMPLEX
分子名称: CALCIUM ION, PROTEIN (TROPONIN C), PROTEIN (TROPONIN I)
著者Li, M.X, Spyracopoulos, L, Sykes, B.D.
登録日1999-04-22
公開日1999-07-06
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C.
Biochemistry, 38, 1999
6LN0
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BU of 6ln0 by Molmil
Crystal structure of three main domains of nonstructural protein 3 from Coronavirus
分子名称: Non-structural protein 3, ZINC ION
著者Li, M.X, Peng, G.Q.
登録日2019-12-27
公開日2021-05-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.455 Å)
主引用文献Structure of the multiple functional domains from coronavirus nonstructural protein 3.
Emerg Microbes Infect, 10, 2021
1IH0
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Structure of the C-domain of Human Cardiac Troponin C in Complex with Ca2+ Sensitizer EMD 57033
分子名称: 5-[1-(3,4-DIMETHOXY-BENZOYL)-1,2,3,4-TETRAHYDRO-QUINOLIN-6-YL]-6-METHYL-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-ONE, CALCIUM ION, TROPONIN C, ...
著者Wang, X, Li, M.X, Spyracopoulos, L, Beier, N, Chandra, M, Solaro, R.J, Sykes, B.D.
登録日2001-04-18
公開日2001-10-10
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033.
J.Biol.Chem., 276, 2001
7KAA
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BU of 7kaa by Molmil
NMR solution structures of tirasemtiv drug bound to a fast skeletal troponin C-troponin I complex
分子名称: 6-ethynyl-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol, CALCIUM ION, Troponin C, ...
著者Mercier, P, Li, M.X, Hartman, J.J, Sykes, B.D.
登録日2020-09-30
公開日2021-03-24
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle.
J.Med.Chem., 64, 2021
1AJ4
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BU of 1aj4 by Molmil
STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 1 STRUCTURE
分子名称: CALCIUM ION, TROPONIN C
著者Sia, S.K, Li, M.X, Spyracopoulos, L, Gagne, S.M, Liu, W, Putkey, J.A, Sykes, B.D.
登録日1997-05-14
公開日1998-05-20
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain.
J.Biol.Chem., 272, 1997
1SMG
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BU of 1smg by Molmil
CALCIUM-BOUND E41A MUTANT OF THE N-DOMAIN OF CHICKEN TROPONIN C, NMR, 40 STRUCTURES
分子名称: CALCIUM ION, TROPONIN C
著者Gagne, S.M, Li, M.X, Sykes, B.D.
登録日1997-02-04
公開日1997-08-12
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Mechanism of direct coupling between binding and induced structural change in regulatory calcium binding proteins.
Biochemistry, 36, 1997
1SPY
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BU of 1spy by Molmil
REGULATORY DOMAIN OF HUMAN CARDIAC TROPONIN C IN THE CALCIUM-FREE STATE, NMR, 40 STRUCTURES
分子名称: TROPONIN C
著者Spyracopoulos, L, Li, M.X, Sia, S.K, Gagne, S.M, Chandra, M, Solaro, R.J, Sykes, B.D.
登録日1997-07-14
公開日1998-09-16
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Calcium-induced structural transition in the regulatory domain of human cardiac troponin C.
Biochemistry, 36, 1997
1LXF
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BU of 1lxf by Molmil
Structure of the Regulatory N-domain of Human Cardiac Troponin C in Complex with Human Cardiac Troponin-I(147-163) and Bepridil
分子名称: 1-ISOBUTOXY-2-PYRROLIDINO-3[N-BENZYLANILINO] PROPANE, CALCIUM ION, TROPONIN C, ...
著者Wang, X, Li, M.X, Sykes, B.D.
登録日2002-06-05
公開日2002-12-11
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil.
J.Biol.Chem., 277, 2002
3CTN
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BU of 3ctn by Molmil
STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES
分子名称: CALCIUM ION, TROPONIN C
著者Sia, S.K, Li, M.X, Spyracopoulos, L, Gagne, S.M, Liu, W, Putkey, J.A, Sykes, B.D.
登録日1997-05-08
公開日1998-05-13
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain.
J.Biol.Chem., 272, 1997
2CTN
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BU of 2ctn by Molmil
STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES
分子名称: CALCIUM ION, TROPONIN C
著者Sia, S.K, Li, M.X, Spyracopoulos, L, Gagne, S.M, Liu, W, Putkey, J.A, Sykes, B.D.
登録日1997-05-06
公開日1998-05-06
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain.
J.Biol.Chem., 272, 1997
2KRD
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BU of 2krd by Molmil
Solution Structure of the Regulatory Domain of Human Cardiac Troponin C in Complex with the Switch Region of cardiac Troponin I and W7
分子名称: CALCIUM ION, N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE, Troponin C, ...
著者Oleszczuk, M, Robertson, I.M, Li, M.X, Sykes, B.D.
登録日2009-12-16
公開日2010-02-16
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7: the basis of W7 as an inhibitor of cardiac muscle contraction.
J.MOL.CELL.CARDIOL., 48, 2010
2L1R
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BU of 2l1r by Molmil
The structure of the calcium-sensitizer, dfbp-o, in complex with the N-domain of troponin C and the switch region of troponin I
分子名称: CALCIUM ION, Troponin C, Troponin I, ...
著者Robertson, I.M, Sun, Y, Li, M.X, Sykes, B.D.
登録日2010-08-03
公開日2010-08-18
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献A structural and functional perspective into the mechanism of Ca(2+)-sensitizers that target the cardiac troponin complex.
J.MOL.CELL.CARDIOL., 49, 2010
2N79
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BU of 2n79 by Molmil
The structural and functional effects of the Familial Hypertrophic Cardiomyopathy-linked cardiac troponin C mutation, L29Q
分子名称: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles
著者Robertson, I.M, Sevrieva, I, Li, M.X, Irving, M, Sun, Y, Sykes, B.
登録日2015-09-06
公開日2015-10-28
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q.
J.MOL.CELL.CARDIOL., 87, 2015
2KDH
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BU of 2kdh by Molmil
The Solution Structure of Human Cardiac Troponin C in complex with the Green Tea Polyphenol; (-)-epigallocatechin-3-gallate
分子名称: (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, CALCIUM ION, Troponin C, ...
著者Robertson, I.M, Li, M.X, Sykes, B.D.
登録日2009-01-09
公開日2009-06-16
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of human cardiac troponin C in complex with the green tea polyphenol, (-)-epigallocatechin 3-gallate
J.Biol.Chem., 284, 2009
7X2M
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BU of 7x2m by Molmil
Crystal structure of nanobody 1-2C7 with SARS-CoV-2 RBD
分子名称: 1-2C7, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-D-mannopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1
著者Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X.
登録日2022-02-25
公開日2022-12-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.
Nat Commun, 13, 2022
7X2J
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BU of 7x2j by Molmil
Crystal structure of nanobody Nb70 with SARS-CoV RBD
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Nb70, Spike protein S1
著者Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X.
登録日2022-02-25
公開日2022-12-21
最終更新日2023-06-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.
Nat Commun, 13, 2022
7X2K
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Crystal structure of nanobody Nb70 with antibody 1F11 fab and SARS-CoV-2 RBD
分子名称: 1F11-H, 1F11-L, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X.
登録日2022-02-25
公開日2022-12-21
最終更新日2023-06-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.
Nat Commun, 13, 2022
7X2L
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Crystal structure of nanobody 3-2A2-4 with SARS-CoV-2 RBD
分子名称: Nanobody 3-2A2-4, Spike protein S1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
著者Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X.
登録日2022-02-25
公開日2022-12-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.
Nat Commun, 13, 2022

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