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PDB: 272 件
4DV9
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BU of 4dv9 by Molmil
Crystal structure of BACE1 with its inhibitor
分子名称: Beta-secretase 1, METHYL (2S)-1-[(2R,5S,8S,12S,13S,16S,19S,22S)-16-(3-AMINO-3-OXOPROPYL)-2,13-DIBENZYL-12,22-DIHYDROXY-3,5,17-TRIMETHYL-8-(2-METHYLPROPYL)-4,7,10,15,18,21-HEXAOXO-19-(PROPAN-2-YL)-3,6,9,14,17,20-HEXAAZATRICOSAN-1-OYL]PYRROLIDINE-2-CARBOXYLATE (NON-PREFERRED NAME), SULFATE ION
著者Xu, Y.C, Chen, W.Y, Li, L, Chen, T.T.
登録日2012-02-23
公開日2013-01-16
最終更新日2021-09-15
実験手法X-RAY DIFFRACTION (2.076 Å)
主引用文献Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases
J.Med.Chem., 55, 2012
8KFO
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BU of 8kfo by Molmil
Crystal structure of BSA in complex with B3
分子名称: 6-[(~{E})-2-[1-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]pyridin-1-ium-4-yl]ethenyl]-~{N},~{N}-dimethyl-naphthalen-2-amine, Albumin
著者Chen, X, Ge, Y.H, Yang, H, Fang, B, Li, L.
登録日2023-08-16
公開日2024-08-21
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Bioinspired two-stage assembled photosensitive protein engineering for tumor-specific mitochondrial targeted phototherapy
To Be Published
3FHA
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BU of 3fha by Molmil
Structure of endo-beta-N-acetylglucosaminidase A
分子名称: CALCIUM ION, Endo-beta-N-acetylglucosaminidase, GLYCEROL, ...
著者Yin, J, Li, L, Shaw, N, Li, Y, Song, J.K, Zhang, W, Xia, C, Zhang, R, Joachimiak, A, Zhang, H.C, Wang, L.X, Wang, P, Liu, Z.J.
登録日2008-12-09
公開日2009-04-28
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis and catalytic mechanism for the dual functional endo-beta-N-acetylglucosaminidase A.
Plos One, 4, 2009
3FHQ
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BU of 3fhq by Molmil
Structure of endo-beta-N-acetylglucosaminidase A
分子名称: 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, Endo-beta-N-acetylglucosaminidase, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose
著者Jie, Y, Li, L, Shaw, N, Li, Y, Song, J, Zhang, W, Xia, C, Zhang, R, Joachimiak, A, Zhang, H.-C, Wang, L.-X, Wang, P, Liu, Z.-J.
登録日2008-12-10
公開日2009-05-05
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.452 Å)
主引用文献Structural basis and catalytic mechanism for the dual functional endo-beta-N-acetylglucosaminidase A
Plos One, 4, 2009
3NSQ
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BU of 3nsq by Molmil
Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron
分子名称: 1,8-dihydroxyanthracene-9,10-dione, Retinoid X receptor, alpha
著者Zhang, H, Hu, T, Li, L, Zhou, R, Chen, L, Hu, L, Jiang, H, Shen, X.
登録日2010-07-02
公開日2010-11-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
3NSP
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BU of 3nsp by Molmil
Crystal structure of tetrameric RXRalpha-LBD
分子名称: Retinoid X receptor, alpha
著者Zhang, H, Hu, T, Li, L, Zhou, R, Chen, L, Hu, L, Jiang, H, Shen, X.
登録日2010-07-02
公開日2010-11-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
7M2P
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BU of 7m2p by Molmil
Structure of the SARS-CoV-2 3CL protease in complex with inhibitor 18
分子名称: 3C-like proteinase, Inhibitor 18 in bound form
著者Yang, K, Li, L.
登録日2021-03-17
公開日2021-08-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.
J.Med.Chem., 64, 2021
3H6X
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Crystal structure of dUTPase from Streptococcus mutans
分子名称: dUTPase
著者Li, G.L, Wang, K.T, Liu, X, Li, L.F, Su, X.D.
登録日2009-04-24
公開日2010-05-05
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure and activity analysis of dUTP nucleotidohydrolase from Streptococcus mutans
To be Published
8FZF
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BU of 8fzf by Molmil
Cryo-EM structure of an E. coli rotated ribosome complex bound with RF3-ppGpp and p/E-tRNAPhe (Composite state I-C)
分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
著者Rybak, M.Y, Li, L, Lin, J, Gagnon, M.G.
登録日2023-01-28
公開日2024-06-26
最終更新日2024-08-07
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献The ribosome termination complex remodels release factor RF3 and ejects GDP.
Nat.Struct.Mol.Biol., 2024
8FZE
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BU of 8fze by Molmil
Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State I-A)
分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
著者Rybak, M.Y, Li, L, Lin, J, Gagnon, M.G.
登録日2023-01-28
公開日2024-07-17
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献The ribosome termination complex remodels release factor RF3 and ejects GDP.
Nat.Struct.Mol.Biol., 2024
8FZI
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BU of 8fzi by Molmil
Cryo-EM structure of an E. coli rotated ribosome bound with RF3-GDPCP and p/E-tRNAPhe (Composite state II-B)
分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
著者Rybak, M.Y, Li, L, Lin, J, Gagnon, M.G.
登録日2023-01-28
公開日2024-07-17
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献The ribosome termination complex remodels release factor RF3 and ejects GDP.
Nat.Struct.Mol.Biol., 2024
8FZJ
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BU of 8fzj by Molmil
Cryo-EM structure of an E. coli rotated ribosome bound with RF3-GDPCP and p/E-tRNAPhe (Composite state II-C)
分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
著者Rybak, M.Y, Li, L, Lin, J, Gagnon, M.G.
登録日2023-01-28
公開日2024-07-17
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献The ribosome termination complex remodels release factor RF3 and ejects GDP.
Nat.Struct.Mol.Biol., 2024
8FZH
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BU of 8fzh by Molmil
Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State II-D)
分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
著者Rybak, M.Y, Li, L, Lin, J, Gagnon, M.G.
登録日2023-01-28
公開日2024-07-17
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献The ribosome termination complex remodels release factor RF3 and ejects GDP.
Nat.Struct.Mol.Biol., 2024
8FZD
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BU of 8fzd by Molmil
Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with apoRF3, RF1, P- and E-site tRNAPhe (Composite state I-B)
分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
著者Rybak, M.Y, Li, L, Lin, J, Gagnon, M.G.
登録日2023-01-28
公開日2024-07-17
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献The ribosome termination complex remodels release factor RF3 and ejects GDP.
Nat.Struct.Mol.Biol., 2024
8FZG
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BU of 8fzg by Molmil
Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF3-GDPCP, RF1, P- and E-site tRNAPhe (Composite state II-A)
分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
著者Rybak, M.Y, Li, L, Lin, J, Gagnon, M.G.
登録日2023-01-28
公開日2024-07-17
最終更新日2024-08-07
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献The ribosome termination complex remodels release factor RF3 and ejects GDP.
Nat.Struct.Mol.Biol., 2024
6SCX
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BU of 6scx by Molmil
Crystal structure of the catalytic domain of human NUDT12 in complex with 7-methyl-guanosine-5'-triphosphate
分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, CADMIUM ION, Peroxisomal NADH pyrophosphatase NUDT12
著者McCarthy, A.A, Chen, K.M, Wu, H, Li, L, Homolka, D, Gos, P, Fleury-Olela, F, Pillai, R.S.
登録日2019-07-25
公開日2020-01-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.
Cell Rep, 29, 2019
4E2A
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BU of 4e2a by Molmil
Crystal Structure of the Putative acetyltransferase from Streptococcus mutans
分子名称: Putative acetyltransferase
著者Li, G.L, Nie, J.K, Li, L.F, Su, X.D.
登録日2012-03-08
公開日2013-03-13
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of the Putative acetyltransferase from Streptococcus mutans
To be Published
3DEZ
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BU of 3dez by Molmil
Crystal structure of Orotate phosphoribosyltransferase from Streptococcus mutans
分子名称: Orotate phosphoribosyltransferase, SULFATE ION
著者Liu, C.P, Gao, Z.Q, Hou, H.F, Li, L.F, Su, X.D, Dong, Y.H.
登録日2008-06-11
公開日2009-06-16
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans
Acta Crystallogr.,Sect.F, 66, 2010
2G0I
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BU of 2g0i by Molmil
Crystal structure of SMU.848 from Streptococcus mutans
分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, hypothetical protein SMU.848
著者Hou, H.-F, Gao, Z.-Q, Li, L.-F, Liang, Y.-H, Su, X.-D, Dong, Y.-H.
登録日2006-02-13
公開日2006-08-08
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of SMU.848 from Streptococcus mutans
To be Published
2HCU
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BU of 2hcu by Molmil
Crystal Structure Of Smu.1381 (or LeuD) from Streptococcus Mutans
分子名称: 3-isopropylmalate dehydratase small subunit, SULFATE ION
著者Gao, Z.Q, Hou, H.F, Li, L.F, Liang, Y.H, Su, X.D, Dong, Y.H.
登録日2006-06-19
公開日2006-07-04
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure Of Smu.1381 (or LeuD) from Streptococcus Mutans
To be Published
7MW8
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BU of 7mw8 by Molmil
Crystal Structure Analysis of Xac Nucleotide Pyrophosphatase/Phosphodiesterase
分子名称: Phosphodiesterase-nucleotide pyrophosphatase, ZINC ION, pApG
著者Fernandez, D, Li, L, Brown, J.A.
登録日2021-05-15
公開日2022-05-18
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling.
Proc.Natl.Acad.Sci.USA, 119, 2022
2G0J
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BU of 2g0j by Molmil
Crystal structure of SMU.848 from Streptococcus mutans
分子名称: hypothetical protein SMU.848
著者Hou, H.-F, Gao, Z.-Q, Li, L.-F, Liang, Y.-H, Su, X.-D, Dong, Y.-H.
登録日2006-02-13
公開日2006-08-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of SMU.848 from Streptococcus mutans
To be Published
6J3O
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BU of 6j3o by Molmil
Crystal structure of the human PCAF bromodomain in complex with compound 12
分子名称: 3-methyl-2-[[(3~{R})-1-methylpiperidin-3-yl]amino]-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one, Histone acetyltransferase KAT2B
著者Huang, L.Y, Li, H, Li, L.L, Niu, L, Seupel, R, Wu, C.Y, Li, G.B, Yu, Y.M, Brennan, P.E, Yang, S.Y.
登録日2019-01-05
公開日2019-05-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.
J.Med.Chem., 62, 2019
6CFF
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Stimulator of Interferon Genes Human
分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of interferon genes protein
著者Fernandez, D, Li, L, Ergun, S.L.
登録日2018-02-14
公開日2019-03-13
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.396 Å)
主引用文献STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
Cell, 178, 2019
3UQP
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BU of 3uqp by Molmil
Crystal structure of Bace1 with its inhibitor
分子名称: Beta-secretase 1, METHYL (2R)-1-[(6S,9S,12S,13S,17S,20S,23R)-9-(3-AMINO-3-OXOPROPYL)-12,23-DIBENZYL-13-HYDROXY-2,2,8,20,22-PENTAMETHYL-17-(2-METHYLPROPYL)-4,7,10,15,18,21,24-HEPTAOXO-6-(PROPAN-2-YL)-3-OXA-5,8,11,16,19,22-HEXAAZATETRACOSAN-24-YL]PYRROLIDINE-2-CARBOXYLATE, SULFATE ION
著者Chen, T.T, Chen, W.Y, Li, L, Xu, Y.C.
登録日2011-11-21
公開日2012-11-21
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases
J.Med.Chem., 55, 2012

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