7M2P

Structure of the SARS-CoV-2 3CL protease in complex with inhibitor 18

Summary for 7M2P

• Entry DOI: 10.2210/pdb7m2p/pdb
• Related PRD ID: PRD_002469
• Descriptor: 3C-like proteinase, Inhibitor 18 in bound form (3 entities in total)
• Functional Keywords: covid-19, sars-cov-2, 3cl protease, aldehyde inhibitor, viral protein-hydrolase inhibitor complex, viral protein/hydrolase inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2, COVID-19 virus); More
• Total number of polymer chains: 2
• Total formula weight: 34396.22

Authors

Yang, K.,Li, L. (deposition date: 2021-03-17, release date: 2021-08-25, Last modification date: 2023-11-15)

• Primary citation: Li, L.,Chenna, B.C.,Yang, K.S.,Cole, T.R.,Goodall, Z.T.,Giardini, M.,Moghadamchargari, Z.,Hernandez, E.A.,Gomez, J.,Calvet, C.M.,Bernatchez, J.A.,Mellott, D.M.,Zhu, J.,Rademacher, A.,Thomas, D.,Blankenship, L.R.,Drelich, A.,Laganowsky, A.,Tseng, C.K.,Liu, W.R.,Wand, A.J.,Cruz-Reyes, J.,Siqueira-Neto, J.L.,Meek, T.D.; Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.; J.Med.Chem., 64:11267-11287, 2021; PubMed: 34288674; DOI: 10.1021/acs.jmedchem.1c00628

Experimental method

X-RAY DIFFRACTION (1.7 Å)