7M2P
Structure of the SARS-CoV-2 3CL protease in complex with inhibitor 18
Summary for 7M2P
Entry DOI | 10.2210/pdb7m2p/pdb |
Related PRD ID | PRD_002469 |
Descriptor | 3C-like proteinase, Inhibitor 18 in bound form (3 entities in total) |
Functional Keywords | covid-19, sars-cov-2, 3cl protease, aldehyde inhibitor, viral protein-hydrolase inhibitor complex, viral protein/hydrolase inhibitor |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2, COVID-19 virus) More |
Total number of polymer chains | 2 |
Total formula weight | 34396.22 |
Authors | |
Primary citation | Li, L.,Chenna, B.C.,Yang, K.S.,Cole, T.R.,Goodall, Z.T.,Giardini, M.,Moghadamchargari, Z.,Hernandez, E.A.,Gomez, J.,Calvet, C.M.,Bernatchez, J.A.,Mellott, D.M.,Zhu, J.,Rademacher, A.,Thomas, D.,Blankenship, L.R.,Drelich, A.,Laganowsky, A.,Tseng, C.K.,Liu, W.R.,Wand, A.J.,Cruz-Reyes, J.,Siqueira-Neto, J.L.,Meek, T.D. Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases. J.Med.Chem., 64:11267-11287, 2021 Cited by PubMed: 34288674DOI: 10.1021/acs.jmedchem.1c00628 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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