3E2Y
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![BU of 3e2y by Molmil](/molmil-images/mine/3e2y) | Crystal structure of mouse kynurenine aminotransferase III in complex with glutamine | Descriptor: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLUTAMINE, GLYCEROL, ... | Authors: | Han, Q, Robinson, R, Cai, T, Tagle, D.A, Li, J. | Deposit date: | 2008-08-06 | Release date: | 2008-12-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III". Mol. Cell. Biol., 38, 2018
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3E2Z
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![BU of 3e2z by Molmil](/molmil-images/mine/3e2z) | Crystal structure of mouse kynurenine aminotransferase III in complex with kynurenine | Descriptor: | (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLYCEROL, ... | Authors: | Han, Q, Robinson, R, Cai, T, Tagle, D.A, Li, J. | Deposit date: | 2008-08-06 | Release date: | 2008-12-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III". Mol. Cell. Biol., 38, 2018
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8HVU
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![BU of 8hvu by Molmil](/molmil-images/mine/8hvu) | Crystal structure of SARS-Cov-2 main protease G15S mutant in complex with PF07304814 | Descriptor: | 3C-like proteinase nsp5, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate | Authors: | Zeng, P, Zhang, J, Li, J. | Deposit date: | 2022-12-28 | Release date: | 2024-01-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Crystal structures of main protease (M pro ) mutants of SARS-CoV-2 variants bound to PF-07304814. Mol Biomed, 4, 2023
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8HVV
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![BU of 8hvv by Molmil](/molmil-images/mine/8hvv) | Crystal structure of SARS-Cov-2 main protease S46F mutant in complex with PF07304814 | Descriptor: | 3C-like proteinase nsp5, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate | Authors: | Zeng, X.Y, Zhang, J, Li, J. | Deposit date: | 2022-12-28 | Release date: | 2024-01-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structures of main protease (M pro ) mutants of SARS-CoV-2 variants bound to PF-07304814. Mol Biomed, 4, 2023
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8HVX
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![BU of 8hvx by Molmil](/molmil-images/mine/8hvx) | Crystal structure of SARS-Cov-2 main protease Y54C mutant in complex with PF07304814 | Descriptor: | 3C-like proteinase nsp5, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate | Authors: | Zhou, X.L, Zhang, J, Li, J. | Deposit date: | 2022-12-28 | Release date: | 2024-01-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structures of main protease (M pro ) mutants of SARS-CoV-2 variants bound to PF-07304814. Mol Biomed, 4, 2023
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8HVZ
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![BU of 8hvz by Molmil](/molmil-images/mine/8hvz) | Crystal structure of SARS-Cov-2 main protease V186F mutant in complex with PF07304814 | Descriptor: | 3C-like proteinase nsp5, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate | Authors: | Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2022-12-28 | Release date: | 2024-01-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of main protease (M pro ) mutants of SARS-CoV-2 variants bound to PF-07304814. Mol Biomed, 4, 2023
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8HVW
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![BU of 8hvw by Molmil](/molmil-images/mine/8hvw) | Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with PF07304814 | Descriptor: | 3C-like proteinase nsp5, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate | Authors: | Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2022-12-28 | Release date: | 2024-01-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structures of main protease (M pro ) mutants of SARS-CoV-2 variants bound to PF-07304814. Mol Biomed, 4, 2023
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3E2F
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![BU of 3e2f by Molmil](/molmil-images/mine/3e2f) | Crystal structure of mouse kynurenine aminotransferase III, PLP-bound form | Descriptor: | GLYCEROL, Kynurenine-oxoglutarate transaminase 3 | Authors: | Han, Q, Robinson, R, Cai, T, Tagle, D.A, Li, J. | Deposit date: | 2008-08-05 | Release date: | 2008-12-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III". Mol. Cell. Biol., 38, 2018
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2K2G
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![BU of 2k2g by Molmil](/molmil-images/mine/2k2g) | Solution structure of the wild-type catalytic domain of human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor | Descriptor: | Macrophage metalloelastase, N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine, ZINC ION | Authors: | Markus, M.A, Dwyer, B, Wolfrom, S, Li, J, Li, W, Malakian, K, Wilhelm, J, Tsao, D.H.H. | Deposit date: | 2008-04-01 | Release date: | 2008-05-20 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of wild-type human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor. J.Biomol.Nmr, 41, 2008
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8HQH
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![BU of 8hqh by Molmil](/molmil-images/mine/8hqh) | |
8HQJ
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![BU of 8hqj by Molmil](/molmil-images/mine/8hqj) | |
7VLN
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![BU of 7vln by Molmil](/molmil-images/mine/7vln) | NSD2-PWWP1 domain bound with an imidazol-5-yl benzonitrile compound | Descriptor: | 4-[5-[4-(aminomethyl)-2,6-dimethoxy-phenyl]-3-methyl-imidazol-4-yl]benzenecarbonitrile, Histone-lysine N-methyltransferase NSD2 | Authors: | Cao, D.Y, Li, Y.L, Li, J, Xiong, B. | Deposit date: | 2021-10-05 | Release date: | 2022-07-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.09 Å) | Cite: | Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors. J.Med.Chem., 65, 2022
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8HQF
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![BU of 8hqf by Molmil](/molmil-images/mine/8hqf) | |
8HVL
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![BU of 8hvl by Molmil](/molmil-images/mine/8hvl) | Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with PF07321332 | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | Authors: | Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2022-12-27 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
M49I mutant in complex with PF07321332 To Be Published
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8HVO
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![BU of 8hvo by Molmil](/molmil-images/mine/8hvo) | Crystal structure of SARS-Cov-2 main protease V186F mutant in complex with PF07321332 | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | Authors: | Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2022-12-27 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
V186F mutant in complex with PF07321332 To Be Published
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7WBJ
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![BU of 7wbj by Molmil](/molmil-images/mine/7wbj) | Cryo-EM structure of N-terminal modified human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Xu, Y.N, Feng, W.B, Zhou, Q.T, Liang, A.Y, Li, J, Dai, A.T, Zhao, F.H, Yan, J.H, Chen, C.W, Li, H, Zhao, L.H, Xia, T, Jiang, Y, Xu, H.E, Yang, D.H, Wang, M.W. | Deposit date: | 2021-12-16 | Release date: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2. Nat Commun, 13, 2022
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8HVK
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![BU of 8hvk by Molmil](/molmil-images/mine/8hvk) | Crystal structure of SARS-Cov-2 main protease G15S mutant in complex with PF07321332 | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | Authors: | Zeng, P, Zhang, J, Li, J. | Deposit date: | 2022-12-27 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
G15S mutant in complex with PF07321332 To Be Published
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7WGW
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![BU of 7wgw by Molmil](/molmil-images/mine/7wgw) | NMR Solution Structure of a cGMP Fill-in Vacancy G-quadruplex Formed in the Oxidized BLM Gene Promoter | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, DNA (20-MER) | Authors: | Wang, K.B, Liu, Y, Li, Y, Li, J, Dickerhoff, J, Yang, M.H, Yang, D, Kong, L.Y. | Deposit date: | 2021-12-29 | Release date: | 2022-05-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Oxidative Damage Induces a Vacancy G-Quadruplex That Binds Guanine Metabolites: Solution Structure of a cGMP Fill-in Vacancy G-Quadruplex in the Oxidized BLM Gene Promoter. J.Am.Chem.Soc., 144, 2022
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1X7Z
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![BU of 1x7z by Molmil](/molmil-images/mine/1x7z) | Crystal structure of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase | Descriptor: | 2-oxoisovalerate dehydrogenase alpha subunit, 2-oxoisovalerate dehydrogenase beta subunit, CHLORIDE ION, ... | Authors: | Wynn, R.M, Kato, M, Machius, M, Chuang, J.L, Li, J, Tomchick, D.R, Chuang, D.T. | Deposit date: | 2004-08-16 | Release date: | 2004-11-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation Structure, 12, 2004
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1X7Y
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![BU of 1x7y by Molmil](/molmil-images/mine/1x7y) | Crystal structure of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase | Descriptor: | 2-oxoisovalerate dehydrogenase alpha subunit, 2-oxoisovalerate dehydrogenase beta subunit, CHLORIDE ION, ... | Authors: | Wynn, R.M, Kato, M, Machius, M, Chuang, J.L, Li, J, Tomchick, D.R, Chuang, D.T. | Deposit date: | 2004-08-16 | Release date: | 2004-11-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation Structure, 12, 2004
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1X80
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![BU of 1x80 by Molmil](/molmil-images/mine/1x80) | Crystal structure of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase | Descriptor: | 2-oxoisovalerate dehydrogenase alpha subunit, 2-oxoisovalerate dehydrogenase beta subunit, CHLORIDE ION, ... | Authors: | Wynn, R.M, Kato, M, Machius, M, Chuang, J.L, Li, J, Tomchick, D.R, Chuang, D.T. | Deposit date: | 2004-08-16 | Release date: | 2004-11-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation Structure, 12, 2004
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8J37
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![BU of 8j37 by Molmil](/molmil-images/mine/8j37) | Crystal structure of SARS-Cov-2 main protease K90R mutant in complex with PF00835231 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Zhou, X.L, Lin, C, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2023-04-16 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
K90R mutant in complex with PF00835231 To Be Published
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8J35
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![BU of 8j35 by Molmil](/molmil-images/mine/8j35) | Crystal structure of SARS-Cov-2 main protease G15S mutant in complex with PF00835231 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Zhou, X.L, Lin, C, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2023-04-16 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
G15S mutant in complex with PF00835231 To Be Published
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8J3A
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![BU of 8j3a by Molmil](/molmil-images/mine/8j3a) | Crystal structure of SARS-Cov-2 main protease Y54C mutant in complex with PF00835231 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Zhou, X.L, Lin, C, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2023-04-16 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease
Y54C mutant in complex with PF00835231 To Be Published
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8J32
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![BU of 8j32 by Molmil](/molmil-images/mine/8j32) | Crystal structure of SARS-Cov-2 main protease in complex with PF00835231 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Zhou, X.L, Lin, C, Zou, X.F, Zhang, J, Li, J. | Deposit date: | 2023-04-16 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Crystal structure of SARS-Cov-2 main protease in complex with PF00835231 To Be Published
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