4K7R
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![BU of 4k7r by Molmil](/molmil-images/mine/4k7r) | Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation | 分子名称: | (2S)-1-(pentanoyloxy)propan-2-yl hexanoate, Cation efflux system protein CusC | 著者 | Su, C.-C, Lei, H.-T, Bolla, J.R, Yu, E.W. | 登録日 | 2013-04-17 | 公開日 | 2013-10-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.094 Å) | 主引用文献 | Crystal Structures of CusC Review Conformational Changes Accompanying Folding and Transmembrane Channel Formation. J.Mol.Biol., 426, 2014
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4K7K
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5TY3
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![BU of 5ty3 by Molmil](/molmil-images/mine/5ty3) | Crystal structure of K72A variant of Human Cytochrome c | 分子名称: | Cytochrome c, HEME C, SULFATE ION | 著者 | Mou, T.C, Nold, S.M, Lei, H, Sprang, S.R, Bowler, B.E. | 登録日 | 2016-11-18 | 公開日 | 2017-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Effect of a K72A Mutation on the Structure, Stability, Dynamics, and Peroxidase Activity of Human Cytochrome c. Biochemistry, 56, 2017
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8ENU
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![BU of 8enu by Molmil](/molmil-images/mine/8enu) | Structure of the C3bB proconvertase in complex with lufaxin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | 著者 | Andersen, J.F, Lei, H. | 登録日 | 2022-09-30 | 公開日 | 2023-08-09 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
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8EOK
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8D2V
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![BU of 8d2v by Molmil](/molmil-images/mine/8d2v) | Zebrafish MFSD2A isoform B in inward open ligand 1B conformation | 分子名称: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | 著者 | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | 登録日 | 2022-05-30 | 公開日 | 2023-05-10 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Lipid flipping in the omega-3 fatty-acid transporter. Nat Commun, 14, 2023
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8D2U
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![BU of 8d2u by Molmil](/molmil-images/mine/8d2u) | Zebrafish MFSD2A isoform B in inward open ligand 1A conformation | 分子名称: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | 著者 | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | 登録日 | 2022-05-30 | 公開日 | 2023-05-10 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Lipid flipping in the omega-3 fatty-acid transporter. Nat Commun, 14, 2023
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8D2S
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![BU of 8d2s by Molmil](/molmil-images/mine/8d2s) | Zebrafish MFSD2A isoform B in inward open ligand bound conformation | 分子名称: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | 著者 | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | 登録日 | 2022-05-30 | 公開日 | 2023-05-10 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Lipid flipping in the omega-3 fatty-acid transporter. Nat Commun, 14, 2023
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8D2W
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![BU of 8d2w by Molmil](/molmil-images/mine/8d2w) | Zebrafish MFSD2A isoform B in inward open ligand 2B conformation | 分子名称: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | 著者 | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | 登録日 | 2022-05-30 | 公開日 | 2023-05-10 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Lipid flipping in the omega-3 fatty-acid transporter. Nat Commun, 14, 2023
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8D2T
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![BU of 8d2t by Molmil](/molmil-images/mine/8d2t) | Zebrafish MFSD2A isoform B in inward open ligand-free conformation | 分子名称: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | 著者 | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | 登録日 | 2022-05-30 | 公開日 | 2023-05-10 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Lipid flipping in the omega-3 fatty-acid transporter. Nat Commun, 14, 2023
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8D2X
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![BU of 8d2x by Molmil](/molmil-images/mine/8d2x) | Zebrafish MFSD2A isoform B in inward open ligand 3C conformation | 分子名称: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | 著者 | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | 登録日 | 2022-05-30 | 公開日 | 2023-05-10 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Lipid flipping in the omega-3 fatty-acid transporter. Nat Commun, 14, 2023
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7F2S
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![BU of 7f2s by Molmil](/molmil-images/mine/7f2s) | Crystal structure of anti S-gatifloxacin antibody Fab fragment apo form | 分子名称: | 1,2-ETHANEDIOL, Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, ... | 著者 | Wang, L.T, Jiao, W.Y, Shen, X, Lei, H.T. | 登録日 | 2021-06-14 | 公開日 | 2021-12-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Conformational adaptability determining antibody recognition to distomer: structure analysis of enantioselective antibody against chiral drug gatifloxacin Rsc Adv, 11, 2021
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7F35
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![BU of 7f35 by Molmil](/molmil-images/mine/7f35) | Crystal structure of anti S-gatifloxacin antibody Fab fragment in complex with S-gatifloxacin | 分子名称: | 1,2-ETHANEDIOL, 1-cyclopropyl-6-fluoro-8-methoxy-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Antibody Fab fragment heavy chain, ... | 著者 | Wang, L.T, Jiao, W.Y, Shen, X, Lei, H.T. | 登録日 | 2021-06-15 | 公開日 | 2021-12-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Conformational adaptability determining antibody recognition to distomer: structure analysis of enantioselective antibody against chiral drug gatifloxacin Rsc Adv, 11, 2021
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3ETA
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![BU of 3eta by Molmil](/molmil-images/mine/3eta) | Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor | 分子名称: | 1-(3-{5-[4-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea, insulin receptor, kinase domain | 著者 | Patnaik, S, Stevens, K, Gerding, R, Deanda, F, Shotwell, B, Tang, J, Hamajima, T, Nakamura, H, Leesnitzer, A, Hassell, A, Shewchuk, L, Kumar, R, Lei, H, Chamberlain, S. | 登録日 | 2008-10-07 | 公開日 | 2009-05-26 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase. Bioorg.Med.Chem.Lett., 19, 2009
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3H98
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![BU of 3h98 by Molmil](/molmil-images/mine/3h98) | Crystal structure of HCV NS5b 1b with (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyrimidine derivative | 分子名称: | GLYCEROL, N-{3-[5-hydroxy-8-(3-methylbutyl)-7-oxo-7,8-dihydroimidazo[1,2-a]pyrimidin-6-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase | 著者 | Wang, G, Lei, H, Wang, X, Das, D, Mackinnon, C, Montalbetti, C.A.G, Mears, R, Gai, X, Bailey, S, Ruhrmund, D, Hooi, L, Misialek, S, Rajagopalan, R, Cheng, R.K.Y, Barker, J.L, Felicetti, B, Stoycheva, A, Buckman, B, Kossen, K, Seiwert, S, Beigelmana, L. | 登録日 | 2009-04-30 | 公開日 | 2009-10-13 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives. Bioorg.Med.Chem.Lett., 19, 2009
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3EKK
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![BU of 3ekk by Molmil](/molmil-images/mine/3ekk) | Insulin receptor kinase complexed with an inhibitor | 分子名称: | 2-[(2-{[1-(N,N-dimethylglycyl)-5-methoxy-1H-indol-6-yl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluoro-N-methylbenzamide, Insulin receptor | 著者 | Chamberlain, S, Atkins, C, Deanda, F, Dumble, M, Gerding, R, Groy, A, Korenchuk, S, Kumar, R, Lei, H, Mook, R, Moorthy, G, Redman, A, Rowland, J, Sabbatini, P, Shewchuk, L. | 登録日 | 2008-09-19 | 公開日 | 2008-12-23 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase. Bioorg.Med.Chem.Lett., 19, 2009
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3ELJ
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![BU of 3elj by Molmil](/molmil-images/mine/3elj) | Jnk1 complexed with a bis-anilino-pyrrolopyrimidine inhibitor. | 分子名称: | 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide, Mitogen-activated protein kinase 8 | 著者 | Chamberlain, S, Atkins, C, Deanda, F, Dumble, M, Gerding, R, Groy, A, Korenchuk, S, Kumar, R, Lei, H, Mook, R, Moorthy, G, Redman, A, Rowland, J, Shewchuk, L, Vicentini, G, Mosley, J. | 登録日 | 2008-09-22 | 公開日 | 2008-12-30 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity. Bioorg.Med.Chem.Lett., 19, 2009
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3EKN
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![BU of 3ekn by Molmil](/molmil-images/mine/3ekn) | Insulin receptor kinase complexed with an inhibitor | 分子名称: | 2-fluoro-6-{[2-({2-methoxy-4-[4-(1-methylethyl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide, Insulin receptor | 著者 | Chamberlain, S, Atkins, C, Deanda, F, Dumble, M, Gerding, R, Groy, A, Korenchuk, S, Kumar, R, Lei, H, Mook, R, Moorthy, G, Redman, A, Rowland, J, Shewchuk, L. | 登録日 | 2008-09-19 | 公開日 | 2008-12-30 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity. Bioorg.Med.Chem.Lett., 19, 2009
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5ACX
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![BU of 5acx by Molmil](/molmil-images/mine/5acx) | VIM-2-2, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR based fragment screening | 分子名称: | 2-(4-fluorophenyl)carbonylbenzoic acid, BETA-LACTAMASE, CHLORIDE ION, ... | 著者 | Christopeit, T, Carlsen, T.J.O, Helland, R, Leiros, H.K.S. | 登録日 | 2015-08-18 | 公開日 | 2015-11-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 by Spr Based Fragment Screening J.Med.Chem., 58, 2015
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5ACS
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![BU of 5acs by Molmil](/molmil-images/mine/5acs) | Y233A-Investigation of the impact from residues W228 and Y233 in the metallo-beta-lactamase GIM-1 | 分子名称: | GIM-1 PROTEIN, ZINC ION | 著者 | Skagseth, S, Carlsen, T.J, Bjerga, G.E.K, Spencer, J, Samuelsen, O, Leiros, H.-K.S. | 登録日 | 2015-08-17 | 公開日 | 2015-12-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.459 Å) | 主引用文献 | Role of Residues W228 and Y233 in the Structure and Activity of Metallo-Beta-Lactamase Gim-1. Antimicrob.Agents Chemother., 60, 2015
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5ACW
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![BU of 5acw by Molmil](/molmil-images/mine/5acw) | VIM-2-1, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR based fragment screening | 分子名称: | 4-methyl-5-(trifluoromethyl)-1,2,4-triazole-3-thiol, BETA-LACTAMASE, CHLORIDE ION, ... | 著者 | Christopeit, T, Carlsen, T.J.O, Helland, R, Leiros, H.K.S. | 登録日 | 2015-08-18 | 公開日 | 2015-11-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 by Spr Based Fragment Screening J.Med.Chem., 58, 2015
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5ACQ
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![BU of 5acq by Molmil](/molmil-images/mine/5acq) | W228A-Investigation of the impact from residues W228 and Y233 in the metallo-beta-lactamase GIM-1 | 分子名称: | BETA-LACTAMASE, ZINC ION | 著者 | Skagseth, S, Carlsen, T.J, Bjerga, G.E.K, Spencer, J, Samuelsen, O, Leiros, H.-K.S. | 登録日 | 2015-08-17 | 公開日 | 2015-12-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Role of Residues W228 and Y233 in the Structure and Activity of Metallo-Beta-Lactamase Gim-1. Antimicrob.Agents Chemother., 60, 2015
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5ACT
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![BU of 5act by Molmil](/molmil-images/mine/5act) | W228S-Investigation of the impact from residues W228 and Y233 in the metallo-beta-lactamase GIM-1 | 分子名称: | GIM-1 PROTEIN, ZINC ION | 著者 | Skagseth, S, Carlsen, T.J, Bjerga, G.E.K, Spencer, J, Samuelsen, O, Leiros, H.-K.S. | 登録日 | 2015-08-17 | 公開日 | 2015-12-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Role of Residues W228 and Y233 in the Structure and Activity of Metallo-Beta-Lactamase Gim-1. Antimicrob.Agents Chemother., 60, 2015
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4V2I
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![BU of 4v2i by Molmil](/molmil-images/mine/4v2i) | Biochemical characterization and structural analysis of a new cold- active and salt tolerant esterase from the marine bacterium Thalassospira sp | 分子名称: | ESTERASE/LIPASE, MAGNESIUM ION | 著者 | Santi, C.D, Leiros, H.-K.S, Scala, A.D, Pascale, D.D, Altermark, B, Willassen, N.-P. | 登録日 | 2014-10-10 | 公開日 | 2016-01-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.686 Å) | 主引用文献 | Biochemical Characterization and Structural Analysis of a New Cold-Active and Salt-Tolerant Esterase from the Marine Bacterium Thalassospira Sp. Extremophiles, 20, 2016
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4V14
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