8FCA
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![BU of 8fca by Molmil](/molmil-images/mine/8fca) | Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate | Descriptor: | (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily V member 4 | Authors: | Kwon, D.H, Lee, S.-Y, Zhang, F. | Deposit date: | 2022-12-01 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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6BPQ
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![BU of 6bpq by Molmil](/molmil-images/mine/6bpq) | Structure of the cold- and menthol-sensing ion channel TRPM8 | Descriptor: | Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Wu, M, Zubcevic, L, Borschel, W.F, Lander, G.C, Lee, S.-Y. | Deposit date: | 2017-11-25 | Release date: | 2017-12-13 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structure of the cold- and menthol-sensing ion channel TRPM8. Science, 359, 2018
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5L2B
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![BU of 5l2b by Molmil](/molmil-images/mine/5l2b) | Structure of CNTnw N149S, E332A in an outward-facing state | Descriptor: | 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease | Authors: | Hirschi, M, Johnson, Z.L, Lee, S.-Y. | Deposit date: | 2016-07-31 | Release date: | 2017-04-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Visualizing multistep elevator-like transitions of a nucleoside transporter. Nature, 545, 2017
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5L26
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![BU of 5l26 by Molmil](/molmil-images/mine/5l26) | Structure of CNTnw in an inward-facing substrate-bound state | Descriptor: | 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease, SODIUM ION, ... | Authors: | Hirschi, M, Johnson, Z.L, Lee, S.-Y. | Deposit date: | 2016-07-31 | Release date: | 2017-04-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Visualizing multistep elevator-like transitions of a nucleoside transporter. Nature, 545, 2017
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5L24
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![BU of 5l24 by Molmil](/molmil-images/mine/5l24) | Structure of CNTnw N149L in the intermediate 2 state | Descriptor: | 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease | Authors: | Hirschi, M, Johnson, Z.L, Lee, S.-Y. | Deposit date: | 2016-07-31 | Release date: | 2017-04-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Visualizing multistep elevator-like transitions of a nucleoside transporter. Nature, 545, 2017
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6NC7
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![BU of 6nc7 by Molmil](/molmil-images/mine/6nc7) | Lipid II flippase MurJ, inward open conformation | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lipid II flippase MurJ, SULFATE ION | Authors: | Kuk, A.C.Y, Lee, S.-Y. | Deposit date: | 2018-12-11 | Release date: | 2019-04-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Visualizing conformation transitions of the Lipid II flippase MurJ. Nat Commun, 10, 2019
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6NC6
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![BU of 6nc6 by Molmil](/molmil-images/mine/6nc6) | Lipid II flippase MurJ, inward closed conformation | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, Lipid II flippase MurJ, ... | Authors: | Kuk, A.C.Y, Lee, S.-Y. | Deposit date: | 2018-12-10 | Release date: | 2019-04-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Visualizing conformation transitions of the Lipid II flippase MurJ. Nat Commun, 10, 2019
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6NR3
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![BU of 6nr3 by Molmil](/molmil-images/mine/6nr3) | Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium | Descriptor: | (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, CALCIUM ION, Icilin, ... | Authors: | Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y. | Deposit date: | 2019-01-22 | Release date: | 2019-02-20 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science, 363, 2019
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6NC8
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![BU of 6nc8 by Molmil](/molmil-images/mine/6nc8) | Lipid II flippase MurJ, inward occluded conformation | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lipid II flippase MurJ, PENTAETHYLENE GLYCOL, ... | Authors: | Kuk, A.C.Y, Lee, S.-Y. | Deposit date: | 2018-12-11 | Release date: | 2019-04-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | Visualizing conformation transitions of the Lipid II flippase MurJ. Nat Commun, 10, 2019
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6NC9
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![BU of 6nc9 by Molmil](/molmil-images/mine/6nc9) | Lipid II flippase MurJ, outward-facing conformation | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lipid II flippase MurJ, ... | Authors: | Kuk, A.C.Y, Lee, S.-Y. | Deposit date: | 2018-12-11 | Release date: | 2019-04-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Visualizing conformation transitions of the Lipid II flippase MurJ. Nat Commun, 10, 2019
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6NR4
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![BU of 6nr4 by Molmil](/molmil-images/mine/6nr4) | Cryo-EM structure of the TRPM8 ion channel with low occupancy icilin, PI(4,5)P2, and calcium | Descriptor: | Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y. | Deposit date: | 2019-01-22 | Release date: | 2019-02-20 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science, 363, 2019
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6NR2
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![BU of 6nr2 by Molmil](/molmil-images/mine/6nr2) | Cryo-EM structure of the TRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2 | Descriptor: | (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y. | Deposit date: | 2019-01-22 | Release date: | 2019-02-20 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science, 363, 2019
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7LPE
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![BU of 7lpe by Molmil](/molmil-images/mine/7lpe) | Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an open state, class 1 | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPA
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![BU of 7lpa by Molmil](/molmil-images/mine/7lpa) | Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPB
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![BU of 7lpb by Molmil](/molmil-images/mine/7lpb) | Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees Celsius | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LP9
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![BU of 7lp9 by Molmil](/molmil-images/mine/7lp9) | Cryo-EM structure of full-length TRPV1 at 4 degrees Celsius | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPD
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![BU of 7lpd by Molmil](/molmil-images/mine/7lpd) | Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an intermediate state, class 2 | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.55 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPC
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![BU of 7lpc by Molmil](/molmil-images/mine/7lpc) | Cryo-EM structure of full-length TRPV1 at 48 degrees Celsius | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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