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PDB: 93 results

8FCA
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BU of 8fca by Molmil
Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate
Descriptor: (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily V member 4
Authors:Kwon, D.H, Lee, S.-Y, Zhang, F.
Deposit date:2022-12-01
Release date:2023-07-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nat Commun, 14, 2023
6BPQ
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BU of 6bpq by Molmil
Structure of the cold- and menthol-sensing ion channel TRPM8
Descriptor: Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y, Wu, M, Zubcevic, L, Borschel, W.F, Lander, G.C, Lee, S.-Y.
Deposit date:2017-11-25
Release date:2017-12-13
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure of the cold- and menthol-sensing ion channel TRPM8.
Science, 359, 2018
5L2B
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BU of 5l2b by Molmil
Structure of CNTnw N149S, E332A in an outward-facing state
Descriptor: 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease
Authors:Hirschi, M, Johnson, Z.L, Lee, S.-Y.
Deposit date:2016-07-31
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Visualizing multistep elevator-like transitions of a nucleoside transporter.
Nature, 545, 2017
5L26
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BU of 5l26 by Molmil
Structure of CNTnw in an inward-facing substrate-bound state
Descriptor: 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease, SODIUM ION, ...
Authors:Hirschi, M, Johnson, Z.L, Lee, S.-Y.
Deposit date:2016-07-31
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Visualizing multistep elevator-like transitions of a nucleoside transporter.
Nature, 545, 2017
5L24
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BU of 5l24 by Molmil
Structure of CNTnw N149L in the intermediate 2 state
Descriptor: 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease
Authors:Hirschi, M, Johnson, Z.L, Lee, S.-Y.
Deposit date:2016-07-31
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Visualizing multistep elevator-like transitions of a nucleoside transporter.
Nature, 545, 2017
6NC7
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BU of 6nc7 by Molmil
Lipid II flippase MurJ, inward open conformation
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lipid II flippase MurJ, SULFATE ION
Authors:Kuk, A.C.Y, Lee, S.-Y.
Deposit date:2018-12-11
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Visualizing conformation transitions of the Lipid II flippase MurJ.
Nat Commun, 10, 2019
6NC6
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BU of 6nc6 by Molmil
Lipid II flippase MurJ, inward closed conformation
Descriptor: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, Lipid II flippase MurJ, ...
Authors:Kuk, A.C.Y, Lee, S.-Y.
Deposit date:2018-12-10
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Visualizing conformation transitions of the Lipid II flippase MurJ.
Nat Commun, 10, 2019
6NR3
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BU of 6nr3 by Molmil
Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium
Descriptor: (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, CALCIUM ION, Icilin, ...
Authors:Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y.
Deposit date:2019-01-22
Release date:2019-02-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
Science, 363, 2019
6NC8
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BU of 6nc8 by Molmil
Lipid II flippase MurJ, inward occluded conformation
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lipid II flippase MurJ, PENTAETHYLENE GLYCOL, ...
Authors:Kuk, A.C.Y, Lee, S.-Y.
Deposit date:2018-12-11
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Visualizing conformation transitions of the Lipid II flippase MurJ.
Nat Commun, 10, 2019
6NC9
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BU of 6nc9 by Molmil
Lipid II flippase MurJ, outward-facing conformation
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lipid II flippase MurJ, ...
Authors:Kuk, A.C.Y, Lee, S.-Y.
Deposit date:2018-12-11
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Visualizing conformation transitions of the Lipid II flippase MurJ.
Nat Commun, 10, 2019
6NR4
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BU of 6nr4 by Molmil
Cryo-EM structure of the TRPM8 ion channel with low occupancy icilin, PI(4,5)P2, and calcium
Descriptor: Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y.
Deposit date:2019-01-22
Release date:2019-02-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
Science, 363, 2019
6NR2
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BU of 6nr2 by Molmil
Cryo-EM structure of the TRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2
Descriptor: (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y.
Deposit date:2019-01-22
Release date:2019-02-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
Science, 363, 2019
7LPE
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BU of 7lpe by Molmil
Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an open state, class 1
Descriptor: (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ...
Authors:Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y.
Deposit date:2021-02-11
Release date:2021-07-28
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
7LPA
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BU of 7lpa by Molmil
Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius
Descriptor: (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ...
Authors:Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y.
Deposit date:2021-02-11
Release date:2021-07-28
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
7LPB
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BU of 7lpb by Molmil
Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees Celsius
Descriptor: (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ...
Authors:Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y.
Deposit date:2021-02-11
Release date:2021-07-28
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
7LP9
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BU of 7lp9 by Molmil
Cryo-EM structure of full-length TRPV1 at 4 degrees Celsius
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ...
Authors:Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y.
Deposit date:2021-02-11
Release date:2021-07-28
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.63 Å)
Cite:Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
7LPD
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BU of 7lpd by Molmil
Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an intermediate state, class 2
Descriptor: (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ...
Authors:Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y.
Deposit date:2021-02-11
Release date:2021-07-28
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
7LPC
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BU of 7lpc by Molmil
Cryo-EM structure of full-length TRPV1 at 48 degrees Celsius
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ...
Authors:Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y.
Deposit date:2021-02-11
Release date:2021-07-28
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
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