1N4M
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![BU of 1n4m by Molmil](/molmil-images/mine/1n4m) | Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2 | Descriptor: | Retinoblastoma Pocket, Transcription factor E2F2 | Authors: | Lee, C, Chang, J.H, Lee, H.S, Cho, Y. | Deposit date: | 2002-10-31 | Release date: | 2003-01-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor GENES DEV., 16, 2002
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1W42
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![BU of 1w42 by Molmil](/molmil-images/mine/1w42) | T. celer L30e R92A variant | Descriptor: | 50S RIBOSOMAL PROTEIN L30E | Authors: | Lee, C.F, Lee, K.M, Chan, S.H, Allen, M.D, Bycroft, M, Wong, K.B. | Deposit date: | 2004-07-22 | Release date: | 2005-04-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Electrostatic Interactions Contribute to Reduced Heat Capacity Change of Unfolding in a Thermophilic Ribosomal Protein L30E J.Mol.Biol., 348, 2005
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1W40
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![BU of 1w40 by Molmil](/molmil-images/mine/1w40) | T. celer L30e K9A variant | Descriptor: | 50S RIBOSOMAL PROTEIN L30E | Authors: | Lee, C.F, Lee, K.M, Chan, S.H, Allen, M.D, Bycroft, M, Wong, K.B. | Deposit date: | 2004-07-22 | Release date: | 2005-04-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Electrostatic Interactions Contribute to Reduced Heat Capacity Change of Unfolding in a Thermophilic Ribosomal Protein L30E J.Mol.Biol., 348, 2005
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1W41
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![BU of 1w41 by Molmil](/molmil-images/mine/1w41) | T. celer L30e E90A variant | Descriptor: | 50S RIBOSOMAL PROTEIN L30E | Authors: | Lee, C.F, Lee, K.M, Chan, S.H, Allen, M.D, Bycroft, M, Wong, K.B. | Deposit date: | 2004-07-22 | Release date: | 2005-04-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Electrostatic Interactions Contribute to Reduced Heat Capacity Change of Unfolding in a Thermophilic Ribosomal Protein L30E J.Mol.Biol., 348, 2005
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8IDU
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![BU of 8idu by Molmil](/molmil-images/mine/8idu) | Crystal structure of substrate bound-form dehydroquinate dehydratase from Corynebacterium glutamicum | Descriptor: | 1,3,4-TRIHYDROXY-5-OXO-CYCLOHEXANECARBOXYLIC ACID, 3-dehydroquinate dehydratase, GLYCEROL, ... | Authors: | Lee, C.H, Kim, S, Kim, K.-J. | Deposit date: | 2023-02-14 | Release date: | 2023-12-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and Biochemical Analysis of 3-Dehydroquinate Dehydratase from Corynebacterium glutamicum . J Microbiol Biotechnol., 33, 2023
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8IDR
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![BU of 8idr by Molmil](/molmil-images/mine/8idr) | |
3MKR
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![BU of 3mkr by Molmil](/molmil-images/mine/3mkr) | |
7RUN
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![BU of 7run by Molmil](/molmil-images/mine/7run) | Crystal structure of phosphorylated RET tyrosine kinase domain complexed with a pyrrolo[2,3-d]pyrimidine inhibitor. | Descriptor: | 1-(4-{(1s,3s)-3-[4-amino-5-(3-amino-4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl}piperazin-1-yl)ethan-1-one, CHLORIDE ION, Proto-oncogene tyrosine-protein kinase receptor Ret | Authors: | Lee, C.C, Spraggon, G. | Deposit date: | 2021-08-17 | Release date: | 2022-01-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.51 Å) | Cite: | Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3- d ]pyrimidine RET Inhibitors. Acs Med.Chem.Lett., 12, 2021
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7DOH
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5HXP
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![BU of 5hxp by Molmil](/molmil-images/mine/5hxp) | Crystal Structure of Z,Z-Farnesyl Diphosphate Synthase (D71M, E75A and H103Y Mutants) Complexed with IPP | Descriptor: | (2Z,6Z)-farnesyl diphosphate synthase, chloroplastic, 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, ... | Authors: | Lee, C.C, Chan, Y.T, Wang, A.H.J. | Deposit date: | 2016-01-31 | Release date: | 2017-04-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure and Potential Head-to-Middle Condensation Function of aZ,Z-Farnesyl Diphosphate Synthase. Acs Omega, 2, 2017
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5HXQ
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![BU of 5hxq by Molmil](/molmil-images/mine/5hxq) | Crystal Structure of Z,Z-Farnesyl Diphosphate Synthase (D71M, E75A and H103Y Mutants) Complexed with DMSPP | Descriptor: | (2Z,6Z)-farnesyl diphosphate synthase, chloroplastic, 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, ... | Authors: | Lee, C.C, Chan, Y.T, Wang, A.H.J. | Deposit date: | 2016-01-31 | Release date: | 2017-04-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z-Farnesyl Diphosphate Synthase Acs Omega, 2, 2017
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5HXT
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![BU of 5hxt by Molmil](/molmil-images/mine/5hxt) | Crystal Structure of Z,Z-Farnesyl Diphosphate Synthase (D71M, E75A and H103Y Mutants) Complexed with IPP and DMSPP | Descriptor: | (2Z,6Z)-farnesyl diphosphate synthase, chloroplastic, 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, ... | Authors: | Lee, C.C, Chan, Y.T, Wang, A.H.J. | Deposit date: | 2016-01-31 | Release date: | 2017-04-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z-Farnesyl Diphosphate Synthase Acs Omega, 2, 2017
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5HXO
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![BU of 5hxo by Molmil](/molmil-images/mine/5hxo) | Crystal Structure of Z,Z-Farnesyl Diphosphate Synthase with D71M, E75A and H103Y Mutants | Descriptor: | (2Z,6Z)-farnesyl diphosphate synthase, chloroplastic | Authors: | Lee, C.C, Chan, Y.T, Wang, A.H.J. | Deposit date: | 2016-01-31 | Release date: | 2017-04-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal Structure and Potential Head-to-Middle Condensation Function of aZ,Z-Farnesyl Diphosphate Synthase. Acs Omega, 2, 2017
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8WZX
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![BU of 8wzx by Molmil](/molmil-images/mine/8wzx) | Cryo-EM structure of the hamster prion 23-144 fibril at pH 3.7 | Descriptor: | Major prion protein | Authors: | Lee, C.-H, Saw, J.-E, Chen, E, Wang, C.-H, Chen, R. | Deposit date: | 2023-11-02 | Release date: | 2024-05-01 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | The Positively Charged Cluster in the N-terminal Disordered Region may Affect Prion Protein Misfolding: Cryo-EM Structure of Hamster PrP(23-144) Fibrils. J.Mol.Biol., 436, 2024
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8TZN
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![BU of 8tzn by Molmil](/molmil-images/mine/8tzn) | |
1EFN
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![BU of 1efn by Molmil](/molmil-images/mine/1efn) | |
5IT1
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![BU of 5it1 by Molmil](/molmil-images/mine/5it1) | Streptomyces peucetius CYP105P2 complex with biphenyl compound | Descriptor: | 4,4'-PROPANE-2,2-DIYLDIPHENOL, PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450 | Authors: | Lee, C.W, Lee, J.H. | Deposit date: | 2016-03-16 | Release date: | 2016-06-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of Cytochrome P450 (CYP105P2) from Streptomyces peucetius and Its Conformational Changes in Response to Substrate Binding Int J Mol Sci, 17, 2016
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4Z1I
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![BU of 4z1i by Molmil](/molmil-images/mine/4z1i) | Crystal structure of human Trap1 with AMPPNP | Descriptor: | Heat shock protein 75 kDa, mitochondrial, MAGNESIUM ION, ... | Authors: | Lee, C, Park, H.K, Ryu, J.H, Kang, B.H. | Deposit date: | 2015-03-27 | Release date: | 2015-04-29 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137, 2015
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4Z1H
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![BU of 4z1h by Molmil](/molmil-images/mine/4z1h) | Crystal structure of human Trap1 with SMTIN-P01 | Descriptor: | 8-[(6-iodo-1,3-benzodioxol-5-yl)sulfanyl]-9-[6-(triphenyl-lambda~5~-phosphanyl)hexyl]-9H-purin-6-amine, Heat shock protein 75 kDa, mitochondrial | Authors: | Lee, C, Park, H.K, Ryu, J.H, Kang, B.H. | Deposit date: | 2015-03-27 | Release date: | 2015-04-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137, 2015
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4Z1F
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![BU of 4z1f by Molmil](/molmil-images/mine/4z1f) | Crystal structure of human Trap1 with PU-H71 | Descriptor: | 8-[(6-IODO-1,3-BENZODIOXOL-5-YL)THIO]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE, Heat shock protein 75 kDa, mitochondrial | Authors: | Lee, C, Park, H.K, Ryu, J.H, Kang, B.H. | Deposit date: | 2015-03-27 | Release date: | 2015-04-22 | Method: | X-RAY DIFFRACTION (2.703 Å) | Cite: | Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137, 2015
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8KB6
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![BU of 8kb6 by Molmil](/molmil-images/mine/8kb6) | Crystal Structure of Canine TNF-alpha | Descriptor: | Tumor necrosis factor | Authors: | Lee, C.C, Wang, A.H.-J. | Deposit date: | 2023-08-03 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.850166 Å) | Cite: | Structure-based development of a canine TNF-alpha-specific antibody using adalimumab as a template. Protein Sci., 33, 2024
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1IZ3
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![BU of 1iz3 by Molmil](/molmil-images/mine/1iz3) | Dimeric structure of FIH (Factor inhibiting HIF) | Descriptor: | FIH, SULFATE ION | Authors: | Lee, C, Kim, S.-J, Jeong, D.-G, Lee, S.M, Ryu, S.-E. | Deposit date: | 2002-09-19 | Release date: | 2003-06-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau. J.Biol.Chem., 278, 2003
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4Z1G
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![BU of 4z1g by Molmil](/molmil-images/mine/4z1g) | Crystal structure of human Trap1 with BIIB-021 | Descriptor: | 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine, Heat shock protein 75 kDa, mitochondrial | Authors: | Lee, C, Park, H.K, Ryu, J.H, Kang, B.H. | Deposit date: | 2015-03-27 | Release date: | 2015-04-22 | Last modified: | 2022-10-05 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137, 2015
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6A4F
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7N3U
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![BU of 7n3u by Molmil](/molmil-images/mine/7n3u) | Crystal structure of human WEE1 kinase domain in complex with ZN-c3 | Descriptor: | 1-[(7R)-7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, Wee1-like protein kinase | Authors: | Lee, C.C. | Deposit date: | 2021-06-02 | Release date: | 2021-09-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer. J.Med.Chem., 64, 2021
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