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PDB: 33 件
6WUQ
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BU of 6wuq by Molmil
Crystal structure of AjiA1 in apo form
分子名称: AjiA1, MAGNESIUM ION, ZINC ION
著者Paiva, F.C.R, Chan, K, Leadlay, P, Dias, M.V.B.
登録日2020-05-05
公開日2020-12-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.003 Å)
主引用文献The crystal structure of AjiA1 reveals a novel structural motion mechanism in the adenylate-forming enzyme family
Acta Crystallogr.,Sect.D, 76, 2020
6UI5
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BU of 6ui5 by Molmil
Tmn9 in complex with cofactor FAD
分子名称: 2-polyprenyl-6-methoxyphenol hydroxylase-like FAD-dependent oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE
著者Paiva, F.C.R, Little, R, Leadlay, P, Dias, M.V.B.
登録日2019-09-30
公開日2020-10-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Tmn9 in complex with cofactor FAD
To Be Published
6NOR
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BU of 6nor by Molmil
Crystal structure of GenD2 from gentamicin A biosynthesis in complex with NAD
分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative NAD dependent dehydrogenase
著者Araujo, N.C, Bury, P.S, Huang, F, Leadlay, P.F, Dias, M.V.B.
登録日2019-01-16
公開日2019-05-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.402 Å)
主引用文献Crystal Structure of GenD2, an NAD-Dependent Oxidoreductase Involved in the Biosynthesis of Gentamicin.
Acs Chem.Biol., 14, 2019
5CXO
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BU of 5cxo by Molmil
Intriguing role of epoxide hydrolase/cyclase-like enzyme SalBIII in pyran ring formation in polyether salinomycin
分子名称: Epoxide hydrolase, HEXAETHYLENE GLYCOL
著者Dias, M.V.B, Luhavaya, H, Williams, S.R, Hong, H, Oliveira, L.G, Leadlay, P.F.
登録日2015-07-29
公開日2015-09-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis.
Angew.Chem.Int.Ed.Engl., 54, 2015
2YJN
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BU of 2yjn by Molmil
Structure of the glycosyltransferase EryCIII from the erythromycin biosynthetic pathway, in complex with its activating partner, EryCII
分子名称: DTDP-4-KETO-6-DEOXY-HEXOSE 3,4-ISOMERASE, GLYCOSYLTRANSFERASE
著者Moncrieffe, M.C, Fernandez, M.J, Spiteller, D, Matsumura, H, Gay, N.J, Luisi, B.F, Leadlay, P.F.
登録日2011-05-20
公開日2011-11-09
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.091 Å)
主引用文献Structure of the Glycosyltransferase Eryciii in Complex with its Activating P450 Homologue Erycii.
J.Mol.Biol., 415, 2012
6NNW
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BU of 6nnw by Molmil
Tsn15 in complex with substrate intermediate
分子名称: (3E)-3-{(1S,4S,4aS,5R,8aS)-1-[(2E,4R,7S,8E,10S)-1,7-dihydroxy-10-{(2R,3S,5R)-5-[(1S)-1-methoxyethyl]-3-methyloxolan-2-yl}-4-methylundeca-2,8-dien-2-yl]-4,5-dimethyloctahydro-3H-2-benzopyran-3-ylidene}oxolane-2,4-dione, PHOSPHATE ION, PROPANOIC ACID, ...
著者Paiva, F.C.R, Little, R, Leadlay, P, Dias, M.V.B.
登録日2019-01-15
公開日2019-10-23
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis
Nat Catal, 2019
6NOI
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BU of 6noi by Molmil
Crystal structure of Tsn15 in apo form
分子名称: DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, TRIETHYLENE GLYCOL, ...
著者Little, R, Paiva, F.C.R, Dias, M.V.B, Leadlay, P.
登録日2019-01-16
公開日2019-10-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis
Nat Catal, 2019
1PZR
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BU of 1pzr by Molmil
Structure of fused docking domains from the erythromycin polyketide synthase (DEBS), a model for the interaction between DEBS2 and DEBS3: the B domain
分子名称: Erythronolide synthase
著者Broadhurst, R.W, Nietlispach, D, Wheatcroft, M.P, Leadlay, P.F, Weissman, K.J.
登録日2003-07-14
公開日2004-02-24
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The structure of docking domains in modular polyketide synthases.
Chem.Biol., 10, 2003
1PZQ
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BU of 1pzq by Molmil
Structure of fused docking domains from the erythromycin polyketide synthase (DEBS), a model for the interaction between DEBS 2 and DEBS 3: The A domain
分子名称: Erythronolide synthase
著者Broadhurst, R.W, Nietlispach, D, Wheatcroft, M.P, Leadlay, P.F, Weissman, K.J.
登録日2003-07-14
公開日2004-02-24
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The structure of docking domains in modular polyketide synthases.
Chem.Biol., 10, 2003
7LLE
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BU of 7lle by Molmil
Crystal structure of GenB4 in complex with PLP
分子名称: C-6' aminotransferase, PYRIDOXAL-5'-PHOSPHATE
著者Bury, P.S, Huang, F, Leadlay, P.F, Dias, M.V.B.
登録日2021-02-03
公開日2021-09-22
実験手法X-RAY DIFFRACTION (1.704 Å)
主引用文献Crystal structure of GenB4 in complex with external aldimine of PLP-sisomicin
Acs Catalysis, 2021
7LM0
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BU of 7lm0 by Molmil
Crystal structure of GenB3 in complex with PLP
分子名称: C-6' aminotransferase, DI(HYDROXYETHYL)ETHER, PYRIDOXAL-5'-PHOSPHATE
著者Bury, P.S, Huang, F, Leadlay, P.F, Dias, M.V.B.
登録日2021-02-04
公開日2021-09-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Crystal structure of GenB4 in complex with external aldimine of PLP-sisomicin
Acs Catalysis, 2021
7LLD
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BU of 7lld by Molmil
Crystal structure of GenB4 in complex with external aldimine of PLP-sisomicin
分子名称: (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,3,4,6-tetradeoxy-6-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-alpha-D-erythro-hexopyranoside, (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,3,4,6-tetradeoxy-6-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-beta-L-threo-hexopyranoside, C-6' aminotransferase, ...
著者Bury, P.S, Huang, F, Leadlay, P.F, Dias, M.V.B.
登録日2021-02-03
公開日2021-09-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structure of GenB4 in complex with external aldimine of PLP-sisomicin
Acs Catalysis, 2021
7RU7
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BU of 7ru7 by Molmil
Crystal structure of BtrK, a decarboxylase involved in butirosin biosynthesis
分子名称: DI(HYDROXYETHYL)ETHER, L-glutamyl-[BtrI acyl-carrier protein] decarboxylase, PYRIDOXAL-5'-PHOSPHATE
著者Arenas, L.A.R, Paiva, F.C.R, Huang, F, Leadlay, P, Dias, M.V.B.
登録日2021-08-16
公開日2022-08-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structure of BtrK, a decarboxylase involved in the (S)-4-amino-2-hydroxybutyrate (AHBA) formation during butirosin biosynthesis
J.Mol.Struct., 1267, 2022
7SFP
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BU of 7sfp by Molmil
Crystal structure of OssO, a spirocyclase involved in the biosynthesis of ossamycin
分子名称: Spirocyclase
著者Bilyk, O, Leadlay, P.F, Dias, M.V.B.
登録日2021-10-04
公開日2022-08-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis.
J.Am.Chem.Soc., 144, 2022
7SFN
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BU of 7sfn by Molmil
Crystal structure of OlmO, a spirocyclase involved in the biosynthesis of oligomycin
分子名称: D-MALATE, OlmO - oligomycin spirocyclase
著者Bilyk, O, Leadlay, P.F, Dias, M.V.B.
登録日2021-10-04
公開日2022-08-17
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis.
J.Am.Chem.Soc., 144, 2022
5U4T
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BU of 5u4t by Molmil
Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IODIDE ION, Putative gentamicin methyltransferase, ...
著者Bury, P, Huang, F, Leadlay, P, Dias, M.V.B.
登録日2016-12-06
公開日2017-11-01
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.086 Å)
主引用文献Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis.
ACS Chem. Biol., 12, 2017
5U18
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BU of 5u18 by Molmil
Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with the Geneticin
分子名称: GENETICIN, N-3'' methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Bury, P, Huang, F, Leadlay, P, Dias, M.V.B.
登録日2016-11-28
公開日2017-11-01
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.195 Å)
主引用文献Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis.
ACS Chem. Biol., 12, 2017
5U1E
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BU of 5u1e by Molmil
Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with the kanamycin B
分子名称: (1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL 2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE, Putative gentamicin methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Bury, P, Huang, F, Leadlay, P, Dias, M.V.B.
登録日2016-11-28
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.213 Å)
主引用文献Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis.
ACS Chem. Biol., 12, 2017
5U19
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BU of 5u19 by Molmil
Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with (1R,2S,3S,4R,6R)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
分子名称: (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside, MAGNESIUM ION, Putative gentamicin methyltransferase, ...
著者Bury, P, Huang, F, Leadlay, P, Dias, M.V.B.
登録日2016-11-28
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.902 Å)
主引用文献Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis.
ACS Chem. Biol., 12, 2017
5U1I
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BU of 5u1i by Molmil
Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with the methylated Kanamycin B
分子名称: (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-3-(methylamino)-alpha-D-glucopyranosyl]oxy}-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, CALCIUM ION, Putative gentamicin methyltransferase, ...
著者Bury, P, Huang, F, Leadlay, P, Dias, M.V.B.
登録日2016-11-28
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.932 Å)
主引用文献Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis.
ACS Chem. Biol., 12, 2017
5U0T
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BU of 5u0t by Molmil
Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-3-(methylamino)-alpha-D-glucopyranosyl]oxy}-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
分子名称: (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-3-(methylamino)-alpha-D-glucopyranosyl]oxy}-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, MAGNESIUM ION, Putative gentamicin methyltransferase, ...
著者Bury, P, Huang, F, Leadlay, P, Dias, M.V.B.
登録日2016-11-27
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.109 Å)
主引用文献Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis.
ACS Chem. Biol., 12, 2017
5TYQ
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BU of 5tyq by Molmil
Crystal structure of a holoenzyme methyltransferase involved in the biosynthesis of gentamicin
分子名称: MAGNESIUM ION, Putative gentamicin methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Bury, P, Huang, F, Leadlay, P, Dias, M.V.B.
登録日2016-11-21
公開日2017-11-01
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.163 Å)
主引用文献Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis.
ACS Chem. Biol., 12, 2017
5U0N
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BU of 5u0n by Molmil
Crystal structure of a methyltransferase in complex with the substrate involved in the biosynthesis of gentamicin
分子名称: (1R,2S,3S,4R,6S)-4,6-diamino-3-[(3-amino-3-deoxy-alpha-D-xylopyranosyl)oxy]-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside, MAGNESIUM ION, Putative gentamicin methyltransferase, ...
著者Bury, P, Huang, F, Li, S, Sun, Y, Leadlay, P, Dias, M.V.B.
登録日2016-11-25
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.115 Å)
主引用文献Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis.
ACS Chem. Biol., 12, 2017
3KVZ
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BU of 3kvz by Molmil
Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA thiesterase FlK - wild type FlK in complex with FAcCPan
分子名称: (2R)-N-{3-[(5-fluoro-4-oxopentyl)amino]-3-oxopropyl}-2,4-dihydroxy-3,3-dimethylbutanamide, Fluoroacetyl-CoA thioesterase FlK
著者Dias, M.V.B, Huang, F, Chirgadze, D.Y, Tosin, M, Spiteller, D, Valentine, E.F, Leadlay, P.F, Spencer, J.B, Blundell, T.L.
登録日2009-11-30
公開日2010-04-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.
J.Biol.Chem., 285, 2010
3KW1
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BU of 3kw1 by Molmil
Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA FlK - Wild type FlK in complex with FAcOPan
分子名称: 2-({N-[(2S)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanyl}amino)ethyl fluoroacetate, Fluoroacetyl-CoA thioesterase
著者Dias, M.V.B, Huang, F, Chirgadze, D.Y, Tosin, M, Spiteller, D, Valentine, E.F, Leadlay, P.F, Spencer, J.B, Blundell, T.L.
登録日2009-11-30
公開日2010-04-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.
J.Biol.Chem., 285, 2010

 

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