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PDB: 10 件

8RXB
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BU of 8rxb by Molmil
Human UPF1 CH domain in complex with SMG6 peptide
分子名称: Regulator of nonsense transcripts 1, Telomerase-binding protein EST1A, ZINC ION
著者Langer, L, Basquin, J, Conti, E.
登録日2024-02-06
公開日2024-05-15
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2.
Nucleic Acids Res., 52, 2024
6Z3R
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BU of 6z3r by Molmil
Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ
分子名称: ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ...
著者Langer, L.M, Gat, Y, Conti, E.
登録日2020-05-21
公開日2020-06-24
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity.
Elife, 9, 2020
7PW9
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BU of 7pw9 by Molmil
Human SMG1-9 kinase complex bound to AMPPNP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ...
著者Langer, L.M, Conti, E.
登録日2021-10-06
公開日2021-12-01
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
7PW8
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BU of 7pw8 by Molmil
Human SMG1-8-9 kinase complex bound to AMPPNP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ...
著者Langer, L.M, Conti, E.
登録日2021-10-06
公開日2021-12-01
実験手法ELECTRON MICROSCOPY (2.82 Å)
主引用文献Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
7PW4
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BU of 7pw4 by Molmil
Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor
分子名称: 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Langer, L.M, Conti, E.
登録日2021-10-06
公開日2021-12-01
実験手法ELECTRON MICROSCOPY (3.27 Å)
主引用文献Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
7PW5
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BU of 7pw5 by Molmil
Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C-terminus, bound to a SMG1 inhibitor
分子名称: 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Langer, L.M, Conti, E.
登録日2021-10-06
公開日2021-12-01
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
7PW6
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BU of 7pw6 by Molmil
Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body
分子名称: 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, INOSITOL HEXAKISPHOSPHATE, Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1
著者Langer, L.M, Conti, E.
登録日2021-10-06
公開日2021-12-01
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
7PW7
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BU of 7pw7 by Molmil
Human SMG1-9 kinase complex bound to a SMG1 inhibitor
分子名称: 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Langer, L.M, Conti, E.
登録日2021-10-06
公開日2021-12-01
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
6RO1
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BU of 6ro1 by Molmil
X-ray crystal structure of the MTR4 NVL complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Exosome RNA helicase MTR4, ...
著者Lingaraju, M, Langer, L.M, Basquin, J, Falk, S, Conti, E.
登録日2019-05-10
公開日2019-07-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.07 Å)
主引用文献The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
Nat Commun, 10, 2019
4IYE
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BU of 4iye by Molmil
Crystal structure of AdTx1 (rho-Da1a) from eastern green mamba (Dendroaspis angusticeps)
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Toxin AdTx1
著者Stura, E.A, Vera, L, Maiga, A.A, Marchetti, C, Lorphelin, A, Bellanger, L, Servant, D, Gilles, N.
登録日2013-01-28
公開日2013-05-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.951 Å)
主引用文献Crystallization of recombinant green mamba rho-Da1a toxin during a lyophilization procedure and its structure determination.
Acta Crystallogr.,Sect.F, 69, 2013

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件を2024-07-10に公開中

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