1K9E
| Crystal structure of a mutated family-67 alpha-D-glucuronidase (E285N) from Bacillus stearothermophilus T-6, complexed with 4-O-methyl-glucuronic acid | Descriptor: | 4-O-methyl-alpha-D-glucopyranuronic acid, GLYCEROL, alpha-D-glucuronidase | Authors: | Golan, G, Shallom, D, Teplitsky, A, Zaide, G, Shulami, S, Baasov, T, Stojanoff, V, Thompson, A, Shoham, Y, Shoham, G. | Deposit date: | 2001-10-29 | Release date: | 2002-10-29 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal Structures of Geobacillus stearothermophilus {alpha}-Glucuronidase Complexed with Its Substrate and Products: MECHANISTIC IMPLICATIONS. J.Biol.Chem., 279, 2004
|
|
1KQE
| Solution structure of a linked shortened gramicidin A in benzene/acetone 10:1 | Descriptor: | MINI-GRAMICIDIN A | Authors: | Arndt, H.D, Bockelmann, D, Knoll, A, Lamberth, S, Griesinger, C, Koert, U. | Deposit date: | 2002-01-05 | Release date: | 2002-11-27 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Cation Control in Functional Helical Programming: Structures of a D,L-Peptide Ion Channel Angew.Chem.Int.Ed.Engl., 41, 2002
|
|
1L8N
| The 1.5A crystal structure of alpha-D-glucuronidase from Bacillus stearothermophilus T-1, complexed with 4-O-methyl-glucuronic acid and xylotriose | Descriptor: | 4-O-methyl-beta-D-glucopyranuronic acid, ALPHA-D-GLUCURONIDASE, GLYCEROL, ... | Authors: | Golan, G, Shallom, D, Teplitsky, A, Zaide, G, Shulami, S, Baasov, T, Stojanoff, V, Thompson, A, Shoham, Y, Shoham, G. | Deposit date: | 2002-03-21 | Release date: | 2003-03-21 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal Structures of Geobacillus stearothermophilus {alpha}-Glucuronidase Complexed with Its Substrate and Products: MECHANISTIC IMPLICATIONS. J.Biol.Chem., 279, 2004
|
|
1K8L
| XBY6: An analog of CK14 containing 6 dithiophosphate groups | Descriptor: | FIRST STRAND OF CK14 DNA DUPLEX, SECOND STRAND OF CK14 DNA DUPLEX | Authors: | Volk, D.E, Yang, X, Fennewald, S.M, King, D.J, Bassett, S.E, Venkitachalam, S, Herzog, N, Luxon, B.A, Gorenstein, D.G. | Deposit date: | 2001-10-24 | Release date: | 2003-04-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure and design of dithiophosphate backbone aptamers targeting transcription factor NF-kappaB Bioorg.Chem., 30, 2002
|
|
1YXR
| NMR Structure of VPS4A MIT Domain | Descriptor: | vacuolar protein sorting factor 4A | Authors: | Scott, J.A, Gaspar, J, Stuchell, M, Alam, S, Skalicky, J, Sundquist, W.I. | Deposit date: | 2005-02-22 | Release date: | 2005-09-06 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR Structure of VPS4A MIT Domain To be Published
|
|
6JOE
| Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor | Descriptor: | PHOSPHATE ION, S-ADENOSYLMETHIONINE, tRNA (guanine-N(1)-)-methyltransferase, ... | Authors: | Zhong, W, Pasunooti, K.K, Balamkundu, S, Wong, Y.W, Nah, Q, Liu, C.F, Lescar, J, Dedon, P.C. | Deposit date: | 2019-03-20 | Release date: | 2019-09-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism. J.Med.Chem., 62, 2019
|
|
6JOF
| Crystal structure of TrmD from Mycobacterium tuberculosis in complex with active-site inhibitor | Descriptor: | tRNA (guanine-N(1)-)-methyltransferase, ~{N}-[[4-[(4-azanylpiperidin-1-yl)methyl]phenyl]methyl]-4-oxidanylidene-3~{H}-thieno[2,3-d]pyrimidine-5-carboxamide | Authors: | Zhong, W, Pasunooti, K.K, Balamkundu, S, Wong, Y.W, Nah, Q, Liu, C.F, Lescar, J, Dedon, P.C. | Deposit date: | 2019-03-20 | Release date: | 2019-09-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism. J.Med.Chem., 62, 2019
|
|
7CJG
| Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase | Descriptor: | 5,6-DIMETHYLBENZIMIDAZOLE, GLYCEROL, Glutamine cyclotransferase-related protein, ... | Authors: | Ruiz-Carrillo, D, Lamers, S, Feng, Q, Yu, S, Sun, B, Jiang, J, Lukman, M. | Deposit date: | 2020-07-10 | Release date: | 2021-05-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase. Biol.Chem., 402, 2021
|
|
7CJE
| Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase | Descriptor: | GLYCEROL, Glutamine cyclotransferase-related protein, MAGNESIUM ION, ... | Authors: | Ruiz-Carrillo, D, Lamers, S, Feng, Q, Yu, S, Sun, B, Jiang, J, Lukman, M. | Deposit date: | 2020-07-10 | Release date: | 2021-05-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.950007 Å) | Cite: | Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase. Biol.Chem., 402, 2021
|
|
2K2D
| Solution NMR structure of C-terminal domain of human pirh2. Northeast Structural Genomics Consortium (NESG) target HT2C | Descriptor: | RING finger and CHY zinc finger domain-containing protein 1, ZINC ION | Authors: | Lemak, A, Sheng, Y, Karra, M, Srisailam, S, Laister, R.C, Duan, S, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-03-31 | Release date: | 2008-04-15 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Molecular basis of Pirh2-mediated p53 ubiquitylation. Nat.Struct.Mol.Biol., 15, 2008
|
|
2K2C
| Solution NMR structure of N-terminal domain of human pirh2. Northeast Structural Genomics Consortium (NESG) target HT2A | Descriptor: | RING finger and CHY zinc finger domain-containing protein 1, ZINC ION | Authors: | Wu, B, Lemak, A, Sheng, Y, Karra, M, Srisailam, S, Sunnerhagen, M, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-03-31 | Release date: | 2008-04-15 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Molecular basis of Pirh2-mediated p53 ubiquitylation. Nat.Struct.Mol.Biol., 15, 2008
|
|
8PTQ
| COMPLEX CRYSTAL STRUCTURE OF MUTANT HUMAN MONOGLYCERIDE LIPASE WITH COMPOUND 5l | Descriptor: | 1,2-ETHANEDIOL, Monoglyceride lipase, methyl 4-[(2~{S},3~{R})-3-(4-fluorophenyl)-1-(1-methanoylpiperidin-4-yl)-4-oxidanylidene-azetidin-2-yl]benzoate | Authors: | Butini, S, Grether, U, Benz, J, Leibrock, L, Maramai, S, Papa, A, Carullo, G, Federico, S, Grillo, A, Di Guglielmo, B, Lamponi, S, Gemma, S, Campiani, G. | Deposit date: | 2023-07-14 | Release date: | 2024-01-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization. J.Med.Chem., 67, 2024
|
|
8PTC
| COMPLEX CRYSTAL STRUCTURE OF MUTANT HUMAN MONOGLYCERIDE LIPASE WITH COMPOUND 5d | Descriptor: | 1,2-ETHANEDIOL, 4-[(3~{R},4~{S})-2-oxidanylidene-3,4-diphenyl-azetidin-1-yl]piperidine-1-carbaldehyde, Monoglyceride lipase | Authors: | Butini, S, Benz, J, Grether, U, Leibrock, L, Papa, A, Maramai, S, Carullo, G, Federico, S, Grillo, A, Di Guglielmo, B, Lamponi, S, Gemma, S, Campiani, G. | Deposit date: | 2023-07-14 | Release date: | 2024-01-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization. J.Med.Chem., 67, 2024
|
|
8PTR
| COMPLEX CRYSTAL STRUCTURE OF MUTANT HUMAN MONOGLYCERIDE LIPASE WITH COMPOUND 5r | Descriptor: | (3~{R},4~{S})-4-(1,3-benzodioxol-5-yl)-1-[1-(benzotriazol-1-ylcarbonyl)piperidin-4-yl]-3-(3-fluorophenyl)azetidin-2-one, 1,2-ETHANEDIOL, Monoglyceride lipase | Authors: | Butini, S, Benz, J, Grether, U, Leibrock, L, Papa, A, Maramai, S, Carullo, G, Federico, S, Grillo, A, Di Guglielmo, B, Lamponi, S, Gemma, S, Campiani, G. | Deposit date: | 2023-07-14 | Release date: | 2024-01-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization. J.Med.Chem., 67, 2024
|
|
2K7I
| Solution NMR structure of protein ATU0232 from AGROBACTERIUM TUMEFACIENS. Northeast Structural Genomics Consortium (NESG) target AtT3. Ontario Center for Structural Proteomics target ATC0223. | Descriptor: | UPF0339 protein Atu0232 | Authors: | Lemak, A, Srisailam, S, Yee, A, Bansal, S, Semesi, A, Prestegard, J, Montelione, G.T, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-08-12 | Release date: | 2008-10-07 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of protein ATU0232 from Agrobacterium Tumefaciens. To be Published
|
|
2JXX
| NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627 | Descriptor: | NFATC2-interacting protein | Authors: | Doherty, R.S, Dhe-Paganon, S, Fares, C, Lemak, A, Butler, C, Srisailam, S, Karra, M, Yee, A, Edwards, A.M, Weigelt, J, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC) | Deposit date: | 2007-11-30 | Release date: | 2007-12-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of Ubiquitin-like domain of NFATC2IP. TO BE PUBLISHED
|
|
6IAR
| Tricyclic indazoles a novel class of selective estrogen receptor degrader antagonists | Descriptor: | 3-[4-[(6~{R})-7-(2-methylpropyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]phenyl]propanoic acid, Estrogen receptor | Authors: | Scott, J.S, Bailey, A, Buttar, D, Carbajo, R.J, Curwen, J, Davies, R.D.M, Degorce, S.L, Donald, C, Gangl, E, Greenwood, R, Groombridge, S.D, Johnson, T, Lamont, S, Lawson, M, Lister, A, Morrow, C, Moss, T, Pink, J.H, Polanski, R. | Deposit date: | 2018-11-27 | Release date: | 2019-01-23 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists. J.Med.Chem., 62, 2019
|
|
6AT9
| Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-A*0101 | Descriptor: | ALK, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Toor, J, Rao, A.A, Salama, S, Tripathi, S, Haussler, D, Sgourakis, N.G. | Deposit date: | 2017-08-28 | Release date: | 2018-03-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9503 Å) | Cite: | A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations. Front Immunol, 9, 2018
|
|
2JN4
| Solution NMR Structure of Protein RP4601 from Rhodopseudomonas palustris. Northeast Structural Genomics Consortium Target RpT2; Ontario Center for Structural Proteomics Target RP4601. | Descriptor: | Hypothetical protein fixU, nifT | Authors: | Lemak, A, Srisailam, S, Yee, A, Karra, M.D, Lukin, J.A, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-12-22 | Release date: | 2007-01-23 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution structure of a hypothetical protein RP4601 from Rhodopseudomonas palustris To be Published
|
|
2JTV
| Solution Structure of protein RPA3401, Northeast Structural Genomics Consortium Target RpT7, Ontario Center for Structural Proteomics Target RP3384 | Descriptor: | Protein of Unknown Function | Authors: | Ignatchenko, A, Gutmanas, A, Lemak, A, Yee, A, Karra, M, Srisailam, S, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-08-07 | Release date: | 2007-10-09 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution Structure of protein RPA3401, Northeast Structural Genomics Consortium Target RpT7, Ontario Center for Structural Proteomics Target RP3384 TO BE PUBLISHED
|
|
2JOQ
| Solution Structure of Protein HP0495 from H. pylori; Northeast structural genomics consortium target PT2; Ontario Centre for Structural Proteomics target HP0488 | Descriptor: | Hypothetical protein HP_0495 | Authors: | Gutmanas, A, Lemak, A, Yee, A, Karra, M, Srisailam, S, Semesi, A, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Ontario Centre for Structural Proteomics (OCSP) | Deposit date: | 2007-03-19 | Release date: | 2007-04-03 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution Structure of Protein HP0495 from H. pylori To be Published
|
|
6TOV
| Crystal Structure of Teicoplanin Aglycone | Descriptor: | DIMETHYL SULFOXIDE, Teicoplanin Aglycone | Authors: | Belviso, B.D, Carrozzini, B, Caliandro, R, Altomare, C.D, Bolognino, I, Cellamare, S. | Deposit date: | 2019-12-12 | Release date: | 2020-01-15 | Last modified: | 2022-01-19 | Method: | X-RAY DIFFRACTION (0.767 Å) | Cite: | Enantiomeric Separation and Molecular Modelling of Bioactive 4-Aryl-3,4-dihydropyrimidin-2(1H)-one Ester Derivatives on Teicoplanin-Based Chiral Stationary Phase Separations, 2022
|
|
5H37
| Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C10 IgG heavy chain variable region, C10 IgG light chain variable region, ... | Authors: | Zhang, S, Kostyuchenko, V, Ng, T.-S, Lim, X.-N, Ooi, J.S.G, Lambert, S, Tan, T.Y, Widman, D, Shi, J, Baric, R.S, Lok, S.-M. | Deposit date: | 2016-10-20 | Release date: | 2016-11-30 | Last modified: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Neutralization mechanism of a highly potent antibody against Zika virus Nat Commun, 7, 2016
|
|
2JLH
| Crystal Structure of the Cytoplasmic domain of Yersinia Pestis YscU N263A mutant | Descriptor: | PENTAETHYLENE GLYCOL, YOP PROTEINS TRANSLOCATION PROTEIN U | Authors: | Lountos, G.T, Austin, B.P, Nallamsetty, S, Waugh, D.S. | Deposit date: | 2008-09-09 | Release date: | 2009-02-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Atomic Resolution Structure of the Cytoplasmic Domain of Yersinia Pestis Yscu, a Regulatory Switch Involved in Type III Secretion. Protein Sci., 18, 2009
|
|
2HG6
| Solution NMR Structure of Protein PA1123 from Pseudomonas aeruginosa. Northeast Structural Genomics Consortium Target PaT4; Ontario Centre for Structural Proteomics Target PA1123. | Descriptor: | Hypothetical protein | Authors: | Lemak, A, Srisailam, S, Yee, A, Lukin, J.A, Orekhov, V.Y, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-06-26 | Release date: | 2006-07-25 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution Structure of a hypothetical protein from Pseudomonas aeruginosa (Northeast Structural Genomics Consortium Target: PaT4; Ontario Centre for Structural Proteomics Target: PA1123) To be Published
|
|