1UUX
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![BU of 1uux by Molmil](/molmil-images/mine/1uux) | Structure of a molybdopterin-bound cnx1g domain links molybdenum and copper metabolism | Descriptor: | COPPER (I) ION, FORMIC ACID, IMIDAZOLE, ... | Authors: | Kuper, J, Llamas, A, Hecht, H.J, Mendel, R.R, Schwarz, G. | Deposit date: | 2004-01-12 | Release date: | 2004-08-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of a Molybdopterin-Bound Cnx1G Domain Links Molybdenum and Copper Metabolism Nature, 430, 2004
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1UUY
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![BU of 1uuy by Molmil](/molmil-images/mine/1uuy) | Structure of a molybdopterin-bound cnx1g domain links molybdenum and copper metabolism | Descriptor: | ADENOSINE MONOPHOSPHATE, COPPER (I) ION, FORMIC ACID, ... | Authors: | Kuper, J, Llamas, A, Hecht, H.J, Mendel, R.R, Schwarz, G. | Deposit date: | 2004-01-12 | Release date: | 2004-08-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure of a Molybdopterin-Bound Cnx1G Domain Links Molybdenum and Copper Metabolism Nature, 430, 2004
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2A20
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![BU of 2a20 by Molmil](/molmil-images/mine/2a20) | Solution structure of Rim2 Zinc Finger Domain | Descriptor: | Regulating synaptic membrane exocytosis protein 2, ZINC ION | Authors: | Dulubova, I, Lou, X, Lu, J, Huryeva, I, Alam, A, Schneggenburger, R, Sudhof, T.C, Rizo, J. | Deposit date: | 2005-06-21 | Release date: | 2005-08-16 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? Embo J., 24, 2005
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2B2N
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![BU of 2b2n by Molmil](/molmil-images/mine/2b2n) | Structure of transcription-repair coupling factor | Descriptor: | O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL, SODIUM ION, SULFATE ION, ... | Authors: | Assenmacher, N, Wenig, K, Lammens, A, Hopfner, K.-P. | Deposit date: | 2005-09-19 | Release date: | 2006-01-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Basis for Transcription-coupled Repair: the N Terminus of Mfd Resembles UvrB with Degenerate ATPase Motifs J.Mol.Biol., 355, 2006
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8B5T
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![BU of 8b5t by Molmil](/molmil-images/mine/8b5t) | |
7UF5
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![BU of 7uf5 by Molmil](/molmil-images/mine/7uf5) | RibB from Vibrio cholera bound with intermediate 2 in the reaction cycle and the products DHBP and formate | Descriptor: | (2R)-2-(dihydroxymethyl)-2-hydroxy-3-oxobutyl dihydrogen phosphate, (2R)-2-hydroxy-3-oxobutyl dihydrogen phosphate, 3,4-dihydroxy-2-butanone 4-phosphate synthase, ... | Authors: | Kenjic, N, Meneely, K.M, Lamb, A.L. | Deposit date: | 2022-03-22 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis. J.Am.Chem.Soc., 144, 2022
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7UEZ
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![BU of 7uez by Molmil](/molmil-images/mine/7uez) | Apo RibB from Vibrio cholera | Descriptor: | 3,4-dihydroxy-2-butanone 4-phosphate synthase | Authors: | Kenjic, N, Meneely, K.M, Lamb, A.L. | Deposit date: | 2022-03-22 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis. J.Am.Chem.Soc., 144, 2022
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7UF0
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![BU of 7uf0 by Molmil](/molmil-images/mine/7uf0) | RibB from Vibrio cholera bound with D-ribulose-5-phosphate (D-Ru5P) | Descriptor: | 3,4-dihydroxy-2-butanone 4-phosphate synthase, RIBULOSE-5-PHOSPHATE | Authors: | Kenjic, N, Meneely, K.M, Lamb, A.L. | Deposit date: | 2022-03-22 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis. J.Am.Chem.Soc., 144, 2022
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7UF1
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![BU of 7uf1 by Molmil](/molmil-images/mine/7uf1) | RibB from Vibrio cholera bound with D-Ribose-5-phosphate (D-R5P) and manganese | Descriptor: | 3,4-dihydroxy-2-butanone 4-phosphate synthase, MANGANESE (II) ION, RIBOSE-5-PHOSPHATE | Authors: | Kenjic, N, Meneely, K.M, Lamb, A.L. | Deposit date: | 2022-03-22 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis. J.Am.Chem.Soc., 144, 2022
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7UF2
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![BU of 7uf2 by Molmil](/molmil-images/mine/7uf2) | RibB from Vibrio cholera bound with D-xylulose-5-phosphate (D-Xy5P) and manganese | Descriptor: | 1,2-ETHANEDIOL, 3,4-dihydroxy-2-butanone 4-phosphate synthase, 5-O-phosphono-D-xylulose, ... | Authors: | Kenjic, N, Meneely, K.M, Lamb, A.L. | Deposit date: | 2022-03-22 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis. J.Am.Chem.Soc., 144, 2022
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7UF4
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![BU of 7uf4 by Molmil](/molmil-images/mine/7uf4) | RibB from Vibrio cholera bound with intermediate 1 of the reaction cycle and D-ribulose-5-phosphate (D-Ru5P) | Descriptor: | (2R)-2-hydroxy-3,4-dioxopentyl dihydrogen phosphate, 1,2-ETHANEDIOL, 3,4-dihydroxy-2-butanone 4-phosphate synthase, ... | Authors: | Kenjic, N, Meneely, K.M, Lamb, A.L. | Deposit date: | 2022-03-22 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis. J.Am.Chem.Soc., 144, 2022
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7UF3
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![BU of 7uf3 by Molmil](/molmil-images/mine/7uf3) | RibB from Vibrio cholera bound with L-xylulose-5-phosphate (L-Xy5P) and manganese | Descriptor: | 3,4-dihydroxy-2-butanone 4-phosphate synthase, L-xylulose-5-phosphate, MANGANESE (II) ION | Authors: | Kenjic, N, Meneely, K.M, Lamb, A.L. | Deposit date: | 2022-03-22 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis. J.Am.Chem.Soc., 144, 2022
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8BM3
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![BU of 8bm3 by Molmil](/molmil-images/mine/8bm3) | H207A mutant of E. coli PgpB, a PAP2 type phosphatidyl glycerol phosphate and C55-PP phosphatase, in complex with farnesyl pyrophosphate | Descriptor: | FARNESYL DIPHOSPHATE, Phosphatidylglycerophosphatase B | Authors: | Delbrassine, F, El Ghachi, M, Lambion, A, Herman, R, Kerff, F. | Deposit date: | 2022-11-10 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | H207A mutant of E. coli PgpB, a PAP2 type phosphatidyl glycerol phosphate and C55-PP phosphatase, in complex with farnesyl pyrophosphate To Be Published
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7UEH
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![BU of 7ueh by Molmil](/molmil-images/mine/7ueh) | Pyruvate kinase from Zymomonas mobilis | Descriptor: | GLYCEROL, PHOSPHATE ION, Pyruvate kinase | Authors: | McFarlane, J.S, Meneely, K.M, Lamb, A.L. | Deposit date: | 2022-03-21 | Release date: | 2023-03-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The 2.4 angstrom structure of Zymomonas mobilis pyruvate kinase: Implications for stability and regulation. Arch.Biochem.Biophys., 744, 2023
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4J18
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![BU of 4j18 by Molmil](/molmil-images/mine/4j18) | Crystal structure of H191L mutant of UDP-glucose pyrophosphorylase from Leishmania major | Descriptor: | UDP-glucose pyrophosphorylase | Authors: | Fuehring, J.I, Routier, F.H, Lamerz, A.-C, Baruch, P, Gerardy-Schahn, R, Fedorov, R. | Deposit date: | 2013-02-01 | Release date: | 2014-01-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Catalytic Mechanism and Allosteric Regulation of UDP-Glucose Pyrophosphorylase from Leishmania major ACS CATALYSIS, 3, 2013
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2QFD
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![BU of 2qfd by Molmil](/molmil-images/mine/2qfd) | Crystal structure of the regulatory domain of human RIG-I with bound Hg | Descriptor: | MERCURY (II) ION, Probable ATP-dependent RNA helicase DDX58 | Authors: | Cui, S, Lammens, A, Lammens, K, Hopfner, K.P. | Deposit date: | 2007-06-27 | Release date: | 2008-02-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I. Mol.Cell, 29, 2008
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2QFB
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![BU of 2qfb by Molmil](/molmil-images/mine/2qfb) | Crystal structure of the regulatory domain of human RIG-I with bound Zn | Descriptor: | Probable ATP-dependent RNA helicase DDX58, ZINC ION | Authors: | Cui, S, Lammens, A, Lammens, K, Hopfner, K.P. | Deposit date: | 2007-06-27 | Release date: | 2008-02-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I. Mol.Cell, 29, 2008
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2J24
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![BU of 2j24 by Molmil](/molmil-images/mine/2j24) | The functional role of the conserved active site proline of triosephosphate isomerase | Descriptor: | TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL | Authors: | Casteleijn, M.G, Alahuhta, M, Groebel, K, El-Sayed, I, Augustyns, K, Lambeir, A.M, Neubauer, P, Wierenga, R.K. | Deposit date: | 2006-08-16 | Release date: | 2007-01-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Functional Role of the Conserved Active Site Proline of Triosephosphate Isomerase. Biochemistry, 45, 2006
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2J27
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![BU of 2j27 by Molmil](/molmil-images/mine/2j27) | The functional role of the conserved active site proline of triosephosphate isomerase. | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, SULFATE ION, TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL | Authors: | Casteleijn, M.G, Alahuhta, M, Groebel, K, El-Sayed, I, Augustyns, K, Lambeir, A.M, Neubauer, P, Wierenga, R.K. | Deposit date: | 2006-08-16 | Release date: | 2007-01-02 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Functional Role of the Conserved Active Site Proline of Triosephosphate Isomerase. Biochemistry, 45, 2006
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6TPE
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![BU of 6tpe by Molmil](/molmil-images/mine/6tpe) | Fragment-based discovery of pyrazolopyridones as JAK1 inhibitors with excellent subtype selectivity | Descriptor: | 2-[4-(3-methyl-6-oxidanylidene-1,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]ethanenitrile, Tyrosine-protein kinase JAK1 | Authors: | Hansen, B.B, Jepsen, T.H, Larsen, M, Sindet, R, Vifian, T, Burhardt, M.N, Larsen, J, Seitzberg, J.G, Carnerup, M.A, Jerre, A, Molck, C, Rai, S, Nasipireddy, V.R, Jestel, A, Lammens, A, Ritzen, A. | Deposit date: | 2019-12-13 | Release date: | 2020-06-10 | Last modified: | 2020-07-22 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Fragment-Based Discovery of Pyrazolopyridones as JAK1 Inhibitors with Excellent Subtype Selectivity. J.Med.Chem., 63, 2020
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8B5U
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![BU of 8b5u by Molmil](/molmil-images/mine/8b5u) | |
6S7P
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![BU of 6s7p by Molmil](/molmil-images/mine/6s7p) | Nucleotide bound ABCB4 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, MAGNESIUM ION, ... | Authors: | Olsen, J.A, Alam, A, Kowal, J, Stieger, B, Locher, K.P. | Deposit date: | 2019-07-05 | Release date: | 2019-12-25 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of the human lipid exporter ABCB4 in a lipid environment. Nat.Struct.Mol.Biol., 27, 2020
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7L5O
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![BU of 7l5o by Molmil](/molmil-images/mine/7l5o) | Crystal structure of the noncovalently bonded complex of rilzabrutinib with BTK | Descriptor: | (2E)-2-{(3R)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Bradshaw, J.M, Brameld, K.A, Mrosek, M, Lammens, A, Blaesse, M. | Deposit date: | 2020-12-22 | Release date: | 2022-06-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.21 Å) | Cite: | The Discovery Rilzabrutinib (PRN1008): A Reversible Covalent BTK Inhibitor for Immune Mediated Diseases To Be Published
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6U4S
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![BU of 6u4s by Molmil](/molmil-images/mine/6u4s) | wild type cysteine dioxygenase | Descriptor: | Cysteine dioxygenase type 1, FE (III) ION | Authors: | Meneely, K.M, Chilton, A.S, Forbes, D.L, Ellis, H.R, Lamb, A.L. | Deposit date: | 2019-08-26 | Release date: | 2020-07-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | The 3-His Metal Coordination Site Promotes the Coupling of Oxygen Activation to Cysteine Oxidation in Cysteine Dioxygenase. Biochemistry, 59, 2020
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6U4L
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![BU of 6u4l by Molmil](/molmil-images/mine/6u4l) | cysteine dioxygenase variant - C93E | Descriptor: | ACETATE ION, Cysteine dioxygenase type 1, FE (III) ION | Authors: | Meneely, K.M, Chilton, A.S, Forbes, D.L, Ellis, H.R, Lamb, A.L. | Deposit date: | 2019-08-26 | Release date: | 2020-07-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.911 Å) | Cite: | The 3-His Metal Coordination Site Promotes the Coupling of Oxygen Activation to Cysteine Oxidation in Cysteine Dioxygenase. Biochemistry, 59, 2020
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